scholarly journals Social Jetlag Is Associated With Impaired Metabolic Control During a 1-Year Follow-Up

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Carliana Mota ◽  
Catarina Mendes Silva ◽  
Laura Cristina Tibiletti Balieiro ◽  
Walid Makin Fahmy ◽  
Elaine Cristina Marqueze ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Metabolic Control ◽  
Fasting Glucose ◽  
Sleep Time ◽  
Metabolic Parameters ◽  
Absolute Difference ◽  
Regression Analyses ◽  
Social Jetlag

Previous studies have identified social jetlag (SJL) as a risk factor for non-communicable chronic diseases (NCCDs), but its association with metabolic control over time is unclear in the literature. Therefore, we examined the influence of SJL on metabolic parameters and blood pressure (BP) in patients with NCCDs over a 1-year follow-up. This retrospective, longitudinal study included 625 individuals (age: 56.0 +12.0 years; 76% female) with NCCDs [type 2 diabetes mellitus (TD2), systemic arterial hypertension (SHA), obesity, or dyslipidemia]. SJL was calculated based on the absolute difference between mid-sleep time on weekends and weekdays. Current metabolic parameters and BP of the patients were compared with data from a year prior. Generalized estimating equations (GEE) and multiple linear regression analyses were used to examine the association among SJL, metabolic parameters, and BP. Multiple linear regression analyses adjusted for confounders showed that SJL was positively associated with the delta difference of fasting glucose (β = 0.11, p = 0.02) and triglyceride levels (β = 0.09, p = 0.04) among all subjects with NCCDs, and with fasting glucose (β = 0.30, p = 0.0001) and triglyceride levels (β = 0.22, p = 0.01) in the TD2 group. GEE analysis demonstrated an isolated effect of SJL on diastolic BP. High SJL impaired clinical and metabolic control in individuals with NCCDs, leading to a worse profile after a 1-year follow-up, particularly among type II diabetics.

scholarly journals Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingying Wang ◽  
Dandan He ◽  
Chaowei Fu ◽  
Xiaolian Dong ◽  
Feng Jiang ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Thyroid Function ◽  
Pubertal Development ◽  
Thyroid Stimulating Hormone ◽  
East China ◽  
Regression Analyses ◽  
Free Triiodothyronine ◽  
Serum Tsh

BackgroundThe onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce.MethodsA cohort study was conducted among girls during puberty in iodine-sufficient regions of East China between 2017 to 2019. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant. Thyroid homeostasis structure parameters (THSPs), including the ratio of FT4 to FT3 (FT4/FT3), Jostel’s TSH index (TSHI), and thyroid feedback quantile-based index (TFQI), were calculated. Puberty category scores (PCS), calculated based on the Puberty Development Scale (PDS), was used to assess the stage of puberty. Girls were grouped into three categories according to PCS changes (△PCS) and six categories according puberty stage (BPFP: pre-pubertal at both baseline and follow-up; BPFL: pre-pubertal at baseline and late-pubertal at follow-up, respectively; BPFT: pre-pubertal at baseline and post-pubertal at follow-up, respectively; BLFL: late-pubertal at both baseline and follow-up; BLFT: late-pubertal at baseline and post-pubertal at follow-up, respectively; BTFT: post-pubertal at both baseline and follow-up). Multiple linear regression analyses were used to evaluate the associations of THs changes with pubertal progress.ResultsThe levels of serum TSH and FT3 decreased while serum FT4 increased during the study period (P<0.001). In multiple linear regression analyses, after adjustment for covariables, FT3 decreased by an additional 0.24 pmol/L (95% CI: -0.47 to -0.01) in the higher △PCS group than the lower △PCS group. Compared with the BLFL group, the BPFT group showed an additional decline in FT3 (β= -0.39 pmol/L, 95%CI: -0.73 to -0.04), the BTFT group showed a lower decline in TSH (β=0.50 mU/L, 95% CI: 0.21 to 0.80) and a lower decline in TSHI (β=0.24, 95%CI: 0.06 to 0.41), respectively. There was no association of △FT4 or △TFQI with △PCS or the puberty pattern.ConclusionsSerum TSH and FT3 decreased while serum FT4 increased among girls during puberty. Both the initial stage and the velocity of pubertal development were related to thyroid hormone fluctuations.

scholarly journals SO081LITHIUM EXPOSURE AND OCCURENCE OF CHRONIC KIDNEY DISEASE IN THE IRISH HEALTH SYSTEM: A COHORT STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Mark Behan ◽  
Leonard Browne ◽  
Stack Austin
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Linear Regression ◽  
Health System ◽  
Multiple Linear Regression ◽  
Kidney Function ◽  
Ckd Progression ◽  
Duration Of Treatment

Abstract Background and Aims Lithium is implicated as a causative factor in the development and progression of chronic kidney disease (CKD). Few studies have assessed the independent impact of plasma levels and duration of lithium therapy on CKD progression. We examined the influence of lithium on CKD progression in the Irish health system. Method We utilised data from the Irish Kidney Disease Surveillance System (IKDSS) to explore associations of lithium levels and duration of exposure with kidney function in a regional cohort. A retrospective cohort study was conducted between 1999 to 2014 from the Midwest Region. All adult patients with lithium levels were identified and followed longitudinally. Kidney function was assessed at baseline and longitudinally using serum creatinine and estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI. Patients with < 2 lithium values, missing data on creatinine were excluded. The index date was the date of the first lithium blood test. Toxicity from lithium was defined as levels >1.2mmol/L as per NICE guidelines while duration of treatment was calculated based on patient –years of exposure as determined by positive blood lithium levels. Relationships between baseline kidney function, lithium levels, duration of exposure and each patients most recent eGFR value on follow up were assessed using multiple linear regression Results We identified 1,978 patients exposed to lithium from 1999-2014, mean age was 47.4 (15.6), 45.1% were men, eGFR [median (IQR)] at baseline was 84.4 (32.1) ml/min1.73m and the median duration of exposure was 3.0 years (IQR=4 years). Frequency of lithium testing increased from 1.77 in 1999 to 2.66 in 2014. In multiple linear regression, the final eGFR on follow-up was significantly lower in older patients (-0.48 ml/min/1.73m per year increase in age), P<0.001; in patients with elevated baseline lithium levels (-2.18 ml/min1.73m lower per unit increase), P<0.05, with long duration of exposure (-1.42 ml/min/1.73m lower for each year on lithium), P<0.001, and for patients with low GFR at baseline (P<0.001). Together these variables explained 58% of the variation in the final model. Conclusion Both the magnitude of and the duration of lithium exposure are both independently associated with CKD progression among lithium users in the Irish health system. Higher baseline lithium values had a more deleterious impact on kidney function. Continued efforts should be expended in minimising the risks of lithium induced nephrotoxicity through switching to alternatives and dose reduction when over possible. Funding This study is funded by the Health Research Board and the Midwest Research and Education Foundation (MKid).

Anxiety sensitivity, disgust sensitivity and aversive reactions to four stimuli

2020 ◽  
pp. 1-12
Author(s):  
Jessica R. Winder ◽  
Katie H. Mangen ◽  
Anna E. Martinez-Snyder ◽  
David P. Valentiner
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Anxiety Sensitivity ◽  
Regression Analyses ◽  
Disgust Sensitivity ◽  
Specific Phobias

Abstract Background: Prior theory and research has implicated disgust as relevant to some, but not all phobias. Aims: The current study examined whether anxiety sensitivity is more relevant to certain specific phobias and whether disgust sensitivity is more relevant to other specific phobias. Method: Participants (n = 201) completed measures of anxiety sensitivity, disgust sensitivity and measures of aversive reactions in the presence of two fear-relevant stimuli (i.e. heights and small, enclosed spaces) and two disgust-relevant stimuli (i.e. spiders and blood/injury). Results: Results of multiple linear regression analyses revealed that disgust sensitivity showed significant associations with aversive reactions in all four stimulus domains after controlling for anxiety sensitivity. After controlling for disgust sensitivity, anxiety sensitivity showed associations with the two fear-relevant phobias but not with the two disgust-relevant phobias included in this study. Anxiety sensitivity also showed an association with variance specific to one of the two fear-relevant specific phobias included in the study. Disgust sensitivity also showed associations with variance specific to both of the disgust-relevant phobias included in the study but not with variance specific to either of the fear-relevant specific phobias. Conclusions: These results provide evidence that the distinction between fear-relevant and disgust-relevant specific phobias is meaningful and also implicate disgust sensitivity as relevant to aversive reactions to all stimuli included in this study.

High Neighborhood Walkability Mitigates Declines in Middle-to-Older Aged Adults’ Walking for Transport

2012 ◽  
Vol 9 (7) ◽  
pp. 1004-1008 ◽  
Author(s):  
Hiroko Shimura ◽  
Takemi Sugiyama ◽  
Elisabeth Winkler ◽  
Neville Owen
Keyword(s):  
Linear Regression ◽  
Positive Relationship ◽  
Baseline Survey ◽  
Regression Analyses ◽  
Cross Sectional ◽  
Significant Positive Relationship ◽  
Neighborhood Walkability ◽  
Cross Sectional Studies ◽  
Multilevel Linear Regression

Background:Neighborhood walkability shows significant positive relationship with residents’ walking for transport in cross-sectional studies. We examined prospective relationships of neighborhood walkability with the change in walking behaviors over 4 years among middle-to-older aged adults (50–65 years) residing in Adelaide, Australia.Methods:A baseline survey was conducted during 2003–2004, and a follow-up survey during 2007–2008. Walking for transport and walking for recreation were assessed at both times among 504 adults aged 50–65 years living in objectively determined high- and low-walkable neighborhoods. Multilevel linear regression analyses examined the associations of neighborhood walkability with changes over 4 years in walking for transport and walking for recreation.Results:On average, participants decreased their time spent in walking for transport (–4.1 min/day) and for recreation (–3.7 min/day) between the baseline and 4-year follow-up. However, those living in high-walkable neighborhoods showed significantly smaller reduction (adjusted mean change: –1.1 min/day) in their time spent in walking for transport than did those living in low-walkable neighborhoods (–6.7 min/day). No such statistically-significant differences were found with the changes in walking for recreation.Conclusions:High-walkable neighborhoods may help middle-to-older aged adults to maintain their walking for transport.

scholarly journals Bruise susceptibilities of kiwifruit as affected by impact and fruit properties

2012 ◽  
Vol 58 (No. 3) ◽  
pp. 107-113 ◽  
Author(s):  
E. Ahmadi
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Fruit Quality ◽  
Prediction Models ◽  
Radius Of Curvature ◽  
Regression Analyses ◽  
Probability Level ◽  
Absorbed Energy ◽  
Bruise Susceptibility ◽  
Damage Susceptibility

Kiwifruit bruise damage is a common postharvest disorder that substantially reduces fruit quality and marketability. Fruit bruise cause tissue softening and make them more susceptible to undesired agents such as diseases-inducing agents. Factors that affect kiwifruit bruise susceptibility such as impact properties and fruit properties were investigated. Two bruise prediction models were constructed for the damage susceptibility of kiwifruit (measured by absorbed energy) using multiple linear regression analyses. Kiwifruits were subjected to dynamic loading by means of a pendulum at three levels of impact. Significant effects of acoustic stiffness, temperature and the radius of curvature and some interactions on bruising were obtained at 5% probability level.

scholarly journals PENGARUH NON PERFORMING LOAN (NPL) DAN LOAN TO DEPOSIT RATIO (LDR) TERHADAP RETURN ON ASSET (ROA) PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

2020 ◽  
pp. 220-230
Author(s):  
Randi Siregar ◽  
Sabeth Sembiring
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Quantitative Research ◽  
Negative Impact ◽  
Coefficient Of Determination ◽  
Regression Analyses ◽  
Independent Variables ◽  
Significant Negative Impact ◽  
Negative Effect ◽  
Positive Effect

The purpose of this research was conducted to know the influence of: (1) Simultaneous Non Performing Loan and Loan to Deposit Ratio against Return On Asset, (2) Partial Non-Performing Loan against Return On Asset and (3) partial Loan to Deposit against Return On Asset Corporate Banking the Go Public period 2010 – 2012.The research uses quantitative research plans. The research subject is a banking company that go public from 2014 – 2016 and the objects are Non Performing Loan, Loan to Deposit Ratio and Return On Asset.Data collected using documentation methods and analyzed with multiple linear regression analyses. The results showed that (1) Non Performing Loan and Loan to Deposit Ratio simultaneously had significant effect on Return On Asset.(2) Non Performing Loan partially negative effect on Return On Asset, (3) Loan to Deposit Ratio positively affects the Return On Asset of the banking company listed on the Indonesia Stock Exchange.The value of the coefficient of determination (adjusted R2) of 0.323 or 32.3%, this translates to 32.3% of ROA variations that can be explained by variations of independent variables of the NPL and LDR.The remaining 67.7% is explained by other reasons outside of the regression model.Based on the results of multiple linear regression analyses indicating that the NPL has a significant negative impact on ROA, LDR has a significant and positive effect on Roa, NPL and LDR.

Exercise intensity is associated with progression of coronary artery calcification in middle-aged and older athletes: findings from the MARC-2 study

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
V Aengevaeren ◽  
A Mosterd ◽  
TL Braber ◽  
S Sharma ◽  
HM Nathoe ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Linear Regression ◽  
Exercise Intensity ◽  
Coronary Artery Calcification ◽  
Moderate Intensity ◽  
Regression Analyses ◽  
Middle Aged ◽  
Older Athletes ◽  
Vigorous Intensity

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation Background  Recent studies have reported increased coronary artery calcification (CAC) in middle-aged male athletes, which is related to the amount and intensity of lifelong exercise. However, previous studies are limited by their cross-sectional study design.  Purpose  We prospectively assessed progression of CAC and its association to exercise volume and intensity in middle-aged and older athletes. Methods  318 asymptomatic middle-aged and older men were recruited in the Measuring Athlete’s Risk of Cardiovascular events (MARC) study between 2012-2014 and invited for follow-up (MARC-2) between 2019-2020. During both study visits, computed tomography imaging was performed to assess CAC. Exercise characteristics during follow-up were used to calculate exercise volumes (Metabolic equivalent of task [MET]-hours/week), whereas intensities were classified as moderate (3-6 MET), vigorous (6-9 MET) and very vigorous (>9 MET). For linear regression analyses, CAC scores were transformed (Ln delta CAC score + 1) and analyses were adjusted for baseline confounders, CAC at baseline and time between CT scans. Exercise intensities were assessed as proportion of MET-hrs/week and separately included, while adjusting for exercise volume. Results  We included 289 men (54.9 ± 6.4 years) for MARC-2, with a follow-up of 6.3 ± 0.5 years. Participants exercised for 41 [25-57] MET-hrs/week, of which the median percentage was 0% [interquartile range 0-19] at moderate, 44% [0-84] at vigorous and 34% [0-80] at very vigorous intensity. At baseline, CAC was present in 151 (52%) men, and increased to 205 (71%) men at follow-up. CAC scores increased from 1 [0-32] to 31 [0-132]. Delta CAC score (26 [0-104]) was not associated with overall exercise volume. However, delta CAC score was negatively associated with vigorous intensity exercise and positively associated with very vigorous intensity exercise (Table). Conclusion  Progression of CAC was not associated with overall exercise volume during 6-year follow-up. However, the degree of vigorous intensity exercise was associated with attenuated CAC progression, whereas very vigorous intensity exercise was associated with accelerated CAC progression. Linear regression analyses Progression of CAC (Ln Delta CAC score +1) B (95% CI) P-Value Exercise volume (MET-hours/week) .001 (-.005 - .008) .70 Exercise Intensity Moderate intensity (%) -.002 (-.009 - .005) .65 Vigorous intensity (%) -.005 (-.009 - .000) .03 Very vigorous intensity (%) .005 (.001 - .009) .02

Risk factors for progression IgA-nephropathy in children

2021 ◽  
Vol 25 (4) ◽  
pp. 48-56
Author(s):  
M. V. Proskura ◽  
E. K. Petrosyan ◽  
P. E. Povilaitite ◽  
B. L. Kushnir
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Iga Nephropathy ◽  
Predictive Value ◽  
Age Of Onset ◽  
Morphological Data ◽  
First Time

BACKGROUND. The course and outcomes of primary IgA nephropathy in children are variable. Early therapy for high-risk individuals can help to delay the development of end-stage renal disease.THE AIM: to analysis of risk factors for progression and outcomes in children with IgA nephropathy, taking into account clinical and morphological data at the onset and during follow-up.PATIENTS AND METHODS. A retrospective study of 75 children was carried out; the median follow-up was 28 months. The median age of onset was 9.1 years. Patients were divided into 2 groups: 1st – patients with idiopathic IgA nephropathy (n= 53), 2nd – patients with Shenlein-Henoch purpura (n = 22). The diagnosis of primary IgA nephropathy was morphologically confirmed in all patients. Nephrobiopsy data were classified according to the Oxford scale (MEST-C score). The age of onset and first-time admission, the level of proteinuria and glomerular filtration rate (GFR) at the onset, at 12 months, at the end of follow-up, mean arterial blood pressure, MEST-C score, medication before nephrobiopsy were investigated. Progression was determined as a decrease in GFR less than 60 ml/min/1.73 m2. Outcomes were assessed by absence/presence of remission. We provided a search for factors influencing GFR at the end of the follow-up. Data analysis was performed using Student's t-test, Mann-Whitney, χ2, Fisher, linear regression model, binary logistic regression.RESULTS. Unlike adults, the predictive value of the MEST-C score in children has not been proven and is not associated with a decrease in GFR <60 ml/min/1.73 m2. GFR at the end of follow-up was lower in the idiopathic IgA nephropathy group than in group 2. The use of multiple linear regression predicts GFR on average after 28 months of observation.RESULTS. Unlike adults, the predictive value of the MEST-C scale in children has not been proven and is not associated with a decrease in GFR <60 ml/min/1.73 m2. GFR at the end of follow-up was lower in the idiopathic IgA nephropathy group. The use of multiple linear regression predicts GFR on average after 28 months of observation.CONCLUSIONS. The influence of morphological factors on the outcome and course of IgA nephropathy has not been proven. The level of GFR at the onset, mean blood pressure, and the age of the first-time admission turned out to be independent variables, which made it possible to identify children with an expected decrease in GFR less than 90 ml/min /1.73 m2 to the group of specific outpatient follow-up.

scholarly journals TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children

2013 ◽  
Vol 168 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Barbara Wolters ◽  
Nina Lass ◽  
Thomas Reinehr
Keyword(s):  
Weight Loss ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Lifestyle Intervention ◽  
Weight Status ◽  
Weight Regain ◽  
Regression Analyses ◽  
Obese Children ◽  
Free Triiodothyronine ◽  
The Impact

ObjectiveThe impact of thyroid hormones on weight loss in lifestyle interventions and on weight regain afterwards is unknown. Therefore, we studied the relationships between TSH, free triiodothyronine (fT3), free thyroxine (fT4), and weight status, as well as their changes during and after a lifestyle intervention in obese children.Materials and methodsWe evaluated the weight status as BMI–SDS in 477 obese children (mean age 10.6±2.7 years, 46% male, mean BMI 28.1±4.5 kg/m2) participating in a 1-year lifestyle intervention in a 2-year longitudinal study. Changes in BMI–SDS at 1 and 2 years were correlated with TSH, fT3, and fT4concentrations at baseline and their changes during the intervention.ResultsA decrease in BMI–SDS during the intervention period (−0.32±0.38;P<0.001) was significantly positively associated with baseline TSH and fT3in multiple linear regression analyses adjusted for age, sex, pubertal stage, and baseline BMI–SDS. An increase in BMI–SDS after the end of the intervention (+0.05±0.36;P=0.011) was significantly related to the decreases in TSH and fT3during the intervention in multiple linear regression analyses adjusted for change in BMI–SDS during the intervention. In contrast to children with weight maintenance, children with weight regain after the end of the intervention demonstrated a decrease in their TSH levels (−0.1±1.6 vs +0.2±1.6 mU/l;P=0.03) and fT3(−0.2±1.1 vs +0.3±1.6 pg/ml;P<0.001) during the intervention.ConclusionsThe decreases in TSH and fT3concentrations during the lifestyle intervention were associated with weight regain after the intervention. Future studies should confirm that the decreases in TSH and fT3levels associated with weight loss are related to the change in metabolism such as resting energy expenditure.

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