scholarly journals Medical Intelligence Team Lessons Learned: Early Activation and Knowledge Product Development Mitigate COVID-19 Threats

2021 ◽  
Vol 186 (Supplement_2) ◽  
pp. 15-22
Author(s):  
Laurie Migliore ◽  
Dawnkimberly Hopkins ◽  
Savannah Jumpp ◽  
Ceferina Brackett ◽  
Jessica Cromheecke
Keyword(s):  
Policy Development ◽  
Lessons Learned ◽  
Therapeutic Interventions ◽  
Response Strategy ◽  
The Novel ◽  
Local Policy ◽  
Infrastructure Policy ◽  
Pandemic Threat ◽  
Threat Mitigation ◽  
Novel Coronavirus

ABSTRACT Leadership during the emergence of the novel coronavirus pandemic is complex and involves coordinated efforts between multiple levels of leadership from the medical, installation, local, state, and federal levels. Medical intelligence is critical to successful pandemic threat mitigation. We describe one of the first coronavirus (Coronavirus Disease-2019 (COVID-19)) impacted Department of Defense Medical Treatment Facility’s strategic activation of a COVID-19 Medical Intelligence Team (MIT), the products developed, and lessons learned during the pandemic onset. The MIT bridged COVID-19 knowledge and policy gaps by developing and delivering daily intelligence briefings on four domains: epidemiology and infectious disease, healthcare capabilities and infrastructure, policy and regulations, and diagnostics and therapeutic interventions. Twenty-three products were developed and delivered to aid in leadership decision-making and local policy development in the absence of higher-level policy and guidance. Employing MITs in future pandemic response strategy may more effectively mitigate pandemic threats and improve force health protection.

scholarly journals Acute motor-sensory axonal polyneuropathy variant of Guillain–Barre syndrome complicating the recovery phase of coronavirus disease 2019 infection: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ahmed Maseh Haidary ◽  
Sarah Noor ◽  
Esmatullah Hamed ◽  
Tawab Baryali ◽  
Soma Rahmani ◽  
...  
Keyword(s):  
Recovery Phase ◽  
Sudden Onset ◽  
Therapeutic Interventions ◽  
Guillain Barre Syndrome ◽  
The Novel ◽  
Case Presentation ◽  
Progressive Muscle Weakness ◽  
Guillain Barré Syndrome ◽  
Novel Coronavirus ◽  
Guillain Barré

Abstract Introduction The novel coronavirus, since its first identification in China, in December 2019, has shown remarkable heterogeneity in its clinical behavior. It has affected humans on every continent. Clinically, it has affected every organ system. The outcome has also been variable, with most of the older patients showing grave outcomes as compared with the younger individuals. Here we present a rare and severe variant of Guillain–Barre syndrome that complicated the disease in recovery phase. Case presentation A 60-year-old Afghan man, who had been recovering from symptoms related to novel coronavirus associated disease, presented with sudden onset of progressive muscle weakness and oxygen desaturation. Electrophysiological workup confirmed the diagnosis of Guillain–Barre syndrome, and early institution of intravenous immunoglobulin resulted in complete resolution. Conclusion Guillain–Barre syndrome has recently been reported in many patients diagnosed with novel coronavirus associated disease. While clinical suspicion is mandatory to guide towards an effective diagnostic workup, early diagnosis of this complication and timely institution of therapeutic interventions are indispensable and lifesaving.

scholarly journals SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Heidi Luise Schulte ◽  
José Diego Brito-Sousa ◽  
Marcus Vinicius Guimarães Lacerda ◽  
Luciana Ansaneli Naves ◽  
Eliana Teles de Gois ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Federal District ◽  
Therapeutic Interventions ◽  
Diagnostic Process ◽  
The Novel ◽  
Prevention Measures ◽  
Laboratory Findings ◽  
Novel Coronavirus ◽  
The Impact

Abstract Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up. Results Of the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days. Conclusions The cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas.

scholarly journals Building Telemedicine Capacity for Trainees During the Novel Coronavirus Outbreak: a Case Study and Lessons Learned

2020 ◽  
Vol 35 (9) ◽  
pp. 2675-2679 ◽  
Author(s):  
Katharine Lawrence ◽  
Kathleen Hanley ◽  
Jennifer Adams ◽  
Daniel J Sartori ◽  
Richard Greene ◽  
...  
Keyword(s):  
Lessons Learned ◽  
The Novel ◽  
Novel Coronavirus

scholarly journals Lessons earned and lessons learned: What should be done next to counter the COVID-19 infodemic?

European View ◽  
2020 ◽  
Vol 19 (2) ◽  
pp. 154-163
Author(s):  
Nad’a Kovalčíková ◽  
Ariane Tabatabai
Keyword(s):  
Public Health ◽  
Lessons Learned ◽  
The Novel ◽  
Health Crisis ◽  
The Public ◽  
Public Health Crisis ◽  
Societal Challenges ◽  
The World ◽  
Information Manipulation ◽  
Novel Coronavirus

As governments and citizens around the world have struggled with the novel coronavirus, the information space has turned into a battleground. Authoritarian countries, including Russia, China and Iran, have spread disinformation on the causes of and responses to the pandemic. The over-abundance of information, also referred to as an ‘infodemic’, including manipulated information, has been both a cause and a result of the exacerbation of the public health crisis. It is further undermining trust in democratic institutions, the independent press, and facts and data, and exacerbating the rising tensions driven by economic, political and societal challenges. This article discusses the challenges democracies have faced and the measures they have adopted to counter information manipulation that impedes public health efforts. It draws seven lessons learned from the information war and offers a set of recommendations on tackling future infodemics related to public health.

scholarly journals Microbes, Clinical trials, Drug Discovery, and Vaccine Development: The Current Perspectives

2021 ◽  
Vol 4 (4) ◽  
pp. 311-323
Author(s):  
Venkataramana Kandi ◽  
Tarun Kumar Suvvari ◽  
Sabitha Vadakedath ◽  
Vikram Godishala
Keyword(s):  
Drug Discovery ◽  
Genetic Variants ◽  
Vaccine Development ◽  
Treatment Options ◽  
Morbidity And Mortality ◽  
Therapeutic Interventions ◽  
Multi Drug Resistance ◽  
The Novel ◽  
Normal Human ◽  
Novel Coronavirus

Because of the frequent emergence of novel microbial species and the re-emergence of genetic variants of hitherto known microbes, the global healthcare system, and human health has been thrown into jeopardy. Also, certain microbes that possess the ability to develop multi-drug resistance (MDR) have limited the treatment options in cases of serious infections, and increased hospital and treatment costs, and associated morbidity and mortality. The recent discovery of the novel Coronavirus (n-CoV), the Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) that is causing the CoV Disease-19 (COVID-19) has resulted in severe morbidity and mortality throughout the world affecting normal human lives. The major concern with the current pandemic is the non-availability of specific drugs and an incomplete understanding of the pathobiology of the virus. It is therefore important for pharmaceutical establishments to envisage the discovery of therapeutic interventions and potential vaccines against the novel and MDR microbes. Therefore, this review is attempted to update and explore the current perspectives in microbes, clinical research, drug discovery, and vaccine development to effectively combat the emerging novel and re-emerging genetic variants of microbes.

scholarly journals Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 52 ◽  
Author(s):  
Veljko Veljkovic ◽  
Júlia Vergara-Alert ◽  
Joaquim Segalés ◽  
Slobodan Paessler
Keyword(s):  
Present Report ◽  
Therapeutic Vaccine ◽  
The Novel ◽  
Natural Reservoir ◽  
Vaccine Target ◽  
Putative Receptor ◽  
Pandemic Threat ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
Actin Protein

A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has expanded the number of highly pathogenic coronaviruses affecting humans. The 2019-nCoV represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. The performed in silico analysis indicates that the newly emerging 2019-nCoV is closely related to severe acute respiratory syndrome (SARS)-CoV and, to a lesser degree, Middle East respiratory syndrome (MERS)-CoV. Moreover, the well-known SARS-CoV receptor (ACE2) might be a putative receptor for the novel virus as well. Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of 2019-nCoV; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. Additional results indicated that civets and poultry are potential candidates for the natural reservoir of the 2019-nCoV, and that domain 288-330 of S1 protein from the 2019-nCoV represents promising therapeutic and/or vaccine target.

scholarly journals Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 52 ◽  
Author(s):  
Veljko Veljkovic ◽  
Júlia Vergara-Alert ◽  
Joaquim Segalés ◽  
Slobodan Paessler
Keyword(s):  
Present Report ◽  
Therapeutic Vaccine ◽  
The Novel ◽  
Natural Reservoir ◽  
Vaccine Target ◽  
Putative Receptor ◽  
Pandemic Threat ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
Actin Protein

A novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. The performed in silico analysis indicates that the newly emerging SARS-CoV-2 is closely related to severe acute respiratory syndrome (SARS)-CoV and, to a lesser degree, Middle East respiratory syndrome (MERS)-CoV. Moreover, the well-known SARS-CoV receptor (ACE2) might be a putative receptor for the novel virus as well. Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. Additional results indicated that civets and poultry are potential candidates for the natural reservoir of the SARS-CoV-2, and that domain 288-330 of S1 protein from the SARS-CoV-2 represents promising therapeutic and/or vaccine target.

Rapid Development and Deployment of Respiratory Evaluation Clinics in Response to the COVID-19 Pandemic to Keep Staff and Patients Safe

2021 ◽  
pp. 38-42
Author(s):  
Charles Haddad ◽  
Christopher Scuderi ◽  
Judelle Haddad-Lacle ◽  
Reetu Grewal ◽  
Jeffrey Jacqmein ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Rapid Development ◽  
Lessons Learned ◽  
The Novel ◽  
Global Pandemic ◽  
Vulnerable Patients ◽  
The World ◽  
Novel Coronavirus ◽  
Geographical Locations ◽  
The U.S

The world as we knew it changed at the beginning of 2020 with the explosion of the global pandemic caused by SARS-CoV-2, a.k.a. COVID-19. As of January 10, 2021, the novel coronavirus has infected over 89 million people worldwide and killed over 1.9 million. In the U.S., there have been 22 million people infected and 373,000 deaths. It has never been more important to protect our vulnerable patients and staff from infectious disease, especially during the time they spend in our offices and clinics. It quickly became apparent that there was a need for a dedicated location where patients could be seen that were too ill to be evaluated via telemedicine, but not ill enough to be sent to the Emergency Department (ED). To fill this need, our primary care network developed the Respiratory Evaluation Clinic (REC) concept. These were two geographical locations where the outlying clinics could send potentially infectious patients to evaluate and test COVID-19. Some recommendations, adaptations, lessons learned and the REC clinics' expansions to other locations throughout our network are discussed.

scholarly journals The potential impact of COVID 19 on poor and conflict-ridden communities in Sub-Sahara Africa (SSA): A conceptual paper

2020 ◽  
Vol 1 (2) ◽  
pp. 125-132
Author(s):  
Mathew Nyashanu ◽  
Tistsi Tsopotsa ◽  
Scovia Nalugo Mbalinda ◽  
Gemma North ◽  
Maureen Mguni ◽  
...  
Keyword(s):  
Policy Development ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Public Health Professionals ◽  
Global Pandemic ◽  
Potential Impact ◽  
Wu Zhao ◽  
Future Policy ◽  
Novel Coronavirus

The first cases of the novel coronavirus disease (COVID-19), previously known as 2019-nCoV, were reported in late December 2019 in Wuhan, China (Wu, Zhao, Yu B, et al 2020). The virus then spread to Malaysia and Thailand and eventually to the Americas, Europe, Australia and Africa. On the 11thof March 2020 the World Health Organisation (WHO) declared the COVID-19 a global pandemic. This concept paper  explores the potential impact of COVID-19 on poverty stricken and conflict-ridden communities in Sub-Sahara Africa. In doing so, the paper also explored the implications for public health professionals working with these communities, including recommendation for future policy development.

scholarly journals Policy and weather influences on mobility during the early U.S. COVID-19 pandemic

2021 ◽  
Author(s):  
Yihan Wu ◽  
Todd Mooring ◽  
Marianna Linz
Keyword(s):  
United States ◽  
Behavioral Change ◽  
The United States ◽  
Behavioral Changes ◽  
Transmission Dynamics ◽  
The Novel ◽  
Local Policy ◽  
Outdoor Air ◽  
Novel Coronavirus ◽  
Device Tracking

Abstract As the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 24 continues to proliferate across the globe, it is a struggle to predict and prevent its spread. The 25 successes of mobility interventions demonstrate how policies can help limit the person-to-person 26 interactions that are essential to infection. With significant community spread, experts predict this 27 virus will continue to be a threat until safe and effective vaccines have been developed and 28 widely deployed. We aim to understand mobility changes during the first major quarantine period 29 in the United States, measured via mobile device tracking, by assessing how people changed their 30 behavior in response to policies and to weather. Here, we show that consistent national messaging 31 was associated with consistent national behavioral change, regardless of local policy. 32 Furthermore, although human behavior did vary with outdoor air temperature, these variations 33 were not associated with variations in a proxy for the rate of encounters between people. The 34 independence of encounters and temperatures suggests that weather-related behavioral changes 35 will, in many cases, be of limited relevance for SARS-CoV-2 transmission dynamics. Both of 36 these results are encouraging for the potential of clear national messaging to help contain any 37 future pandemics, and possibly to help contain COVID-19.Published in PNAS: https://www.pnas.org/content/118/22/e2018185118

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