scholarly journals EXPERIMENTALLY INDUCED CHANGES IN NASAL MUCOUS SECRETORY SYSTEMS AND THEIR EFFECT ON VIRUS INFECTION IN CHICKENS

1969 ◽  
Vol 130 (1) ◽  
pp. 121-140 ◽  
Author(s):  
Frederik B. Bang ◽  
Marie A. Foard
Keyword(s):  
Virulent Strain ◽  
Time Intervals ◽  
Sharp Drop ◽  
Ciliary Action ◽  
Infected Cells ◽  
Unanesthetized Animals ◽  
Induced Changes ◽  
Ciliated Epithelial Cells ◽  
Relationship Of ◽  
The Relationship

Chickens 3 wk old, inoculated intranasally with a mesogenic (moderately virulent) strain of Newcastle disease virus, developed necrotic lesions of the mucous acini, predominantly of the middle turbinates. The infection subsequently spread to involve much of the rest of the mucosa, including mucous and ciliated epithelial cells, and other acini. The early phase of adsorption of a virulent strain of the virus to the middle turbinates of chicks 5–21 days of age was studied by giving a standard inoculum intranasally to unanesthetized animals. Variation in amounts adsorbed by individual chickens was large, but was minimized by making measurements on pools of turbinates from three chicks at intervals of 1, 3, and 5 hr after exposure of the excised turbinates to antibody, by washing, and by trypsinization. The virus released from the cells into the trypsin was designated as adherent virus, and the infectious virus in the cells after destruction of the cells by water grinding, as cell virus. Paralysis of ciliary action by cocaine increased the number of infected cells in the turbinates about 10-fold at all three time intervals. Pilocarpine injection before virus inoculation caused a large increase in the amount of infected cells 1 hr after virus administration, but was followed by a sharp drop in infected cells by 3 or 5 hr. Pilocarpine given after the virus decreased the number of infected cells and changed the relationship of infected cells to adherent virus. Exposure of chicks to sustained or severe cold caused a similar but less marked effect. The drop in infected cells was restored to control values if chicks were returned to brooder temperatures. The marked drop of infected cells produced by pilocarpine and cold in living chicks, and in cultures of chicken trachea (previous study), is consonant with the idea that virus has been adsorbed on mucus granules in the mucous cells of the turbinates and then has been reexcreted, as unincorporated virus, into the moving mucous sheet. A series of accessory data support this interpretation.

scholarly journals Hubungan Perilaku Perdagangan Investor Dengan Volume Perdagangan Di Bursa Efek Indonesia

2009 ◽  
Vol 2 (1) ◽  
Author(s):  
Ghazali Syamni
Keyword(s):  
Trading Volume ◽  
Stock Exchange ◽  
Time Interval ◽  
Time Intervals ◽  
Using Data ◽  
Changes Over Time ◽  
Relationship Of ◽  
The Relationship ◽  
Order Pattern ◽  
Over Time

This paper examines the relationship of behavior trading investor using data detailed transaction history-corporate edition demand and order history in Indonesia Stock Exchange during period of March, April and May 2005. Peculiarly, behavior placing of investor order at trading volume. The result of this paper indicates that trading volume order pattern to have pattern U shape. The pattern happened that investors have strong desires to places order at the opening and close of compared to in trading periods. While the largest orders are of market at the opening indicates that investor is more conservatively when opening, where many orders when opening has not happened transaction to match. In placing order both of investor does similar strategy. By definition, informed investors’ orders more large than uninformed investors. If comparison of order examined hence both investors behavior relatively changes over time. But, statistically shows there is not ratio significant. This implies behavior trading of informed investors and uninformed investors stable relative over time. The result from regression analysis indicates that informed investors to correlate at trading volume in all time intervals, but not all uninformed investors correlates in every time interval. This imply investor order inform is more can explain trading volume pattern compared to uninformed investor order in Indonesia Stock Exchange. Finally, result of regression also finds that order status match has greater role determines trading volume pattern intraday especially informed buy match and informed sale match. While amend, open and withdraw unable to have role to determine intraday trading volume pattern.

scholarly journals Formation features and a geodynamic map of the Ural-Timan-Paleo-Asian segment of Eurasia

LITOSFERA ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 607-629
Author(s):  
V. A. Koroteev ◽  
V. M. Necheukhin ◽  
V. A. Dushin ◽  
E. N. Volchek
Keyword(s):  
Time Intervals ◽  
Subsequent Transformation ◽  
The North ◽  
Upper Proterozoic ◽  
Geological Information ◽  
Formation Conditions ◽  
Orogenic Belts ◽  
Relationship Of ◽  
The Relationship ◽  
North Western

Research subject. This article is devoted to the formation features of the Ural-Timan-Paleo-Asian segment of Eurasia. Materials and methods. The research was based on the authors’ data and those obtained following a review of available publications on the geology of segmentation. The Timan region was investigated using the geological information obtained by V.G. Olovyanishnikov.Results. A geodynamic map of the Ural-Timan-Paleo-Asian segment with a scale of 1 : 2 500 000 was compiled, which allowed further research into the structure and formation of the north-western part of the Eurasian area. This part was found to be mostly composed of geodynamic associations of orogens, orogenic systems and orogenic belts of the Upper Proterozoic (Riphean) and Paleozoic time intervals, as well as by elements of the Mesozoic-Cenozoic neoplate. These processes were supplemented by the formation of tectonic systems of superimposed depressions and protoplate protrusions. The formation of orogens, orogenic systems and orogenic belts is associated with the development and subsequent transformation of paleooceanic basins under the conditions of accretion and collision. The terranes of the ancient continental crust also participated in the formation of the segment’s geodynamic elements, for which a typification scheme was proposed. The articles present new data on the formation conditions of the segment’s orogenic elements and the relationship of the orogeny with global reconstructions, including the problem of closing the surrounding oceanic space.

scholarly journals Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells

2007 ◽  
Vol 81 (10) ◽  
pp. 4973-4980 ◽  
Author(s):  
Michael S. Bennett ◽  
Hwee L. Ng ◽  
Mirabelle Dagarag ◽  
Ayub Ali ◽  
Otto O. Yang
Keyword(s):  
Infected Cell ◽  
Viral Infections ◽  
Cytotoxic T Lymphocyte ◽  
Cell Killing ◽  
Target Cells ◽  
Functional Avidity ◽  
Viral Epitope ◽  
Infected Cells ◽  
Relationship Of ◽  
The Relationship

ABSTRACT Cytotoxic T lymphocytes (CTLs) are crucial for immune control of viral infections. “Functional avidity,” defined by the sensitizing dose of exogenously added epitope yielding half-maximal CTL triggering against uninfected target cells (SD50), has been utilized extensively as a measure of antiviral efficiency. However, CTLs recognize infected cells via endogenously produced epitopes, and the relationship of SD50 to antiviral activity has never been directly revealed. We elucidate this relationship by comparing CTL killing of cells infected with panels of epitope-variant viruses to the corresponding SD50 for the variant epitopes. This reveals a steeply sigmoid relationship between avidity and infected cell killing, with avidity thresholds (defined as the SD50 required for CTL to achieve 50% efficiency of infected cell killing [KE50]), below which infected cell killing rapidly drops to none and above which killing efficiency rapidly plateaus. Three CTL clones recognizing the same viral epitope show the same KE50 despite differential recognition of individual epitope variants, while CTLs recognizing another epitope show a 10-fold-higher KE50, demonstrating epitope dependence of KE50. Finally, the ability of CTLs to suppress viral replication depends on the same threshold KE50. Thus, defining KE50 values is required to interpret the significance of functional avidity measurements and predict CTL efficacy against virus-infected cells in pathogenesis and vaccine studies.

Low-Km mannose-6-phosphatase as a criterion for microsomal integrity

1998 ◽  
Vol 76 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Bartholomew A Pederson ◽  
James D Foster ◽  
Robert C Nordlie
Keyword(s):  
Endoplasmic Reticulum ◽  
Structural Integrity ◽  
Kinetic Studies ◽  
Reliable Index ◽  
Single Mechanism ◽  
Induced Changes ◽  
Relationship Of ◽  
The Relationship ◽  
Low K ◽  
Hydrolysis Of

The low-Km activity of mannose-6-phosphatase (Man-6-Pase) has been used for many years to measure the structural integrity of microsomes. Recently histone II-A has been shown to activate glucose-6-phosphatase (Glc-6-Pase) and Man-6-Pase activities. However, in contrast to detergents, this compound appears to activate without disrupting microsomal vesicles (J.-F. St-Denis, B. Annabi, H. Khoury, and G. van de Werve. 1995. Biochem. J. 310: 221-224). This suggests that Man-6-Pase latency can be abolished without disrupting microsomal integrity and that even normally microsomes may manifest some low-Km Man-6-Pase activity without being "leaky." We have studied the relationship of Man-6-Pase with microsomal integrity further by measuring the latency of several enzymes reported to reside within the lumen of endoplasmic reticulum. We have also correlated this latency with the microsomal permeability of substrates for these enzymes. We found that (i) lumenal enzymes have different degrees of latency when compared with each other, (ii) permeability, as determined via osmotically induced changes in light scattering, is not always consistent with enzymatic latency, (iii) increases in the hydrolysis of Glc-6-P and Man-6-P were not parallel when microsomes were treated with low but increasing concentrations of detergent, and (iv) kinetic studies suggest that mannose-6-phosphate is hydrolyzed by untreated microsomes by more than a single mechanism. We propose that Man-6-Pase is not a reliable index of the integrity of microsomes.Key words: glucose-6-phosphatase, mannose-6-phosphatase, microsomes, rat liver, intactness.

scholarly journals Regulation of pyruvate dehydrogenase activity in rat epididymal fat-pads and isolated adipocytes by adrenaline

1978 ◽  
Vol 174 (1) ◽  
pp. 119-130 ◽  
Author(s):  
S J Smith ◽  
E D Saggerson
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Acid Synthesis ◽  
Maximum Decrease ◽  
Isolated Adipocytes ◽  
Induced Changes ◽  
Relationship Of ◽  
The Relationship ◽  
Dose Dependent ◽  
Fat Pads

1. Dose-dependent effects of adrenaline on PDHa activity were investigated with both incubated rat epidiymal fat-pads and isolated adipocytes. 2. Adrenaline (10nM- 5 micrometer) decreased PDHa activity in fat-pads incubated with 5 mM-[U-14C]glucose + insulin (20 munits/ml). Changes in [U-14C]glucose incorporation into fatty acids in these tissues correlated only loosely with changes in PDHa activity. There was a good inverse relationship between adrenaline-induced changes in PDHa activity and increases in lipolysis (glycerol release). 3. Adrenaline (10nM - 0.5 micrometer) decreased PDHa activity in fat-pads incubated with 5 mM-[U-14C]pyruvate + insulin (20 munits/ml), whereas 1 micrometer- and 5 micrometer-adrenaline slightly increased PDHa activity. All concentrations of adrenaline tested decreased [U-14C]pyruvate incorporation into fatty acids. Between 10nM- and 0.5 micrometer-adrenaline percentage decreases in PDHa activity paralleled decreases in faty acid synthesis. 4. Effects of adrenaline on PDHa activity and fatty acid synthesis in fat-pads incubated with 5mM-[U-14C]pyruvate + insulin (20 munits/ml) could not be mimicked by addition of albumin-bound palmitate. 5. The response of PDHa activity to adrenaline (0.1 nM - 1 micrometer) in isolated adipocytes differed with the carbohydrate substrate used in the incubations. With 5 mM-glucose + insulin (20 munits/ml), PDHa activity was significantly increased by 10 nM-adrenaline, but not by 1 micrometer-adrenaline, the response to adrenaline being biphasic. There was some correlation between PDHa activity and accumulation of non-esterified fatty acids. With 5 mM-glucose alone adrenaline (0.1 nM - 1 micrometer) had no effect on PDHa activity even though lipolysis was increased by adrenaline (0.1 micrometer - 1 micrometer). With 5mM-fructose in the presence and absence of insulin, lipolytic doses of adrenaline decreased PDHa activity. No tested concentrations of adrenaline increased PDHa with this substrate. 6. In the presence of 5 mM-fructose, palmitate was significantly more effective than adrenaline with respect to the maximum decrease in PDHa activity that could be elicited. 4. The relationship of changes in PDHa activity to changes in lipogenesis and the likelihood of adrenaline-induced changes in PDHa activity being secondary to changes in non-esterified fatty acid metabolism are discussed.

scholarly journals Training management, employability and stakeholders

2015 ◽  
Vol 5 (6) ◽  
Author(s):  
ES-SAADIA AOULA
Keyword(s):  
Higher Education ◽  
Vocational Training ◽  
Professional Training ◽  
Complex Object ◽  
Central Question ◽  
Job Market ◽  
Great Capacity ◽  
Induced Changes ◽  
Relationship Of ◽  
The Relationship

The offers of professional training at the level of Moroccan higher education establishments have increased markedly since 2008. In addition, the intensification of the process of globalization and the known changes in the world of work, have induced changes in the relationship of employment. The latter has become more complex requiring qualified graduates, with a very great capacity for adaptation and flexibility. Employability has become a complex object designating not only reintegration after a period of unemployment but also access to and maintenance of employment. This communication focuses on the winners from vocational training (license or master) in transition to the job market and questions their employability by asking the central question: to what extent the strategic management of training involving salient stakeholders in interaction with the establishment of higher education, can contribute to a better employability of the laureates?

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