Both Iron Deficiency and Daily Iron Supplements Increase Lipid Peroxidation in Rats

Anaemia has remained a widespread public health problem in countries of the Eastern Mediterranean Region. Prevalence figures vary from a low of 17% to a high of over 70% among preschool children; from 14% to 42% among adolescents and from 11% to over 40% among women of childbearing age. Although the prevalence of anaemia has often been used as a proxy indicator for iron deficiency anaemia, this approach is not valid in settings where the etiology of anaemia is complex or unknown or where other micronutrient deficiencies of folate, vitamin B12 and vitamin A can co-exist. An integrated, multifactorial and multisectoral approach has to be adopted comprising targeted interventions to provide iron supplements to especially vulnerable segments of the population, in particular pregnant women; food-based approaches to increase iron intake through food fortification and dietary diversification; and other measures combined with iron interventions where other causes of anaemia are prevalent

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Iron deficiency among pregnant women attending an antenatal clinic in Northern Uganda: a cross-sectional study

10.21203/rs.2.14386/v1 ◽

2019 ◽

Author(s):

Samson Udho ◽

Joyce Nankumbi ◽

Mariam Namutebi ◽

Grace Ndeezi ◽

Joshua Epuitai ◽

...

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Serum Ferritin ◽

Antenatal Clinic ◽

Cross Sectional Study ◽

Sectional Study ◽

Third Trimester ◽

Cross Sectional ◽

Iron Supplements ◽

The Third

Abstract Background Iron deficiency is a leading cause of anemia among pregnant women in Uganda. However, due to the high cost of biochemical tests required to determine iron deficiency, the prevalence and factors associated with iron deficiency remain largely unstudied in our setting. Therefore, this study aimed at determining the prevalence of iron deficiency and its associated factors among pregnant women attending an antenatal clinic, Lira District-Uganda.Methods A cross-sectional study was conducted among 320 pregnant women attending an antenatal clinic at Lira Regional Referral Hospital. Maternal serum ferritin was used as a measure of iron deficiency and was determined using a Cobas 6000 Automated Analyzer. Iron deficiency was based on serum ferritin of <30 μg/L. A semi-structured questionnaire was used to obtain the characteristics of the study participants. Binary and multivariate logistic regression were performed to identify the associated factors.Results The prevalence of iron deficiency was 45%. Non-adherence to iron supplements (AOR: 2.05 95% CI: 1.02-4.12) & third trimester pregnancy (AOR: 1.88 95% CI: 1.20-2.94) were significantly associated with iron deficiency during pregnancy.Conclusion Nearly 5 in 10 of the participants had iron deficiency. Iron deficiency during pregnancy was associated with non-adherence to iron supplements and being in the third trimester of pregnancy. Midwives should encourage pregnant women to adhere to iron supplements during pregnancy especially pregnant women who are in the third trimester.

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Incidence and prevalence of iron deficiency anaemia

Medical Council ◽

10.21518/2079-701x-2018-13-78-81 ◽

2018 ◽

pp. 78-81

Author(s):

V. E. Zhorova ◽

E. G. Khilkevich

Keyword(s):

Adverse Effect ◽

Iron Deficiency ◽

General Condition ◽

Iron Deficiency Anaemia ◽

Ferric Iron ◽

Clinical Manifestations ◽

Iron Supplements ◽

Deficiency Anaemia ◽

Neonatal Complications ◽

In Pregnancy

Iron deficiency anaemia (IDA) is one of the most common complications in pregnancy. It is known that IDA has an adverse effect on the condition of the mother, fetus and new-borns. The article presents modern views of the aetiology, pathogenesis, prevalence of iron deficiency anaemia, describes the clinical manifestations of this condition. The rational of treatment of IDA with modern ferric iron supplements is substantiated. It is shown that IDA therapy in pregnant and puerperal women with Maltofer is highly effective, leads to normalization of hemogram parameters, improvement of general condition, and reduction of obstetric and neonatal complications.

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Effect of lead on proliferation, oxidative stress and genotoxic damage of 3T3-L1 fibroblasts

Toxicology Research ◽

10.1093/toxres/tfaa018 ◽

2020 ◽

Vol 9 (3) ◽

pp. 158-163

Author(s):

Claudia Noemi Martini ◽

Fernando Nicolás Sosa ◽

Julio Fuchs ◽

María del Carmen Vila

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Cell Line ◽

Public Health Problem ◽

Cell Counting ◽

Trypan Blue Exclusion ◽

Genotoxic Damage ◽

Trypan Blue Exclusion Assay ◽

A Cell ◽

Increase Lipid Peroxidation

Abstract Lead (Pb) is an environmental and industrial contaminant that still represents a public health problem. In this paper, we investigated the effect of Pb on proliferation, lipid peroxidation and the number of micronucleated cells in exponentially growing 3T3-L1 fibroblasts, a cell line previously used to evaluate different environmental contaminants. We found that Pb (10 μM or higher) was able to inhibit proliferation of exponentially growing cells after 24-h treatment, which was evaluated by the MTT assay and cell counting in Neubauer chamber, but cell survival was not affected according to the trypan blue exclusion assay. On the other hand, Pb was able to increase lipid peroxidation and the number of micronucleated cells, which are indicative of oxidative stress and genotoxic damage respectively. We also found that removal of Pb after 24-h treatment allowed cells to recover proliferation. Our results indicate that Pb was able to induce oxidative stress and genotoxicity in this cell line under standardized conditions, which supports the involvement of Pb in similar effects observed in human exposed to this heavy metal. In addition, Pb inhibits proliferation of exponentially growing fibroblasts but cells resume proliferation after removal of this metal, which suggests that it is important to move away Pb-exposed individuals from the source of contamination.

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Lipid Peroxidation in Iron Deficiency Anemia / Reply

Acta Haematologica ◽

10.1159/000204327 ◽

1994 ◽

Vol 91 (3) ◽

pp. 170-170 ◽

Cited By ~ 2

Author(s):

Şinasi Özsoylu ◽

M. Bartal ◽

D. Mazor ◽

A. Dvilansky ◽

N. Meyerstein

Keyword(s):

Lipid Peroxidation ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Deficiency Anemia

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Availability Of Iron

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/53.4.791 ◽

1970 ◽

Vol 53 (4) ◽

pp. 791-800

Author(s):

Gwendolyn W Pla ◽

James C Fritz

Keyword(s):

United States ◽

Iron Deficiency ◽

Animal Studies ◽

The United States ◽

Deficiency Anemia ◽

Iron Intake ◽

Iron Compounds ◽

Iron Supplements ◽

High Incidence

Abstract The high incidence of iron deficiency anemia in the United States and elsewhere is caused by insufficient iron intake, plus poor utilization of many dietary sources of iron. There is need to select assimilable sources of iron for fortification of foods; animal studies show that many of the iron compounds used for cereal enrichment are poorly utilized. A method to measure availability of iron is proposed and is currently being studied collaboratively. Preliminary data indicate that in vitro solubility tests are not satisfactory to evaluate availability of iron supplements.

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Effect of microalgae as iron supplements on iron-deficiency anemia in rats

Food & Function ◽

10.1039/c8fo01834k ◽

2019 ◽

Vol 10 (2) ◽

pp. 723-732 ◽

Cited By ~ 8

Author(s):

Fengzheng Gao ◽

Wei Guo ◽

Mingyong Zeng ◽

Yinong Feng ◽

Guangxin Feng

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Deficiency Anemia ◽

Iron Supplements ◽

Nanosized Iron

Microalgae are functional iron nutritive fortifiers that can supply more intestinal nanosized iron.

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The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia

British Journal Of Nutrition ◽

10.1017/s0007114507797040 ◽

2008 ◽

Vol 99 (2) ◽

pp. 416-420 ◽

Cited By ~ 5

Author(s):

Xiao-Ming Lin ◽

Wei Tian ◽

Le Ma ◽

Zhu Long ◽

Juan Zhang ◽

...

Keyword(s):

Iron Deficiency ◽

Serum Ferritin ◽

Fe Deficiency ◽

Serum Transferrin ◽

Transferrin Receptors ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Iron Supplements ◽

Deficiency Anaemia ◽

Biochemical Indices

We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal, Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently, seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrousl-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0, 3, 6, 9 and 12.The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe supplements.

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