In the article the results of an empirical research of the professional focus of psychological well-being of the personnel of the State Border Guard Service of Ukraine are represented. The author's position on the content of the phenomenon of psychological well-being of the border guards is to study it as a holistic global subjective reflexive experiencing of the border guards of the positivity and significance of their own «I-existence» as a whole and through the prism of their life in the environment of professional activity, representing an integrated assessment of professional life, positive affections in relation to the work performed, the organizational environment and, consequently, life in general, and, secondly, as a subjective experiencing-living of situational experience in the context of professional activity as a harmonious combination of efforts to accomplish work, achieved goals and profits (rewards, recognition, prospects, etc.). The peculiarities of manifestation of indicators of professional focus of psychological well-being, which promote the growth of psychological well-being of border guards (professional self-acceptance, satisfaction professional achievements, professional development, availability of professional goals, satisfaction level of competence, positive relations in the community, autonomy in professional work, professional growth, subjective assessment and experience of professional demand, the attitude of other people (colleagues, leadership, etc.), self-assessment, self-rating of personal growth, professional credibility, evaluation of professional activities, serving as an opportunity to further the work of the ideals and values self-efficacy, belonging to a professional community satisfaction with the implementation of professional capacity, professional competence, self in the profession, self-esteem, a conscious choice of challenges and their solving and overcoming obstacles for the sake of victory, stability in work, self-confidence, self-affirmation, orientation towards the integration of the efforts of oneself and others people and responsible for the final result of professional identity and the needs for recognition and self-improvement) and indicators that reduce to lower psychological well-being of border guards (self-abasement, internal conflict as an objective professional self-attitude inconsistency professional requirements and individual capabilities and resources of border guards, self-prosecution, stability of residence, the need for social contacts as a desire to work in a team, to communicate with a lot of people, belief and close ties with colleagues) are ascertained.