scholarly journals Using conceptual modeling to improve genome data management

Author(s):  
Óscar Pastor ◽  
Ana Palacio León ◽  
José Fabián Román Reyes ◽  
Alberto Simón García ◽  
Juan Carlos Rodenas Casamayor

Abstract With advances in genomic sequencing technology, a large amount of data is publicly available for the research community to extract meaningful and reliable associations among risk genes and the mechanisms of disease. However, this exponential growth of data is spread in over thousand heterogeneous repositories, represented in multiple formats and with different levels of quality what hinders the differentiation of clinically valid relationships from those that are less well-sustained and that could lead to wrong diagnosis. This paper presents how conceptual models can play a key role to efficiently manage genomic data. These data must be accessible, informative and reliable enough to extract valuable knowledge in the context of the identification of evidence supporting the relationship between DNA variants and disease. The approach presented in this paper provides a solution that help researchers to organize, store and process information focusing only on the data that are relevant and minimizing the impact that the information overload has in clinical and research contexts. A case-study (epilepsy) is also presented, to demonstrate its application in a real context.

2020 ◽  
Vol 15 (2) ◽  
pp. 95-109
Author(s):  
Heba Aziz ◽  
Osman El-Said ◽  
Marike Bontenbal

The objective of this study was to measure the level of cruise tourists' satisfaction as well as the relationship between satisfaction, recommendation, return intention, and expenditure. Also, the impact of factors such as nationality, length of the visit, and age on the level of expenditure was measured. An empirical approach for data collection was followed and a total of 152 questionnaires were collected from cruise tourists visiting the capital city of Oman, Muscat, as cruise liners anchor at Sultan Qaboos Port. Results of the regression analysis supported the existence of a causal relationship between satisfaction with destination attributes, overall satisfaction, recommendation, return intention, and expenditure. It was found that the average expenditure varies according to age and length of the visit. Recommendations for policy makers were suggested on how to increase the role of cruise tourism in strengthening the economy.


Author(s):  
Iwona Niewiadomska ◽  
Rafał P. Bartczuk ◽  
Joanna Chwaszcz ◽  
Stanisław Fel ◽  
Weronika Augustynowicz ◽  
...  

Abstract This article explores the question, to what degree religiosity contributes, as a protecting factor against a broad category of socially deviant adolescent and youth behaviours. It also tests the hypothesis that gender plays a moderating role in the relationship between religiosity and problem behaviour. It employs a modified version of the Problem Behaviour Syndrome Measure (PBSM), in concert with Jessor and Jessor’s conceptual work. It also makes use of the Duke Religion Index (DUREL) to assess religiosity. The empirical study deals with a representative group of 960 students of upper-secondary schools in the Lubelskie province, Poland. The results were analyzed using canonical analysis and ANOVA. The achievements of the article are twofold. First, it identifies significant correlations between the different levels of religiosity among youth, and the occurrence and intensification of problem behaviours, particularly in regard to organized activity. Organized and intrinsic religiosity play principal protective roles, while the impact of personal religious practices is less significant. Secondly, while analyzing the moderating role of gender in the relationship between religiosity and the intensity of problem behaviour, it was found that gender does not have a significant interactive impact. An affirmative conclusion was confirmed in only two instances.


2021 ◽  
Author(s):  
SANGHAMITRA CHOUDHURY ◽  
Shailendra Kumar

<p>The relationship between women, technology manifestation, and likely prospects in the developing world is discussed in this manuscript. Using India as a case study, the paper goes on to discuss how ontology and epistemology views utilised in AI (Artificial Intelligence) and robotics will affect women's prospects in developing countries. Women in developing countries, notably in South Asia, are perceived as doing domestic work and are underrepresented in high-level professions. They are disproportionately underemployed and face prejudice in the workplace. The purpose of this study is to determine if the introduction of AI would exacerbate the already precarious situation of women in the developing world or if it would serve as a liberating force. While studies on the impact of AI on women have been undertaken in developed countries, there has been less research in developing countries. This manuscript attempts to fill that need.</p>


10.28945/3041 ◽  
2006 ◽  
Author(s):  
Karlheinz Kautz ◽  
Bjarke Nielsen

Information systems development takes place within an economical context. However, the economical conditions, which shape systems development in practice, are hardly researched. In this paper we are investigating the question how a given price structure influences systems development projects. Our analysis is based on a multi case study and a Grounded Theory inspired research approach. Our work is informed by economic theories, which deal with the relationship of suppliers and customers and their mutual dependency. We thus apply principal-agent theory and economic game theory in form of the prisoner’s dilemma. As a result we provide three interlinked models for understanding the impact of pricing structure on systems development practice. The main elements of these models are pricing structure, risk distribution and price level, and opportunistic behavior. We discuss how these elements are interrelated and examine their impact on information systems development in practice.


2019 ◽  
Vol IV (I) ◽  
pp. 108-119
Author(s):  
Mujib Ur Rahman ◽  
Muhammad Faizan Malik ◽  
Wisal Ahmad

The paper examined the impact of relational capitals on community economic development. For this purpose, the handloom business community was taken as a case study from Peshawar Valley. Data was collected through purposive sampling from169 handlooms firms. The results concluded that the impact of relational capital is significant, and the relationship is positive. This study hereby suggests that government and policymakers should invest in making ties and a strong network of firms within and outside of the community; hence with high investment in making strong social-relational capital can develop the entire entrepreneurial communities.


Author(s):  
Edy Effendi ◽  
Muhammad Imron

Research on the role of the APIP review of the Ministry/agency Work Plan and Budget document to determine the impact on the efficiency of ministry/agency spending (case study at the Ministry of Religion). The method used in this study uses simple linear regression with dummy. The use of linear regression is used to examine the relationship between independent variables (certain types of expenditure) and dependent variables (total expenditure). Whereas, dummy is used to find out before and after the APIP review is done. Throughout the author's search, this research has never been done. Based on the results of linear regression obtained, the APIP review significantly had a positive effect on official travel expenditure and honorarium but did not significantly affect building spending and equipment. Abstrak   Penelitian atas peran reviu APIP atas dokumen Rencana Kerja dan Anggaran Kementerian Negara/Lembaga untuk mengetahui dampaknya terhadap efisiensi belanja kementerian/lembaga (studi kasus pada Kementerian Agama). Metode yang digunakan dalam penelitian ini menggunakan regresi linier sederhana dengan dummy. Penggunaan regresi liner digunakan untuk meneliti hubungan antara variable independen (jenis belanja tertentu) dan variable dependen (total belanja). Sedangkan, dummy digunakan untuk mengetahui sebelum dan setelah reviu APIP dilakukan. Sepanjang penelusuran penulis, penelitian ini belum pernah dilakukan. Berdasarkan hasil regresi linier diperoleh, reviu APIP signifikan berpengaruh positif terhadap  belanja perjalanan dinas dan honorarium tetapi tidak signifikan berbengaruh terhadap belanja gedung dan alat.


Author(s):  
Najmudin Najmudin

The results shows that there are changes of social capital of dairy farmers groups in the process of institutionalization of SAMESTA cooperatives. The change is the impact of the conditions of Indonesian dairy. These changes occur in several elements of social capital, as follows: (1) Value, as a guide and reinforcement of farmers’ positive behavior. The existing values among farmers are klangenan (like), titen (scrutinize deeply), honesty, and togetherness. These values ​​become the fuel that forces the farmers to relate each other and realize the more transparent and fairer cooperative. This case shows the influence of cultural values ​​on the farmers’ economic behavior. They calculate inputs and outputs, and make some adjustments to prevent them from losing and calculate the standard number of cows that they have. (2) Trust changes positively, especially by raising the milk price from farmers, although it gives a risk to the cooperative income. This decision is expected to increase the farmers' ethos, thus impacts on the increase of milk production. (3) Networks, in which the relationship between farmers firstly occurs in hamlet area, then it extends the network beyond those limits. Farmers from different villages are connected naturally. This inter-subject's relationship occurs due to the same goals, which are wishes to be more dignified, prosperous, and get fair treatment.


2017 ◽  
Vol 39 (3) ◽  
pp. 5
Author(s):  
Solano Dos Santos Nascimento

ResumoO artigo apresenta o resultado de um estudo de casos múltiplos a respeito da relação entre três reportagens que trataram de problemas sociais – publicadas pela revista Época e pelos jornais O Globo e Correio Braziliense - e mudanças na legislação que teoricamente buscaram resolver os problemas apontados pelas reportagens. O estudo concluiu que houve influência das reportagens nas mudanças em leis, mas que esse impacto teve nuanças bastante distintas.AbstractThis report presents the results of a multiple case study about the relationship between three stories  that dealt with social problems - published by Época magazine and O Globo and Correio Braziliense newspapers  - and changes in legislation that theoretically sought to solve the problems pointed out by the stories . The study conclusion was that there was influence of the stories in laws  changes, the impact had quite different shades. ResumenEl artículo presenta el resultado de un estudio de casos múltiples acerca de la relación entre tres reportajes sobre problemas sociales-publicados por la revista Época y por los periódicos O Globo y Correio Braziliense - y cambios en la legislación que teóricamente buscaron resolver los problemas señalados por los reportajes . El estudio concluyó que hubo influencia de los reportajes en los cambios de leyes, pero que ese impacto tuvo matices muy distintos.


Author(s):  
Tamara Y. Gertsog

We analyze the concept of legal awareness of citizens, its structure, significance for a particular individual and for society as a whole, ways to increase the level of legal awareness of the population, as well as the con-sequences due to an increase in the level of legal awareness. We cover the is-sue of excess information in the legal sphere, its causes and consequences. We consider the essence of legal information burnout, its signs, potential danger and impact, identified preventive measures and methods to combat this phenomenon. We comprehend the impact of excessive legal information on professional deformation and professional burnout of lawyers, we have determined the functional significance of excessive legal information to citi-zens to maintain the proper level of their legal functional literacy. The pur-pose of the study is to determine the relationship between the increased vol-ume of legal awareness, information overload, legal information burnout and, as a consequence, the professional deformation of lawyers. We make an attempt to declare the existence of the phenomenon, which is conventionally called by the author legal information burnout. The study will be of interest to specialists in the field of jurisprudence, psychology, information technology, and may also be useful for other specialists and all those who are interested in the issues of this issue.


Author(s):  
Mustafa Doğan

Purpose The purpose of this paper is to examine the relationship between the ecomuseum and solidarity tourism and to measure their impact on community development. Design/methodology/approach The study presented here adopts two methods for collecting qualitative data: in-depth interviews and observations. The total number of village households was 42 and the number of households that hosted tourists in their home was 20. Due to the exploratory nature of this study, qualitative methods were employed in the form of lengthy interviews with 13 residents. Findings The findings indicate that tourism for the Bogatepe Village ecomuseum has focused on a solidarity perspective which has provided significant benefits to the community ensuring local sustainable development. The ecomuseum as a concept and a destination has helped to control tourism and strengthened the impact of solidarity tourism on the local community. Research limitations/implications The research presented here must be seen as exploratory. More generally, further research is needed to look at the possibility of developing this type of tourism in other rural areas and similar regions of Turkey (covering both small and large areas) with an important cultural heritage. Originality/value The combination of the ecomuseum and solidarity tourism can provide a sustainable solution for tourism in rural areas and provide a model in the development of tourism to other villages in Turkey. The question is whether it could also be used in larger rural areas. The study underlines that Bogatepe is certainly worthy of future study.


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