Skin Signs

2015 ◽  
Author(s):  
Aziz Shaibani
Keyword(s):  
Inflammatory Diseases ◽  
Neuromuscular Diseases ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Congenital Disorders ◽  
Amyopathic Dermatomyositis ◽  
Dark Skin ◽  
Skin Changes ◽  
Neurocutaneous Syndromes ◽  
Skin Signs

Many neuromuscular diseases are expressed by skin manifestations such as dermatomyositis. Skin changes of dermatomyositis are of many types and can be subtle in dark skin. Skin rash may be the only finding in dermatomyositis (amyopathic dermatomyositis). Many systemic inflammatory diseases are associated with skin lesions and neuromuscular involvement such as vasculitis, SLE, and scleroderma. Steroids may lead to acne-like skin lesions that should be differentiated from the rash of the underlying disease. Since the skin and nervous system are both ectodermal in origin, many hereditary and congenital disorders affect both (neurocutaneous syndromes). This chapter provides examples of skin signs that are associated with neuromuscular diseases.

Skin Signs

2018 ◽  
Author(s):  
Aziz Shaibani
Keyword(s):  
Lupus Erythematosus ◽  
Neuromuscular Disease ◽  
Inflammatory Diseases ◽  
Neuromuscular Diseases ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Systemic Lupus ◽  
Dark Skin ◽  
Skin Changes ◽  
Skin Signs

Many neuromuscular diseases are expressed by skin manifestations such as dermatomyositis. Skin changes of dermatomyositis can be of many types and be subtle in dark skin. They include heliotropes, periungual telangiectasia, and thickening and fissuring of the skin. Unlike SLE rash, dermatomyositis rash affects the knuckles. Many systemic inflammatory diseases are associated with neuromuscular disease, such as vasculitis, systemic lupus erythematosus (SLE), and scleroderma. Steroids may lead to acne like skin lesions that should be differentiated from the rash of the underlying disease. This chapter provides examples of skin signs that are associated with neuromuscular diseases.

Successful Treatment with Tacrolimum for Skin Lesions in Amyopathic Dermatomyositis

2007 ◽  
Vol 69 (6) ◽  
pp. 595-600
Author(s):  
Naoko TAKEO ◽  
Kazushi ISHIKAWA ◽  
Sakuhei FUJIWARA ◽  
Itomi MATSUSHIMA ◽  
Koji ISHII
Keyword(s):  
Successful Treatment ◽  
Skin Lesions ◽  
Amyopathic Dermatomyositis

Anemia of Inflammation

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 276-280 ◽  
Author(s):  
Cindy N. Roy
Keyword(s):  
Inflammatory Diseases ◽  
Underlying Disease ◽  
Comorbid Condition ◽  
Regulatory Pathways ◽  
Hepcidin Expression ◽  
Disease States ◽  
Poor Outcomes ◽  
The Impact ◽  
Inflammatory Insult ◽  
Anemia Of Inflammation

Abstract Inflammation arising from various etiologies, including infection, autoimmune disorders, chronic diseases, and aging, can promote anemia. The anemia of inflammation (AI) is most often normocytic and normochromic and is usually mild. Characteristic changes in systemic iron handling, erythrocyte production, and erythrocyte life span all contribute to AI. The preferred treatment is directed at the underlying disease. However, when the inflammatory insult is intractable, or the cause has not been diagnosed, there are limited options for treatment of AI. Because anemia is a comorbid condition that is associated with poor outcomes in various chronic disease states, understanding its pathogenesis and developing new tools for its treatment should remain a priority. Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability. As the technology for quantitative hepcidin analysis improves, hepcidin's role in various disease states is also being revealed. Recent insights concerning the regulatory pathways that modify hepcidin expression have identified novel targets for drug development. As the field advances with such therapeutics, the analysis of the impact of normalized hemoglobin on disease outcomes will confirm whether anemia is a reversible independent contributor to the morbidity and mortality associated with inflammatory diseases.

scholarly journals HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE

1963 ◽  
Vol 118 (4) ◽  
pp. 635-648 ◽  
Author(s):  
Peter Stastny ◽  
Vernie A. Stembridge ◽  
Morris Ziff
Keyword(s):  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Adult Rats ◽  
Hydropic Degeneration ◽  
Skin Changes ◽  
Adult Rat ◽  
The One

The cutaneous lesions of adult rats with homologous disease are described, and evidence is presented to indicate that they have an immunologic basis. The skin changes included erythema, purpura, edema, and a variety of inflammatory lesions. In the more active lesions, dermal infiltration, hydropic degeneration, acanthosis, and atrophy of the epidermis with hyperkeratosis and follicular plugging were present. In some cases, ulceration and sloughing were also observed. More chronic lesions were characterized by atrophy of the epidermis and collagenization of the dermis with disappearance of the skin appendages. Rejection of autografts was observed simultaneously with acceptance of homografts. The histologic appearance of autografts undergoing rejection was similar to that of the spontaneous skin lesions, suggesting that the latter, too, had an immunologic basis. In favor of this, also, was the specificity of the dermatitis for the skin of the host, with sparing of neighboring homograft tissue. There was a histologic similarity between the spontaneous skin lesions of homologous disease and those of lupus erythematosus on the one hand, and scleroderma on the other, thus supporting the possibility that the cutaneous lesions of these connective tissue diseases of man may also have an immunologic basis. It was concluded that the adult rat with homologous disease may furnish a model for human autoimmune disease.

Medyczne i humanistyczne zagadnienia związane z psychodermatologią w praktyce lekarza rodzinnego, ginekologa i seksuologa

2020 ◽  
Vol 23 (3) ◽  
Author(s):  
Grażyna Jarząbek-Bielecka ◽  
Katarzyna Plagens-Rotman ◽  
Małgorzata Mizgier ◽  
Piotr Merks ◽  
Magdalena Czarnecka-Operacz ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Family Doctor ◽  
Holistic Approach ◽  
Self Esteem ◽  
Skin Lesions ◽  
The Body ◽  
Skin Changes ◽  
Developmental Age ◽  
Pain And Suffering ◽  
Similar Search

A family doctor, as well as a sexologist, gynecologist, in his medical practice encounters problems related to skin diseases significantly affecting the sense of femininity or masculinity. An example of such an issue, especially in gynecology of developmental age, is the problem of skin changes associated with androgenization syndromes. Typical dermatological diseases are sometimes associated with enormous pain, not only physical, but also mental, resulting from the fact that skin disease processes significantly disfigure the body, lower self-esteem and significantly affect the sexual sphere. Selected aspects related to the holistic approach to the issue of pain and suffering, also related to skin lesions, are presented. This issue, like all medical fields, is a source of philosophical reflection. It is inseparable from psychodermatology. The experience of the SARS-CoV-2 coronavirus pandemic, taking into account skin lesions, also prompts a similar search.

scholarly journals Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 249 ◽  
Author(s):  
Kim ◽  
Seong ◽  
Choung
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Skin Barrier ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Morinda Citrifolia ◽  
Skin Barrier Function ◽  
Immune Balance

Morinda citrifolia, a fruit generally known as “Noni”, has been traditionally used in parts of East Asia to relieve inflammatory diseases. Although several studies using noni have been reported, the effect of fermented Morinda citrifolia (F.NONI) on atopic dermatitis (AD) has not been investigated. Thus, we aimed to investigate the improving effect of F.NONI treatment on AD-like skin lesions and elucidate molecular mechanisms. F.NONI was prepared by the fermentation of noni fruit with probiotics and then extracted. F.NONI was orally administrated to NC/Nga mice to evaluate its therapeutic effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD. Oral administration of F.NONI significantly alleviated AD lesions and symptoms such as dermatitis scores, ear thickness, scratching behavior, epidermal thickness, and infiltration of inflammatory cells (e.g., mast cells and eosinophils). In addition, F.NONI treatment reduced the levels of histamine, IgE and IgG1/IgG2a ratio, thymus and activation regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) in serum and beneficially modulated the expressions of Th1, Th2, Th17, and Th22-mediated cytokines in lesioned skin and splenocytes. Furthermore, the expressions of the skin barrier-related proteins including filaggrin (FLG), loricrin (LOR), involucrin (IVL), zonula occludens-1 (ZO-1), and occludin (OCC) were restored by F.NONI treatment. Taken together, these results suggest that F.NONI could be a therapeutic agent to attenuate AD-like skin lesions through modulating the immune balance and skin barrier function.

scholarly journals Scalp Pruritus: Review of the Pathogenesis, Diagnosis, and Management

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Ploysyne Rattanakaemakorn ◽  
Poonkiat Suchonwanit
Keyword(s):  
Therapeutic Strategy ◽  
Skin Diseases ◽  
Underlying Disease ◽  
Review Article ◽  
Skin Changes ◽  
Underlying Condition ◽  
Appropriate Treatment ◽  
Underlying Diseases ◽  
Frequent Problem

Scalp pruritus is a frequent problem encountered in dermatological practice. This disorder is caused by various underlying diseases and is a diagnostic and therapeutic challenge. Scalp pruritus may be localized to the scalp or extended to other body areas. It is sometimes not only associated with skin diseases or specific skin changes, but also associated with lesions secondary to rubbing or scratching. Moreover, scalp pruritus may be difficult to diagnose and manage and may have a great impact on the quality of life of patients. It can be classified as dermatologic, neuropathic, systemic, and psychogenic scalp pruritus based on the potential underlying disease. A thorough evaluation of patients presenting with scalp pruritus is important. Taking history and performing physical examination and further investigations are essential for diagnosis. Therapeutic strategy comprises removal of the aggravating factors and appropriate treatment of the underlying condition. All treatments should be performed considering an individual approach. This review article focuses on the understanding of the pathophysiology and the diagnostic and therapeutic management of scalp pruritus.

Amyopathic dermatomyositis combined with peripheral neuropathy

2020 ◽  
Vol 13 (11) ◽  
pp. e237250
Author(s):  
Zenshi Miyake ◽  
Akiko Ishii ◽  
Naoko Okiyama ◽  
Akira Tamaoka
Keyword(s):  
Peripheral Neuropathy ◽  
Interstitial Pneumonia ◽  
Muscle Weakness ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Skin Lesions ◽  
Amyopathic Dermatomyositis ◽  
First Report ◽  
Controversial Concept

We provide the first report of amyopathic dermatomyositis combined with peripheral neuropathy. Our patient, a 49-year-old woman, initially experienced muscle weakness and tingling sensations in her legs, and nerve conduction study findings and the detection of antiganglioside antibodies indicated that she had autoimmune peripheral neuropathy. The unexpected presence of skin lesions, interstitial pneumonia and antibodies to melanoma differentiation-associated protein 5 prompted an additional diagnosis of amyopathic dermatomyositis. No previous report has described amyopathic dermatomyositis with peripheral neuropathy, and the present case provides evidence for the once-controversial concept of neuromyositis.

scholarly journals Chrysin Inhibits NF-κB-Dependent CCL5 Transcription by Targeting IκB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment

2020 ◽  
Vol 21 (19) ◽  
pp. 7348
Author(s):  
Hyunjin Yeo ◽  
Young Han Lee ◽  
Dongsoo Koh ◽  
Yoongho Lim ◽  
Soon Young Shin
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Binding Pocket ◽  
Skin Lesions ◽  
Transcriptional Level ◽  
Inflammatory Microenvironment ◽  
Design And Synthesis ◽  
Iκb Kinase ◽  
Chemokine Ligand

Chrysin (5,7-dihydroxyflavone) is a natural polyphenolic compound that induces an anti-inflammatory response. In this study, we investigated the molecular mechanism underlying the chrysin-induced suppression of C-C motif chemokine ligand 5 (CCL5) gene expression in atopic dermatitis (AD)-like inflammatory microenvironment. We showed that chrysin inhibited CCL5 expression at the transcriptional level through the suppression of nuclear factor kappa B (NF-κB) in the inflammatory environment. Chrysin could bind to the ATP-binding pocket of the inhibitor of κB (IκB) kinase (IKK) and, subsequently, prevent IκB degradation and NF-κB activation. The clinical efficacy of chrysin in targeting IKK was evaluated in 2,4-dinitrochlorobenzene-induced skin lesions in BALB/c mice. Our results suggested that chrysin prevented CCL5 expression by targeting IKK to reduce the infiltration of mast cells to the inflammatory sites and at least partially attenuate the inflammatory responses. These findings suggested that chrysin might be useful as a platform for the design and synthesis of small-molecule IKK-targeting drugs for the treatment of chronic inflammatory diseases, such as AD.

scholarly journals Variations of Dermatological Findings in New-Borns of a Community Hospital in Nepal

2018 ◽  
Vol 37 (3) ◽  
pp. 261-266
Author(s):  
Asim Shrestha ◽  
Smriti Shrestha
Keyword(s):  
Community Hospital ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Term Pregnancy ◽  
Cross Sectional ◽  
Skin Changes ◽  
Caesarean Section Delivery ◽  
Mongolian Spot

Introduction: Skin manifestations are common in neonates. The prevalence of skin changes and their association with neonatal and maternal factors are not adequately documented in Nepal. It is important to differentiate common benign skin lesions from infrequent skin changes that cause morbidity, requiring medical management. The objectives of this study were to determine the pattern of skin lesions in new-borns and their association with maternal and neonatal variables.Material and Methods: This was a prospective, cross-sectional study conducted in obstetric unit of the hospital from December 2016 to May 2017. Outborn babies and babies shifted to NICU were excluded.Results: A total of 935 new-borns were examined. The commonest skin lesions were Mongolian spot (66.7%), Erythema toxicum (46.6%), Milia (44.4%), Epstein pearls (26.4%) and Salmon patch (11.9%). Mothers aged 35 years or older (63.6%) had statistically significant association with Erythema toxicum (p=0.01). Erythema toxicum was more in primiparity, term pregnancy and caesarean section delivery. Milia was associated with male babies. Salmon patch was seen more in term pregnancy. Congenital melanocytic nevus, haemangioma and port-wine stain were noted in three, two and one new-borns respectively, which alter morbidity and hence are important to diagnose in time.Conclusion: We found that 93.8% of neonates had at one or more skin lesions. The majority of skin lesions were benign and transient. Erythema toxicum was seen commonly in mothers aged 35 and more. Salmon patch was seen more in term pregnancy.  

Sign in / Sign up

Export Citation Format

Share Document