scholarly journals OTEH-10. Evolutionary trajectory of epigenomic of gliomas

2021 ◽  
Vol 3 (Supplement_2) ◽  
pp. ii12-ii12
Author(s):  
Tathiane Malta ◽  
Thais Sabedot ◽  
Indrani Datta ◽  
Frederick Varn ◽  
AnaValeria Castro ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Disease Progression ◽  
Molecular Data ◽  
Evolutionary Trajectory ◽  
Cell Cycle Deregulation ◽  
Changes Over Time ◽  
Composition Changes ◽  
Over Time

Abstract Gliomas are the most common malignant brain tumor, have an aggressive behavior, and invariably relapse and progress. Despite the recent advancements, little is known about the role of the epigenome in glioma disease progression and recurrence. To investigate the molecular dynamics over time and in response to therapeutic pressures, the Glioma Longitudinal AnalySiS (GLASS) Consortium, a multinational collaboration, is investigating epigenome-wide molecular data from primary and recurrent matched pairs, including IDH mutant (IDHmut) and IDH wildtype (IDHwt) gliomas. We have compiled a total of 357 samples comprising 143 primary-recurrent pairs profiled by DNA methylation, of which 157 samples have genomic data (WXS/WGS) and 120 have transcriptomic data (RNAseq). IDHwt gliomas have a distinct epigenetic evolution compared to IDHmut after treatment. IDHwt gliomas are more epigenetically stable over time, while IDHmut gliomas display a loss of DNA methylation throughout disease progression. Next, we investigated the molecular drivers of longitudinal gliomas by integration of DNA methylation and gene expression data. We identified epigenetic activation of cell cycle pathways in recurrent IDHmut compared to initial tumors. Transcription factors musculin, ZNF367, and ZNF682 are enriched among recurrent IDHmut gliomas and potentially regulate IDHmut recurrence and/or progression. We next used a DNA methylation-based deconvolution approach to estimate the tumor microenvironment (TME) composition. We found that the TME among IDHmut subtypes (Codel, GCIMP-high, and GCIMP-low) presented less immune infiltration than IDHwt (Classic-like, Mesenchymal-like, and PA-like). Post-treatment, we found a decrease of CD4+T and an increase of CD8+T cells in IDHmut. In conclusion, IDHmut gliomas present a more unstable epigenome, while the epigenome of IDHwt gliomas seems relatively preserved after treatment. We identified potential master regulators of cell cycle deregulation of IDHmut recurrence. Finally, the TME differs across IDHmut and IDHwt gliomas and the cell composition changes over time.

Deregulation of cell cycle and related microRNA expression induced by vinyl chloride monomer in hepatocytes of rats

2021 ◽  
pp. 074823372110155
Author(s):  
Weizhe Pan ◽  
Shengnan Yu ◽  
Jin Jia ◽  
Junyang Hu ◽  
Liang Jie ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Vinyl Chloride ◽  
Male Rats ◽  
Cell Cycle Distribution ◽  
Vinyl Chloride Monomer ◽  
Dynamic Changes ◽  
Cell Cycle Deregulation ◽  
Change Dynamic ◽  
Related Proteins

Vinyl chloride (VC) is a confirmed human carcinogen associated with hepatocellular carcinoma and angiosarcoma. However, the role of microRNAs (miRNAs) in liver cell cycle changes under VC exposure remains unclear, which prevents research on the mechanism of VC-induced carcinogenesis. In this study, male rats were injected intraperitoneally with VC (0, 5, 25, and 125 mg/kg body weight) for 6, 8, and 12 weeks. Cell cycle analysis of liver cells, miRNA-222, miRNA-199a, miRNA-195, and miRNA-125b expression in the liver and serum, and target protein expression were performed at different time points. The results showed a higher percentage of hepatocytes in the G1/G0 and S phases at the end of 6 and 12 weeks of VC exposure, respectively. MiRNA-222 expression decreased initially and then increased, whereas miRNA-199a, miRNA-195, and miRNA-125b expression increased initially and then decreased, which corresponded with changes in cell cycle distribution and related target proteins expression (p27, cyclinA, cyclinD1, and CDK6). The corresponding expression levels of miRNAs in serum did not change. Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.

A five-decade review of gender-based occupational segregation: A bibliometric study of influential authors, institutions, and research clusters

2021 ◽  
Vol 30 (2) ◽  
pp. 117-128
Author(s):  
Leena Sachdeva ◽  
Kumkum Bharti ◽  
Mridul Maheshwari
Keyword(s):  
Wage Differential ◽  
Web Of Science ◽  
Occupational Segregation ◽  
Extensive Field ◽  
Organisational Structures ◽  
Gender Based ◽  
Changes Over Time ◽  
Over Time ◽  
The Web

Despite the proliferation of occupational segregation research, only a limited amount has explored it from a gender perspective. The attention that has been given is widely scattered and requires an analysis to identify the major works undertaken and the changes over time. This study aimed to examine and assimilate articles published on gender-based occupational segregation through a bibliometric analysis. The study examined 512 articles published from the early 1970s to 2020 that were retrieved from the Web of Science database. The findings suggest that gender and occupational segregation remain an extensive field of research, although this research comes mainly from North American and European countries. The low representation from developing countries indicates that more research is needed based on these different socio-cultural settings. This study identified three dominant research clusters, namely gendered organisational structures and systems, measurement of occupational segregation, and wage differential. Studies also covered areas including conceptualization, LGBTQ issues, and the role of legislation and institutions in reducing workplace inequalities; thus, providing a direction for scholars and practitioners.

scholarly journals Knowledge in (Trans)Training and the Role of Experts: Curricula, Mathematics Education and Teacher Training, 1920-2020

2020 ◽  
Vol 22 (5) ◽  
pp. 65-83
Author(s):  
Wagner Rodrigues Valente ◽  
André Francisco de Almeida ◽  
Marylúcia Cavalcante Silva
Keyword(s):  
Elementary Schools ◽  
Teacher Training ◽  
Main Question ◽  
Study Results ◽  
New Knowledge ◽  
In Trans ◽  
Teaching Programs ◽  
Changes Over Time ◽  
Over Time

Background: Mathematics for basic and elementary schools and teacher education changes over time; and their official expression is given by these documents that guide teaching work in schools. Objective: What processes and dynamics are involved in the systematisation of new knowledge in the production of curriculum references? In particular, the text focuses on mathematics for the first school years. Design: The analysis of curricular reforms, considering official documents, prioritises the role of specialists, treated as experts, considering that following the actions of these researchers it may be possible to answer the main question of the study. Results: Analysis shows that the changes that have occurred over time, from teaching programs to the current BNCC, are linked to the progressive stratification of experts who go from being a highly visible public authority to an increasing set of representatives from different social segments interested in the curricular debate. Conclusions: This stratification makes it more difficult to locate those specialists responsible for the internal organisation of the proposals with regard to teaching objects, the content of mathematics to be present in teaching and teacher training.

Tracking the development of co-management: using network analysis in a case from the Canadian Arctic

Polar Record ◽  
2014 ◽  
Vol 51 (4) ◽  
pp. 422-431 ◽  
Author(s):  
John-Erik Kocho-Schellenberg ◽  
Fikret Berkes
Keyword(s):  
Network Analysis ◽  
Management Strategies ◽  
Land Claims ◽  
Joint Management ◽  
Management Processes ◽  
Functional Problem ◽  
Changes Over Time ◽  
Over Time ◽  
Indigenous Land

ABSTRACTTo understand the interplay of factors that shape changes in management strategies, we tracked the evolution of beluga whale co-management involving the Department of Fisheries and Oceans Canada, the Fisheries Joint Management Committee (FJMC), and the Tuktoyaktuk Hunter and Trapper Committee from its beginnings in the mid-1980s to the present. The objective was to analyse changes over time in the communication network involved in dealing with the Husky Lakes beluga entrapment issue, using social network analysis (SNA). Along with qualitative information, the use of SNA provided quantitative data to document the development of co-management over time. According to both government and indigenous parties, a fully functional problem-solving partnership developed over the course of two decades. Using the beluga case as the illustration, we traced the development of joint management processes, overcoming some of the initial obstacles and accommodating the needs of the various parties. This case demonstrates the importance of legal arrangements (the indigenous land claims agreement), the role of key individuals and the bridging organisation (FJMC) created by the agreement, and the maturation of co-management over time.

scholarly journals SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1

2019 ◽  
Author(s):  
Huifang Zhang ◽  
Qinqin Gao ◽  
Shuo Tan ◽  
Jia You ◽  
Cong Lyu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Cell Division ◽  
Global Dna Methylation ◽  
Protein Methylation ◽  
Accessory Factor ◽  
Protein Methyltransferase ◽  
A Cell ◽  
Do So

Abstract Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein stability of both UHRF1 and DNMT1 through methylation-mediated, ubiquitin-dependent degradation and consequently prevents excessive DNA methylation. SET8 methylates UHRF1 at lysine 385 and this modification leads to ubiquitination and degradation of UHRF1. In contrast, LSD1 stabilizes both UHRF1 and DNMT1 by demethylation. Importantly, SET8 and LSD1 oppositely regulate global DNA methylation and do so most likely through regulating the level of UHRF1 than DNMT1. Finally, we show that UHRF1 downregulation in G2/M by SET8 has a role in suppressing DNMT1-mediated methylation on post-replicated DNA. Altogether, our study reveals a novel role of SET8 in promoting DNA methylation homeostasis and identifies UHRF1 as the hub for tuning DNA methylation through dynamic protein methylation.

scholarly journals Role of DNA Methylation in Cell Cycle Arrest Induced by Cr (VI) in Two Cell Lines

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71031 ◽  
Author(s):  
Jianlin Lou ◽  
Yu Wang ◽  
Chunji Yao ◽  
Lingzhi Jin ◽  
Xiuzhi Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cycle Arrest

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

2015 ◽  
Vol 12 (6) ◽  
pp. 669-682 ◽  
Author(s):  
Ruth Nussinov ◽  
Chung-Jung Tsai ◽  
Serena Muratcioglu ◽  
Hyunbum Jang ◽  
Attila Gursoy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cancer Initiation ◽  
Cell Cycle Deregulation

scholarly journals The NAIRU in Theory and Practice

2002 ◽  
Vol 16 (4) ◽  
pp. 115-136 ◽  
Author(s):  
Laurence Ball ◽  
N. Gregory Mankiw
Keyword(s):  
United States ◽  
Monetary Policy ◽  
Productivity Growth ◽  
Inflation Rate ◽  
The United States ◽  
Theory And Practice ◽  
Business Cycle Theory ◽  
Changes Over Time ◽  
Over Time

This paper discusses the NAIRU—the non-accelerating inflation rate of unemployment. It first considers the role of the NAIRU concept in business cycle theory, arguing that this concept is implicit in any model in which monetary policy influences both inflation and unemployment. The exact value of the NAIRU is hard to measure, however, in part because it changes over time. The paper then discusses why the NAIRU changes and, in particular, why it fell in the United States during the 1990s. The most promising hypothesis is that the decline in the NAIRU is attributable to the acceleration in productivity growth.

scholarly journals The Role of Authentic Leadership on Athletes’ Achievement and Moral Outcomes

2021 ◽  
Author(s):  
Ella Malloy ◽  
Maria Kavussanu ◽  
Mariya Yukhymenko
Keyword(s):  
Authentic Leadership ◽  
Team Sport ◽  
Positive Outcomes ◽  
Research Attention ◽  
Team Culture ◽  
Moral Outcomes ◽  
Prosocial Behaviours ◽  
Changes Over Time ◽  
Over Time

Introduction Authentic leadership is a form of leadership which could result in positive outcomes in athletes, yet, it has received limited research attention in sport. We conducted two studies, in which we investigated: (a) whether authentic leadership is related to athletes’ achievement and moral outcomes via trust and the culture of the team (Study 1); and (b) whether authentic leadership is related to changes in athlete outcomes directly and indirectly through changes in trust and cohesion over time (Study 2). MethodIn both studies data were collected via questionnaires. In Study 1, participants were 366 (240 females, Mage = 21.07) team sport athletes. In Study 2, they were 421 (227 females, Mage = 20.32) team sport athletes at time 1 and 247 athletes at time 2 (5 months later). ResultsIn Study 1, authentic leadership was positively related to athletes’ trust and team culture which in turn were related to athletes’ commitment, positive affect and perceptions of their teammates’ prosocial behaviours. In Study 2, changes over time in authentic leadership were related to athletes’ perceptions of their teammates’ prosocial behaviours and enjoyment, both directly and indirectly via changes in trust and cohesion.ConclusionsOur findings enhance our understanding of authentic leadership in sport and highlight its importance in predicting crucial positive athlete outcomes.

scholarly journals South Korea’s and China’s catching-up: a new-developmentalist analysis

2020 ◽  
Vol 40 (2) ◽  
pp. 264-284
Author(s):  
LUIZ CARLOS BRESSER-PEREIRA ◽  
ELIAS JABBOUR ◽  
LUIZ FERNANDO DE PAULA
Keyword(s):  
Exchange Rate ◽  
Industrial Policy ◽  
Dynamic Process ◽  
Development Process ◽  
Fundamental Question ◽  
Balance Of Payments ◽  
Catching Up ◽  
Changes Over Time ◽  
Over Time

ABSTRACT The purpose of this paper is to analyze the catching-up processes of South Korea and post-1978 reforms China, based on a new-developmentalist approach that considers four fundamental factors: 1) a complementarity relationship between the state and the market as a dynamic process that changes over time; 2) necessary complementarity between macroeconomic policy and industrial policy; 3) the key role of public and development banks in attacking the problem of “development financing”; and a particular focus on 4) the centrality of exchange rate and balance of payments administration for the development process in these countries. The paper’s fundamental question is to what extent the catching-up process in these countries can be understood as the application of a new-developmentalist strategy, taking each country’s particular historical traits into account.

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