Biotin Use Can Interfere with the Management of Thyroid Diseases, Including Thyroid Cancer

2021 ◽  
Vol 33 (12) ◽  
pp. 520-522
Author(s):  
Grigoris Effraimidis ◽  
Linda Maria Hilsted ◽  
Ulla Feldt-Rasmussen
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Diseases

scholarly journals A Screening Study of Thyroid Cancer and Other Thyroid Diseases among Individuals Exposed in Utero to Iodine-131 from Chernobyl Fallout

2009 ◽  
Vol 94 (3) ◽  
pp. 899-906 ◽  
Author(s):  
M. Hatch ◽  
A. Brenner ◽  
T. Bogdanova ◽  
A. Derevyanko ◽  
N. Kuptsova ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Odds Ratio ◽  
Needle Aspiration ◽  
In Utero ◽  
Thyroid Diseases ◽  
Chernobyl Fallout ◽  
Cross Sectional ◽  
Screening Study ◽  
Iodine 131

Abstract Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid cancer risk in exposed children. Data on exposure to the embryonic/fetal thyroid are rare, raising questions about use of iodine 131 (I-131) in pregnant women. We present here estimated risks of thyroid disease from exposure in utero to I-131 fallout from the Chernobyl nuclear accident. Methods: We conducted a cross-sectional thyroid screening study (palpation, ultrasound, thyroid hormones, and, if indicated, fine needle aspiration) from 2003 to 2006. Participants were 2582 mother-child pairs from Ukraine in which the mother had been pregnant at the time of the accident on April 26, 1986, or 2 months after the time during which I-131 fallout was still present (1494 from contaminated areas, 1088 in the comparison group). Individual cumulative in utero thyroid dose estimates were derived from estimated I-131 activity in the mother’s thyroid (mean 72 mGy; range 0–3230 mGy). Results: There were seven cases of thyroid carcinoma and one case of Hurthle cell neoplasm identified as a result of the screening. Whereas the estimated excess odds ratio per gray for thyroid carcinoma was elevated (excess odds ratio per gray 11.66), it was not statistically significant (P = 0.12). No radiation risks were identified for other thyroid diseases. Conclusion: Our results suggest that in utero exposure to radioiodines may have increased the risk of thyroid carcinoma approximately 20 yr after the Chernobyl accident, supporting a conservative approach to medical uses of I-131 during pregnancy.

scholarly journals NA cohort study of thyroid cancer and other thyroid diseases after the Chernobyl accident

2009 ◽  
Vol 117 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Yuriy Bozhok ◽  
Ellen Greenebaum ◽  
Tetyana I. Bogdanova ◽  
Robert J. McConnell ◽  
Anna Zelinskaya ◽  
...  
Keyword(s):  
Cohort Study ◽  
Thyroid Cancer ◽  
Chernobyl Accident ◽  
Thyroid Diseases

scholarly journals Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

2021 ◽  
pp. FSO699
Author(s):  
Giuseppa Graceffa ◽  
Gregorio Scerrino ◽  
Gabriella Militello ◽  
Iole Laise ◽  
Brenda Randisi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Observational Study ◽  
Thyroid Hormones ◽  
Thyroid Surgery ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Disorders

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.

scholarly journals The first experience of laser spectroscopy in the surgical treatment of thyroid diseases

2019 ◽  
Vol 45 (1) ◽  
pp. 17-20
Author(s):  
P. S. Vetshev ◽  
K. E. Chilingaridi ◽  
L. I. Ippolitov ◽  
S. S. Harnas ◽  
V. B. Loshchenov ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Surgical Treatment ◽  
Laser Spectroscopy ◽  
Histological Analysis ◽  
Follicle Cell ◽  
Rapid Diagnosis ◽  
Thyroid Diseases ◽  
Subtotal Resection ◽  
Intraoperative Rapid Diagnosis

For assessing the efficacy of intraoperative laser autofluorescent spectroscopy (IOLAS), 46 patients with thyroid diseases of different etiology are examined. The patients ’ aged varied from 30 to 65 years. The following morphological types of diseases were observed: benign nodular formations in 42 patients, thyroid cancer in 4, papillary TINO MO in 2, and follicular cancer TINO MO in 2 cases. Out of benign formations, 36 were multinodular colloid goiter and 6 follicle-cell adenomas. As a result of using IOLAS, thyroid cancer was diagnosed during surgery in 8 (17.4%) out of 36 patients with multinodular colloid goiter; this diagnosis necessitated more extensive intervention than was planned: subtotal resection had to be extended to thyroidectomy. In all the cases IOLAS data were confirmed by urgent and later planned histological analyses. Due to this method, no reoperations were needed, which previously had to be performed because of the data of planned histological analysis, and therefore, the probable complications of reoperations were prevented. Our data indicate that IOLAS more accurately identifies the type and morphology of thyroid involvement and helps choose adequate volume of intervention. The first experience with laser fluorescent study as optic biopsy holds good promise as regards improvement of intraoperative rapid diagnosis of thyroid diseases.

scholarly journals The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Giovanni Docimo ◽  
Angelo Cangiano ◽  
Roberto Maria Romano ◽  
Marcello Filograna Pignatelli ◽  
Chiara Offi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Bacterial Infections ◽  
Association Studies ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Human Microbiota ◽  
Organ Specific ◽  
Benign Nodules ◽  
The Impact

The human microbiota is an integral component in the maintenance of health and of the immune system. Microbiome-wide association studies have found numerous diseases associated to dysbiosis. Studies are needed to move beyond correlations and begin to address causation. Autoimmune thyroid diseases (ATD) are one of the most common organ-specific autoimmune disorders with an increasing prevalence, higher than 5% worldwide. Most frequent manifestations of ATD are Hashimoto’s thyroiditis and Graves’ disease. The exact etiology of ATD remains unknown. Until now it is not clear whether bacterial infections can trigger ATD or modulate the efficacy of treatment and prognosis. The aim of our review is to characterize the microbiota and in ATD and to evaluate the impact of dysbiosis on treatment and prognosis. Moreover, variation of gut microbiome has been associated with thyroid cancer and benign nodules. Here we will characterize the microbioma in benign thyroid nodules, and papillary thyroid cancer to evaluate their implications in the pathophysiology and progression.

scholarly journals Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study

2018 ◽  
Vol 103 (6) ◽  
pp. 2216-2224 ◽  
Author(s):  
Cari M Kitahara ◽  
Dóra Kӧrmendiné Farkas ◽  
Jens Otto L Jørgensen ◽  
Deirdre Cronin-Fenton ◽  
Henrik Toft Sørensen
Keyword(s):  
Cohort Study ◽  
Thyroid Cancer ◽  
Thyroid Diseases ◽  
Benign Thyroid

scholarly journals Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Differentiating Benign Thyroid Diseases from Thyroid Cancer

2015 ◽  
Vol 6 (12) ◽  
pp. 1276-1281 ◽  
Author(s):  
Yaping Zhang ◽  
Ling Qiu ◽  
Chengyan He ◽  
Yanmin Wang ◽  
Yujie liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Thyroid Cancer ◽  
Free Fatty Acids ◽  
Thyroid Diseases ◽  
Biomarker Panel ◽  
Potential Biomarker ◽  
Benign Thyroid

scholarly journals Advances in diagnostic practices affect thyroid cancer incidence in France

2004 ◽  
pp. 133-139 ◽  
Author(s):  
L Leenhardt ◽  
MO Bernier ◽  
MH Boin-Pineau ◽  
B Conte Devolx ◽  
R Marechaud ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Incidence ◽  
Thyroid Diseases ◽  
Proportional Hazard ◽  
Clinical Practices ◽  
Cancer Prevalence ◽  
Diagnostic Practices ◽  
The Impact ◽  
Thyroid Cancer Incidence ◽  
Over Time

OBJECTIVE: To analyse trends in diagnostic practices of thyroid diseases and to relate them to the increase in thyroid cancer incidence in France over time. DESIGN: From 1980 to 2000, a French retrospective multicentric (three endocrinology and three nuclear medicine centres) study of thyroid diseases was conducted on 20 consecutive unselected patients' records, sampled every 5 years in each centre. METHODS: Characteristics of the population and diagnosis procedures (thyroid ultrasonography (US), radionuclide scan, cytology and hormonal measurements) were described over time. Changing trends in operated patients and in cancer prevalence were analysed as well as the impact of practices on cancer incidence. RESULTS: The study included 471 patients (82% female, mean age 46.7, range 9-84 years), referred for nodular thyroid diseases (66.7%) or thyroid dysfunctions (33.3%). A significant increase in US (3 to 84.8%) and cytological practices (4.5 to 23%), and a decrease (89.4 to 49.6%) in radionuclide scan procedures were observed over time. Although the proportion of patients undergoing surgery remained constant (24.8%), the prevalence of cancer increased among operated patients from 12.5 to 37% (P=0.006). In a Cox's proportional hazard model stratified on the clinical characteristics of patients, only the cytological practice, regardless of its results, was significantly associated with the occurrence of cancer: relative risk (RR)=4.4 (95% confidence interval (CI): 1.1-16; P=0.04). CONCLUSIONS: From 1980 to 2000, a major evolution in clinical practices has led to the increase in thyroid cancer reported in France. Such changes in medical, as well as in surgical and pathological, practices must be taken into account in incidence measurement.

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