The Univariation and Multiple Linear Regression Analyses for Seventeen SNPs in Thirteen Cardiovascular Disease-Predisposing Genes and Blood Pressure in Chinese Han Males

2008 ◽  
Vol 30 (7) ◽  
pp. 648-661 ◽  
Author(s):  
Min Tang ◽  
Yong Dai ◽  
YuanShuai Huang ◽  
XiaoZhong Cai ◽  
XiaoYuan Tian ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Regression Analyses ◽  
Chinese Han ◽  
Predisposing Genes

scholarly journals Retinal Vessel Diameters and Their Relationship with Cardiovascular Risk and All-Cause Mortality in the Inter99 Eye Study: A 15-Year Follow-Up

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Dragana Drobnjak ◽  
Inger Christine Munch ◽  
Charlotte Glümer ◽  
Kristine Faerch ◽  
Line Kessel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Cox Regression ◽  
Hdl Cholesterol ◽  
Retinal Vessel ◽  
Regression Analyses ◽  
All Cause Mortality ◽  
Retinal Vessel Diameters

Purpose. To describe associations between retinal vessel diameters and cardiovascular risk markers and mortality.Methods. The present study included 908 persons aged 30 to 60 years. Vessel diameters were expressed as central retinal venular equivalent (CRVE) and central retinal arteriolar equivalent (CRAE). Multiple linear regression analyses and Cox regression models were used.Results. Multiple linear regression analyses showed that narrower CRAE was associated with higher systolic blood pressure, age, and higher HDL cholesterol, whereas wider CRAE and CRVE were associated with smoking. Narrower CRVE was associated with higher HDL cholesterol. In an age-adjusted model, associations between wider CRVE and risk of ischemic heart disease were found (P<0.001). Wider CRVE was associated with all-cause mortality (HR = 2.02,P=0.033) in a model adjusted for age, gender, and blood pressure. However, the association was not statistically significant after additional adjustment for smoking.Conclusions. The associations between retinal vessel diameters and known cardiovascular risk factors were confirmed. All-cause mortality was not associated with retinal vessel diameters when adjusting for relevant confounders.

scholarly journals Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingying Wang ◽  
Dandan He ◽  
Chaowei Fu ◽  
Xiaolian Dong ◽  
Feng Jiang ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Thyroid Function ◽  
Pubertal Development ◽  
Thyroid Stimulating Hormone ◽  
East China ◽  
Regression Analyses ◽  
Free Triiodothyronine ◽  
Serum Tsh

BackgroundThe onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce.MethodsA cohort study was conducted among girls during puberty in iodine-sufficient regions of East China between 2017 to 2019. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant. Thyroid homeostasis structure parameters (THSPs), including the ratio of FT4 to FT3 (FT4/FT3), Jostel’s TSH index (TSHI), and thyroid feedback quantile-based index (TFQI), were calculated. Puberty category scores (PCS), calculated based on the Puberty Development Scale (PDS), was used to assess the stage of puberty. Girls were grouped into three categories according to PCS changes (△PCS) and six categories according puberty stage (BPFP: pre-pubertal at both baseline and follow-up; BPFL: pre-pubertal at baseline and late-pubertal at follow-up, respectively; BPFT: pre-pubertal at baseline and post-pubertal at follow-up, respectively; BLFL: late-pubertal at both baseline and follow-up; BLFT: late-pubertal at baseline and post-pubertal at follow-up, respectively; BTFT: post-pubertal at both baseline and follow-up). Multiple linear regression analyses were used to evaluate the associations of THs changes with pubertal progress.ResultsThe levels of serum TSH and FT3 decreased while serum FT4 increased during the study period (P&lt;0.001). In multiple linear regression analyses, after adjustment for covariables, FT3 decreased by an additional 0.24 pmol/L (95% CI: -0.47 to -0.01) in the higher △PCS group than the lower △PCS group. Compared with the BLFL group, the BPFT group showed an additional decline in FT3 (β= -0.39 pmol/L, 95%CI: -0.73 to -0.04), the BTFT group showed a lower decline in TSH (β=0.50 mU/L, 95% CI: 0.21 to 0.80) and a lower decline in TSHI (β=0.24, 95%CI: 0.06 to 0.41), respectively. There was no association of △FT4 or △TFQI with △PCS or the puberty pattern.ConclusionsSerum TSH and FT3 decreased while serum FT4 increased among girls during puberty. Both the initial stage and the velocity of pubertal development were related to thyroid hormone fluctuations.

scholarly journals The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People

2020 ◽  
Vol 17 (8) ◽  
pp. 2824
Author(s):  
Mengying Wang ◽  
Wenyong Li ◽  
Ren Zhou ◽  
Siyue Wang ◽  
Hongchen Zheng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Alcohol Consumption ◽  
Linear Regression ◽  
Smoking Status ◽  
Public Health Practice ◽  
Regression Coefficients ◽  
Regression Analyses ◽  
Chinese People ◽  
Health Practice ◽  
Real World Evidence

Background: The association between smoking and blood pressure (BP) has been explored extensively, yet the results remain inconclusive. Using real-world evidence of a large Chinese population, we examine the effect of smoking on BP levels. Methods: We utilize half a million adults from the China Kadoorie Biobank (CKB) study with baseline sampling collected between 2004 and 2008. Multivariable linear regression analyses are used to estimate linear regression coefficients of smoking for systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: 459,815 participants (180,236 males and 279,579 females) are included in the analysis. Regular smoking is significantly associated with lower SBP (−0.57 mm Hg, p < 0.001) and DBP (−0.35 mm Hg, p < 0.001) when compared with non-smoking in men. Additionally, SBP and DBP decrease significantly among all groups of different smoking status in women (p < 0.001). Additionally, pack-years show negative associations with SBP and DBP in both men and women. Further analysis shows the interaction of smoking and alcohol consumption is associated with an increase of SBP and DBP (men: 2.38 mm Hg and 0.89 mm Hg; women: 5.21 mm Hg and 2.62 mm Hg) among co-regular smokers and regular drinkers when compared with regular smokers who are not exposed to alcohol consumption. Conclusions: A negative association between smoking and BP is observed. However, the interaction between smoking and alcohol consumption is associated with BP increase. The findings suggest the importance of considering smoking and alcohol consumption in BP control in addition to antihypertensive treatment in clinical and public health practice.

Anxiety sensitivity, disgust sensitivity and aversive reactions to four stimuli

2020 ◽  
pp. 1-12
Author(s):  
Jessica R. Winder ◽  
Katie H. Mangen ◽  
Anna E. Martinez-Snyder ◽  
David P. Valentiner
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Anxiety Sensitivity ◽  
Regression Analyses ◽  
Disgust Sensitivity ◽  
Specific Phobias

Abstract Background: Prior theory and research has implicated disgust as relevant to some, but not all phobias. Aims: The current study examined whether anxiety sensitivity is more relevant to certain specific phobias and whether disgust sensitivity is more relevant to other specific phobias. Method: Participants (n = 201) completed measures of anxiety sensitivity, disgust sensitivity and measures of aversive reactions in the presence of two fear-relevant stimuli (i.e. heights and small, enclosed spaces) and two disgust-relevant stimuli (i.e. spiders and blood/injury). Results: Results of multiple linear regression analyses revealed that disgust sensitivity showed significant associations with aversive reactions in all four stimulus domains after controlling for anxiety sensitivity. After controlling for disgust sensitivity, anxiety sensitivity showed associations with the two fear-relevant phobias but not with the two disgust-relevant phobias included in this study. Anxiety sensitivity also showed an association with variance specific to one of the two fear-relevant specific phobias included in the study. Disgust sensitivity also showed associations with variance specific to both of the disgust-relevant phobias included in the study but not with variance specific to either of the fear-relevant specific phobias. Conclusions: These results provide evidence that the distinction between fear-relevant and disgust-relevant specific phobias is meaningful and also implicate disgust sensitivity as relevant to aversive reactions to all stimuli included in this study.

scholarly journals The magnitude of undiagnosed diabetes and Hypertension among adult psychiatric patients receiving antipsychotic treatment

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Agete Tadewos Hirigo ◽  
Tesfaye Teshome
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Mental Illness ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Psychiatric Patients ◽  
Hdl Cholesterol ◽  
Antipsychotic Therapy

Abstract Background Patients with severe mental illness (SMI) are at increased risk of developing non-communicable diseases that could cause significantly lower life expectancy when compared to the general population. This study aimed to assess the magnitude and predictors of undiagnosed type-2 diabetes and hypertension among adult patients with SMI on antipsychotic treatments. Methods A hospital-based cross-sectional study was conducted on 237 psychiatric patients from January to June 2019 at Hawassa University Comprehensive Specialized Hospital, Hawassa, Southern Ethiopia. All relevant information was collected using a structured interviewer-administered questionnaire with a systematic random sampling technique. A total of 4–5 mL of overnight fasting venous blood was collected from each patient. Serum lipid profiles and fasting blood sugar (FBS) were measured using the A25™ BioSystem Random Access chemistry analyzer. To identify predictors of hyperglycemia and raised blood pressure, multiple linear regression analysis was done using SPSS version 23. Statistical significance was set at p value < 5%. Results From 247 patients with SMI approached, 237 (58.2% male and 41.8% females) were take part in the study giving a response rate of 95.9%. The overall 31.2% (95%CI: 24.1–37.6) and 27.8% (95%CI: 23.2–33.4) of patients had hyperglycemia and raised BP. The magnitude of prediabetes and type-2 diabetes was 24.9% (95%CI:19.4–30.4), and 6.3% (95% CI: 3.4–10.1), respectively. While the magnitude of prehypertension and hypertension was 23.2% (95%CI: 17.3–29.5) and 4.6% (95%CI: 2.1–8.0), respectively. In multiple linear regression analyses: age, HDL-cholesterol, physical activity and Triglyceride/HDL-cholesterol ratio were positively correlated with FBS. While, HDL-cholesterol, waist circumference, physical activity, total cholesterol/HDL-c ratio, and body mass index were positively correlated with systolic and diastolic blood pressures. Conclusion The findings indicate a need to assess blood glucose and blood pressure at baseline before the commencement of any antipsychotic therapy and during therapeutic follow up to manage any increasing trends. Moreover, close monitoring of patients with severe mental illness on antipsychotic therapy is exclusively recommended.

scholarly journals Bruise susceptibilities of kiwifruit as affected by impact and fruit properties

2012 ◽  
Vol 58 (No. 3) ◽  
pp. 107-113 ◽  
Author(s):  
E. Ahmadi
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Fruit Quality ◽  
Prediction Models ◽  
Radius Of Curvature ◽  
Regression Analyses ◽  
Probability Level ◽  
Absorbed Energy ◽  
Bruise Susceptibility ◽  
Damage Susceptibility

Kiwifruit bruise damage is a common postharvest disorder that substantially reduces fruit quality and marketability. Fruit bruise cause tissue softening and make them more susceptible to undesired agents such as diseases-inducing agents. Factors that affect kiwifruit bruise susceptibility such as impact properties and fruit properties were investigated. Two bruise prediction models were constructed for the damage susceptibility of kiwifruit (measured by absorbed energy) using multiple linear regression analyses. Kiwifruits were subjected to dynamic loading by means of a pendulum at three levels of impact. Significant effects of acoustic stiffness, temperature and the radius of curvature and some interactions on bruising were obtained at 5% probability level.

Biomechanics and Blood Pressure with Modeling of Pulse Wave Velocity Based on Multiple Linear Regression

2014 ◽  
Vol 952 ◽  
pp. 261-264
Author(s):  
Long Jia
Keyword(s):  
Blood Pressure ◽  
Linear Regression ◽  
Pulse Wave Velocity ◽  
Regression Model ◽  
Multiple Linear Regression ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Model Assessment ◽  
Practical Test ◽  
Significant Difference

The purpose of present study is to build a multiple linear regression model using biomechanical theory to assess the relationship of pulse wave velocity (PWV) with blood pressure, height and age. By testing the PWV, blood pressure, height, weight of 164 female adults aged above 45 and existing data, the author constructed a multiple linear regression equation. Through comparing the practical test PWV values with the estimate values from regression model, the result showed that there was no significant difference between the model assessment and practical test values (t=0.833, p=.423>.05). Therefore, the regression model is fit for assessing PWV value by height, age, systolic and diastolic pressure.

scholarly journals PENGARUH NON PERFORMING LOAN (NPL) DAN LOAN TO DEPOSIT RATIO (LDR) TERHADAP RETURN ON ASSET (ROA) PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

2020 ◽  
pp. 220-230
Author(s):  
Randi Siregar ◽  
Sabeth Sembiring
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Quantitative Research ◽  
Negative Impact ◽  
Coefficient Of Determination ◽  
Regression Analyses ◽  
Independent Variables ◽  
Significant Negative Impact ◽  
Negative Effect ◽  
Positive Effect

The purpose of this research was conducted to know the influence of: (1) Simultaneous Non Performing Loan and Loan to Deposit Ratio against Return On Asset, (2) Partial Non-Performing Loan against Return On Asset and (3) partial Loan to Deposit against Return On Asset Corporate Banking the Go Public period 2010 – 2012.The research uses quantitative research plans. The research subject is a banking company that go public from 2014 – 2016 and the objects are Non Performing Loan, Loan to Deposit Ratio and Return On Asset.Data collected using documentation methods and analyzed with multiple linear regression analyses. The results showed that (1) Non Performing Loan and Loan to Deposit Ratio simultaneously had significant effect on Return On Asset.(2) Non Performing Loan partially negative effect on Return On Asset, (3) Loan to Deposit Ratio positively affects the Return On Asset of the banking company listed on the Indonesia Stock Exchange.The value of the coefficient of determination (adjusted R2) of 0.323 or 32.3%, this translates to 32.3% of ROA variations that can be explained by variations of independent variables of the NPL and LDR.The remaining 67.7% is explained by other reasons outside of the regression model.Based on the results of multiple linear regression analyses indicating that the NPL has a significant negative impact on ROA, LDR has a significant and positive effect on Roa, NPL and LDR.

scholarly journals Social Jetlag Is Associated With Impaired Metabolic Control During a 1-Year Follow-Up

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Carliana Mota ◽  
Catarina Mendes Silva ◽  
Laura Cristina Tibiletti Balieiro ◽  
Walid Makin Fahmy ◽  
Elaine Cristina Marqueze ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Metabolic Control ◽  
Fasting Glucose ◽  
Sleep Time ◽  
Metabolic Parameters ◽  
Absolute Difference ◽  
Regression Analyses ◽  
Social Jetlag

Previous studies have identified social jetlag (SJL) as a risk factor for non-communicable chronic diseases (NCCDs), but its association with metabolic control over time is unclear in the literature. Therefore, we examined the influence of SJL on metabolic parameters and blood pressure (BP) in patients with NCCDs over a 1-year follow-up. This retrospective, longitudinal study included 625 individuals (age: 56.0 +12.0 years; 76% female) with NCCDs [type 2 diabetes mellitus (TD2), systemic arterial hypertension (SHA), obesity, or dyslipidemia]. SJL was calculated based on the absolute difference between mid-sleep time on weekends and weekdays. Current metabolic parameters and BP of the patients were compared with data from a year prior. Generalized estimating equations (GEE) and multiple linear regression analyses were used to examine the association among SJL, metabolic parameters, and BP. Multiple linear regression analyses adjusted for confounders showed that SJL was positively associated with the delta difference of fasting glucose (β = 0.11, p = 0.02) and triglyceride levels (β = 0.09, p = 0.04) among all subjects with NCCDs, and with fasting glucose (β = 0.30, p = 0.0001) and triglyceride levels (β = 0.22, p = 0.01) in the TD2 group. GEE analysis demonstrated an isolated effect of SJL on diastolic BP. High SJL impaired clinical and metabolic control in individuals with NCCDs, leading to a worse profile after a 1-year follow-up, particularly among type II diabetics.

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