Origin and Use of Hydrogen Peroxide in Neurosurgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
David Bailey ◽  
Elias B Rizk
Keyword(s):  
Hydrogen Peroxide ◽  
Hemostatic Agent ◽  
Medical Field ◽  
Wide Range ◽  
Actual Effectiveness ◽  
Fatal Complications

Abstract Hydrogen peroxide (H2O2) is a chemical with a wide range of applications. This includes its use in the medical field, in which its use has been ubiquitous but is most useful as an antiseptic and in achieving hemostasis. Neurosurgeons have been using H2O2 for well over a century, primarily for its hemostatic and antiseptic effects. This is in spite of the fact that the actual effectiveness of H2O2 as an antiseptic is questionable, and its use, in general, may be more dangerous than it appears. We review the application of H2O2 in medicine generally and, more specifically, in neurosurgery. This review outlines the reasoning behind the use of H2O2 as an antiseptic and details why it may not be as effective as one might think. We also detail its use as a hemostatic agent in neurosurgery, reviewing a number of techniques in which it has been useful in this role. Finally, we review the documented cases of complications associated with the use of H2O2 in neurosurgery. Ultimately, we conclude that the use of H2O2 in neurosurgery be reconsidered because of its lack of effectiveness as an antiseptic and potentially fatal complications.

scholarly journals Applicability of Honey on Silkworms (Bombyx mori) and Quality Improvement of Its Biomaterials

2021 ◽  
Vol 11 (10) ◽  
pp. 4613
Author(s):  
Gabriela-Maria Baci ◽  
Alexandra-Antonia Cucu ◽  
Adela Ramona Moise ◽  
Daniel Severus Dezmirean
Keyword(s):  
Quality Improvement ◽  
Bombyx Mori ◽  
Human Health ◽  
Recombinant Proteins ◽  
Therapeutic Agent ◽  
Life Sciences ◽  
Model Organism ◽  
Medical Field ◽  
Wide Range ◽  
Ancient Times

Since ancient times, honey has been considered one of the most illustrious and esteemed natural products. Honey plays two key roles; specifically, it is an appreciated nutritional product, and also exhibits a wide range of beneficial properties for human health as a therapeutic agent. Furthermore, it has been shown that honey has valuable effects on the biological and physiological features of mulberry silkworms (Bombyx mori). Bombyx mori exhibits importance not only for the economy, but it also serves as an important biotechnological bioreactor for the production of recombinant proteins that have a great impact in the medical field and beyond. It also represents an important model organism for life sciences. In view of the fact that silk fibroin serves as a natural biopolymer that displays high biocompatibility with human organisms and due to honey’s various and remarkable properties for human health, the two elements are currently used together in order to develop ideal biomaterials for a wide range of purposes. In this review, by discussing the applicability of honey on Bombyx mori and beyond, the importance of honey for life sciences and related fields is spotlighted.

scholarly journals Reactivity and Chemical Sintering of Carey Lea Silver Nanoparticles

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1525
Author(s):  
Sergey Vorobyev ◽  
Elena Vishnyakova ◽  
Maxim Likhatski ◽  
Alexander Romanchenko ◽  
Ivan Nemtsev ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Silver Nanoparticles ◽  
Flexible Electronics ◽  
Photoelectron Spectroscopy ◽  
Colloidal Solutions ◽  
Ag Nps ◽  
Wide Range ◽  
Carboxylic Groups ◽  
The Media ◽  
Sulfide Ions

Carey Lea silver hydrosol is a rare example of very concentrated colloidal solutions produced with citrate as only protective ligands, and prospective for a wide range of applications, whose properties have been insufficiently studied up to now. Herein, the reactivity of the immobilized silver nanoparticles toward oxidation, sulfidation, and sintering upon their interaction with hydrogen peroxide, sulfide ions, and chlorocomplexes of Au(III), Pd(II), and Pt(IV) was investigated using SEM and X-ray photoelectron spectroscopy (XPS). The reactions decreased the number of carboxylic groups of the citrate-derived capping and promoted coalescence of 7 nm Ag NPs into about 40 nm ones, excluding the interaction with hydrogen peroxide. The increased nanoparticles form loose submicrometer aggregates in the case of sulfide treatment, raspberry-like micrometer porous particles in the media containing Pd(II) chloride, and densely sintered particles in the reaction with inert H2PtCl6 complexes, probably via the formation of surface Ag-Pt alloys. The exposure of Ag NPs to HAuCl4 solution produced compact Ag films along with nanocrystals of Au metal and minor Ag and AgCl. The results are promising for chemical ambient temperature sintering and rendering silver-based nanomaterials, for example, for flexible electronics, catalysis, and other applications.

scholarly journals Synthesis of HTPB using a semi-batch method

2020 ◽  
pp. 192-202
Author(s):  
Michał Chmielarek ◽  
Wincenty Skupiński ◽  
Zdzisław Wieczorek
Keyword(s):  
Mechanical Properties ◽  
Hydrogen Peroxide ◽  
Synthesis Method ◽  
Batch Method ◽  
Synthesis Conditions ◽  
Rocket Propellants ◽  
Wide Range ◽  
Military Applications ◽  
Solid Rocket ◽  
Solid Rocket Propellants

Hydroxyl-terminated polybutadiene is widely used in industry for both civil and military applications. In munitions, HTPB is mostly used as a binder for heterogenic rocket propellants and as a component of plastic bonded explosives, as well as a phlegmatizer in explosives sensitive to friction and impact. The wide range of HTPB applications results from the good mechanical properties of HTPB-based polyurethanes, in particular at temperatures down to –40 °C. A synthesis method for HTPB, different from the commonly used semi-batch and continuous methods, is presented. The effect of parameters including reaction temperature, 1,3-butadiene pressure and hydrogen peroxide concentration on the properties of the obtained polymer is determined. The synthesis conditions enabling new HTPB species to be obtained, which meet the requirements for binders used in solid rocket propellants, are specified.

scholarly journals Elements Identification in Golden Strawberries (Physalis Peruviana L.) using Wavelength Dispersive X-Ray Fluorescence

2019 ◽  
Vol 7 (6) ◽  
pp. 851
Author(s):  
Uğur Akbaba
Keyword(s):  
Weight Loss ◽  
Functional Food ◽  
Medical Field ◽  
X Ray ◽  
Physalis Peruviana ◽  
Food Properties ◽  
Wide Range ◽  
Important Health ◽  
Fluorescence Spectrometer ◽  
Non Destructive

Physalis peruviana (PP) is a popular exotic fruit due to its functional food properties. This product has a wide range of uses in the medical field, including treatments for cancer, malaria, hepatitis, dermatitis, rheumatism, weight loss, and diabetes. In this study, the PP element concentrations were investigated using a Wave Dispersive X-ray Fluorescence Spectrometer (WDXRF). Al, Ca, Fe, Mn, P, S, Zn, Cl, K, Mg, Na, F, Si, and B were detected, and the Ca, Fe, Zn, P, Na, Mg elements were found in significant amounts. Therefore, PP has some important health elements. For example, Mg and Mn may be associated with diabetes control. WDXRF is a cheap, quick, and non-destructive technique used in the elemental analysis of plant samples.

scholarly journals Actin filaments mediated root growth inhibition by changing their distribution under UV-B and hydrogen peroxide exposure in Arabidopsis

2020 ◽  
Vol 53 (1) ◽  
Author(s):  
Meiting Du ◽  
Yanhong Wang ◽  
Huize Chen ◽  
Rong Han
Keyword(s):  
Hydrogen Peroxide ◽  
Actin Filaments ◽  
Root Elongation ◽  
Root Tip ◽  
Root Growth Inhibition ◽  
Control Group ◽  
Dependent Manner ◽  
Elongation Zone ◽  
Wide Range ◽  
Root Morphogenesis

Abstract Background UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce. As a wide range of functional cytoskeletons, how actin filaments respond to UV-B-induced root morphogenesis has not been reported. The aim of this study was to investigate the effect of actin filaments on root morphogenesis under UV-B and hydrogen peroxide exposure in Arabidopsis. Results A Lifeact-Venus fusion protein was used to stain actin filaments in Arabidopsis. The results showed that UV-B inhibited hypocotyl and root elongation and caused an increase in H2O2 content only in the root but not in the hypocotyl. Additionally, the actin filaments in hypocotyls diffused under UV-B exposure but were gathered in a bundle under the control conditions in either Lifeact-Venus or uvr8 plants. Exogenous H2O2 inhibited root elongation in a dose-dependent manner. The actin filaments changed their distribution from filamentous to punctate in the root tips and mature regions at a lower concentration of H2O2 but aggregated into thick bundles with an abnormal orientation at H2O2 concentrations up to 2 mM. In the root elongation zone, the actin filament arrangement changed from lateral to longitudinal after exposure to H2O2. Actin filaments in the root tip and elongation zone were depolymerized into puncta under UV-B exposure, which showed the same tendency as the low-concentration treatments. The actin filaments were hardly filamentous in the maturation zone. The dynamics of actin filaments in the uvr8 group under UV-B exposure were close to those of the control group. Conclusions The results indicate that UV-B inhibited Arabidopsis hypocotyl elongation by reorganizing actin filaments from bundles to a loose arrangement, which was not related to H2O2. UV-B disrupted the dynamics of actin filaments by changing the H2O2 level in Arabidopsis roots. All these results provide an experimental basis for investigating the interaction of UV-B signaling with the cytoskeleton.

DEPOLYMERIZATION OF DEXTRAN BY HYDROGEN PEROXIDE

1955 ◽  
Vol 33 (1) ◽  
pp. 448-452 ◽  
Author(s):  
Irving Levi ◽  
Ezra Lozinski
Keyword(s):  
Hydrogen Peroxide ◽  
Molecular Weight ◽  
Blood Plasma ◽  
Dilute Solutions ◽  
Pressure Time ◽  
Wide Range ◽  
Aqueous Dextran

It was observed that when very dilute solutions of hydrogen peroxide were employed for the purpose of destroying pyrogens in aqueous dextran solutions, a marked depolymerization of the polysaccharide molecule occurred. Further study demonstrated this effect to occur over a wide range of temperature, pressure, time, and concentration of hydrogen peroxide. It was therefore possible to use hydrogen peroxide in place of the usual hydrolytic agents, such as acids, for the depolymerization of native dextran to smaller molecular weight fragments suitable for use as a blood plasma extender.

scholarly journals Hormesis in Plants: The Role of Oxidative Stress, Auxins and Photosynthesis in Corn Treated with Cd or Pb

2020 ◽  
Vol 21 (6) ◽  
pp. 2099 ◽  
Author(s):  
Eugeniusz Małkowski ◽  
Krzysztof Sitko ◽  
Michał Szopiński ◽  
Żaneta Gieroń ◽  
Marta Pogrzeba ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Shoot Growth ◽  
Photosynthetic Apparatus ◽  
Growth Stimulation ◽  
Photosynthetic Parameters ◽  
Toxic Substances ◽  
Wide Range ◽  
The Common ◽  
Stimulation Of

Hormesis, which describes the stimulatory effect of low doses of toxic substances on growth, is a well-known phenomenon in the plant and animal kingdoms. However, the mechanisms that are involved in this phenomenon are still poorly understood. We performed preliminary studies on corn coleoptile sections, which showed a positive correlation between the stimulation of growth by Cd or Pb and an increase in the auxin and H2O2 content in the coleoptile sections. Subsequently, we grew corn seedlings in hydroponic culture and tested a wide range of Cd or Pb concentrations in order to determine hormetic growth stimulation. In these seedlings the gas exchange and the chlorophyll a fluorescence, as well as the content of chlorophyll, flavonol, auxin and hydrogen peroxide, were measured. We found that during the hormetic stimulation of growth, the response of the photosynthetic apparatus to Cd and Pb differed significantly. While the application of Cd mostly caused a decrease in various photosynthetic parameters, the application of Pb stimulated some of them. Nevertheless, we discovered that the common features of the hormetic stimulation of shoot growth by heavy metals are an increase in the auxin and flavonol content and the maintenance of hydrogen peroxide at the same level as the control plants.

scholarly journals Prolonged Cold Storage Affects Pollen Viability and Germination along with Hydrogen Peroxide and Nitric Oxide Content in Rosa hybrida

2016 ◽  
Vol 44 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Anca MACOVEI ◽  
Matteo CASER ◽  
Mattia DONÀ ◽  
Alberto VALASSI ◽  
Annalisa GIOVANNINI ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Pollen Viability ◽  
Storage Period ◽  
Pollen Grains ◽  
Rosa Hybrida ◽  
Tube Growth ◽  
Oxide Content ◽  
Breeding Programs ◽  
Wide Range

Roses (Rosa hybrida) are the most important ornamental cut-flowers and breeders’ main focus is to develop new desirable modern cultivars. Rose breeding programs center on the introduction of new flower colors, thornless stems, higher production and good post-harvest performance. The study of the main pollen traits, such as pollen quantity and quality, viability, longevity, morphological homogeneity, germination and tube growth, is important for building suitable breeding programs. Recently, a number of studies have shown that reactive oxygen species, like hydrogen peroxide, and nitric oxide, are involved in a wide range of signaling processes including pollen tube growth and pollen-pistil recognition. Pollen viability after anther dehiscence is crucial for successful crossbreeding. In the present work, pollen grains from 5 hybrid tea rose cultivars were stored at -20 °C up to 12 months. Pollen viability and germination rate was monitored in order to provide useful information about pollen storage length. Additionally, pollen grains were tested for their content in hydrogen peroxide and nitric oxide by using a novel approach where the fluorescence is read in a quantitative RealTime PCR (qRT-PCR) machine. Pollen viability and in vitro pollen germination capacity varied among the rose genotypes, while a progressive decrease was evidenced during 12 months of storage at low temperature. Both hydrogen peroxide and nitric oxide production were found to be genotype-dependent, whilst accumulation of the two molecules was observed during the storage period. A putative detrimental effect of these molecules during pollen conservation is hypothesized.

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