scholarly journals 1211 Beta-hydroxy-beta-methylbutyrate (HMB) supplementation to mouse dams in gestation does not affect birth weight variation or growth of offspring

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 110-110
Author(s):  
Anna S Clarke ◽  
Nathan Horn ◽  
Gerald C Shurson ◽  
Christopher D Faulk ◽  
Lee J Johnston

Abstract The objective of this study was to determine if supplementing diets with β-hydroxy-β-methylbutyrate (HMB) calcium salt for mouse dams throughout gestation would improve pup birth weight uniformity and growth performance of offspring. Dams were assigned to one of 4 treatments as follows: control (CON; n = 6), Low Level HMB (LL; 3.5 mg/g diet; n = 7), High Level HMB (HL; 35 mg/g diet; n = 8), and Low Level Pulse fed from gestational days 6 to 10 (PUL; 3.5 mg/g diet; n = 7). Supplementation began at mating and continued until birth. Dams gave birth and lactated for 28 days. Offspring were reared until 8 weeks of age. All mice had ad libitum access to a corn-soybean meal diet, with HMB supplementation provided only to dams during gestation. Supplementation of HMB had no effects on overall gestation and lactation performance of mouse dams. Dietary treatment during gestation did not affect total number of pups born per litter, birth weight of pups, or number weaned. Within litter variation, expressed as standard deviation and coefficient of variation, was not different among treatments for birth weight or weaning weight. Range of body weights within litter at birth, weaning, and 8 weeks of age were not affected by HMB supplementation. Overall, offspring growth performance was similar among treatments. However, body weight at 5 and 8 weeks of age was lower for offspring from the HL dams compared to offspring from LL dams (P < 0.05). Body composition of offspring at 5 and 8 weeks of age was similar regardless of HMB supplementation in dam diets during gestation. In conclusion, dietary HMB supplementation of mouse dams during gestation had no effect on birth weight of offspring, variation in birth weight, or growth performance of offspring.

1965 ◽  
Vol 5 (19) ◽  
pp. 390 ◽  
Author(s):  
AJ Williams ◽  
RJ Winston

The efficiency of conversion of feed to wool was measured with adult ewes at three levels of nutrition. During the period at which each level was fed, changes in body weight and feed intake were minimized. These ewes were chosen as representative of the total drops of three flocks, one of which had been selected for high clean fleece weight (Fleece Plus), one for low clean fleece weight (Fleece Minus) and a control flock selected at random (Random). The intermediate and high levels of nutrition were intended to maintain 20 per cent and 44 per cent higher body weights than at the low level of nutrition. The average intakes of lucerne pellets at the low, .intermediate, and high levels of nutrition were approximately 500, 800, and 950 grams a day respectively. The average body weights at these intakes were 30, 36, and 45 kg and the average gains in body weight were -11, +7, and +16 grams a day during the 18 weeks of measurement at each level. There were no differences between the flocks in these measurements. The relative wool production of the Fleece Plus, Random, and Fleece Minus flocks changed between levels of nutrition, being 101 : 100 : 96 at the low level, 120 : 100 : 88 at the intermediate and 121 : 100 : 96 at the high level of nutrition. Part of this differential response could be attributed to different feed intakes between the flocks and part to a smaller decrease in the efficiency of the Fleece Plus flock with increasing level of nutrition. The relative net efficiencies measured at the intermediate level were 116 : 100 : 86.5 for the Fleece Plus, Random, and Fleece Minus flocks respectively.


2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 311-311
Author(s):  
Nicole M Tillquist ◽  
Amanda S Reiter ◽  
Mia Y Kawaida ◽  
Brandon I Smith ◽  
Sarah A Reed ◽  
...  

Abstract The objective was to determine the effects of poor maternal nutrition during gestation on growth and feed efficiency of offspring. We hypothesized that body weights (BW) would decrease and residual feed intake (RFI) would increase (reduced feed efficiency) in offspring of restricted- and over-fed ewes. Forty-six multiparous Dorset ewes pregnant with twins were fed 100%, 60% or 140% of NRC requirements from d 30 of gestation until parturition. Offspring are referred to as CON (n = 10 ewes; 12 rams), RES (n = 13 ewes; 21 rams), and OVER (n = 16 ewes; 13 rams), respectively. Lamb BW were measured weekly from birth to d 28 and biweekly until d 252 of age. Starting at d 167±13.6, daily intake of a complete pelleted feed was recorded using a Super SmartFeed (C-lock Inc., Rapid City, SD) over a 77 d- feeding period. Average BW were taken two days before, at mid-point, and two days after the feeding trial period and RFI was calculated for each animal. Rams were euthanized at d 284±12 and body morphometrics, loin eye area (LEA), back fat thickness, and organ weights were collected. From birth to d 252, ram lambs were 5.4 kg heavier (P < 0.001) than ewe lambs. Control ewe lambs were 4.3 kg heavier than RES and OVER (P < 0.05) from birth to 9 months and CON rams were 4.7 kg heavier (P < 0.01) than RES. Rams (-0.17) were more efficient than ewes (0.23; P < 0.01); however, no dietary treatment difference was observed (P ≥ 0.57). No differences in muscle mass, LEA, and adipose deposition were observed (P ≥ 0.41). These data indicate that poor maternal diet during gestation impacts offspring growth but not RFI. Further investigation is warranted to determine if differences in BW are a result of metabolic alterations impacted by poor maternal nutrition during gestation.


2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 37-37
Author(s):  
Lauren Hansen ◽  
Victoria Stewart ◽  
Ira Mandell ◽  
Lee-Anne Huber

Abstract A total of 141 pigs from 24 litters were used to determine the effects of closely meeting estimated lysine and energy requirements for first parity sows during gestation on subsequent offspring growth performance until slaughter and carcass and loin quality. Sows were assigned a control (static diet composition; CON) or precision (specialized daily blend of two diets to meet estimated nutrient and energy requirements; PF) feeding regimen between d7 and 110 of gestation (n=12). At weaning (21 days of age), six pigs per litter were randomly selected and placed in a pen (1 pen per litter). All pens received ad libitum access to commercial diets in 6 phases (4-phase nursery, grower, and finisher, respectively). Individual body weights and per pen feed intakes were recorded weekly (nursery and finishing phases) or biweekly (growing phase). Four pigs per pen were slaughtered at ~125kg BW to measure carcass and loin quality. During nursery phase-3, ADG (0.60 vs. 0.53±0.02 kg/d;P< 0.05) and G:F (0.88 vs. 0.79±0.02;P< 0.05) were greater for pigs from PF versus CON sows. The ADFI in nursery phase-4 tended to be greater for pigs from PF versus CON sows (1.9 vs. 1.2±0.06 kg/d; P=0.05). By day 66 of age (end of nursery phase), pigs from PF sows had greater BW than those from CON (31.8 vs. 30.0±0.5 kg; P< 0.05); no further differences were observed for growth performance. After slaughter, there were no differences in carcass quality (e.g., hot carcass weight and lean yield) but the loin color for pigs from PF sows tended to be darker (L*; 47.4 vs. 46.5±0.1; P=0.06) and less red (a*; 6.5 vs. 6.8±0.3P=0.09) than CON. Closely meeting daily requirements for first parity sows during gestation improved offspring growth in the nursery phase, while carcass and loin quality at ~125 kg BW were generally not affected.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zuzanna Całyniuk ◽  
Ewelina Cholewińska ◽  
Paweł Konieczka ◽  
Katarzyna Ognik ◽  
Dariusz Mikulski ◽  
...  

Abstract The aim of the study was to determine the effect of two proportions of arginine (95% and 105%) relative to lysine (Lys), where Lys content in the diet is in accordance with NRC (1994) recommendations or 10% higher, on the metabolism, antioxidant status, and growth performance of turkeys. The experiment had a 2x2 factorial design with two levels of Lys and Arg. The diets with a low level of Lys were according to the NRC (1994) requirements. In the diets with a high level of Lys, the content of Lys was increased by 10% relative to the low level Lys. The two Arg levels in the experimental diets were determined so as to provide 95% and 105% Arg relative to the content of dietary Lys. An increase in the amount of Lys in the diet of turkeys by 10% relative to NRC nutritional recommendations (1994) was not shown to improve growth performance, but had beneficial effects on the metabolism and antioxidant status of the birds, as evidenced by the improvement of hepatic indices (reduction of AST and ALT activity at 9th week of life) and renal indices (reduction of UREA at 9th week of life and reduction of TP and increase level of ALB levels at 16th week of life), as well as an increase in the level of glutathione with strong antioxidant properties at 16th week of life. In comparison to the lower level of Arg in the diet, an increase in the amount of this amino acid to 105% Lys did not improve growth performance, metabolism, or antioxidant status. An Arg level of 95% Lys can be used in a diet for turkeys containing 10% more Lys than the level recommended by the NRC (1994).


1950 ◽  
Vol 40 (4) ◽  
pp. 311-340 ◽  
Author(s):  
I. E. Coop

Seven different experiments over 3 years and involving a total of 1750 ewes have been designed to study the effects of high and low levels of nutrition during pregnancy and during lactation on grazing sheep. The trials were run as nearly as possible under typical fat-lamb producing conditions. Commencing with breeding ewes in average store condition before tupping, a live-weight gain of 25–40 lb. from tupping to lambing was adopted as a standard of a high level of feeding and a gain of ± 5 lb. was considered to be a low level of feeding. Differential feeding was obtained by keeping the ewes on high-quality pasture as a high level of nutrition, and by stocking heavily on poor pasture as a low level. Under these conditions the following results were obtained:(1) Level of nutrition during pregnancy. The high level of nutrition during pregnancy increased birth weight by about 0.5 lb., but had little if any influence on the rate of growth and the weaning weight of the lambs, irrespective of the subsequent level of nutrition. The high level did not reduce ewe and lamb mortality and there was some evidence to the contrary when the high plane was applied early, leading to large live-weight gain.


2015 ◽  
Vol 17 (1) ◽  
pp. 8 ◽  
Author(s):  
Debby Jacqueline Jochebed Rayer ◽  
Hera Maheswari ◽  
Muladno Muladno ◽  
Wasmen Manalu

Abstract. An experiment was conducted to produce superior pigs with improved growth phenotypes and survival during postnatal growth by injecting the sows with gonadotropin prior to mating.  The experiment consisted of 2 stages.  In the first stage, 12 sows were divided into 2 groups i.e., sows injected with NaCl0.95% as a control (NSO) and sows injected with PG600 (SO) prior to mating.  Parameters measured were growth phenotypes and survival at birth and during pre-weaning period.  In the second stage, 24 of weaned pigs (age 8 weeks) from the first stage were selected (6 males and 6 females from NSO group and 6 males and 6 females from SO group) to be used for measurement of growth performance.  The experimental pigs were raised and observed until the age of 28 weeks (7 month).  The body weights were measured monthly.  The results of the experiment showed that improvement of uterine environment by gonadotropin injection of the sows prior to mating dramatically improved birth weight with a very homogenous birth weight within litter size.  Improved birth weight and within-litter variation of birth weight improved pre-weaning growth performance and survival that finally dramatically increased weaning weight and total weight of weaned pigs per sow.  After weaning, pigs born to SO sows grew faster and had around 10 kg higher body weight as compared to control at the age of 7 month.   It was concluded that superior pigs could be produced by improving endogenous secretion of pregnant hormone during pregnancy. Key words: Birth weight, growth phenotypes, survival, prenatal growth, postnatal growth Abstrak. Penelitian ini dilakukan untuk menghasilkan anak-anak babi unggul dengan fenotipe pertumbuhan dan daya hidup yang lebih baik selama pertumbuhan pascalahir dengan cara menyuntik induk babi dengan gonadotropin sebelum pengawinan.  Penelitian terdiri atas dua tahapan.  Penelitian tahap pertama, 12 ekor induk babi dikelompokkan ke dalam 2 kelompok, 1) kelompok kontrol, yaitu induk yang disuntik dengan NaCl 0.95% (NSO) dan 2) kelompok yang disuntik dengan PG600 sebelum pengawinan (SO).  Parameter yang diukur ialah fenotipe pertumbuhan dan daya hidup anak pada saat lahir dan selama periode prasapih.  Tahap kedua, 24 anak babi lepas sapih dari percobaan tahap pertama (umur 8 minggu) dipilih (6 jantan dan 6 betinadari kelompok NSOdan 6 jantan dan 6 betina dari kelompok SO) untuk digunakan dalam pengukuran kinerja pertumbuhan pascasapih.  Babi percobaan dibesarkan dan diamati sampai umur 28 minggu (7 bulan).  Bobot badan diukur setiap bulan.  Hasil penelitian menunjukkan bahwa perbaikan lingkungan uterus dengan cara penyuntikan induk dengan gonadotropin sebelum pengawinan secara dramatis memperbaiki bobot lahir anak dengan bobot lahir per induk yang lebih seragam.  Perbaikan bobot lahir dan keseragaman bobot lahir memperbaiki kinerja pertumbuhan prasapih dan kelangsungan hidup anak yang pada akhirnya secara dramatis meningkatkan bobot sapih dan total bobot anak yang disapih per ekor induk.  Setelah penyapihan, anak babi yang dilahirkan oleh induk yang disuntik gonadotropin tumbuh lebih cepat dengan bobot badan yang lebih tinggi sekitar 10 kg dibandingkan dengan kontrol pada umur 7 bulan.  Disimpulkan bahwa anak babi unggul dapat dihasilkan melalui perbaikan sekresi endogen hormon kebuntingan selama kebuntingan. Kata kunci: Bobot lahir, fenotipe pertumbuhan, daya hidup, pertumbuhan prenatal, pertumbuhan pascalahir


1986 ◽  
Vol 112 (3) ◽  
pp. 396-403 ◽  
Author(s):  
Jean Paul Dupouy ◽  
Alain Chatelain

Abstract. CBG and pituitary-adrenal activities were investigated in intact rat foetuses, in newborns spontaneously delivered by vaginal way and in postmature foetuses from mothers with delayed parturition caused by daily progesterone injection from day 20 of gestation. The postmature foetuses had lower body weights and higher adrenal weights on day 22, 23 and 24 of gestation than newborns of the same conceptional age. The corticosterone binding capacity of the plasma as well as the binding capacity of CBG for corticosterone decreased in intact foetuses for the last 3 days of gestation and stayed very low in pups from day 0 to day 8 postpartum. These parameters decreased more slowly in postmature foetuses; however, the differences between the latter and intact foetuses or newborns were not statistically significant. Similar evolution occurred in intact pregnant and suckling females as well as in females with prolonged gestation. The fall in CBG activity in normal rat pups and the subsequent rise in free steroids could explain a sharp decrease in plasma ACTH levels as well as the drop in adrenal and plasma corticosterone concentration. In foetuses with prolonged gestation, the same phenomenon did not occur. Stress conditions produced by maintaining growing foetuses in utero and the development of severe jaundice maintained high ACTH levels. In contrast, the fall in adrenal and plasma corticosterone concentrations in spite of the high level of circulating ACTH could be mainly due to the progesterone inhibition of the steroidogenic activity of the foetal adrenals.


2019 ◽  
Vol 1 (1) ◽  
pp. 31-39
Author(s):  
Ilham Safitra Damanik ◽  
Sundari Retno Andani ◽  
Dedi Sehendro

Milk is an important intake to meet nutritional needs. Both consumed by children, and adults. Indonesia has many producers of fresh milk, but it is not sufficient for national milk needs. Data mining is a science in the field of computers that is widely used in research. one of the data mining techniques is Clustering. Clustering is a method by grouping data. The Clustering method will be more optimal if you use a lot of data. Data to be used are provincial data in Indonesia from 2000 to 2017 obtained from the Central Statistics Agency. The results of this study are in Clusters based on 2 milk-producing groups, namely high-dairy producers and low-milk producing regions. From 27 data on fresh milk production in Indonesia, two high-level provinces can be obtained, namely: West Java and East Java. And 25 others were added in 7 provinces which did not follow the calculation of the K-Means Clustering Algorithm, including in the low level cluster.


Author(s):  
Margarita Khomyakova

The author analyzes definitions of the concepts of determinants of crime given by various scientists and offers her definition. In this study, determinants of crime are understood as a set of its causes, the circumstances that contribute committing them, as well as the dynamics of crime. It is noted that the Russian legislator in Article 244 of the Criminal Code defines the object of this criminal assault as public morality. Despite the use of evaluative concepts both in the disposition of this norm and in determining the specific object of a given crime, the position of criminologists is unequivocal: crimes of this kind are immoral and are in irreconcilable conflict with generally accepted moral and legal norms. In the paper, some views are considered with regard to making value judgments which could hardly apply to legal norms. According to the author, the reasons for abuse of the bodies of the dead include economic problems of the subject of a crime, a low level of culture and legal awareness; this list is not exhaustive. The main circumstances that contribute committing abuse of the bodies of the dead and their burial places are the following: low income and unemployment, low level of criminological prevention, poor maintenance and protection of medical institutions and cemeteries due to underperformance of state and municipal bodies. The list of circumstances is also open-ended. Due to some factors, including a high level of latency, it is not possible to reflect the dynamics of such crimes objectively. At the same time, identification of the determinants of abuse of the bodies of the dead will reduce the number of such crimes.


2021 ◽  
pp. 002224372199837
Author(s):  
Walter Herzog ◽  
Johannes D. Hattula ◽  
Darren W. Dahl

This research explores how marketing managers can avoid the so-called false consensus effect—the egocentric tendency to project personal preferences onto consumers. Two pilot studies were conducted to provide evidence for the managerial importance of this research question and to explore how marketing managers attempt to avoid false consensus effects in practice. The results suggest that the debiasing tactic most frequently used by marketers is to suppress their personal preferences when predicting consumer preferences. Four subsequent studies show that, ironically, this debiasing tactic can backfire and increase managers’ susceptibility to the false consensus effect. Specifically, the results suggest that these backfire effects are most likely to occur for managers with a low level of preference certainty. In contrast, the results imply that preference suppression does not backfire but instead decreases false consensus effects for managers with a high level of preference certainty. Finally, the studies explore the mechanism behind these results and show how managers can ultimately avoid false consensus effects—regardless of their level of preference certainty and without risking backfire effects.


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