scholarly journals 1419. High Prevalence of Fluoroquinolone-Resistant Urinary Tract Infection Among US Emergency Department Patients Diagnosed with UTI, 2018-2020

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S793-S794
Author(s):  
Brett Faine ◽  
Megan A Rech ◽  
Priyanka Vakkalanka ◽  
David A Talan
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
International Classification Of Diseases ◽  
Fluoroquinolone Resistance ◽  
Extended Spectrum Beta Lactamase ◽  
Resistance Risk ◽  
E Coli ◽  
Research Grant

Abstract Background Uropathogen resistance, Fluoroquinolone-resistance (FQR) and Extended spectrum beta-lactamase (ESBL), has been observed to be emerging worldwide with prevalences above recommended thresholds for routine empirical treatment. We sought to determine recent resistance prevalence from a geographically diverse sample of US Emergency Departments (ED). Methods We conducted a multi-center, observational cohort study utilizing a network of 15 geographically diverse US EDs. Patients ≥ 18 years of age with the primary international classification of diseases (ICD-10) diagnosis code of cystitis, pyelonephritis, or urinary tract infection (UTI) and were discharged home from the ED from 2018-2020 were included. We calculated descriptive statistics for uropathogens and susceptibilities. Logistic regression analysis was used to identify antimicrobial resistance risk factors associated with fluoroquinolone (FQ)-resistant Escherichia coli. Results Among 3,779 patients who met inclusion criteria, median age was 62.9 years (IQR: 41-77.6) and 76.3% were female. The most common diagnoses were complicated (40.9%) and uncomplicated cystitis (39.4%). Six hundred and forty-five (17%) patients reported receiving antimicrobials in the previous 90-days. E. coli was the most common pathogen (62.9%), followed by Klebsiella pneumoniae (13%) and Enterococcus species (5.8%). Across all sites, overall E. coli FQ-resistance prevalence was 22.1%, ranging from 10.5 to 29.7% by site. The prevalence of ESBL-producing uropathogen was 4.4%, ranging from 2.3% to 8.6% by site. Previous IV or oral antimicrobial use in the last 90-days and complicated vs. uncomplicated UTI were associated with FQ-resistant E. coli (OR 1.69, 95% CI: 1.33-2.14, and OR 1.60, 95% CI: 1.26-2.02, respectively). Of the most prescribed oral antibiotics upon patients discharged from the ED, E. coli resistance to nitrofurantoin and cephalexin was 1.8% and 0.9%, respectively. Conclusion FQ-resistant E. coli is widely prevalent and ESBL-mediated resistance appears to be emerging across US sites highlighting the need for ongoing monitoring of antimicrobial resistance and, at some locations, modification of empirical treatments. Disclosures Brett Faine, PharmD, Spero Therapeutics (Research Grant or Support) Megan A. Rech, PharmD, MS, BCCCP, FCCM, Spero (Research Grant or Support) David A. Talan, MD, AbbVie (Consultant)GSK (Consultant)SPERO Therapeutics (Grant/Research Support)

scholarly journals Biofilm Production and Antimicrobial Resistance among Uropathogens in Pediatric Cases: a Hospital Based Study

2018 ◽  
Vol 16 (2) ◽  
pp. 178-183
Author(s):  
Dhiraj Shrestha ◽  
Pratigya Thapa ◽  
Dinesh Bhandari ◽  
Hiramani Parajuli ◽  
Prakash Chaudhary ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
Tertiary Care ◽  
Multidrug Resistant ◽  
Resistance Pattern ◽  
E Coli ◽  
Biofilm Production ◽  
Resistance Patterns

Background: The study was designed to provide account of etiological agents of urinary tract infection in pediatric patients and the antimicrobial resistance pattern plus biofilm producing profile of the isolates.Methods: The prospective study was conducted in Alka Hospital, Nepal with 353 clean catch urine samples from children. It was obtained during July 2014 to January 2015 which were first cultured by semi-quantitative method, followed by antimicrobial susceptibility testing and biofilm production assay on Congo red agar. Multidrug- resistance, extensively drug- resistance and pandrug- resistance among isolates were considered as per international consensus.Results: Out of 353 samples, 64 (18.13%) showed positive growth in culture, confirming urinary tract infection. E. coli, 44 (68.8%) was the predominant organism followed by Klebsiella spp. 6 (14.1%). Most E. coli were sensitive to amikacin (93.2%) followed by nitrofurantoin (86.4%), and highly resistant to ampicillin (95.5%). Of 64 isolates, 23 (35.93%) were found to be multidrug- resistant strains. Biofilm was produced by 36 (56.25%) isolates.Conclusions: This study showed higher biofilm production and resistance to in-use antibiotics rendering ineffective for empirical use. Regular surveillance of resistance patterns should be done to regulate multidrug- resistant bugs and to ensure effective management of urinary tract infection in children in a tertiary care setups.Keywords: AMR; antimicrobial resistance; biofilm; urinary tract infection; UTI.

scholarly journals Antimicrobial Resistance in Urinary Isolates of Escherichia coli with Special Reference to Fluoroquinolone Resistance and Extended Spectrum Beta-Lactamase (ESBL) Production

2021 ◽  
Vol 10 (9) ◽  
pp. 583-588
Author(s):  
Jyoti Rajowar ◽  
Sangeeta Dey Akoijam ◽  
Aninda Sen ◽  
Kahkashan Akhter ◽  
Shreshy Singh
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urine Samples ◽  
Fluoroquinolone Resistance ◽  
Beta Lactamase ◽  
Esbl Production ◽  
Extended Spectrum Beta Lactamase ◽  
Esbl Producers

BACKGROUND The commonest bacterial agent involved in causation of urinary tract infection (UTI) is Escherichia coli, both in the community as well as in the hospital. In this study Escherichia coli strains isolated from patients with UTI were studied especially for extended spectrum beta-lactamase (ESBL) production and determination of fluoroquinolone resistance. METHODS This descriptive study was conducted in the Department of Microbiology, Katihar Medical College and Hospital from December 2018 to May 2020. Urine samples from suspected UTI cases were processed and bacterial isolates were identified as per standard protocol. Antimicrobial susceptibility testing was done by Kirby-Bauer discdiffusion method on Mueller-Hinton agar. ESBL detection was done as per Clinical and Laboratory Standards Institute (CLSI) guidelines. RESULTS Out of 3938 urine samples received in the microbiology laboratory, 708 samples showed significant growth of various bacteria and candida species, out of these only 105 patients had urinary tract infection caused by Escherichia coli. The male to female ratio was 0.25:1. Isolates were highly sensitive to nitrofurantoin (80.9 %) followed by amikacin (72.4 %) and imipenem (71.5 %). Maximum resistance was seen with amoxicillin (98.1 %), cefuroxime (96.2 %), cefpodoxime and cefotaxime (90.5 %), ceftriaxone (85.7 %), nalidixic acid (91.4 %) and ciprofloxacin (70.5 %). 70.5 % were found to be ESBL producers and 29.5 % were non-ESBL producers. The double disc synergy test (DDST) could detect only 42.8 % of ESBL producers whereas phenotypic confirmatory disc diffusion (PCDDT) detected 70.5 % of ESBL producers. CONCLUSIONS It was seen in the present study that a high proportion of community acquired strains of Escherichia coli were ESBL producers. In this study, 70.5 % of Escherichia coli strains were ESBL positive. It can therefore be recommended that all gram-negative isolates be tested for ESBL production preferably by the PCDDT test as this test was found to be most sensitive for detection of ESBL production. The PCDDT test requires minimum laboratory infrastructure, is cheap and easy as compared to molecular methods. KEY WORDS Escherichia coli, UTI, ESBL, PCDDT, DDST

scholarly journals FLUOROQUINOLONE RESISTANCE PATTERN AMONG THE PATHOGENS CAUSING URINARY TRACT INFECTION IN A TERTIARY CARE HOSPITAL IN KANCHIPURAM DISTRICT, TAMIL NADU, INDIA

2017 ◽  
Vol 10 (11) ◽  
pp. 292
Author(s):  
Shanthi Bamukumar ◽  
Kannan I ◽  
Sukumar Rg
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Tamil Nadu ◽  
Tertiary Care ◽  
Fluoroquinolone Resistance ◽  
Diffusion Method ◽  
Resistance Pattern ◽  
Care Hospital ◽  
E Coli

  Objective: The aim is to study the fluoroquinolone resistance pattern among the pathogens causing urinary tract infection (UTI).Methods: This study was done during January to July 2016 in Tagore Medical College including both hospitalized and out patients. During this 7-month study, around 2695 urine samples were analyzed for the evidence of UTI. 718 samples were culture positive. 366 samples showed fluoroquinolones resistance (50.9%). They were screened for all fluoroquinolone drugs by doing antimicrobial susceptibility testing by Kirby-Bauer disc diffusion method as per the Clinical and Laboratory Standards Institute CLSI guidelines.Results: The resistance pattern of different isolates to norfloxacin is Klebsiella pneumoniae - 20%, Escherichia coli - 51.4%, Enterococci - 11.1%, Proteus mirabilis - 50%, and Staphylococcus saprophyticus - 37.5%; For nalidixic acid is K pneumoniae - 25%, E. coli - 6.8%, Pseudomonas aeruginosa - 71.4%, Enterococci - 11.1%, P. mirabilis - 25%, and S. saprophyticus - 25%; For ciprofloxacin is K. pneumoniae - 5%, E. coli - 5.4%, P. mirabilis - 25%, and S. saprophyticus - 25%; and For ofloxacin is K. pneumoniae - 10%, E. coli - 5.4%, Enterococci 11.1%, and S. saprophyticus 62.5%.Conclusion: Due to increasing resistance to fluoroquinolones in many hospitals and to make the developing resistance rates under control, empirical usage of it is either abandoned or should be restricted.

scholarly journals 1457. Antimicrobial Resistance of Urinary Tract Infection Pathogens in South Korea: A Surveillance Report of the One-Year Assessment in 2017

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S532-S533
Author(s):  
Changseung Liu ◽  
Eun-Jeong Yoon ◽  
Dokyun Kim ◽  
Jong Hee Shin ◽  
Jeong Hwan Shin ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
Surveillance System ◽  
Resistance Rate ◽  
E Coli ◽  
One Year ◽  
The One ◽  
Tract Infections

Abstract Background Korean Antimicrobial Surveillance System (Kor-GLASS) was established in 2016, which is compatible with the Global Antimicrobial Resistance Surveillance System launched by WHO. Here, we report a one-year assessment of Kor-GLASS in 2017, focusing on the antimicrobial resistance of urine isolates. Methods Non-duplicated clinical isolates of E. coli and K. pneumoniae recovered from urine cultures were collected from 8 sentinel hospitals. Demographic information, infection origin (hospital origin or community origin), and admission type were investigated. Bacterial species were confirmed using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer. Antimicrobial susceptibility was tested by disk diffusion and broth microdilution methods. Results During the one-year period of surveillance from January 2017 to December 2017, a total of 9,130 (11.9%) isolates of target pathogens were recovered from urine specimens of 76,625 patients with suspected urinary tract infection (UTI). The rate of culture-positive was the highest in the < 1 age group (AG) (22.5%), stiffly decreased in the 5–<15 AG to 3.4%, and gradually increased with age up to 19.6% in the ≥ 85 AG. The mean occurrence of UTI per 10,000 patient-days for inpatients was 19.3 (range, 3.4–46.1) for E. coli and 4.0 (range, 1.5–7.3) for K. pneumoniae. Resistance rate for cefotaxime was higher than those for ceftazidime both in E. coli (31.3% vs. 10.3%) and K. pneumoniae isolates (39.0% vs. 29.8%). Resistance rate for ciprofloxacin in E. coli isolates was 40.9%, and that in K. pneumoniae isolates was 31.9%. Only 4.9% and 10.9% of E. coli and K. pneumoniae isolates exhibited resistance phenotype to cefoxitin, respectively. Ertapenem-resistance was more frequently identified in K. pneumoniae isolates (1.6%) than in E. coli isolates (0.1%). Multidrug-resistance (MDR) phenotype was identified in 61.4% of the E. coli and 44.8% of K. pneumoniae urine isolates. Conclusion Kor-GLASS generated well-curated surveillance data devoid of collection bias or isolate duplication. Cefoxitin was an alternative treatment to ciprofloxacin for urinary tract infections caused by Enterobacteriaceae. About one-half of urine isolates belonged to either MDR or XDR. Disclosures All authors: No reported disclosures.

scholarly journals Antimicrobial Resistance in Escherichia coli and Resistance Genes in Coliphages from a Small Animal Clinic and in a Patient Dog with Chronic Urinary Tract Infection

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 652
Author(s):  
Veronika Zechner ◽  
Dmitrij Sofka ◽  
Peter Paulsen ◽  
Friederike Hilbert
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
Resistance Genes ◽  
Small Animal ◽  
Laboratory Strain ◽  
Coli Strain ◽  
E Coli ◽  
Chronic Urinary Tract Infection

Antimicrobial resistance is on the rise in certain pathogens that infect pets and their owners. This has raised concerns about the use of antibiotics and the transfer of resistance elements in small animal clinics. We sampled a surgery unit, diagnostic rooms after disinfection, and a dog with chronic urinary tract infection (UTI), in a small animal clinic in Austria, and isolated/characterized phages and Escherichia (E.) coli for antimicrobial resistance, resistance genes and transduction ability. Neither the coliphages nor E. coli were isolated in the 20 samples of the surgery units and diagnostic rooms. From the urinary tract of the dog, we recovered 57 E. coli isolates and 60 coliphages. All of the E. coli isolates were determined as resistant against nalidixic acid, 47 against ampicillin, 34 against sulfonamides, and 33 against streptomycin. No isolate held resistance against tetracycline, trimethoprim, kanamycin, or chloramphenicol. Among the 60 phages, 29 tested positive for one or more resistance gene(s) by PCR, but none was able to transduce it to a laboratory strain or to an E. coli isolated from samples. Nevertheless, six phages out of 60 were able to transduce ampicillin resistance (bla gene) after being grown on a puc19 harboring E. coli strain.

scholarly journals Prevalence of antimicrobial resistance genes and integrons in commensal Gram-negative bacteria in a college community

2019 ◽  
Author(s):  
Julia Rubin ◽  
Kaitlyn Mussio ◽  
Yuqi Xu ◽  
Joy Suh ◽  
Lee W. Riley
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
Resistance Genes ◽  
Healthy Population ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Fecal Samples ◽  
E Coli

AbstractAlthough the human intestinal microbiome has been shown to harbor antimicrobial drug-resistance genes (ARG), the prevalence of such genes in a healthy population and their impact on extraintestinal infections that occur in that community are not well established. This study sought to identify ARG prevalence and their mobile elements in the intestines of a healthy community population at a California university, and compared these genes to those found in uropathogenic Escherichia coli isolated from patients with community-acquired urinary tract infection (CA-UTI). We isolated Gram-negative bacteria (GNB) from fecal samples of healthy volunteers and screened them by polymerase chain reaction (PCR) for ARG encoding resistance against ampicillin (AMP), trimethoprim-sulfamethoxazole (TMP-SMX), gentamicin (GENT), and colistin (COL). We found antimicrobial resistant GNB from 85 (83%) of 102 non-redundant rectal swab samples. Sixty-seven (66%) of these samples contained ß-lactamase genes (blaTEM, blaSHV, blaCTX-M, blaOXA,blaOXY), dihydrofolate reductase (DHFR) genes (dhfr-A17, dhfr-A7, dhfr-A5, dhfr-A21, dhfr-A1, dhfr-A15, and dhfr-B3), and aminoglycoside resistance genes (aadA5, aadA1, and aadB). Integron sequences were found in 37 fecal samples. These genes were found in 11 different GNB species isolated from the fecal samples. The same ARG were found in E. coli strains isolated from patients with CA-UTI examined at the college outpatient health clinic. The high prevalence of clinically-common ARG and integrons harbored by GNB in the intestine of a healthy population suggest that human intestines may serve as a major reservoir of these mobile ARG that appear in E. coli strains causing extraintestinal infections in the same community.ImportanceIncreasing frequency of antimicrobial resistance (AMR) in human pathogenic bacteria has compromised our ability to treat infections. Since mobile antibiotic resistance genes (ARG) are readily exchanged between different species of bacteria through horizontal gene transfer, there is interest in investigating sources of these genes. The normal intestinal flora has been shown to contain a wide variety of ARG, which may have been introduced via food-containing AMR bacteria. We sought to assess the prevalence of ARG carriage in the intestines of a healthy population and determine if these ARG are found in E. coli strains that cause community-acquired urinary tract infection (CA-UTI) in the same community. Our findings indicate that the human intestine may serve as an important reservoir as well as a site in which ARG are transferred into E. coli that cause UTI. Further research is needed to reduce ARG carriage and devise new strategies to prevent AMR infections.

scholarly journals Microbiological analysis of urinary tract infection in diabetic patients

2020 ◽  
Vol 8 (12) ◽  
pp. 4410
Author(s):  
Sarita Otta ◽  
Bichitrananda Swain ◽  
Priyadarshini Bhoi
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Tract Infection ◽  
Resistance Pattern ◽  
Urine Specimen ◽  
Diabetic Patients ◽  
Microbiological Analysis ◽  
E Coli ◽  
Sensitivity Pattern

Background: Diabetes mellitus is a predisposing condition to different infections especially the complicated urinary tract infection (UTI). The susceptibility pattern of organisms in diabetics is different from their counterparts. So, there is always a dilemma while administering empirical regimen for UTI in diabetics. The study aims to find the common organisms implicated in the UTI in diabetic patients and their sensitivity pattern.Methods: Properly collected urine specimen from all the diabetic (cases) and non-diabetic (controls) patients included in this study was processed. Sensitivity pattern and extended spectrum beta lactamase (ESBL) production for the isolated uropathogens was noted.Results: E. coli was the most common organism isolated from both 68 cases and 85 controls in this study. Most of UTI patients with diabetes, 46 (67.7 %) had uncontrolled blood sugar level. Diabetics are more prone for catheter associated UTI (CAUTI) and fungal UTI. Most of the E coli and Atypical E coli isolated were ESBL positive for the diabetic patients (60.5%) than that for the non-diabetics (40.4%). Antimicrobial resistance pattern was similar in both the groups with maximum patients’ sensitivity to tigecycline, colistin, fosphomycin and least susceptibility to cefixime. Both E. coli and Klebsiella also showed high resistance to the fluoroquinolones.Conclusions: E. coli is the predominant uropathogen for both the diabetic & non-diabetic cases. But diabetics are more prone to get ESBL positive UTI. CAUTI and the fungal UTI are more common in diabetics. Diabetic condition does not affect the antimicrobial resistance pattern of uropathogens. But their rising resistance to fluoroquinolones, cephalosporins is a matter of concern while prescribing empiric regimen.

scholarly journals Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Desie Kasew ◽  
Setegn Eshetie ◽  
Abeje Diress ◽  
Zerubabiel Tegegne ◽  
Feleke Moges
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Stone ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Specialized Hospital ◽  
History Of ◽  
The University

Abstract Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital. Methods An institution based cross sectional study was conducted. Basic sociodemographic data were collected using a structured questionnaire. Bacterial identification of uropathogens and drug susceptibility testing were done following standard microbiological techniques. The data were entered and analyzed using SPSS version-23. Bivariate and multivariate logistic regressions were used to identify possible associated risk factors. Results with P value < 0.05 was considered statistically significant. Result A total of 300 urinary stone patients were enrolled. Of these, 153 (51%) were male and 261(87%) were urban residents. The overall prevalence of urinary tract infection was 49 (16.3%) (95% CI 12–21%). A high level of resistance was observed to ampicillin, penicillin and trimethoprim-sulfamethoxazole while majority of isolates were most sensitive to nitrofurantoin and ciprofloxacin. Multi-drug resistant isolates were 16/49 (32.7%), 75% of them being Enterobacteriaceae isolates. More than one-third 9/26 (34.6%) of Gram-negative isolates were Extended Spectrum Beta-Lactamase (ESBL) producing E. coli and K. pneumoniae. Being female, history of urinary tract infection and history of drug use were the independent risk factors. Conclusion Most of the bacterial isolates from urinary stone patients were resistant to ampicillin, penicillin and trimethoprim-sulfamethoxazole. E. coli and K. pneumoniae were the most common extended spectrum beta-lactamase producing isolates. Sex, history of urinary tract infection and previous drug use were found to be risk factors. Routine diagnosis of urinary stone patients for urinary tract infection should be promoted and further researches are encouraged.

scholarly journals A study on urinary tract infection in a tertiary care hospital

2017 ◽  
Vol 4 (5) ◽  
pp. 1401
Author(s):  
V. Rajendran ◽  
R. Nepoleon ◽  
Prashant V. Solanke ◽  
M. Shahbaz Zailu ◽  
P. Valli
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Oral Antibiotic ◽  
Care Hospital ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Extended Spectrum ◽  
The People

Background: Urinary tract infection is defined as bacteriuria along with urinary symptoms. It is one of the most common bacterial infections in humans and a major cause of morbidity. UTI has become difficult to treat because of appearance of pathogens with increasing resistance to antimicrobial agents. The objective of this study was to determine the bacteriological profile of pathogens responsible for urinary tract infection and to assess the antibiotic sensitivity pattern of the causative uropathogens.Methods: This cross-sectional study was performed at the hospital of Sree Mookambika Institute of Medical Sciences, Kulasekharam during January 1, 2016 to December 12, 2016. Institutional ethical committee clearance was obtained. We surveyed 628 patients, who had clinical manifestations of UTI. Urine specimens were cultured for isolation of the microbial agents of UTI. The isolated bacteria were identified using biochemical tests. Data was entered in Microsoft Excel Version 2016.Statistical analysis was done using SPSS TRIAL VERSION 21C.Results: The commonest organism isolated overall was extended spectrum beta lactamase positive E. coli (35.5%) followed by extended spectrum beta lactamase negative E. coli and Enterococcus. Females (68.63%) were mostly affected than males in our study. The people in the age group of 41-60 years are found to be more (48.46%) affected than the people of other age groups. The most sensitive oral antibiotic to almost all organisms in our study is Nitrofurantoin followed by Cotrimoxazole and Norfloxacin and among parenteral antibiotics, Amikacin stands first followed by Piperacillin-Tazobactam and Gentamicin. Apart from the above antibiotics, Klebsiellapnemoniae also shows good response to Cefotaxime (96.15%) and Cefipime (96.15%) and Aztreonam (92.3%).Conclusions: From our study, it is observed that the most common causative organism for Urinary tract infection is found to be extended spectrum beta lactamase positive E. coli followed by Extended Spectrum Beta Lactamase negative E. coli and Enterococcus. The current status of sensitivity of common organism rests mainly on Nitrofurantoin (oral) and Amikacin, Piperacillin-Tazobactam (parenteral).

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