scholarly journals Metabolism in calves two weeks before diarrhea at the age of 19-52 days of life

2021 ◽  
Vol 935 (1) ◽  
pp. 012008
Author(s):  
N Malkova ◽  
M Ostyakova ◽  
S Shcherbinina ◽  
V Irkhina
Keyword(s):  
Liver Function ◽  
Protein Metabolism ◽  
Blood Test ◽  
Digestive System ◽  
Mineral Metabolism ◽  
Metabolic Status ◽  
Disease Manifestation ◽  
Holstein Breed ◽  
Blood Tests ◽  
Young Cattle

Abstract The article presents data on the study of metabolism in calves two weeks before diarrhea at the age of 19-52 days of life. For this purpose, three groups of conditionally healthy animals of the Holstein breed were formed at the age of 19, 30, 52 days of life. To assess the metabolic status of young cattle, biochemical and general clinical blood tests were carried out. In the course of a laboratory blood test in young cattle, two weeks before disease manifestation, disorders of mineral and protein metabolism, a decrease in liver function were established. At the same time, with the increase in the age of the calves, the imbalance in protein metabolism was aggravated against the background of a change in diet and mineral metabolism improved as a result of the maturation of the digestive system.

Blood Analysis Requests of Patients’ and Clinical Reflections in Primary Care

2020 ◽  
Vol 9 (2) ◽  
pp. 96-102
Author(s):  
Zerrin Gamsizkan ◽  
Mehmet Ali Sungur ◽  
Yasemin Çayır
Keyword(s):  
Chronic Disease ◽  
Blood Test ◽  
Family Health ◽  
Cross Sectional Study ◽  
Blood Analysis ◽  
Primary Role ◽  
Cross Sectional ◽  
High Expectations ◽  
Blood Tests ◽  
Study Results

Aim: The aim of the study is to determine the factors that may affect the demands of patients who come with the request to have a blood test without any chronic disease or a planned examination check. Methods: The data of this descriptive, cross-sectional study, were collected with a questionnaire that was prepared to examine the opinions of the patients who claim to have a blood test by coming to the family health center without any complaints. Patients over 18 years of age, who did not have any chronic disease and had no scheduled examination appointments were included in the study. Results: A total of 278 patients who wanted to have a blood test within the 6-months period were included in the study. Female patients who wanted to have a blood test were significantly more than male patients. When we look at the causes of patients who wanted to have a blood test; 61.2% (n=170) patients stated that they are concerned about their health and 6.1% (n=17) stated that they were affected by media warnings. There was no significant relationship between the frequency of blood test requests of patients and their age, gender, education, and general health status. Conclusion: Patients with high expectations and anxiety may be more willing to perform blood tests at inappropriate intervals. Family physicians, whose primary role is preventive medicine, have consultancy and information duties in order to protect their patients from the risk of over-examination and diagnosis. Keywords: blood tests, patient, screening, routine diagnostic tests

scholarly journals 236 Novel Guidelines to Avoid Routine Blood Tests After Robotic Assisted Radical Prostatectomy (RARP)

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Nathan ◽  
N Hanna ◽  
A Rashid ◽  
S Patel ◽  
Y Phuah ◽  
...  
Keyword(s):  
Blood Test ◽  
Open Surgery ◽  
Clinical Judgement ◽  
Robotic Assisted ◽  
Blood Tests ◽  
Routine Blood ◽  
Operative Complications ◽  
Robotic Assisted Radical Prostatectomy ◽  
The Uk ◽  
Post Operative Complications

Abstract Introduction Patients undergoing RARP commonly require routine post-operative blood tests. This practice dates from an era of open surgery, with increased blood loss and complications. We aim to improve specificity of blood test requests with novel guidelines. Method 1039 consecutive RARP patients at two tertiary urology centres in the UK were audited. Novel guidelines constructed based on risk stratified evidence from the initial audit were used to prospectively audit 133 patients. Results 16% had clinical concerns post-operatively. 1% and 4% had an intra- and post-operative complication. Intra- or post-operative clinical judgement flagged post-operative complications in 99.9%. 80% had routine blood tests with no clinical concerns. 6% had delayed discharge due to delayed processing of blood tests. 0.9% received a peri-operative transfusion. Re-Audit Novel guidelines reduced the number of blood tests requested from 100% to 36%. Specificity in diagnosing a complication improved from 0% to 67%. Discharge delays reduced from 6% to 0% and no post-operative complications were missed (sensitivity 100%). Conclusions Routine blood tests, without an indication, did not flag any additional post-operative complications. Blood transfusion is rare for RARP. Novel guidelines to request post-operative blood tests will reduce costs and discharge delays whilst maintaining appropriate patient safety and care.

scholarly journals The use of routine blood tests to assist the diagnosis of COVID-19 in symptomatic hospitalized patients

2021 ◽  
pp. 000456322199907
Author(s):  
IT Parsons ◽  
AT Parsons ◽  
E Balme ◽  
G Hazell ◽  
R Gifford ◽  
...  
Keyword(s):  
Cell Count ◽  
Retrospective Review ◽  
Blood Test ◽  
Patient Flow ◽  
White Cell Count ◽  
Area Under The Curve ◽  
White Cell ◽  
Test Results ◽  
Rt Pcr ◽  
Blood Tests

Introduction Specific patterns of blood test results are associated with COVID-19 infection. The aim of this study was to identify which blood tests could be used to assist in diagnosing COVID-19. Method A retrospective review was performed on consecutive patients referred to hospital with a clinical suspicion of COVID-19 over a period of four weeks. The patient’s clinical presentation and severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction (SARS-CoV-2 RT-PCR) were recorded. The patients were divided by diagnosis into COVID (COVID-19 infection) or CONTROL (an alternate diagnosis). A retrospective review of consecutive patients over a further two-week period was used for the purposes of validation. Results Overall, 399 patients (53% COVID, 47% CONTROL) were analysed. White cell count, neutrophils and lymphocytes were significantly lower, while lactate dehydrogenase and ferritin were significantly higher, in the COVID group in comparison to CONTROL. Combining the white cell count, lymphocytes and ferritin results into a COVID Combined Blood Test (CCBT) had an area under the curve of 0.79. Using a threshold CCBT of –0.8 resulted in a sensitivity of 0.85 and a specificity of 0.63. Analysing this against a further retrospective review of 181 suspected COVID-19 patients, using the same CCBT threshold, resulted in a sensitivity of 0.73 and a specificity of 0.75. The sensitivity was comparable to the SARS-CoV-2 RT PCR. Discussion Mathematically combining the blood tests has the potential to assist clinical acumen allowing for rapid streaming and more accurate patient flow pending definitive diagnosis. This may be of particular use in low-resource settings.

Predicting abnormal laboratory blood test results in the intensive care unit using novel features based on information theory and historical conditional probability (Preprint)

2021 ◽  
Author(s):  
Camilo E. Valderrama ◽  
Daniel J. Niven ◽  
Henry T. Stelfox ◽  
Joon Lee
Keyword(s):  
Machine Learning ◽  
Intensive Care ◽  
Conditional Probability ◽  
Blood Test ◽  
Laboratory Tests ◽  
Conditional Entropy ◽  
Admission Diagnosis ◽  
Test Results ◽  
Abnormal Laboratory ◽  
Blood Tests

BACKGROUND Redundancy in laboratory blood tests is common in intensive care units (ICU), affecting patients' health and increasing healthcare expenses. Medical communities have made recommendations to order laboratory tests more judiciously. Wise selection can rely on modern data-driven approaches that have been shown to help identify redundant laboratory blood tests in ICUs. However, most of these works have been developed for highly selected clinical conditions such as gastrointestinal bleeding. Moreover, features based on conditional entropy and conditional probability distribution have not been used to inform the need for performing a new test. OBJECTIVE We aimed to address the limitations of previous works by adapting conditional entropy and conditional probability to extract features to predict abnormal laboratory blood test results. METHODS We used an ICU dataset collected across Alberta, Canada which included 55,689 ICU admissions from 48,672 patients with different diagnoses. We investigated conditional entropy and conditional probability-based features by comparing the performances of two machine learning approaches to predict normal and abnormal results for 18 blood laboratory tests. Approach 1 used patients' vitals, age, sex, admission diagnosis, and other laboratory blood test results as features. Approach 2 used the same features plus the new conditional entropy and conditional probability-based features. RESULTS Across the 18 blood laboratory tests, both Approach 1 and Approach 2 achieved a median F1-score, AUC, precision-recall AUC, and Gmean above 80%. We found that the inclusion of the new features statistically significantly improved the capacity to predict abnormal laboratory blood test results in between ten and fifteen laboratory blood tests depending on the machine learning model. CONCLUSIONS Our novel approach with promising prediction results can help reduce over-testing in ICUs, as well as risks for patients and healthcare systems. CLINICALTRIAL N/A

scholarly journals Polymethylsiloxane polyhydrate (Enterosgel) in the complex treatment of children of the first year of life with diseases of the digestive system

2019 ◽  
Vol 64 (3) ◽  
pp. 91-96
Author(s):  
A. I. Khavkin ◽  
G. V. Volynets
Keyword(s):  
Side Effects ◽  
Digestive System ◽  
Length Of Hospital Stay ◽  
First Year ◽  
Complex Treatment ◽  
Blood Tests ◽  
Digestive Organs ◽  
Study Evaluation ◽  
First Year Of Life ◽  
Rapid Relief

Purpose of the study. Evaluation of the clinical efficacy of polymethylsiloxane polyhydrate (Enterosgel) in the complex treatment of children of the first year of life with diseases of the digestive system.Patients and methods. The authors carried out a retrospective analysis of the clinical course of diseases of the digestive organs of noninfectious etiology, the study included 38 patients of the first year of life (age 0.40 [0.25; 0.58] years; a continuousstudy of patients), who were treated with Enterosgel in the complex treatment. The comparison group consisted of 12 children (age 0.42 [0.25; 0.60] years) with diseases of the digestive organs, who did notreceive Enterosgel in complex treatment. The authors carried out a comparative assessment of the symptoms of intoxication, the nature of the stool, indicators of clinical blood tests and length of stay in the hospital.Results. The patients treated with Enterosgel demonstrated faster relief of intoxication symptoms and stool normalization; the length of hospital stay decreased 2 times, negative changes in blood tests and side effects of the drug were not observed.Conclusion. Complex treatment with Enterosgel of the diseases of the digestive organs in children of the first year of life is accompanied by more rapid relief of pathological symptoms and it reduces stay in the hospital, it is not accompanied by side effects, allowing us to recommend Enterosgel for the complex treatment of children of the first year of life.

scholarly journals Reasons for cattle retirement on feeding farms

2020 ◽  
Vol 17 ◽  
pp. 00098
Author(s):  
Maksim Zhukov ◽  
Yurij Alekhin ◽  
Ivan Kalyuzhny ◽  
Vasiliy Dorozhkin ◽  
Anatoliy Stekolnikov
Keyword(s):  
Urinary Tract ◽  
Detection Rate ◽  
Digestive System ◽  
Causes Of Death ◽  
Morphological Changes ◽  
Underlying Disease ◽  
Expert Evaluation ◽  
Cardiovascular Pathology ◽  
Young Cattle

The study has been carried out at two livestock complexes specializing in the production of beef to investigate the causes of non-productive retirement of animals. The structure of the causes of death or necessary slaughter of young cattle was determined by the results of pathological autopsy (n = 2816). Moreover, it was revealed that in 83.5 % of the animals, morphological changes in the respiratory organs prevailed, which in 40.2 % of the cases were thanatogenetically significant. The pathology of the digestive system was found in 29.6 % of animals, and in 14.9 % of cases they caused death. Pathology of the kidneys and urinary tract most often occurred at the age of 4–6 months and caused the retirement of 7.6–9.4 % of the animals. The role of cardiovascular pathology in the structure of the causes of retirement increases in young animals aged 8–11 months, while that of diseases of the joints and distal extremities rises at the final stage of their fattening. Clinical and expert evaluation of the activity of veterinary specialists (n = 12) showed that they correctly identified the underlying disease in 74 %, concomitant pathologies in 17.9 %, and complications in 5 % of diseased. Therefore, one of the problems of diagnosing diseases in young cattle during the period of growing and fattening is an incomplete diagnosis due to the low detection rate of concomitant pathologies and complications, some of which are of decisive thanatogenetic significance.

A multianalyte algorithm PCR-based gene blood test compared to single analyte ELISA-based blood tests for neuroendocrine tumor detection.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e15168-e15168
Author(s):  
Irvin Mark Modlin ◽  
Daniele Alaimo ◽  
Stephen Callahan ◽  
Nancy S. Teixeira ◽  
Lisa Bodei ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Blood Test ◽  
Tumor Detection ◽  
Blood Tests

scholarly journals Autism Spectrum Disorders — in Search of Mechanistic Biomarkers

2019 ◽  
Vol 17 (1) ◽  
pp. 15-23
Author(s):  
N. Rabbani ◽  
P.J. Thornalley
Keyword(s):  
Autism Spectrum Disorders ◽  
Blood Test ◽  
Early Stage ◽  
Clinical Chemistry ◽  
Scientific Basis ◽  
Autism Spectrum ◽  
Blood Tests ◽  
Recent Emergence ◽  
Spectrum Disorders ◽  
Neuropsychiatric Conditions

Autism spectrum disorders are a group of neuropsychiatric conditions of increasing prevalence. They are initially detected in early development of children. Diagnosis is currently made on the basis of clinical behaviour and cognition. Improvements in accuracy, timeliness and access to diagnosis to help manage the condition is high on the agenda of the autistic communities. A blood test may help for early-stage detection of autism spectrum disorders to focus support where required — particularly when symptoms are most challenging. This article discusses briefly the scientific basis of diagnosis of autism spectrum disorders and recent emergence of candidate blood tests for autism. We conclude that further validation and improvements in understanding of autism spectrum disorders are required to provide the scientific basis and classifier characteristics for accurate and reliable diagnosis by clinical chemistry blood test.

scholarly journals Are alveolar bone changes a determinant factor for "cara inchada" in cattle?

1997 ◽  
Vol 17 (2) ◽  
pp. 45-48 ◽  
Author(s):  
Jürgen Döbereiner ◽  
Klaus Dämmrich
Keyword(s):  
Cross Sections ◽  
Alveolar Bone ◽  
Proximal Humerus ◽  
Mineral Metabolism ◽  
Bone Changes ◽  
The Status ◽  
Young Cattle ◽  
Determinant Factor

In order to study possible alterations of the skeleton which might play a role in the pathogenesis of the periodontitis of "cara inchada" in young cattle, ribs from 20 affected calves, 2 to 10 months old, were examined. Electrolytically decalcified longitudinal sections of the costochondral junction and cross sections through the corpus costae, stained with Haematoxylin-Eosin, were studied. In five calves, longitudinal sections of the proximal humerus were examined as well. The status of mineralization was checked by microradiograms. Systemic alteration of the skeleton due to disturbances of mineral metabolism could not be shown in any of the animals. In seven 2 to 4 months old calves, no bone changes were found. The reduced osteogenesis in six 3 to 5 months old calves and the reduced osteogenesis and diminished chondral growth in seven 5 to 10 months old calves are therefore a consequence of the disease. The results show that the development of the alveolar bone was not defective, so this cannot be a determinant factor for the development of the periodontitis of "cara inchada" in cattle.

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