TAMI-39. AGE-DEPENDENT PHENOTYPIC CONVERSION FROM NEURONAL ACTIVITY TO NEURO-INFLAMMATION IN GLIOBLASTOMA PROGRESSION

Abstract The rise in population aging worldwide is causing an unparalleled increase in death from many cancers, including glioblastoma (GBM). Here, we have explored the impact of aging and rejuvenation on GBM tumorigenesis. Compared with neuro-inflammatory old GBM, young GBM displayed elevated neuronal/synaptic signaling via brain-derived neurotrophic factor (BDNF) and SLIT and NTRK like-family member 6 (SLITRK6), promoting favorable survival rates. These effects were attributed to the rise in nicotinamide adenine dinucleotide (NAD+) levels, as brain rejuvenation by parabiosis or administration of nicotinamide mononucleotide (NMN) in mice elicited a younger phenotype with activated neuronal/synaptic signaling and improved outcomes. Our data indicate that age-associated NAD+ loss contributes to the highly aggressive GBM by the shift from neuronal/synaptic activity to neuro-inflammation in the elderly brain. These findings have therapeutic and preventive implications in GBM and provide mechanistic insights into the exacerbation of GBM tumorigenesis by aging.

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CBMS-01 AGE-DEPENDENT GLIOBLASTOMA PROGRESSION SUPPRESSED BY NAD+

Neuro-Oncology Advances ◽

10.1093/noajnl/vdz039.021 ◽

2019 ◽

Vol 1 (Supplement_2) ◽

pp. ii5-ii5

Author(s):

Daisuke Yamashita ◽

Saya Ozaki ◽

Satoshi Suehiro ◽

Kazuhiro Sonomura ◽

Toru Kondo ◽

...

Keyword(s):

Nicotinamide Adenine Dinucleotide ◽

Population Aging ◽

Survival Rates ◽

The Elderly ◽

Synaptic Signaling ◽

Therapeutic Implications ◽

Nicotinamide Mononucleotide ◽

Improved Outcomes ◽

Age Dependent ◽

The Impact

Abstract The rise in population aging worldwide is causing an unparalleled increase in death from many cancers, including glioblastoma (GBM). Here, we have explored the impact of aging and rejuvenation on GBM tumorigenesis. Compared with old GBM, young GBM displayed elevated neuronal/synaptic signaling via brain-derived neurotrophic factor (BDNF) and SLIT and NTRK like-family member 6 (SLITRK6), promoting favorable survival rates. These effects were attributed to the rise in nicotinamide adenine dinucleotide (NAD+) levels, as brain rejuvenation by parabiosis or administration of nicotinamide mononucleotide (NMN) in mice elicited a younger phenotype with activated neuronal/synaptic signaling and improved outcomes. Our data indicate that age-associated NAD+ loss contributes to the highly aggressive GBM in the elderly. These findings have therapeutic implications in GBM and provide mechanistic insights into the exacerbation of GBM tumorigenesis with age.

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Forms of physical activity of the elderly

European Journal of Clinical and Experimental Medicine ◽

10.15584/ejcem.2020.3.10 ◽

2020 ◽

Vol 18 (3) ◽

pp. 221-228

Author(s):

Piotr Czarnecki ◽

◽

Justyna Podgórska-Bednarz ◽

Lidia Perenc ◽

◽

...

Keyword(s):

Physical Activity ◽

Elderly People ◽

Population Aging ◽

Human Life ◽

Good Health ◽

The Elderly ◽

Polish Society ◽

Central Statistical ◽

Key Phrases ◽

The Impact

Introduction. Physical activity is known to be an important factor influencing health throughout human life. This issue has become crucial for public health due to the aging of the population in both developed and developing countries. Aim. is to present a literature review on the forms of physical activity undertaken by the elderly, as well as on issues related to physical activity and the population aging. Material and methods. The study was prepared on the basis of a review of Polish and foreign literature. The following databases and data sources were used: EBSCO, ScienceDirect and Google Scholar. An additional source of data were the websites of the Central Statistical Office. Strictly defined key phrases were used during the collection of literature. The work has been divided into thematic subsections on the aging of the society, the impact of physical activity on health and the main topic, i.e. forms of physical activity selected by the elderly. Analysis of the literature. The number of elderly people in Polish society has increased by almost 3.7 million over three decades. Therefore, an important topic is prophylaxis aimed at increasing the number of days in good health, largely covering the broadly understood activation of the elderly. The available data indicate that only 12% of elderly people undertake physical activity once a week. The most common form of spending free time actively is walking (as many as 73% of people in this population declare this form of physical activity in one of the presented studies). Conclusion. Organized forms of physical activity are undertaken much less frequently by the analyzed age group mainly due to financial limitations and limited availability of sports infrastructure.

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Population Aging, Household Savings and Asset Prices: A Study Based on Urban Commercial Housing Prices

Sustainability ◽

10.3390/su11113194 ◽

2019 ◽

Vol 11 (11) ◽

pp. 3194 ◽

Cited By ~ 2

Author(s):

Shihong Zeng ◽

Xinwei Zhang ◽

Xiaowei Wang ◽

Guowang Zeng

Keyword(s):

Asset Prices ◽

Negative Impact ◽

Interaction Analysis ◽

Population Aging ◽

Housing Prices ◽

The Elderly ◽

Dependency Ratio ◽

Household Savings ◽

Savings Rate ◽

The Impact

Currently, China’s aging population, high savings rate and high housing asset prices coexist, which has become a hot issue in academic research. First, considering the life-cycle hypothesis and overlapping generations model, asset prices are negatively correlated with the population dependency ratio and positively correlated with household savings. Second, based on census data from prefecture-level cities, a pooled regression model and two-stage least squares (2SLS) are used in this empirical research. The child dependency ratio was found to have a significant negative impact on housing prices, while the elderly dependency ratio had a positive impact on housing prices. The positive relationship between household savings and housing prices is highly significant. Finally, the interaction analysis shows that the impact of population aging on housing prices differs under different levels of household savings; thus, population aging affects housing prices through household savings, and the mediator dilutes and weakens this impact. The elderly generation’s release of savings could gradually inhibit housing prices. Population aging causes long-run downside risks but not a market meltdown.

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Do Younger Patients with Muscle-Invasive Bladder Cancer have Better Outcomes?

Journal of Clinical Medicine ◽

10.3390/jcm8091459 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1459 ◽

Cited By ~ 1

Author(s):

Florian Janisch ◽

Hang Yu ◽

Malte W. Vetterlein ◽

Roland Dahlem ◽

Oliver Engel ◽

...

Keyword(s):

Cox Regression ◽

Care Center ◽

Tertiary Care ◽

Tumor Biology ◽

Survival Rates ◽

Multivariable Analysis ◽

Young Patients ◽

The Elderly ◽

Cancer Of The Bladder ◽

The Impact

Urothelial cancer of the bladder (UCB) is usually a disease of the elderly. The influence of age on oncological outcomes remains controversial. This study aims to investigate the impact of age on UCB outcomes in Europe focusing particularly on young and very young patients. We collected data of 669 UCB patients treated with RC at our tertiary care center. We used various categorical stratifications as well as continuous age to investigate the association of age and tumor biology as well as endpoints with descriptive statistics and Cox regression. The median age was 67 years and the mean follow-up was 52 months. Eight patients (1.2%) were ≤40 years old and 39 patients (5.8%) were aged 41–50 years, respectively. In multivariable analysis, higher continuous age and age above the median were independent predictors for disease recurrence, and cancer-specific and overall mortality (all p-values ≤ 0.018). In addition, patients with age in the oldest tertile group had inferior cancer-specific and overall survival rates compared to their younger counterparts. Young (40–50 years) and very young (≤40 years) patients had reduced hazards for all endpoints, which, however, were not statistically significant. Age remains an independent determinant for survival after RC. Young adults did, however, not have superior outcomes in our analyses. Quality of life and complications are endpoints that need further evaluation in patients undergoing RC.

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Medical system and nutrition improvement for the rural elderly

Journal of Health Population and Nutrition ◽

10.1186/s41043-019-0189-x ◽

2019 ◽

Vol 38 (1) ◽

Author(s):

Zhenhua Wang ◽

Jinqi Jiang ◽

Qiyan Zeng

Keyword(s):

Population Aging ◽

Rural China ◽

The Elderly ◽

Rural Elderly ◽

Medical System ◽

Carbohydrate Intake ◽

Nutrition Survey ◽

Difference In Differences ◽

Nutrition Intake ◽

The Impact

Abstract Background Insufficient nutrition intake has negatively influenced the health of the elderly in rural China where the problem of population aging is serious. The present study aims to explore whether the medical system, called the New Rural Cooperative Medical System (NRCMS), can improve the rural elderly’s nutrition intake and the mechanism behind it. Methods The difference in differences (DID) model and the propensity score matching-difference in differences (PSM-DID) model are both performed to investigate the impact of the medical system on nutrition improvement for the rural elderly. Two thousand seven hundred eighty rural elderly samples tracked in 2000 and 2006 from the China Health and Nutrition Survey are analyzed. Indices for the elderly’s nutrition intake includes daily average intake of energy, fat, protein, and carbohydrate. Results The results show that participation in the NRCMS can significantly increase the rural elderly’s total energy intake, carbohydrate intake, and protein intake by 206.688 kcal, 36.379 g, and 6.979 g, respectively. A more significant impact of the NRCMS on nutrition intake is observed in the central and near-western where economic development is lagging behind. Also, compared to people of 18–60 age group, such impact is statistically more significant in the elderly for the carbohydrate intake. Conclusions The NRCMS can improve the rural elderly’s nutrition intake in China. As the population ages rapidly in rural China, the present study provides recommendations on how to improve nutrition and health status of the elderly from the aspect of the medical system.

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International Real Estate Review

International Real Estate Review ◽

10.53383/100310 ◽

2020 ◽

Vol 23 (4) ◽

pp. 467-482

Author(s):

Fathali Firoozi ◽

◽

Abolhassan Jalilvand ◽

Donald Lien ◽

Mikiko Oliver ◽

...

Keyword(s):

Real Estate ◽

Economic Impact ◽

Population Aging ◽

Housing Prices ◽

The Elderly ◽

Damping Effect ◽

The World ◽

Behavioral Divergence ◽

The Impact ◽

The U.S

Population aging and its economic impact have been receiving increasing attention in many countries around the world. This study offers an analysis of the impact of aging on the housing prices in Singapore relative to the U.S. as the benchmark. The study uses semiannual series over the period of 1998 to 2019 with the age subgroups organized in 5-year intervals. The literature contains conflicting arguments on the impacts of aging on housing prices. Based on observations made for Singapore and the U.S., this study supports the arguments that the elderly part of a population has a damping effect on housing prices. A novel behavioral divergence between Singapore and the U.S. emerges when the analysis focuses on the impact of the finer age subgroups on housing prices in the two countries. The “turning age”, which is defined as the approximate cut-off age when the impact of aging on housing prices turns from positive to negative, is approximately 55 years old in Singapore and 60 years old in the U.S.

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The Psycho-geriatric Patient in the Emergency Room (ER) of the Maggiore della Carità Hospital in Novara

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1079 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S648-S649 ◽

Cited By ~ 1

Author(s):

E. Di Tullio ◽

C. Vecchi ◽

A. Venesia ◽

L. Girardi ◽

C. Molino ◽

...

Keyword(s):

Mental Disorders ◽

Population Aging ◽

Common Mental Disorder ◽

Cognitive Disorders ◽

Late Life ◽

Resource Planning ◽

The Elderly ◽

Psychiatric Evaluation ◽

Axis I ◽

The Impact

IntroductionDue to population aging, the health system will face increasing challenges in the next years. Concerning mental disorders, they are major public health issues in late life, with mood and anxiety disorders being some of the most common mental disorder among the elderly. For this reason, increasing attention has to be paid to the evaluation of the elderly in psychiatry emergency settings.ObjectivesTo evaluate the socio-demographic and clinical features of over 65 patients referred to psychiatric consultations in the ER of “Maggiore della Carità” Hospital in Novara, in a 7 years period.AimsThe analysis of the characteristics of the study sample could be potentially useful in resource planning in order to better serve this important segment of the general population.MethodsDeterminants of ER visits for over 65 patients referred to psychiatric evaluation were studied retrospectively from 2008 to 2015.ResultsElderly patients made up 14,7% (n = 458) of all psychiatric evaluation in the ER (n = 3124). About two thirds (65,9%) were females and one third were males (34,1%). The mean age of patients recruited was 75.11 years. The majority of subjects (68.6%) presented without a diagnosis of Axis I according to DSM-IV. The other most frequent diagnosis was “cognitive disorders” (11.4%) and “mood disorders” (10.9%).ConclusionsThe large proportion of patients without a diagnosis of Axis I, could be related to the misunderstanding of the psychosocial aspects of aging. Preliminary results highlight the importance of research on this topic, considering population aging and the impact of mental disorders in late-life.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Abstract 169: A Comprehensive Multicenter Evaluation of the Impact of Age on Stroke Thrombectomy Outcomes - Insights From the STAR Collaboration

Stroke ◽

10.1161/str.51.suppl_1.169 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Reda M Chalhoub ◽

Ali M Alawieh ◽

Mohammad Anadani ◽

Maya Eid ◽

Adam Arthur ◽

...

Keyword(s):

Age Groups ◽

Star Collaboration ◽

The Elderly ◽

Complication Rates ◽

Good Outcome ◽

Poor Outcome ◽

Age Dependent ◽

Poor Outcomes ◽

The Impact

Introduction: Elderly patients, octogenarians and nonagenarians, were excluded or under-represented in the majority of stroke endovascular thrombectomy (ET) trials. There is conflicting data on the outcomes of ET in the elderly. We evaluated age-dependent outcomes of ET for stroke in a large dataset from the Stroke Thrombectomy and Aneurysm Registry (STAR). Methods: Patients undergoing ET for acute ischemic stroke at 12 comprehensive stroke centers in the US and Europe between 01/2013 and 12/2018 were reviewed. Data was collected retrospectively from patient charts, procedure notes, and patient follow-up in neurology clinics. The primary endpoint was the modified Rankin score (mRS) at 90-days which was dichotomized into good outcome (mRS 0-2) or poor outcome (mRS 3-6). Results: Of 3,850 patients reviewed, 2,827 had 90-day follow-up (mean age 69±14), and were divided into 6 age groups: 20-49 (G1, 10%), 50-59 (G2, 10%), 60-69 (G3, 23%), 70-79 (G4, 27%), 80-89 (G5, 21%), 90 or more (G6, 4%). When adjusted for confounding variables, age was an independent predictor of poor outcome (OR=1.4, p<0.001) and mortality (OR=1.5, p<0.0001). When used as categorical variable, adjusted OR (aOR) for good outcomes were significantly lower in groups G2-G6 compared to G1 (p<0.01, figure), and OR for mortality were significantly higher in G2-G6 compared to G1 (p<0.01, figure). An age increment of 10 years was associated with 23% higher odds of symptomatic hemorrhage, and 50% higher odds of mRS 5-6. The impact of procedure time on good outcome (mRS 0-2) was also age-dependent with aOR=0.84 (p<0.05) in G1,2 compared to aOR=0.65 (p<0.05) in G5,6. Conclusions: Age is a major predictor of functional recovery after ET, and this study demonstrates a clear age-dependent increase in rate of mortality and poor outcomes after ET with exponentially worse outcomes above 80 years of age. Complication rates were not age-dependent. Further studies are required to optimize patient selection for ET in the elderly.

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Social-LCA. Methodological Proposal Applied to Physical Activity Program Implementation into Old People’s Routines

Sustainability ◽

10.3390/su12124965 ◽

2020 ◽

Vol 12 (12) ◽

pp. 4965

Author(s):

Francisco Javier Flor-Montalvo ◽

Jorge Luis García-Alcaraz ◽

Agustín Sánchez-Toledo Ledesma ◽

Leandro Álvarez-Kurogi

Keyword(s):

Physical Activity ◽

Program Implementation ◽

Social Life ◽

Local Community ◽

Positive Impact ◽

Population Aging ◽

The Elderly ◽

Social Lca ◽

Complete Evaluation ◽

The Impact

Progressive population aging and life expectancy increase in Spain, resulting from medical and social improvements, have put this population segment in a privileged position for the implementation of new methodologies aimed at improving the quality of life of the elderly. Social life cycle analysis (S-LCA) is a widely studied technique to evaluate the social and environmental impacts generated by a product, service, or process. Throughout this paper, S-LCA is applied to the implementation of physical activity programs in routines for older people, allowing a complete evaluation of the impact of such activities. From this study, it is deduced that the execution phase of the program is the one that causes the most positive impact. Design and programming have a much more notable impact than expected. With regard to the involved categories, the user is the greatest beneficiary of the implementation of these programs, although the local community and administration are other interest groups that will highly benefit, although the impact will be much less than in the case of users.

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Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

10.1101/2020.10.10.334748 ◽

2020 ◽

Cited By ~ 2

Author(s):

Daisuke Yamashita ◽

Victoria L Flanary ◽

Rachel B Munk ◽

Kazuhiro Sonomura ◽

Saya Ozaki ◽

...

Keyword(s):

Brain Aging ◽

Tumor Burden ◽

Synaptic Activity ◽

Aging Brain ◽

Neuronal Signaling ◽

Nicotinamide Mononucleotide ◽

Brain Responses ◽

Phenotypic Reversal ◽

The Impact ◽

Old Mice

SummaryThe rise in aging population worldwide is increasing death from cancer, including glioblastoma. Here, we explore the impact of brain aging on glioma tumorigenesis. We find that glioblastoma in older patients and older mice displayed reduced neuronal signaling, including a decline of NTRK-like family member 6 (SLITRK6), a receptor for neurotrophic factor BDNF. This reduction was linked to the systemic decline of nicotinamide adenine dinucleotide (NAD+) with aging, as old mice exposed to young blood via parabiosis or supplemented with the NAD+ precursor NMN (nicotinamide mononucleotide) reverted phenotypically to young-brain responses to glioma, with reactivated neuronal signaling and reduced death from tumor burden. Interestingly, the phenotypic reversal by NMN was largely absent in old mice undergoing parabiosis with BDNF+/- young mice and in BDNF+/- mice undergoing tumor challenge, supporting the notion that the lower NAD+-BDNF signaling in the aging brain aggravated glioma tumorigenesis. We propose that the aging-associated decline in brain NAD+ worsens glioma outcomes at least in part by decreasing neuronal/synaptic activity and increasing neuroinflammation.

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