scholarly journals NIMG-61. UNUSUAL PRESENTATION OF NEUROSARCOIDOSIS: A CASE SERIES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii161-ii161
Author(s):  
B K Kleinschmidt-Demasters ◽  
David Ormond ◽  
Evan Winograd
Keyword(s):  
Systemic Disease ◽  
Case Series ◽  
White Matter Lesions ◽  
Meningeal Enhancement ◽  
Neoplastic Lesions ◽  
Typical Appearance ◽  
Rare Diagnosis ◽  
Radiographic Presentation ◽  
Or History ◽  
Rule Out

Abstract INTRODUCTION Neurosarcoidosis is a rare diagnosis, and even with known systemic disease or history, often remains a diagnosis of exclusion. Typical imaging findings of neurosarcoidosis include white matter lesions coupled with meningeal enhancement, or “sugarcoating” near the skull base. Occasionally, imaging can be quite unusual and mimic other entities. Other diagnoses to rule out include neoplastic, autoimmune, or infectious pachymeningitis, neoplastic lesions, neurosyphilis or tuberculosis. METHODS Our neuropathology database was queried for neurosarcoidosis from January 2008 until December 2019. These cases were then reviewed for cases with unusual presentations for further review and discussion. RESULTS Here we present 16 cases of neurosarcoidosis with histories and/or imaging that did not conform to the typical appearance of neurosarcoidosis. Along with a rare radiographic presentation, these cases also lacked CSF, laboratory, or systemic findings to suggest a diagnosis of neurosarcoidosis. 15 of these cases presented intracranially while 1 case presented within the spinal cord. CONCLUSIONS Neurosarcoidosis presentations can vary greatly. A better understanding of some unique patient presentations can help improve noninvasive diagnosis, although biopsy often remains necessary for confirmation.

scholarly journals Neoplastic lesions in domestic pigs detected at slaughter: literature review and a 20-year review (1998–2018) of carcass inspection in Catalonia

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Antonia Morey-Matamalas ◽  
Enric Vidal ◽  
Jorge Martínez ◽  
Jaume Alomar ◽  
Antonio Ramis ◽  
...  
Keyword(s):  
B Cell ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Support Network ◽  
Published Data ◽  
Nerve Sheath Tumor ◽  
Lymphoid Leukemia ◽  
Lymphoid Neoplasms ◽  
Neoplastic Lesions ◽  
Slaughtered Pigs

Abstract Background The present paper reviews the occurrence of neoplasms in swine and presents a case series of 56 tumors submitted to the Slaughterhouse Support Network (Servei de Suport a Escorxadors [SESC] IRTA-CReSA]) from slaughtered pigs from 1998 to 2018 (April) in Catalonia (Spain). The aim of the study was to describe the spectrum of spontaneous neoplastic lesions found in slaughtered pigs and to compare the reported tumor cases with previous published data. Lymphoid neoplasms were characterized and classified using the WHO classification adapted for animals. Results The most reported neoplasm during this period was lymphoma (28). Within lymphomas, the B-cell type was the most common, being the diffuse large B-cell lymphoma (15/28) the most represented subtype. Other submitted non-lymphoid neoplasms included melanoma (7), nephroblastoma (3), mast cell tumor (2), liposarcoma (2), osteochondromatosis (2), papillary cystadenocarcinoma (1), peripheral nerve sheath tumor (1), lymphoid leukemia (1), fibropapilloma (1), hemangiosarcoma (1), hepatoma (1), histiocytic sarcoma (1), pheochromocytoma (1) and osteosarcoma (1). Conclusions The existence of a well-established Slaughterhouse Support Network allowed the compilation of comprehensive data for further epidemiological and pathological studies, particularly about less commonly reported lesions in livestock such as neoplasms in pigs.

Incidental mastoiditis on magnetic resonance imaging scans: clinical relevance and cost implications

2018 ◽  
Vol 132 (11) ◽  
pp. 1010-1012 ◽  
Author(s):  
Y Abbas ◽  
H S Yuen ◽  
A Trinidade ◽  
G Watters
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Incidental Finding ◽  
Case Series ◽  
Resonance Imaging ◽  
Retrospective Case ◽  
Reporting Practice ◽  
Significant Pathology ◽  
Cost Implications ◽  
Rule Out

AbstractObjectivesTo determine: (1) the incidence of incidental ‘mastoiditis’ reported on magnetic resonance imaging scans performed in patients with asymmetrical sensorineural hearing loss and/or unilateral tinnitus; (2) how many of those patients have actual otological pathology and/or require treatment; and (3) the financial implications of such a reporting practice.MethodRetrospective case series.ResultsBetween October 2015 and November 2016, 500 patients underwent magnetic resonance imaging of the internal auditory meatus to rule out cerebellopontine angle lesions. There was an incidental finding of increased mastoid signalling in 5.8 per cent (n= 29), of which 20.7 per cent (6 of 29) were reported as bilateral cases. The diagnosis of ‘mastoiditis’ was found in 39.7 per cent (29 of 73). None of these patients had any pathology identified clinically. Other significant pathology was identified in a further 8.8 per cent (n= 44).ConclusionThe diagnosis of mastoiditis is primarily clinical. An incidental finding of high signalling in the mastoid region on magnetic resonance imaging is highly unlikely to represent actual clinical disease. In patients who are scanned for other reasons and who do not complain of otological symptoms, such findings are unlikely to require otolaryngology input.

scholarly journals Varied presentations of cutaneous vasculitis: a case series

2020 ◽  
Vol 8 (8) ◽  
pp. 3066
Author(s):  
Pinky Gupta ◽  
Shweta Ganorkar ◽  
Surekha Bhalekar ◽  
Rajiv Rao
Keyword(s):  
Blood Vessels ◽  
Histopathological Examination ◽  
Wide Spectrum ◽  
Systemic Disease ◽  
Case Series ◽  
Clinical Severity ◽  
Cutaneous Vasculitis ◽  
Venous Stasis ◽  
Duration Of Symptoms ◽  
Organ Systems

Vasculitis involves a wide spectrum of clinicopathological process with reactive damage to the involved blood vessels. There is loss of vessel integrity instigating haemorrhage & luminal compromise leading to ischemia and necrosis of the tissue supplied by the involved vessels. It may affect varied size and type of blood vessels at different locations. It may be primary or secondary to systemic disease. It may involve a single organ like skin or may involve different organ systems at the same time. This case series include six cases of cutaneous vasculitis affecting different organs with varied presentations. Skin biopsies of six patients with unusual presentations were studied. Their complete history, physical examinations, laboratory investigations including serology were analysed and correlated with histopathological findings. The patients presented with different duration of symptoms varying from as short as 15 days to 1 year. Skin lesions were present in all cases while cardiac manifestation was seen in one. Serology and autoimmune disease markers were negative in all cases except one. However, histopathological features were in concordance with the clinical diagnosis of vasculitis. They were further classified as vasculitis secondary to Churg Strauss syndrome, venous stasis, Henoch Schonlein purpura or leucocytoclastic vasculitis.Vasculitis though a rare disease may manifest as an acute or chronic condition. It needs timely diagnosis by histopathological examination to aid in further management. It is important to assess the clinical severity in primary and secondary vasculitis, as it determines morbidity and mortality.

scholarly journals COVID-19: is it just a lung disease? A case-based review

2020 ◽  
Vol 2 (9) ◽  
pp. 1401-1406 ◽  
Author(s):  
Valerio Spuntarelli ◽  
M. Luciani ◽  
E. Bentivegna ◽  
V. Marini ◽  
F. Falangone ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Systemic Disease ◽  
Case Series ◽  
Level Of Evidence ◽  
Acute Lung Failure ◽  
Clinical Presentations ◽  
Case Series Report ◽  
Lung Failure ◽  
Case Based ◽  
Clinical Cases

Abstract Due to its extreme virulence, COVID-19 virus has rapidly spread, developing a severe pandemic. SARS-COV-2 mostly affected the respiratory tract, causing a severe acute lung failure. Although the infection of airways, COVID-19 can be associated with chronic and systemic damages still not so much known. The purpose of this research is to collect recent evidence in literature about systemic diseases caused by COVID-19. The format of the present article has features of a systematic case-based review (level of evidence), and it is structured as a case series report (patients of our COVID-19 Medicine Ward have been selected as cases). Data for this review have been selected systematically, taking evidence only from indexed journals and databases: PubMed, Scopus, MEDLINE, and Cochrane systems. Papers chosen included systematic reviews, case series, clinical cases, meta-analysis studies, and RCTs. We start collecting studies since 2003. The main keywords used were “COVID-19” “OR” “SARS” “OR” “SARS – COV 2” “AND” “systemic disease” / “nephropathy” / “cardiac pathology” / “central nervous system.” Clinical cases belong to our COVID-19 Medicine Ward. One of the most severe COVID-19 clinical presentations includes cardiovascular problems, like myocarditis, pericarditis, and acute hearth failure. Cytokine release syndrome caused by COVID-19 develops severe acute kidney failure. It is still unknown the way coronavirus damages the liver, brain, and reproductive system. Considering the majority of the new studies about this pathology, it issues that COVID-19 is considered to be a multi-organ disease.

PS01.018: PERSISTENT DYSPHAGIA AFTER FUNDOPLICATION WITH MESH PLASTY –MISSED OR MISTAKEN –A CASE REPORT

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 55-55
Author(s):  
Servarayan Chandramohan ◽  
Visvarath Varadharajan ◽  
Madeshwaran Chinnathambi ◽  
Kanagavel Manickavasagam ◽  
Abishai Jebaraj ◽  
...  
Keyword(s):  
Skin Biopsy ◽  
Mesh Repair ◽  
Conflicts Of Interest ◽  
Case Reports ◽  
Systemic Disease ◽  
Transhiatal Esophagectomy ◽  
High Resolution Manometry ◽  
Failed Fundoplication ◽  
Rule Out

Abstract Background Scleroderma esophagus is a rare entity. Only few case reports of esophagectomy were done and reported for this condition. We are presenting this rare case of failed fundoplication and mesh repair with a diagnosis of GERD and hiatus hernia, which was found later on due to Scleroderma with Esophageal involvement. Methods 58 year old female admitted with dysphagia following laproscopic fundoplication with mesh repair of crura with a diagnosis of GERD and hiatus hernia.She presented with persistent vomiting and loss of weight.On evaluation, her Upper GI scopy revealed dilated esophagus with sluggish peristalisis. Since the patient had tightness of skin over the distal extremities, face and fish mouth appearance with thinning of nail, Skin biopsy was taken. The skin biopsy was reported to be scleroderma.The esophageal manometry demonstrated failed esophageal peristalisis with high normal LES pressure due to tight fundal wrap.The patient was treated with mesh remova, Transhiatal esophagectomy with gastric pull-up and cervical Anastomosis.Post operatively the patient was treated with hydrocholoroquine and predinisolone. Results The patient is free of dysphagia and is on regular follow up. Conclusion In case of failure, detailed evaluation including High resolution manometry (MII HRM) has to be done before doing laparoscopic fundoplication for GERD has to rule out uncommon and rare disorders of esophagus. Detailed clinical examination in GERD patients has to be done to rule out systemic disease like scleroderma.In case of failed fundoplication for GERD, patients have to investigated for the failure.So patients with incapacitating esophageal neuromotor disease, a more radical approach in the form of esophagectomy may be safer and more reliable than attempting another procedure and risk another failure. Disclosure All authors have declared no conflicts of interest.

Extensive meningeal enhancement in acute central nervous system Lyme: Case series and review of literature

2019 ◽  
Vol 64 ◽  
pp. 25-27 ◽  
Author(s):  
Mahbobeh Niksefat ◽  
Bassam Albashiti ◽  
Devin Burke ◽  
Pouria Moshayedi ◽  
Riddhi Patira ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Series ◽  
Review Of Literature ◽  
Meningeal Enhancement

scholarly journals Intraoperative ultrasonography for presumed brain metastases: a case series study

2012 ◽  
Vol 70 (10) ◽  
pp. 793-798 ◽  
Author(s):  
Helder Picarelli ◽  
Marcelo de Lima Oliveira ◽  
Edson Bor-Seng-Shu ◽  
Eduardo Santamaria Carvalhal Ribas ◽  
Alexandre Maria Santos ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Functional Outcomes ◽  
Systemic Disease ◽  
Survival Rates ◽  
Tumor Resection ◽  
Intraoperative Ultrasound ◽  
Case Series ◽  
Case Series Study ◽  
Actual Contribution ◽  
Series Study

Brain metastases (BM) are one of the most common intracranial tumors and surgical treatment can improve both the functional outcomes and patient survival, particularly when systemic disease is controlled. Image-guided BM resection using intraoperative exams, such as intraoperative ultrasound (IOUS), can lead to better surgical results. METHODS: To evaluate the use of IOUS for BM resection, 20 consecutives patients were operated using IOUS to locate tumors, identify their anatomical relationships and surgical cavity after resection. Technical difficulties, complications, recurrence and survival rates were noted. RESULTS: IOUS proved effective for locating, determining borders and defining the anatomical relationships of BM, as well as to identify incomplete tumor resection. No complications related to IOUS were seen. CONCLUSION: IOUS is a practical supporting method for the resection of BM, but further studies comparing this method with other intraoperative exams are needed to evaluate its actual contribution and reliability.

scholarly journals Superimposed Nephrotic Syndrome in Diabetic Patients: 15 Cases of Mismatched Clinicopathological Correlation

2020 ◽  
Vol 5 (07) ◽  
pp. 252-256
Author(s):  
Kamel El-Reshaid ◽  
Shaikha Al-Bader
Keyword(s):  
Nephrotic Syndrome ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Kidney Biopsy ◽  
Case Series ◽  
Diabetic Patients ◽  
Clinicopathological Correlation ◽  
Diabetic Kidney ◽  
Patients With Diabetes ◽  
Rule Out

The spectrum of renal disease in patients with diabetes encompasses both diabetic kidney disease (including albuminuric and non-albuminuric phenotypes) and non-diabetic kidney disease (NDKD). Acute nephrotic syndrome (NS) with short duration of diabetes indicates NDKD. Moreover, such presentation is atypical in patients with IgA nephropathy and pre-eclampsia and hence warrants kidney biopsy to rule out treatable glomerulopathy. In this case series; we present our experience with 15 patients with atypical NS and outline their management.

scholarly journals Clinicopathological study of thyroid swellings in HSK hospital in Karnataka, India

2018 ◽  
Vol 5 (2) ◽  
pp. 420
Author(s):  
Subhash N. Halbhavi ◽  
Mahantayya Ganjigatti ◽  
Shrikant B. Kuntoji ◽  
Mohammedgouse A. Karikazi
Keyword(s):  
Clinical Diagnosis ◽  
Pressure Effect ◽  
Malignant Lesion ◽  
Case Series ◽  
Nodular Goiter ◽  
First Line ◽  
Case Series Study ◽  
One Year ◽  
Series Study ◽  
Rule Out

Background: A thyroid enlargement whether diffuses or in the form of nodules have to be investigated to rule out neoplasm. FNAC is the first line of investigation. USG and TFT are also used. The cases which are at high risk are considered for surgery. Aims and objectives of the study was the clinical presentation of thyroid swellings, incidence of various thyroid swelling, benign versus malignant lesion and to correlate the clinical diagnosis with that of pathological diagnosis.Methods: A case series study of 60 patients attending surgical OPD IPD with symptoms of thyroid in SNMRC and HSK hospital Bagalkot between 1-1-2015 to 30-6-2016. After detailed history thorough, clinical examination was carried out all the patients underwent routine investigations TFT FNAC USG neck. Few patients underwent surgery and all the thyroid specimens were sent for HPE and the clinical diagnosis is correlated with that of pathological diagnosis.Results: Of 60 cases female to male ratio was 9:1. The age group involved is between 31-40 years (31.67%). Duration of goiter is less than one year in 60% of cases. The chief complaint was swelling in front of the neck 100%. Duration of swelling ranged from 15 days to 15 years. Toxic features were present in 18.33% of cases, but after TFT the toxic cases were only 6.67%. Most of the patient showed colloid goiter (43.33%) on FNAC. Out of 60 cases only 22 cases did undergo surgery histopathological specimen were colloid versus nodular goiter in 81.88% out of 22 cases only.Conclusions: Thyroid swellings are common in females they occur in 3rd and 4th decade most commonly. FNAC is very useful in the diagnosis. The main indications of surgery are cosmetic problems, pressure effect symptoms are suspicion of malignancy.

scholarly journals Visceral leishmaniasis in Lebanon a report of four cases: case series and review

2018 ◽  
Vol 12 (02.1) ◽  
pp. 31S ◽  
Author(s):  
Oussaima Eldbouni ◽  
Pierre Abihanna ◽  
Mona Beaini ◽  
Afaf Minari ◽  
Ibrahim Khalife ◽  
...  
Keyword(s):  
Middle East ◽  
Visceral Leishmaniasis ◽  
Systemic Disease ◽  
Case Series ◽  
Complete Response ◽  
Human Migration ◽  
Treatment Modalities ◽  
Lipid Complex ◽  
Vector Borne Diseases ◽  
Middle East Countries

Introduction: Leishmaniasis comprises a complex of vector-borne diseases, caused by more than 20 species of the protozoan genus Leishmania, and ranging from localized skin ulcers to lethal systemic disease. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. In the Middle East countries like Syria reports high incidence of the disease. In addition to the endemicity of the region for leishmaniasis, the Middle East has seen a great deal of human migration either for earning of livelihood or due to political upheaval in the region. Cutaneous form can be disfiguring but visceral form can be lethal. Methodology: In this article we report the clinical presentation of 4 cases of visceral leishmaniasis; 3 cases were pediatrics and one immunosuppressed adult patient all of them were from Syria from different regions. The diagnosis was made by bone marrow aspirate; PCR was made for 2 of them and was positive for leishmania infantum. All of them were treated with Amphotericn B lipid formulation (ABELCET) with complete response (definite cure). Results: We report in this article 4 cases of visceral leishmaniasis treated with amphotericin B lipid complex (Abelcet) following the guidelines with complete remission. Conclusion: Visceral leishmaniasis is a serious disease and if not treated can lead to death. Lebanon is not known to be endemic for leishmania but since the war the ministry of health reported an outbreak of leishmania and mainly cutaneous leishmania. Here we present 4 cases of visceral leishmania and a review of the latest guidelines on the treatment modalities and protocols.

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