Treatment: infectious diseases

2015 ◽  
Author(s):  
David A. Warrell ◽  
Matthew Dryden ◽  
Alastair Miller ◽  
Clare Morgan ◽  
David A. Warrell
Keyword(s):  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Emerging Infections ◽  
Sexually Transmitted

Introduction: infectious diseases - Viral infections - Bacterial infections - Malaria - Other protozoal infections - Filarial worms - Worm infections - Flukes - Emerging infections - Sexually transmitted infections

Treatment: infectious diseases

2018 ◽  
Author(s):  
David A. Warrell ◽  
Matthew Dryden ◽  
Alastair Miller ◽  
Clare Morgan ◽  
David A. Warrell
Keyword(s):  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Emerging Infections ◽  
Sexually Transmitted

Introduction: infectious diseases - Viral infections - Bacterial infections - Malaria - Other protozoal infections - Filarial worms - Worm infections - Flukes - Emerging infections - Sexually transmitted infections

The role of PCSK9 in infectious diseases.

2021 ◽  
Vol 28 ◽  
Author(s):  
Laura Magnasco ◽  
Chiara Sepulcri ◽  
Roberta Maria Antonello ◽  
Stefano Di Bella ◽  
Laura Labate ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Malaria Infection ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Physiological Role ◽  
Protective Role ◽  
Loss Of Function ◽  
Pcsk9 Inhibition ◽  
Sepsis And Septic Shock

Background: In recent years, many aspects of the physiological role of PCSK9 have been elucidated, particularly regarding its role in lipid metabolism, cardiovascular risk, and its role in innate immunity. Increasing evidence is available about the involvement of PCSK9 in the pathogenesis of viral infections, mainly HCV, and the regulation of host response to bacterial infections, primarily sepsis and septic shock. Moreover, the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria infection and disease severity. Objective: This paper aims to review the available published literature on the role of PCSK9 in a wide array of infectious diseases. Conclusion: Besides the ongoing investigation on PCSK9 inhibition among HIV-infected patients to treat HIV- and ART-related hyperlipidemia, preclinical studies indicate how PCSK9 is involved in reducing the replication of HCV. Interestingly, high plasmatic PCSK9 levels have been described in patients with sepsis. Moreover, a protective role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral infections. Finally, a loss of function in the PCSK9-encoding gene has been reported to reduce malaria infection mortality.

scholarly journals Surveillance of sexually transmitted infections in England and Wales

1998 ◽  
Vol 3 (6) ◽  
pp. 61-5 ◽  
Author(s):  
G Hughes ◽  
M Catchpole
Keyword(s):  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Human Behaviour ◽  
England And Wales ◽  
Sexually Transmitted

Owing to the unique link between the epidemiology of sexually transmitted infections (STIs) and human behaviour, the surveillance of STIs requires the collection of more demographic and behavioural data than for other infectious diseases. In order to supp

IMPACT OF INFECTIOUS DISEASES ON PUBERTAL TIMING IN UKRAINIAN GIRLS: RESULTS A MULTICENTER STUDY

2021 ◽  
Vol 74 (10) ◽  
pp. 2392-2399
Author(s):  
Aidyn G. Salmanov ◽  
Orusia A. Kovalyshyn ◽  
Roman S. Scoreiko ◽  
Victor M. Zinchenko ◽  
Serhiy M. Baksheev ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Age Of Onset ◽  
Final Height ◽  
Pubertal Development ◽  
Age At Onset ◽  
Peak Height ◽  
Height Velocity ◽  
Peak Height Velocity

The aim: To determine current age at the initiation of puberty for Ukrainian school-aged girls and infections impact to puberty. Materias and methods: We performed a multicentre cohort study. The analyses are based on data that were collected and evaluated biannually on Ukrainian school girls aged 6-17 years from 5 regions of Ukraine. Pubertal development was classified according to the Marshall and Tanner criteria. Results: Overall, 2,784 girls have been included in the study. Mean age of onset of puberty in Ukrainian girls was 10.1±1.0 yrs. Age of onset of pubic hair was 11.0±1.0 yrs and that of axillary hair was 11.6±1.0 yrs. Mean age in girls of menarche was 12.2±0.9 yrs. There were no significant correlations between age at onset of puberty and body mass index, final height, total peak height velocity, duration of puberty, and peak height velocity. A total of 2,420 infectious diseases were diagnosted. Of these, 64.8% were viral and 35.2% bacterial infections, respectively. Ukrainian girls with infectious diseases (especially viral infections) had older age at pubertal onset and positive association of infections in childhood with late age of menarche. Conclusions: Infectious morbidity (especially viral infections) in girls may be associated with later puberty. The lowering of the number of infections in childhood could be an additional factor that contributes to earlier puberty. To reduce infectious diseases, more attention should be paid to the vaccination of children.

Posttravel Evaluation

2019 ◽  
pp. 603-652
Author(s):  
Gary W. Brunette ◽  
Jeffrey B. Nemhauser
Keyword(s):  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Diagnostic Tests ◽  
Rapid Diagnostic Tests ◽  
Sexually Transmitted

General Approach to the Returned Traveler Jessica K. Fairley Screening Asymptomatic Returned Travelers Michael Libman, Sapha Barkati Fever Mary Elizabeth Wilson Rapid Diagnostic Tests for Infectious Diseases Elizabeth Rabold, Jesse Waggoner Antimicrobial Resistance D. Cal Ham, Joseph Lutgring, Aditya Sharma Sexually Transmitted Infections Jodie Dionne-Odom...

scholarly journals Infections and Immunotherapy in Lung Cancer: A Bad Relationship?

2020 ◽  
Vol 22 (1) ◽  
pp. 42
Author(s):  
Lorenzo Belluomini ◽  
Alberto Caldart ◽  
Alice Avancini ◽  
Alessandra Dodi ◽  
Ilaria Trestini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Infectious Diseases ◽  
Cancer Patients ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Checkpoint Inhibitors ◽  
Current Evidence ◽  
Human Immune Deficiency Virus ◽  
Prognostic Impact ◽  
Lung Cancer Patients

Infectious diseases represent a relevant issue in lung cancer patients. Bacterial and viral infections might influence the patients’ prognosis, both directly affecting the immune system and indirectly impairing the outcome of anticancer treatments, mainly immunotherapy. In this analysis, we aimed to review the current evidence in order to clarify the complex correlation between infections and lung cancer. In detail, we mainly explored the potential impact on immunotherapy outcome/safety of (1) bacterial infections, with a detailed focus on antibiotics; and (2) viral infections, discriminating among (a) human immune-deficiency virus (HIV), (b) hepatitis B/C virus (HBV-HCV), and (c) Sars-Cov-2. A series of studies suggested the prognostic impact of antibiotic therapy administration, timing, and exposure ratio in patients treated with immune checkpoint inhibitors, probably through an antibiotic-related microbiota dysbiosis. Although cancer patients with HIV, HBV, and HCV were usually excluded from clinical trials evaluating immunotherapy, some retrospective and prospective trials performed in these patient subgroups reported similar results compared to those described in not-infected patients, with a favorable safety profile. Moreover, patients with thoracic cancers are particularly at risk of COVID-19 severe outcomes and mortality. Few reports speculated about the prognostic implications of anticancer therapy, including immunotherapy, in lung cancer patients with concomitant Sars-Cov-2 infection, showing, to date, inconsistent results. The correlation between infectious diseases and immunotherapy remains to be further explored and clarified in the context of dedicated trials. In clinical practice, the accurate and prompt multidisciplinary management of lung cancer patients with infections should be encouraged in order to select the best treatment options for these patients, avoiding unexpected toxicities, while maintaining the anticancer effect.

Emerging sexually transmitted viral infections: Review of human T-lymphotropic virus-1 disease

2020 ◽  
Vol 31 (2) ◽  
pp. 92-99 ◽  
Author(s):  
RJ Caswell ◽  
K Manavi
Keyword(s):  
Sexual Health ◽  
Sexually Transmitted Infections ◽  
Sexually Transmitted Infection ◽  
Viral Infections ◽  
Sexual Transmission ◽  
Significant Morbidity ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
T Lymphotropic Virus ◽  
The Third

Human T-lymphotropic virus-1 is a preventable sexually transmitted infection. In the majority of people it is asymptomatic, remaining undiagnosed and thereby contributing to its silent transmission. When it does manifest it causes significant morbidity and mortality. This review summarises the existing evidence for its role in sexual transmission and offers suggestions for those working in the area of sexual health. This is the third part of a series looking at novel sexually transmitted infections.

Clinical Syndromes in Infectious Diseases

2012 ◽  
Author(s):  
Robert Orenstein
Keyword(s):  
Urinary Tract ◽  
Infective Endocarditis ◽  
Soft Tissue ◽  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Soft Tissue Infections ◽  
Gastrointestinal Infections ◽  
Sexually Transmitted ◽  
Clinical Syndromes ◽  
Tract Infections

This chapter approaches the field of infectious diseases from 3 perspectives. This second part covers clinical syndromes associated with various infections, such as infective endocarditis, meningitis, sexually transmitted infections, urinary tract infections, gastrointestinal infections, and soft-tissue infections. Symptoms, diagnosis, and treatment of these conditions are reviewed.

Issues of primary and secondary prevention: the role of sexually transmitted infections on the development of cervical cancer in Kazakhstan

2021 ◽  
Vol 7-8 (217-218) ◽  
pp. 13-19
Author(s):  
Dilyara Kaidarova ◽  
◽  
Gulnur Igissinova ◽  
Saule Yessenkulova ◽  
Tolkyn Sadykova ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Secondary Prevention ◽  
Sexually Transmitted Infections ◽  
Viral Infections ◽  
Medical Center ◽  
Cervical Canal ◽  
Primary And Secondary Prevention ◽  
Sexually Transmitted ◽  
Gynecological Examination

This article analyzes the role of sexually transmitted infections, which are one of the risk factors in the occurrence of cervical cancer. The directions of preventive measures regarding the prevention of cervical cancer are presented. Aim. To analyze the role of sexually transmitted infections (STIs) on the development of cervical cancer. Material and methods. The material used was clinical and diagnostic examinations of 180 patients on the bases of polyclinics №4, №26, «SunАrМed» Medical Center, data from the "cancer register" of the Kazakh research Institute of Oncology and radiology for 2014-2015. When contacting women, they collected complaints, history, gynecological examination, examination in mirrors, a fence from the cervix and cervical canal for oncocytological examination, an enzyme immunoassay for viral infections, as well as chlamydia, ureаplasma, trichomonosis, gardnerellosis, sexually transmitted infections. Results and discussion. The distribution by number of infections among 180 women was as follows: one infection - 42 (23.3%), two infections - 89 (49.4%), three or more infections - 49 (27.2%). From the presence of STI infections, the examined patients were diagnosed with cytomegalovirus - 63, genetic herpes - 52, ureаplasmosis - 32, chlamydia - 28, trichomoniasis - 26, candidiasis - 29, gardnerellosis - 18, papillomavirus infection - 12. During the examination, more often pseudoeroias were diagnosed - 126, cervicitis - 43, and polyps - 11. Cytological examination showed in most cases dystrophic changes in the cervical epithelium with varying degrees of damage to the layers. Dysplastic changes in Cytology smears were observed in 34 patients (18.8%), of which mild to moderate dysplasia prevailed (16%). Conclusion. Evaluating the results obtained, it can be noted that the chronic inflammatory process of the cervix affects the processes of metaplasia in ectopias (proliferation and differentiation of reserve cells) and in some cases can lead to the development of dysplasia. Keywords: cervical cancer, STI infections, papillomavirus, primary and secondary prevention.

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