scholarly journals Association of dietary patterns with the gut microbiota in older, community-dwelling men

2019 ◽  
Vol 110 (4) ◽  
pp. 1003-1014 ◽  
Author(s):  
James M Shikany ◽  
Ryan T Demmer ◽  
Abigail J Johnson ◽  
Nora F Fino ◽  
Katie Meyer ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Beta Diversity ◽  
Older Men ◽  
Community Dwelling ◽  
Microbial Composition ◽  
Cross Sectional ◽  
Alpha And Beta Diversity ◽  
Bacterial Phyla

ABSTRACT Background While the gut microbiota is relatively stable through adulthood, its composition is influenced by various host and environmental factors, including changes in health, gastrointestinal processes (e.g., transit time, gastric acidity), medication use, and diet. The association of habitual diet, in the form of a posteriori–derived dietary patterns, and microbiota composition has not been adequately studied, particularly in older men. Objective The objective was to investigate the association of dietary patterns with the composition and diversity of the gut bacterial microbiota in community-dwelling, older men. Methods This cross-sectional study included 517 men who were participants in the Osteoporotic Fractures in Men (MrOS) Study (≥65 y of age at baseline in 2000–2002) and who provided a stool sample and completed an FFQ at MrOS Visit 4 in 2014–2016. Dietary patterns were derived by factor analysis. 16S ribosomal RNA target gene sequencing was performed and taxonomy assignments were derived using the Greengenes database. Linear regression and permutational multivariate analysis of variance (PERMANOVA) considered variations in alpha and beta diversity by dietary pattern, and a model that implements a 0-inflated Gaussian distribution of mean group abundance for each taxa (metagenomeSeq) assessed taxonomic variations by dietary pattern. Results In multivariable-adjusted models, greater adherence to the Western pattern was positively associated with families Mogibacteriaceae and Veillonellaceae and genera Alistipes, Anaerotruncus, CC-115, Collinsella, Coprobacillus, Desulfovibrio, Dorea, Eubacterium, and Ruminococcus, while greater adherence to the prudent pattern was positively associated with order Streptophyta, family Victivallaceae, and genera Cetobacterium, Clostridium, Faecalibacterium, Lachnospira, Paraprevotella, and Veillonella. The relative abundance of the dominant gut bacterial phyla, Bacteroidetes and Firmicutes, did not differ between participants with greater adherence to the Western pattern, compared with those with greater adherence to the prudent pattern. Dietary patterns were not associated with measures of alpha diversity, but beta diversity measures were significantly associated with both Western and prudent patterns. Conclusions We observed significant associations between dietary patterns and measures of gut microbial composition in this sample of community-dwelling, older men.

scholarly journals Associations of Dietary Patterns With the Gut Microbiota in Older, Community-Dwelling Men

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 839-840
Author(s):  
James Shikany ◽  
Ryan Demmer ◽  
Abigail Johnson ◽  
Katie Meyer ◽  
Kristine Ensrud ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Dietary Pattern ◽  
Beta Diversity ◽  
Target Gene ◽  
Alpha Diversity ◽  
Osteoporotic Fractures ◽  
Community Dwelling ◽  
Food Frequency ◽  
Alpha And Beta Diversity ◽  
Bacterial Microbiota

Abstract We investigated associations of dietary patterns with composition and diversity of the gut bacterial microbiota in 517 community-dwelling older men (mean age 84.3 y) who were participants in the Osteoporotic Fractures in Men (MrOS) study. Eligible participants provided a stool sample and completed a food frequency questionnaire at the MrOS Visit 4 in 2014-2016. Dietary patterns were derived by factor analysis. 16S rRNA target gene sequencing was performed. Linear regression and PERMANOVA considered variation in alpha and beta-diversity by dietary pattern, and metagenomeSeq assessed taxonomic variation by dietary pattern. In multivariable-adjusted models, greater adherence to the Western pattern was positively associated certain taxa, including Alistipes, Desulfovibrio, Dorea, Eubacterium, and Ruminococcus, while greater adherence to the prudent pattern was positively associated with certain taxa, including Faecalibacterium, Lachnospira, and Paraprevotella. Dietary patterns were not associated with measures of alpha diversity; beta diversity measures were significantly associated with both Western and prudent patterns.

Human Milk Feeding Patterns at 6 Months of Age are a Major Determinant of Fecal Bacterial Diversity in Infants

2020 ◽  
pp. 089033442095757
Author(s):  
Kameron Y. Sugino ◽  
Tengfei Ma ◽  
Jean M. Kerver ◽  
Nigel Paneth ◽  
Sarah S. Comstock
Keyword(s):  
Gut Microbiota ◽  
Human Milk ◽  
Beta Diversity ◽  
Maternal Obesity ◽  
Alpha Diversity ◽  
Major Determinant ◽  
Cross Sectional ◽  
Alpha And Beta Diversity ◽  
Infant Diet ◽  
Milk Feeding

Background Maternal pre-pregnancy obesity and human milk feeding have been associated with altered infant gut microbiota. Research aim Determine the relationships between maternal pre-pregnancy BMI, human milk exposure, and their influence on the infant microbiota simultaneously. Methods This was a cross-sectional study of infants at 6 months of age ( N = 36), a time when many infants are fed a mixed diet of human milk and other foods. Fecal samples and participant information were collected from a subset of dyads enrolled in two related prospective cohorts (ARCHGUT and BABYGUT) in Michigan. Sequencing the V4 region of the 16S gene was used to analyze fecal bacterial samples collected from 6-month-old infants. Participants were grouped into four categories designated by their extent of human milk exposure (100%, 80%, 50%–80%, ≤ 20% human milk in the infant diet) and by maternal pre-pregnancy BMI category (normal, overweight, obese). Results Fewer participants with pre-pregnancy obesity were breastfeeding at 6 months postpartum compared to non-obese participants (35.7% and 81.8%, respectively). In univariate analyses, maternal pre-pregnancy BMI and human milk exposure were both significantly associated with alpha and beta diversity of the infant microbiota. However, in multivariate analyses, human milk exposure accounted for 20% of the variation in alpha diversity, but pre-pregnancy BMI was not significantly associated with any form of microbiota diversity. Conclusions The proportion of the infant diet that was human milk at 6 months was the major determinant of alpha and beta diversity of the infant. Maternal obesity contributes to the gut microbiota by its association with the extent of human milk feeding.

scholarly journals Associations between dietary patterns and demographics, lifestyle, anthropometry and blood pressure in Chinese community-dwelling older men and women

2012 ◽  
Vol 1 ◽  
Author(s):  
Ruth Chan ◽  
Dicken Chan ◽  
Jean Woo
Keyword(s):  
Blood Pressure ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Smoking Habit ◽  
Community Dwelling ◽  
Dietary Advice ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Milk Products ◽  
Multiple Regressions

AbstractThis cross-sectional study examined dietary patterns, and the associations of these patterns with demographics, lifestyle, anthropometry and blood pressure in 3707 Chinese people aged 65 years and above taking part in a population-based cohort study investigating the risk factors for osteoporosis. Baseline dietary data were collected using a validated FFQ. Dietary patterns were identified using factor analysis. Scores were calculated for each pattern. Demographics, lifestyle factors and self-reported hypertension history were collected through a questionnaire. BMI, waist circumference (WC), hip circumference (HC), waist-to-hip ratio, systolic blood pressure and diastolic blood pressure (DBP) were measured. Three dietary patterns were identified, namely ‘vegetables–fruit’, ‘snacks–drinks–milk products’ and ‘meat–fish’. Participants who were more physically active, more educated, non-smokers and non-drinkers were more likely to have higher ‘vegetables–fruit’ dietary pattern scores. Current smoking habit and alcohol use were associated with higher ‘snacks–drinks–milk products’ dietary pattern scores and ‘meat–fish’ dietary pattern scores. ‘Vegetables–fruit’ dietary pattern scores were inversely (unstandardised regression coefficient B = −0·60 mmHg, 95 % CI −1·04, −0·16) and ‘snacks–drinks–milk products’ dietary pattern scores were positively (B = 0·50 mmHg, 95 % CI 0·08, 0·92) associated with DBP in men in multiple regressions. Higher ‘meat–fish’ dietary pattern scores were associated with higher BMI (B = 0·19 kg/m2, 95 % CI 0·06, 0·33), waist-to-hip ratio (B = 0·004, 95 % CI 0·002, 0·007) and WC (B = 0·57 cm, 95 % CI 0·18, 0·97) in men, and higher BMI (B = 0·40 kg/m2, 95 % CI 0·22, 0·57), WC (B = 0·87 cm, 95 % CI 0·39, 1·36) and HC (B = 0·61 cm, 95 % CI 0·26, 0·96) in women in multiple regressions. The influence of demographic and lifestyle characteristics on dietary patterns and the health risks associated with dietary patterns provides insights for the provision of tangible dietary advice to this population.

scholarly journals Associations between Taste Perception Profiles and Empirically Derived Dietary Patterns: An Exploratory Analysis among Older Adults with Metabolic Syndrome

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 142
Author(s):  
Julie E. Gervis ◽  
Rebeca Fernández-Carrión ◽  
Kenneth K. H. Chui ◽  
Jiantao Ma ◽  
Oscar Coltell ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Multinomial Logistic Regression ◽  
Principal Component ◽  
Community Dwelling ◽  
Taste Perception ◽  
Cross Sectional ◽  
Animal Fats

Taste perception is a primary driver of food choices; however, little is known about how perception of all five tastes (sweet, salt, sour, bitter, umami) collectively inform dietary patterns. Our aim was to examine the associations between a multivariable measure of taste perception—taste perception profiles—and empirically derived dietary patterns. The cohort included 367 community-dwelling adults (55–75 years; 55% female; BMI = 32.2 ± 3.6 kg/m2) with metabolic syndrome from PREDIMED-Plus, Valencia. Six taste perception profiles were previously derived via data-driven clustering (Low All, High Bitter, High Umami, Low Bitter and Umami, High All But Bitter, High All But Umami); three dietary patterns were derived via principal component analysis (% variance explained = 20.2). Cross-sectional associations between profiles and tertials of dietary pattern adherence were examined by multinomial logistic regression. Overall, there were several significant differences in dietary pattern adherence between profiles: the vegetables, fruits, and whole grains pattern was significantly more common for the High All But Umami profile (OR range for high vs. low adherence relative to other profiles (1.45–1.99; 95% CI minimum lower, maximum upper bounds: 1.05, 2.74), the non-extra virgin olive oils, sweets, and refined grains pattern tended to be less common for Low All or High Bitter profiles (OR range: 0.54–0.82), while the alcohol, salty foods, and animal fats pattern tended to be less common for Low Bitter and Umami and more common for High All But Bitter profiles (OR range: 0.55–0.75 and 1.11–1.81, respectively). In conclusion, among older adults with metabolic syndrome, taste perception profiles were differentially associated with dietary patterns, suggesting the benefit of integrating taste perception into personalized nutrition guidance.

scholarly journals Physical activity and gut microbiota: a cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F Gallè ◽  
F Valeriani ◽  
M Antinozzi ◽  
R Liguori ◽  
G Gianfranceschi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gut Microbiota ◽  
Amplicon Sequencing ◽  
Cross Sectional Study ◽  
Microbiota Composition ◽  
Sectional Study ◽  
Microbial Composition ◽  
Cross Sectional ◽  
Bacterial Phyla ◽  
Gut Microbiota Composition

Abstract Background The composition of gut microbiota, and in particular the intestinal abundance of the two main bacterial phyla of Firmicutes and Bacteroidetes, are associated with human health and diseases and may be conditioned by host and environmental factors such as age, gender and diet. The role of Physical Activity (PA) in determining gut microbiota composition has not been yet completely clarified. A cross-sectional study involving undergraduates from two Italian cities is ongoing to explore this relationship. Methods Students were invited to provide a fecal sample and to complete the International Physical Activity Questionnaire (IPAQ) in order to define their habitual PA level (inactive, minimally active, health enhancing physical activity -HEPA- active). Demographic and anthropometric information were also collected. DNA from fecal samples was analyzed through the 16S amplicon sequencing. Microbial composition and variability of the samples were evaluated on the light of participants' PA levels. Results A total of 153 students (47.7% males, mean age 22.4±2.9, mean BMI 22.3±2.7) participated to the study so far. Firmicutes and Bacteroidetes were the main represented phyla. An increase in Firmicutes (58.3±16 to 61.4±13.3, p = 0.68) and a reduction in Bacteroidetes (32.6±14.8 to 30.3±11.4, p = 0.51) have been registered with the increase of PA level. A higher variability (expressed as Shannon α-index) has been detected in minimally active (3.39±0.03) and HEPA-active (3.41±0) individuals respect to inactive subjects (3.35±0.07) (p = 0.05). Conclusions Even if they are not significant, these preliminary results suggest a relationship between PA levels and gut microbiota composition. An active lifestyle seems to be associated with a greater microbial diversity in the gut. Further researches are needed to explain these findings. Key messages Physical activity seems to be associated with gut microbiota composition. A greater variability in gut microbiota was found in active people.

scholarly journals Association of nutrient-derived dietary patterns with sarcopenia and its components in community-dwelling older Japanese: a cross-sectional study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuri Yokoyama ◽  
Akihiko Kitamura ◽  
Satoshi Seino ◽  
Hunkyung Kim ◽  
Shuichi Obuchi ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Dietary Pattern ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Dietary Factors ◽  
Sectional Study ◽  
Reduced Rank Regression ◽  
Cross Sectional ◽  
Rank Regression ◽  
And Function

Abstract Background Diet is a modifiable factor affecting sarcopenia, and accumulating evidence links dietary factors to muscle mass, strength, and function in older adults. However, few studies have examined the association of dietary patterns with sarcopenia. This study examined the association of dietary patterns derived by reduced-rank regression (RRR) with sarcopenia and its components in community-dwelling older Japanese. Methods We conducted a cross-sectional study of 1606 community-dwelling adults aged 65 years or older. Dietary intake was assessed by a validated, self-administered diet history questionnaire. Nutrient-derived dietary patterns were identified by using RRR, with sarcopenia-related nutrients (protein, vitamin D, vitamin C, vitamin E, folate, vitamin K, magnesium, iron, and calcium intakes) as response variables. Sarcopenia was defined by using the algorithm of the Asian Working Group for Sarcopenia 2019. Multivariate regression and logistic regression were used to examine the association of dietary patterns with sarcopenia and its components. Results The first RRR dietary pattern was characterized by high intakes of fish, soybean products, potatoes, most vegetables, mushrooms, seaweeds, and fruit and a low intake of rice and was associated with decreased prevalence of sarcopenia: the multivariable-adjusted odds ratio of sarcopenia was 0.57 (95% confidence interval, 0.34–0.94; p for trend=0.022) in the highest versus the lowest tertile of dietary pattern. This dietary pattern was also significantly positively associated with usual gait speed (β: 0.02, p=0.024). Conclusions A dietary pattern characterized by high intakes of fish, soybean products, potatoes, most vegetables, mushrooms, seaweeds, and fruits and low rice intake was inversely associated with sarcopenia in community-dwelling older Japanese.

scholarly journals The relationship between protein intake and gut microbiota in community-dwelling older men from the MrOS study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 992-993
Author(s):  
Samaneh Farsijani ◽  
Jane Cauley ◽  
Shyamal Peddada ◽  
Lisa Langsetmo ◽  
James Shikany ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Energy Intake ◽  
Dietary Protein ◽  
Gut Microbiome ◽  
Protein Intake ◽  
Older Men ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Β Diversity ◽  
Α Diversity

Abstract Despite growing evidence supporting the role of protein consumption in promoting muscle health, the possible mediation by gut microbiota remains unclear. Here, we determined the association between the quantity of dietary protein and gut microbiome composition in community-dwelling older adults. We performed a cross-sectional analysis on 775 older men from the Osteoporotic Fractures in Men (MrOS) study with available dietary information and stool samples at visit 4 (2014-16). Protein intake extracted from a brief Food Frequency Questionnaire and adjusted to total energy intake using the residual method. Gut microbial taxa were determined by 16S (v4) sequencing (Greengenes references). 11,534 Operational Taxonomic Units were identified and assigned to 21 phyla with dominance of Firmicutes (45%) and Bacteroidetes (43%). We performed distribution-based analysis (α-diversity), distance-based Permutation Multivariate Analysis of Variance (β-diversity), and taxa abundance (by ANCOM-BC R-package) to determine associations between protein intake and gut microbiome. Mean energy-adjusted protein intake was 62.0±10.8 g/d [0.8±0.3 g/kgBW/d]. Participants with higher protein intake had higher Shannon and Chao1 α-diversity indices (P<0.05). For β-diversity analysis, participants with higher protein intake had a different center in weighted and unweighted UniFrac PCoA vs. those with lower intake (P<0.05) adjusted for age, race, clinical center, energy intake, weight, height, and medications. Tenericutes phylum and several genus-level OTUs, including Klebsiella, Tyzzerella, Christensenellaceae, Ruminococcaceae, Blautia, and Veillonella were differentially abundant between quartiles of protein intake (FDR corrected P<0.05). Our data support an association between dietary protein and gut microbiota diversity, a relationship that could potentially influence physical function and sarcopenia development.

scholarly journals Association between Dietary Patterns and Low HDL-C among Community-Dwelling Elders in North China

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3308
Author(s):  
Pengkun Song ◽  
Qingqing Man ◽  
Yuqian Li ◽  
Shanshan Jia ◽  
Dongmei Yu ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Dietary Pattern ◽  
Elderly Population ◽  
North China ◽  
The Elderly ◽  
Community Dwelling ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Increased Risk ◽  
Low Hdl

We aimed to investigate the association between dietary patterns and low HDL-C among the elderly population living in North China. The data were from a national cross-sectional survey conducted in 2015. General information in terms of living habits, health status, and food intake using 24 h dietary recall for three consecutive days was procured, and the weight of edible oil and condiments recorded. Anthropometric index, blood pressure, and fasting serum lipids were measured using standard methods. Dietary patterns were derived from food categories by exploratory factor analysis, and multivariate logistic regression was used to estimate the odds ratios of low HDL-C across quartiles of dietary patterns. Among 3387 elderly participants, 21.9% had low HDL-C levels. After adjusting for potential confounding factors, participants with highest score versus lowest score in the balanced dietary pattern had a decreased risk of low HDL-C (OR = 0.38, 95% CI: 0.16–0.88, p for trend = 0.013) in the group with a BMI of 27.1 kg/m2 and above. Compared to the lowest quartile, there was a statistically significant negative association between the highest scores of the Western dietary pattern and low HDL-C (OR = 0.37, 95% CI: 0.17–0.82, p for trend = 0.018) in the group with a BMI of 21.6–24.8 kg/m2. However, greater adherence to a thrifty dietary pattern (highest quartiles vs. lowest quartiles) was associated with increased risk of low HDL-C (OR = 3.31, 95% CI: 1.05–10.40, p for trend = 0.044), especially in the subgroup with a BMI of 21.6 kg/m2 and below. The study revealed that it is urgent to develop district-specific dietary improvement plans for dyslipidemia based on the nutritional status of the elderly population in North China.

scholarly journals Gut Microbiome in Psoriasis: An Updated Review

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 463
Author(s):  
Mariusz Sikora ◽  
Albert Stec ◽  
Magdalena Chrabaszcz ◽  
Aleksandra Knot ◽  
Anna Waskiel-Burnat ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Beta Diversity ◽  
Large Scale ◽  
Skin Diseases ◽  
Intestinal Barrier ◽  
Alpha Diversity ◽  
Current Data ◽  
Intestinal Microbiome ◽  
Microbial Composition ◽  
Alpha And Beta Diversity

(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.

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