scholarly journals 1189. COVID 19 Infection in Children in Colombia, Experience from a Nationwide Network (CORONARED)

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S686-S686
Author(s):  
Juan Gonzalo Mesa-Monsalve ◽  
Ivan Felipe Gutiérrez Tobar ◽  
Alejandro Diaz Diaz ◽  
Juan Pablo Calle-Giraldo ◽  
Yamile K Chaucanez-Bastidas ◽  
...  

Abstract Background Worldwide SARS-CoV-2 infections increase every day. Despite the infection is less severe in children, it can be severe and associated with complications. However, local data remain scarce. We sought to describe epidemiological and clinical characteristics of COVID-19 infection in this population across different age groups. Methods Observational, multicenter study across 23 Colombian hospitals from 22 different territories. We included all patients from 0 months to 17 years with confirmed SARS-CoV-2 infection by either antigen or RT-PCR testing. Results From March 1, 2020, to October 31, 2021, we identified 1,186 patients: neonates (88), 1 to 3 months (130), 4 to 23 months (306), 2 to 4 years (169), 5 to 11 years (229) and 12 to 18 years (226) with confirmed COVID-19 infection. Of those,77(6.2%) were asymptomatic, 631(53.2%) hospitalized, 132(11.2%) required PICU. 58 cases met WHO definition of MIS-C. Patients less than 24 months of age were characterized by fever (74%) and more respiratory distress (30.1%) compared to other groups. Patients >5yo seemed to have a more severe presentation. They had more gastrointestinal (GI) symptoms (31% vs 37.8%), had more need for ICU care given presentation with shock increased with age ( >5yo 9.5%; 5-12yo 10.6%; 12-18yo 11.5%). Lab markers including thrombocytopenia and Lymphopenia were more common on this age group. Antibiotic treatment was common (%%) especially in neonates (40.9%), despite bacterial coinfection was rare (8.7%), length of hospitalization was longer in older than 2-year-old groups. 23(1.9%) patients died, similar across different age groups. Heat map by age group Conclusion COVID-19 infection in Colombian children presented differently across different age groups. Children older than 5 years had a more severe clinical course and prolonged hospital stays. Clinical findings according to age groups could help clinicians in characterizing and identifying COVID 19 infections in Children. Disclosures Ivan Felipe Gutiérrez Tobar, n/a, Pfizer and MSD (Advisor or Review Panel member, Research Grant or Support, Speaker’s Bureau, Has received support from Pfizer and MSD for participation in congresses and has received conference payments from Pfizer)Pfizer and MSD (Speaker’s Bureau, Other Financial or Material Support, Has received support from Pfizer for participation in congresses) Juan P. Rojas -Hernandez, Candidate for doctorate in Public Health, Pfizer (Other Financial or Material Support, Has received support from Pfizer for participation in congresses) Eduardo López Medina, n/a, Pfizer (Other Financial or Material Support, Has received support from Pfizer for participation in congresses)

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S832-S832
Author(s):  
Keith S Kaye ◽  
Vikas Gupta ◽  
Aruni Mulgirigama ◽  
Ashish V Joshi ◽  
Nicole Scangarella-Oman ◽  
...  

Abstract Background An estimated 12% of women experience ≥ 1 episode of urinary tract infection (UTI) annually. Incidence is bimodal, with peaks occurring in young, sexually active women (18–24 years) and in post-menopausal women. Previous studies suggest the prevalence of antimicrobial resistance (AMR) in UTI is rising; however recent AMR data for community-acquired UTI are lacking. We estimated the prevalence of AMR among US females with outpatient UTI in 2011–2019, stratified by age. Methods A retrospective, multicenter, cohort study of AMR among non-duplicate urine isolates in US females (≥ 12 years of age) from 296 institutions from 2011–2019 (BD Insights Research Database, Franklin Lakes, NJ). Phenotypes examined for Enterobacterales (ENT) were: extended spectrum β-lactamase positive (ESBL+; determined by commercial panels or intermediate/resistant to ceftriaxone, cefotaxime, ceftazidime or cefepime); nitrofurantoin (NFT) not-susceptible (NS); fluoroquinolone (FQ) NS; trimethoprim-sulfamethoxazole (TMP-SMX) NS; and NS to ≥ 2 or ≥ 3 drug classes (including ESBL+). Gram-positive phenotypes were, methicillin resistant S. aureus and S. saprophyticus and vancomycin-resistant Enterococcus. Isolates were stratified by patient age (≥ 12 to < 18, ≥ 18 to < 55, ≥ 55 to < 65, ≥ 65 to < 75, ≥ 75 years). Chi-square tests were used to evaluate AMR difference between groups. Results In total, urine isolates were collected from 106 to 296 (2011–2019) US sites. Overall, the prevalence of antimicrobial NS increased with age for all E. coli phenotypes (all P< 0.001; Table 1), and for non-E. coli ENT (all P< 0.001), except NFT NS, which decreased from 70.6% to 59.7% (P=0.002; Table 2). The greatest difference between age groups in prevalence of resistance was observed for FQ NS E.coli: 5.8% (≥ 12 to < 18 years) vs 34.5% (≥ 75 years). For the multi-drug resistant E. coli phenotypes, resistance increased with age, ranging from 4.8–22.4% and 0.9–6.5% for ≥ 2 and ≥ 3 drug NS, respectively. Overall, the prevalence of resistance for Gram-positive phenotypes increased with age (all P< 0.001; Table 3). Table 1. Prevalence of antimicrobial resistance among E. coli isolates in US females with outpatient UTI by age group. Table 2. Prevalence of antimicrobial resistance among non-E. coli ENT isolates in US females with outpatient UTI by age group. Table 3. Prevalence of antimicrobial resistance among Gram-positive isolates in US females with outpatient UTI by age group. Conclusion The prevalence of AMR in E. coli and non-E. coli ENT increased with age among US females presenting for care in the outpatient setting overall. A similar trend increase by age is also seen in Gram-positive isolates. Disclosures Vikas Gupta, PharmD, BCPS, Becton, Dickinson and Company (Employee, Shareholder)GlaxoSmithKline plc. (Other Financial or Material Support, Funding) Aruni Mulgirigama, MBBS, GlaxoSmithKline plc. (Employee, Shareholder) Ashish V. Joshi, PhD, GlaxoSmithKline plc. (Employee, Shareholder) Nicole Scangarella-Oman, MS, GlaxoSmithKline plc. (Employee, Shareholder) Kalvin Yu, MD, Becton, Dickinson and Company (Employee)GlaxoSmithKline plc. (Other Financial or Material Support, Funding) Gang Ye, PhD, Becton, Dickinson and Company (Employee)GlaxoSmithKline plc. (Other Financial or Material Support, Funding) Fanny S. Mitrani-Gold, MPH, GlaxoSmithKline plc. (Employee, Shareholder)


2002 ◽  
Vol 3 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Kris Fernando ◽  
Lynette Eaton ◽  
Morag Faulkner ◽  
Yogi Moodley ◽  
Raylene Setchell

AbstractThe aim of this study was to develop and pilot a posttraumatic amnesia scale (PTA) scale for children aged between four and six years. The scale consists of seven orientation questions and five memory items modelled on the Westmead PTA Scale which assesses posttraumatic amnesia in children from eight years onwards and adults. The sample consisted of 45 four-year-olds, 82 five-year-olds and 49 six-year-old children from a variety of cultural and socioeconomic backgrounds. Children were recruited from hospitals, kindergartens and schools. Results were analysed across age groups using means and standard deviations. The orientation and memory items were analysed separately as well as in combination. Early analyses indicate that the majority of normal children in the four to 6 year age group can answer most of the orientation questions correctly and remember the memory stimuli from day to day. The results indicate that the Starship PTA Scale is suitable for young children aged 4 to 6 years. It is simple and quick to administer and utilises an operational definition of posttraumatic amnesia in terms of measuring continuous memory.


Author(s):  
N. P. Andryushkova

The article is devoted to the analysis of the phenomenon of superstition as a psychological property of the individual. The current research is based on various studies aimed at establishing the reasons that encourage people to appeal to superstitions, and features the main motives for using superstitious and rituals in everyday life. The initial stage of superstition formation has been analyzed. A thorough study on the transformation of superstitiousness at different age stages together with the analysis of its causes involved 300 respondents aged 19 – 60 that were divided into three age groups – the young, the first period maturity and the second period maturity. The author has compared the views on the nature and definition of superstitions, the characteristics of various superstitious ritual activities in different age groups, analyzed the level of expression of average superstition and its individual components in each age group.


2020 ◽  
Vol 2 (2) ◽  
pp. 1-12
Author(s):  
Paulus Labai

Abstract: Christian education learning serves as a guide to help Christian educators in training adults in the church so that the congregation will understand more about the image or concept of identity, role and responsibility as adults more clearly and steadily in everyday life and in their relationship with society. around. The problems that arise are: What is the definition of adult andragogy? What is the significance of Christian education for adults? What is the Christian education learning strategy for adult congregations in the BEM Taman Tunku Miri church, Malaysia? The answers to the problems are: (1) Christian education for adult congregations is an effort to educate or educate church members in all existing age groups, including the adult age group. (2) significant Christian education for adults is one form of the church's efforts in educating or educating its citizens by planning a learning program designed in such a way as to achieve the goals of Christian education for adults. (3) The Christian education learning strategy for adult congregations at the BEM Taman Tunku Miri church, Malaysia is to develop Christian education learning for adults who should understand and have skills with regard to design procedures so that Christian education programs for adults become more accommodating and effective.Abstrak: Pembelajaran pendidikan Kristen berfungsi sebagai pedoman untuk menolong pendidik Kristen dalam melatih orang-orang dewasa dalam gereja sehingga jemaat semakin memahami gambar atau konsep jati diri, peran dan tanggung jawabnya sebagai orang dewasa secara lebih jelas dan mantap dalam kehidupan sehari-hari serta dalam relasinya dengan masyarakat sekitar. Persoalan yang timbul adalah: Apakah pengertian andragogi orang dewasa? Apakah signifikan pendidikan Kristen bagi orang dewasa? Bagaimanakah strategi pembelajaran pendidikan Kristen bagi Jemaat dewasa di gereja BEM Taman Tunku Miri, Malaysia? Jawaban dari persoalan-persoalan adalah: (1) pendidikan Kristen kepada jemaat dewasa merupakan usaha mendidik atau membelajarkan warga gereja dalam segala kelompok usia yang ada, tidak terkecuali kelompok usia dewasa. (2) signifikan pendidikan Kristen bagi orang dewasa merupakan salah satu bentuk upaya gereja dalam mendidik atau membelajarkan warganya adalah dengan adanya perencanaan program pembelajaran yang didesain sedemikian rupa untuk mencapai tujuan pendidikan Kristen bagi orang dewasa.  (3) Strategi pembelajaran pendidikan Kristen bagi Jemaat dewasa di gereja BEM Taman Tunku Miri, Malaysia adalah mengembangkan pembelajaran pendidikan Kristen bagi orang dewasa hendaknya memahami dan memiliki keterampilan berkenaan dengan prosedur desain sehingga demikian program pendidikan Kristen bagi orang dewasa menjadi lebih akomodatif dan efektif.


2012 ◽  
Vol 34 (1) ◽  
pp. 38-41 ◽  
Author(s):  
Fernando Michel ◽  
Francine Harb ◽  
Maria Paz Loayza Hidalgo

INTRODUCTION: Children and adolescents use different markers to elaborate the concept of time, and such markers change along their development. The objective of the present article was to analyze changes in time concepts in different age groups. METHODS: The study included 81 children and adolescents aged 6 to 17 years, attending elementary or high school at a public school in southern Brazil. Participants were asked to provide their definition of time, either orally (children) or in writing (older children and adolescents). RESULTS: Twenty-one words were identified as related with the definition of time. The term "hours" was the most frequently cited (24.7%), followed by "clock" and "family" (11.1% each). Among children aged 6 to 8 years, "family" was the term most frequently mentioned to refer to time. Between 9 to 11 years of age, the notion of time was essentially related to the use of a clock, and in the 12-17-year age group, time was mostly associated with the word "days." The word "family" appears to be a frequent temporal marker in childhood, but loses this function during adolescence, as new social relationships are established. CONCLUSION: The results of this study show that the concept of time varies according to age. Chronobiological studies should therefore take into consideration the temporal perception peculiar to each age group.


2019 ◽  
Vol 147 (7-8) ◽  
pp. 443-449
Author(s):  
Mioljub Ristic ◽  
Vesna Stojanovic ◽  
Vladimir Petrovic ◽  
Ulrich Heininger

Introduction/Objective. Global surveillance systems use different clinical case definitions of pertussis. The aim of this study was to identify sign and symptom combinations with best relation with laboratory confirmed pertussis. Methods. A one-year prospective observational study, proposed by the Global Pertussis Initiative (GPI) for three age groups (0?3 months, four months to nine years, and ? 10 years) was performed in Novi Sad to evaluate the performance of the clinical case definition of pertussis. Laboratory confirmation of B. pertussis infection was obtained using the DNA polymerase chain reaction (PCR) or ELISA serology tests. Results. From October 1, 2013 to September 30, 2014, 103 (32.3%) out of 319 participants with suspected pertussis had laboratory-confirmed pertussis. Combined whooping, post-tussive emesis, and worsening of symptoms at night was the best predictor of pertussis in outpatients aged four months to nine years (positive likelihood ratio (LR+) 11.6), while among inpatients of the same age group it was apnoea (LR+ 13.5). The LR+ in outpatients aged ?10 years for combinations of apnoea and post-tussive emesis, or a combination of whooping and sweating episodes between paroxysms and post-tussive emesis was 16.8, while among in-patients LR+ was < 2.3 for all combinations in the same age group. Conclusions. The GPI case definitions for pertussis are good predictors for laboratory-confirmed pertussis and are useful for the purpose of pertussis surveillance.


2011 ◽  
Vol 05 (04) ◽  
pp. 380-386 ◽  
Author(s):  
Sevgi Sener ◽  
Faruk Akgunlu

ABSTRACTObjectives: To investigate the differences in healthy persons and patients with myofacial pain without limitation, objective signs of temporomandibular dysfunctions (TMDs), and both subjective and objective features with respect to age, gender, effects of TMDs on daily life, economic condition, smoking habit, marital status, and education. Methods: Sociodemographic information of 296 persons (212 females and 84 males) was evaluated. Subjects were categorized into 4 groups according to clinical findings: no TMD symptoms (control, C); myofacial pain without limitation (MP); objective signs (PWOS); or both subjective and objective features (MP/PWOS). Results: The C, MP, PWOS, and MP/PWOS groups comprised 64 (22%), 66 (22%), 68 (23%), and 98 (33%) subjects. PWOS and MP/PWOS differed significantly between the 15–30 and 30–45 year age groups. Although patients with PWOS were significantly higher in the 15–30 year age group, patients with MP/PWOS were significantly higher in the 30–45 year age group. A significant difference was observed with respect to gender in all groups except the control group. The effects of TMD symptoms on daily life differed statistically among the groups. Conclusions: Female gender is a risk factor for TMDs. Females are more vulnerable to subjective and objective signs than males. During general dental examinations, females should be checked for TMD symptoms. PWOS manifest before MP. Moreover, mechanical derangements can cause myofacial pain. MP can mostly affect daily life, but PWOS tend to be prohibitive. (Eur J Dent 2011;5:380-386)


Author(s):  
William Crossan ◽  
Milos Bednar ◽  
Ronald Quinn

Abstract A philosophical framework for success in coaching is established, upon which the results of 571 coaches’ views of success in coaching is consequently evaluated. The coaches are Czech nationals from seven sports, who coach all age groups from U8 to adult professional teams, with length of experience ranging from 1 to 26 years (mean 7.1). Success definitions were coded and categorized before being analyzed across sport, age group coached, experience and licensing level. Hal-lowell’s success cycle is used as a standard of evaluation. Results were also assessed in terms of modern coaching philosophies. Overall, it was shown that the most common definition of success by coaches fell into the Sport Growth domain (31.7%), by which they primarily meant Player Development (20.6% of these coaches). The second most common domain for defining success was Performance (28.2%), primarily defined in terms of Winning (15.5%). Emotional Growth (21.1%) and Personal Growth (7.6%), though emphasized in modern coaching philosophies, were largely undervalued by Czech coaches. Enjoyment, a key element of success from Aristotle to Seligman, and essential to Hallowell’s success cycle was evident in only a small number (5.6%) of the success definitions of coaches.


2018 ◽  
pp. 63-67

Estancia hospitalaria prolongada asociada a mortalidad en Hospital Regional Docente de Trujillo, 2014 Prolonged hospital stay associated with mortality in Regional Teaching Hospital in Trujillo, 2014 Marie Herrera-Viloche, Edward Chávez-Cruzado, Carlos Barba-Chirinos, Germán Fiestas-Pflucker, Miguel Tresierra-Ayala Universidad Privada Antenor Orrego DOI: https://doi.org/10.33017/RevECIPeru2015.0010/  Resumen La estancia hospitalaria prolongada, considerada aquella que supera los 13 días, genera costos adicionales al hospital, deficiente accesibilidad a los servicios de hospitalización para nuevos pacientes y riesgos de adquirir infecciones intrahospitalarias, así como una crisis social y familiar. Este estudio pretende determinar si la estancia hospitalaria prolongada se encuentra asociada a mortalidad en los pacientes atendidos en las diferentes salas de hospitalización del  Hospital Regional Docente de Trujillo en el 2014.  Se registraron 11866 hospitalizaciones, y de estos 1193 tuvieron estancia hospitalaria prolongada, de los cuales el 56.58% fueron de sexo masculino y  43.42% de sexo femenino. Los departamentos de medicina y cirugía con 45.1% y 31.3% y los grupo etarios extremos mayores de 61 y menores de 20 con 29.76% y 27.75% fueron los que presentaron estancia hospitalaria prolongada. La asociación pacientes con estancia hospitalaria prolongada y mortalidad, nos da un Odds Radio de 3.276, con IC de 2.615-4.104, con una p=0.0000. Descriptores: Estancia hospitalaria prolongada, mortalidad Abstract Prolonged hospital stay, considered one that exceeds 13 days, generates additional costs to the hospital, poor access to inpatient services for new patients and risk of acquiring nosocomial infections, as well as social and family crisis. This study aims to determine the specialties and age groups associated with prolonged stay of Regional Hospital of Trujillo in 2014. 11866 hospitalizations were recorded, and of these 1193 had prolonged hospital stay, of which 56.58% were male and 43.42 % female. The departments of medicine and surgery with 45.1% and 31.3% and the extreme age group over 61 and under 20 with 29.76% and 27.75% were those with longer hospital stay. Patients with prolonged hospital stay and mortality, gives an odds ratio of 3.276, with IC 2615-4104, with p = 0.0000. Keywords: prolonged hospital stay


1984 ◽  
Vol 51 (01) ◽  
pp. 037-041 ◽  
Author(s):  
K M Weerasinghe ◽  
M F Scully ◽  
V V Kakkar

SummaryCollagen mediated platelet aggregation caused -5.6 ± 6.7% inhibition and +39.1 ± 15.2% potentiation of prekallikrein activation in plasma from normal healthy volunteers between 20–40 and 50–65 years of age, respectively (n = 15, p <0.01). The amouns of platelet factor-four (PF4) released in the two groups were not significantly different. Collagen treatment in the presence of indomethacin caused +11.5 ± 3.6% and +59.6 ± 19.5% potentiation in the 20–40 and 50–65 age groups respectively (p <0.02). Adrenaline mediated platelet aggregation caused -55.2 ± 7.1% and -35.2 ± 8.3% inhibition in the 20–40 and 50–65 age groups, respectively. Collagen treatment of platelet-deficient-plasma and platelet-rich-plasma in EDTA also caused potentiation of prekallikrein activation.The results indicate that the observed degree of prekallikrein activation after platelet aggregation is a net result of the inhibitory effect of PF4 and the potentiatory effect of activated platelets. The potentiatory effect was greater after collagen treatment as compared to adrenaline treatment, and in the 50–65 age group as compared to the 20–40 age group.


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