P3783A higher habitual flavonoid intake is associated with a lower risk of atrial fibrillation

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
N Bondonno ◽  
K Murray ◽  
C P Bondonno ◽  
J R Lewis ◽  
K D Croft ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Lower Risk ◽  
Disease Risk ◽  
Smoking Status ◽  
Cardiovascular Disease Risk ◽  
Cox Proportional Hazards ◽  
Total Flavonoid ◽  
Health Study ◽  
Inverse Association ◽  
Flavonoid Intake

Abstract Background Our understanding of how diet affects future risk of atrial fibrillation (AF) is limited. Evidence suggests that higher habitual intakes of flavonoids, bio-active compounds found in plant-based foods and beverages, lower cardiovascular disease risk, attenuate inflammation, and may have anti-arrhythmic properties. Purpose To investigate the association between flavonoid intake and clinically apparent AF in a large cohort of Danish men and women. Methods Baseline data from 55 634 participants without AF of the Danish Diet, Cancer and Health Study, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and AF hospitalisation were examined using restricted cubic splines based on Cox proportional hazards models with adjustments for age, sex, BMI, smoking status, physical activity, alcohol intake, income, and hyperthyroidism. Results After a median [IQR] follow-up of 21 [18–22] years, 6 301 participants were hospitalised with AF. Non-linear associations were observed for total flavonoid intake and for all flavonoid sub-classes. For total flavonoid intake, after adjusting for potential lifestyle confounders and compared to participants in quintile 1 (median intake: 173 mg/day), those in quintile 3 (median intake: 320 mg/day) and quintile 4 (median intake: 494 mg/day) had a significantly lower risk of AF, with hazard ratios (95% CI) of 0.93 (0.87, 0.99) and 0.92 (0.86, 0.98), respectively. Compared to median intake in the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.05)], a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.94)] but not in low-to-moderate alcohol consumers [<20 g/d: 0.97 (0.89, 1.06], a trending lower risk of AF in diabetics [0.76 (0.51, 1.14)] but not in non-diabetics [0.95 (0.89, 1.02)], and a trending lower risk of AF in those with ischaemic heart disease [0.84 (0.65, 1.09)] but not in those without [0.96 (0.89, 1.03), Figure 1]. Figure 1 Conclusion We observed an inverse association between total flavonoid intake and AF, most notably in sub-populations with known lifestyle and disease risk factors for AF. This finding warrants investigation in randomised controlled trials. If confirmed, ensuring the adequate consumption of flavonoid-rich foods, particularly in individuals “at risk”, may be an important strategy to mitigate AF risk. Acknowledgement/Funding The Danish Diet, Cancer, and Health Study was funded by the Danish Cancer Society.

Abstract MP66: Higher Habitual Flavonoid Intakes Are Associated With A Lower Incidence Of Diabetes

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Nicola P Bondonno ◽  
Frederik Dalgaard ◽  
Kevin Murray ◽  
Raymond J Davey ◽  
Catherine P Bondonno ◽  
...  
Keyword(s):  
Body Fat ◽  
Lower Risk ◽  
Smoking Status ◽  
Absolute Risk ◽  
Total Flavonoid ◽  
Incident Diabetes ◽  
Health Study ◽  
Lower Body ◽  
Obesity And Diabetes ◽  
Flavonoid Intake

Introduction: The promotion of evidence-based diets is an important s trategy to mitigate the global health and economic burden of diabetes. Higher flavonoid intakes are associated with a lower risk of obesity and diabetes. Less clear are associations of the flavonoid subclasses with diabetes, the mediating impact of body fat, and the identification of subpopulations that may receive the greatest benefit. Hypothesis: Higher flavonoid intakes will be associated with lower body fat at baseline and a lower risk of diabetes during follow-up. Methods: Incident diabetes was assessed in 54,787 participants of the Danish Diet, Cancer, and Health Study followed-up for 23 years. Dietary intake and objective measures of body fat were assessed at baseline; habitual flavonoid intake was calculated using the Phenol-Explorer database and body fat was objectively assessed using bioelectrical impedance. Incidence of diabetes was obtained using Danish National Patient and Prescription Registries. Cross-sectional associations between flavonoid intakes and body fat were assessed using multivariable-adjusted linear regression models. Non-linear associations between flavonoid intake and incident diabetes were examined using restricted cubic splines based on multivariable-adjusted Cox proportional hazards models. Results: Among 54,787 participants without diabetes at baseline (median [IQR] age of 56 [52 - 60] years; (47.3%) men), 6,700 individuals were diagnosed with diabetes. Participants in the highest total flavonoid intake quintile (median, 1,202 mg/d) had a 1.52 kg lower body fat (95% CI: -1.74, -1.30) and a 19% lower risk of diabetes [HR (95% CI): 0.81 (0.75, 0.87)] after multivariable adjustments and compared to participants in the lowest intake quintile (median, 174 mg/d). Body fat mediated 51.6% of the association between flavonoid intake and incident diabetes. Neither smoking status, BMI, nor sex appeared to modify the association between total flavonoid intake and incident diabetes. However, the difference (flavonoid intake quintile 5 - quintile 1) in the 20-year estimated absolute risk of diabetes was greatest for current smokers (males: 2.19%, females: 1.65%) and those with a BMI ≥30 kg/m 2 (males: 5.56%, females: 4.59%), likely owing to the higher prevalence of diabetes in these “at risk” subgroups. Moderate to high intakes of flavonols, flavanol monomers, flavanol oligo+polymers, and anthocyanins, and the individual compounds within these subclasses, were associated with a lower risk of diabetes. Conclusion: In this Danish prospective cohort study, we observed that higher flavonoid intakes were cross-sectionally associated with lower body fat, and longitudinally associated with a lower risk of diabetes. Our results suggest that promoting a diet abundant in flavonoid-rich foods may help to ameliorate diabetes risk, in part through a reduction in body fat.

scholarly journals Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations

2020 ◽  
Vol 113 (1) ◽  
pp. 187-199
Author(s):  
Nicola P Bondonno ◽  
Kevin Murray ◽  
Aedin Cassidy ◽  
Catherine P Bondonno ◽  
Joshua R Lewis ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Lower Risk ◽  
Smoking Status ◽  
Total Flavonoid ◽  
Health Study ◽  
Atherosclerotic Cardiovascular Disease ◽  
Peripheral Artery ◽  
Diabetes Status ◽  
Flavonoid Intake ◽  
Artery Disease

ABSTRACT Background The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD. Objectives We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD. Methods Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated from FFQs using the Phenol-Explorer database. Associations were examined using multivariable-adjusted restricted cubic splines based on Cox proportional hazards models. Results After a median [IQR] follow-up time of 21 [20–22] y, 2131 participants had been hospitalized for any PAD. The association between total flavonoid intake and total PAD hospitalizations was nonlinear, reaching a plateau at ∼750–1000 mg/d. Compared with the median flavonoid intake in quintile 1 (174 mg/d), an intake of 1000 mg/d was associated with a 32% lower risk of any PAD hospitalization (HR: 0.68; 95% CI: 0.60, 0.77), a 26% lower risk of atherosclerosis (HR: 0.74; 95% CI: 0.62, 0.88), a 28% lower risk of an aneurysm (HR: 0.72; 95% CI: 0.59, 0.88), and a 47% lower risk of a hospitalization for other peripheral vascular disease (HR: 0.53; 95% CI: 0.42, 0.67). A higher total flavonoid intake was also significantly associated with a lower incidence of revascularization or endovascular surgery and lower extremity amputation. The association between total flavonoid intake and PAD hospitalizations differed according to baseline smoking status, alcohol intake, BMI, and diabetes status. Conclusions Ensuring the adequate consumption of flavonoid-rich foods, particularly in subpopulations prone to the development of atherosclerosis, may be a key strategy to lower the risk of PAD.

Abstract P175: High-density Lipoprotein Cholesterol and Mortality Prior to Age 90 in a Cohort of Male Physicians

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Catherine Rahilly-Tierney ◽  
Howard D Sesso ◽  
J. Michael Gaziano ◽  
Luc Djousse
Keyword(s):  
High Density Lipoprotein ◽  
Lower Risk ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cox Proportional Hazards ◽  
High Density ◽  
Health Study ◽  
Inverse Association ◽  
Cvd Mortality

BACKGROUND: Few studies have examined prospectively the relationship between baseline high-density lipoprotein (HDL) cholesterol and longevity. OBJECTIVES: We sought to examine whether higher HDL levels were associated with lower risk of all-cause, cardiovascular (CVD), and non-CVD mortality prior to age 90 in the Physicians’ Health Study (PHS). METHODS: We considered a baseline cohort of 1351 PHS participants who provided bloods between 1997 and 2001 and were old enough to reach age 90 by March 4, 2009. Included subjects had complete baseline data on HDL and total cholesterol; lifestyle factors including smoking, exercise, alcohol consumption, and BMI; and comorbidities including hypertension, diabetes mellitus, congestive heart failure, cancer, and stroke. We used Cox proportional hazards to determine the HRs and 95% CIs for all-cause, CVD, and non-CVD mortality prior to age 90, adjusting for baseline age, co-morbidities, and non-HDL cholesterol. RESULTS: At baseline, the cohort had a mean (SD) age of 81.9 (2.9) years and a mean (SD) HDL cholesterol of 44.8(16.5) mg/dL. After a mean follow-up of 6.8 years (maximum 12.3 years), 501 (37.1%) of men died prior to age 90. In multi-variable adjusted analyses, men in the highest HDL-C quartile (≥54.1 mg/dL) had a 28% lower risk (HR 0.72, 95% CI 0.55-0.95) of all-cause mortality prior to age 90 compared to men in the lowest HDL-C quartile (<32.8 mg/dL). From the lowest to highest HDL quartile, age-adjusted HR(95%CI) for CVD mortality prior to age 90 were 0.66 (0.44-0.99), 0.58 (0.38-0.90), and 0.53 (0.34-0.82) (p for trend 0.004). There was no significant association between baseline HDL cholesterol and non-CVD death. CONCLUSION: In a cohort of older male physicians with long-term follow-up, baseline HDL cholesterol was inversely associated with the risk of dying prior to age 90, largely explained by an inverse association between HDL and CVD mortality.

Abstract 15328: Higher Non-exercise Estimated Cardiorespiratory Fitness in Midlife is Associated With Lower Risk of Incident Heart Failure: The Framingham Heart Study

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Joowon Lee ◽  
Tara Shrout ◽  
Ramachandran S Vasan ◽  
Vanessa Xanthakis
Keyword(s):  
Heart Failure ◽  
Cardiorespiratory Fitness ◽  
Lower Risk ◽  
Proportional Hazards ◽  
Disease Risk ◽  
Smoking Status ◽  
Later Life ◽  
Continuous Variable ◽  
Cox Proportional Hazards ◽  
Exercise Tests

Introduction: Non-exercise estimated cardiorespiratory fitness (eCRF) algorithms have shown similar accuracy to CRF estimated from submaximal and maximal exercise tests in healthy adults. Using easily accessible health indicators, eCRF measurement does not involve in-person exercise testing, trained personnel, or specialized equipment for measuring CRF. Thus, eCRF may be a cost-effective alternative for heart disease risk stratification. The relation between eCRF and Heart failure (HF) remains unclear. Hypothesis: We hypothesized that higher midlife eCRF is associated with a lower risk of incident HF in later life. Methods: We evaluated 2,226 Framingham Offspring cohort participants attending examination cycles 2 and 7 (mean age of 42- 61years; 53% women). We used a validated longitudinal non-exercise algorithm for eCRF including age, sex, body mass index, waist circumference, resting heart rate, physical activity, and smoking status. Midlife eCRF was defined as a sex-specific standardized average of eCRF (z-score of the average eCRF with mean=0 and a standard deviation [SD]=1) between cycles 2 and 7. The sex-specific midlife eCRF were then categorized into three groups based on tertiles and was also analyzed as a continuous variable (per 1 SD increment). We used multivariable Cox proportional hazards regression models for pooled sexes to relate the midlife eCRF to incident HF after examination cycle 7. Results: Overall, 189 participants developed HF during a median of 17 years of follow-up. Participants in either moderate or high eCRF group experienced a 52% lower risk of HF compared to those in the low eCRF group, after adjustment for potential confounders. Additionally, each SD increment in midlife eCRF was associated with a 40% lower risk of HF in later life. The associations remained significant after excluding participants on antihypertensive treatment (Table). Conclusions: Lower eCRF during midlife may be a marker of higher HF risk in later life.

Abstract 022: Plasma Metabolome Related To Plant-based Diets And The Association With Type 2 Diabetes: A Prospective Cohort Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Fenglei Wang ◽  
Megu Y Baden ◽  
Jun Li ◽  
Marta Guasch-Ferré ◽  
Yanping Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lower Risk ◽  
Proportional Hazards ◽  
Metabolic Response ◽  
Cox Proportional Hazards ◽  
Diabetes Risk ◽  
Health Study ◽  
Inverse Association ◽  
Plasma Metabolome

Background: Plant-based diets have been associated with a lower risk of type 2 diabetes. However, the underlying mechanisms are not completely understood, and the evidence using objective approaches to assess the adherence of plant-based diets is limited. Methods: In the Nurses’ Health Study (NHS), NHSII, and Health Professionals Follow-Up Study, we characterized the plasma metabolome related to plant-based diets and examined its association with the incidence of type 2 diabetes among 10 699 participants. Plasma metabolomic profiling was conducted by liquid chromatography-tandem mass spectrometry. Adherence to plant-based diets was assessed by three plant-based diet indices derived from the food frequency questionnaire: an overall plant-based diet index (PDI), a healthful PDI (hPDI), and an unhealthful PDI (uPDI). Metabolomic signatures reflecting the adherence to plant-based diets were created using elastic net regression, and their associations with risk of type 2 diabetes were subsequently evaluated using multivariable Cox proportional hazards regression. Results: Among 263 metabolites measured, nearly half were significantly associated with PDI (41.4%, 109 of 263), hPDI (51.7%, 136 of 263), and uPDI (40.3%, 106 of 263) after Bonferroni correction. We developed a metabolomic signature comprising 53 metabolites for PDI, 76 metabolites for hPDI, and 88 metabolites for uPDI, each robustly correlated with the corresponding diet index (r=0.34-0.36 for PDI, 0.43-0.44 for hPDI, and 0.36-0.37 for uPDI). We observed an inverse association of PDI metabolomic signature (HR 0.86, 95% CI 0.79-0.93 per one standard deviation) and hPDI metabolomic signature (0.79, 0.72-0.86) with type 2 diabetes risk after adjustment for body mass index and other potential confounders. These two inverse associations remained significant even further adjusting for the corresponding diet index PDI and hPDI. The metabolomic signature for uPDI was not associated with type 2 diabetes risk (1.00, 0.93-1.09). Conclusion: Plasma metabolome can robustly reflect adherence and metabolic response to plant-based diets. Metabolomic signatures reflecting greater adherence to an overall plant-based diet, especially a healthful plant-based diet, were associated with a lower risk of type 2 diabetes. These findings support and provide mechanistic insights on the important role of healthful plant-based diets in diabetes prevention.

Abstract P380: Steps Per Day and Step Intensity are Associated With a Lower Risk of Diabetes. The Hispanic Community Health Study / Study of Latinos (HCHS/SOL)

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Carmen Cuthbertson ◽  
Christopher Moore ◽  
Daniela Sotres-Alvarez ◽  
Gerardo M HEISS ◽  
Olga Garcia-Bedoya ◽  
...  
Keyword(s):  
Lower Risk ◽  
Smoking Status ◽  
The United States ◽  
Incidence Rates ◽  
Incident Diabetes ◽  
Health Study ◽  
Inverse Association ◽  
Hispanic Community ◽  
Steps Per Day ◽  
Rate Ratios

Introduction: Physical activity has been associated with a lower risk of diabetes but less is known about the association of steps per day (steps/d) and step intensity with incident diabetes. Hypothesis: We hypothesized an inverse association between both number of steps/d and time spent at a stepping rate corresponding to purposeful steps ( > 40 steps/min) with the risk of incident diabetes. Methods: We included 7247 participants free of diabetes at baseline in the prospective HCHS/SOL cohort of Latinos sampled from four communities in the United States. Steps/d and minutes per day (min/d) at a stepping rate > 40 steps/min were assessed at baseline with the Actical accelerometer (2008-2011), and incident diabetes was ascertained at a follow-up visit (2014-2017). The association of steps with incidence rates (per 1,000 person-years) of diabetes and incidence rate ratios (IRR) was estimated using Poisson regression, accounting for the sampling design and adjusted for age, ethnicity, gender, education, smoking status, alcohol intake, and accelerometer wear time. Results: The average age at baseline was 38 years (range 18 - 74 years) and 52% were female. Over a median of 5.9 years, 850 participants (9%) developed diabetes. The median step count was 7360 steps/d and the median minutes per day at a stepping rate of > 40 steps/min was 55 minutes. For each 1,000 step/d increment, the risk of diabetes was 5% lower (Table, IRR= 0.95(95% confidence interval (CI) 0.88, 1.02)). Compared to adults who engaged in 2,000 steps/d, those who engaged in 5,000 and 10,000 steps/d had a 13% and 26% lower risk of diabetes. The risk of diabetes was 5% lower (IRR=0.95 (95% CI 0.89, 1.00)) per 10 minute increase in time spent at a stepping rate > 40 steps/min. Compared to adults who spent 10 min/d at > 40 step/min, those who spent 30, 60, and 120 min/d had a 10%, 20%, and 32% lower risk of diabetes. Conclusion: The number of steps per day and time spent at a stepping rate that corresponds to purposeful steps are inversely associated with the risk of developing diabetes among adults.

scholarly journals 326Flavonoid intake and ischemic stroke incidence in the Danish Diet, Cancer, and Health Cohort

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Ben Parmenter ◽  
Frederik Dalgaard ◽  
Kevin Murray ◽  
Aedin Cassidy ◽  
Catherine P Bondonno ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Lower Risk ◽  
Smoking Status ◽  
Health Study ◽  
Stroke Incidence ◽  
Cox Proportional Hazard ◽  
Flavonoid Intake ◽  
Cox Proportional Hazard Models ◽  
Habitual Intake ◽  
Incident Cases

Abstract Background Flavonoid-rich foods may contribute to a lower risk of ischemic stroke through their anti-inflammatory, anti-atherogenic, and anti-thrombotic properties. We aimed to examine the relationship between flavonoid intake and ischemic stroke incidence in participants from the Danish Diet, Cancer, and Health study. Methods In this prospective cohort study, 55,169 Danish citizens without a prior ischemic stroke (median [IQR] age at enrolment of 56 [52 – 60] years), were followed for 21 [20 – 22] years. Baseline flavonoid intake was estimated from food frequency questionnaires using the Phenol-Explorer database. Incident cases of stroke were identified from Danish nation-wide public health registries. Associations between quintiles of flavonoid intake and incident ischemic stroke were assessed using Cox proportional hazard models adjusting for age, sex, BMI, smoking status, physical activity, alcohol intake, education, and income. Results During follow-up, 4,317 individuals experienced an ischemic stroke. Compared to participants in quintile one and after multivariable adjustments, those in quintile five for intake of total flavonoids, flavonols and oligo+polymers had a 12% [HR (95% CI): 0.88 (0.81, 0.96)], 10% [0.90 (0.82, 0.98)], and 18% [0.82 (0.75, 0.89)], lower risk of ischemic stroke incidence, respectively. Intake of flavan-3-ol monomers, anthocyanins, flavanones and flavones were not associated with incident ischemic stroke. Conclusions A moderate habitual intake of flavonoids, in particular the flavonol and flavan-3-ol oligo+polymer subclasses, is associated with a lower risk of ischemic stroke. Key messages Flavonoid rich foods appear protective against ischemic stroke.

scholarly journals An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk

2020 ◽  
Vol 11 (8) ◽  
pp. 6777-6806
Author(s):  
Benjamin H. Parmenter ◽  
Kevin D. Croft ◽  
Jonathan M. Hodgson ◽  
Frederik Dalgaard ◽  
Catherine P. Bondonno ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Prospective Cohort Studies ◽  
Flavonoid Intake

Higher intakes of flavonoid-rich foods are associated with a lower risk of cardiovascular disease in prospective cohort studies.

scholarly journals Increased Nut Consumption and Subsequent Cardiovascular Disease Risk Among U.S. Men and Women: Three Large Prospective Cohort Studies (OR17-08-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Xiaoran Liu ◽  
Marta Guasch-Ferré ◽  
Jean-Philippe Drouin-Chartier ◽  
Deirdre Tobias ◽  
Shilpa Bhupathiraju ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lower Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Health Study ◽  
Total Consumption ◽  
Men And Women ◽  
Tree Nuts ◽  
Subsequent Risk

Abstract Objectives To evaluate the association of changes in total consumption of nuts and in specific type of nuts (e.g., walnuts, other tree nuts, peanuts) and subsequent risk of incident cardiovascular disease (CVD) in three large prospective cohorts of U.S. men and women. Methods We included 34,222 men from the Health Professionals Follow-up Study (1986–2012), 77,957 women from the Nurses’ Health Study (1986–2012), and 80,756 women from the Nurses’ Health Study II (1991–2013). We assessed nut consumption every 4 years using validated food frequency questionnaires. We used multivariable Cox proportional regression models to examine the association between 4-year changes in nut consumption and risk of confirmed CVD endpoints (composite nonfatal myocardial infarction, fatal coronary heart disease [CHD], and nonfatal or fatal stroke) in the subsequent 4 years with a median follow-up of 17.2 years. Models were adjusted for age, sex, race, family history of CVD, intake of nuts at beginning of each-4 year and simultaneous changes of correlated dietary and lifestyle confounders. Results During 2818,760 person-years of follow-up, we documented 8478 cases of incident CVD, including 4989 cases of CHD and 3489 cases of stroke. Per 0.5 serving/day (1 serving = 28 g) increase in total consumption of nuts was associated with a lower risk of CVD (RR = 0.92, 95% CI = 0.88–0.96), CHD (0.94, 0.89–0.99), and stroke (0.89, 0.83–0.95) (Figure 1). For each 0.5 serving increase per day, the RR for CVD in the subsequent 4 years was 0.86 (0.76–0.98) for walnuts, 0.93 (0.86–1.02) for other tree nuts, and 0.92 (0.86–0.99) for peanuts, respectively. We evaluated the joint association of initial and final nut consumption over 4 years with the subsequent risk of CVD, CHD and stroke. Compared with individuals who remained non-consumers, individuals who consistently had a high nut consumption (≥0.5 serving/day) had a significantly lower risk of CVD (0.75, 0.67–0.84), CHD (0.80, 0.69–0.93), and stroke (0.68, 0.57–0.82) (Figure 2). Conclusions Increasing intake of total nuts, including walnuts, other tree nuts, or peanuts, was associated with a subsequent lower risk of CVD. Funding Sources NIH: UM1 CA186107, UM1 CA176726, UM1 CA167552. Partly funded by The Peanut Institution and the California Walnut Commission. The funders had no role in study design, data collection, analyses, interpretation and publication. Supporting Tables, Images and/or Graphs

Abstract MP08: Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Emily A Hu ◽  
Elizabeth Selvin ◽  
Morgan E Grams ◽  
Lyn M Steffen ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Lower Risk ◽  
Disease Risk ◽  
Smoking Status ◽  
Coffee Consumption ◽  
Dietary Factors ◽  
Inverse Association ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

Background: Moderate coffee consumption has been consistently associated with a lower risk of diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Hypothesis: We hypothesized that coffee consumption was associated with a lower risk of incident CKD after adjustment for major covariates among adults in the Atherosclerosis Risk in Communities (ARIC) study. Methods: We conducted a prospective analysis of 14,209 participants aged 45-64 years from the ARIC study. Coffee consumption (cups/day) was assessed at visit 1 (1987-89) and visit 3 (1993-95) using food frequency questionnaires. Our primary outcome was incident CKD defined as eGFR <60 mL/min/1.73 m 2 accompanied by ≥25% eGFR decline, CKD-related hospitalization or death, or end-stage renal disease. Results: There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbidities were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk of incident CKD ( Table ). Compared to participants who never consumed coffee, participants who consumed any amount of coffee had an 11% lower risk of CKD (HR: 0.89; 95% CI: 0.82-0.96; p for trend<0.001). In the continuous analysis, for each additional cup of coffee consumed per day, the risk of incident CKD was lower by 3% (HR: 0.97, 95% CI: 0.95-0.99, p<0.001). Results were consistent across the three progressively adjusted models and in a sensitivity analysis using a secondary definition of CKD. Stratification of analyses by smoking status suggested an inverse association among never smokers and former smokers. Conclusions: Coffee consumption was inversely associated with incident CKD after adjusting for covariates. Coffee consumption may not adversely affect kidney disease risk and may instead be protective.

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