Heroes, Villains, and Victims

2021 ◽  
pp. 165-197
Author(s):  
Mohammed Cheded ◽  
Gillian Hopkinson
Keyword(s):  
Breast Cancer ◽  
Collective Action ◽  
Social Movement ◽  
Emotional Appeal ◽  
Central Characters ◽  
Political Realities ◽  
Shed Light

This chapter explores the construction of dramaturgic characters in social movement narratives surrounding breast cancer. It contributes to developing a better understanding of the role of plotting and characterization in these social movement narratives by highlighting three primary functions. First, the authors elaborate on the functions of the plotting of the central characters of a social movement narrative and their emotional appeal, in contributing to mobilizing collective action as well as operating a disciplining tool for the biological citizen. Second, they shed light on the effects of the simplification versus complexification of the characterization of the villain on mobilizing the audience’s emotions. Finally, they discuss the role of the individualization and collectivization dynamics in the various social movement narratives in stabilizing and/or destabilizing certain political realities.

scholarly journals Exosomes: A Forthcoming Era of Breast Cancer Therapeutics

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4672
Author(s):  
Banashree Bondhopadhyay ◽  
Sandeep Sisodiya ◽  
Faisal Abdulrahman Alzahrani ◽  
Muhammed A. Bakhrebah ◽  
Atul Chikara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapeutics ◽  
Therapeutic Strategies ◽  
Breast Cancer Patients ◽  
Liquid Biopsies ◽  
Non Invasive ◽  
Tumor Tissues ◽  
Circulating Markers

Despite the recent advancements in therapeutics and personalized medicine, breast cancer remains one of the most lethal cancers among women. The prognostic and diagnostic aids mainly include assessment of tumor tissues with conventional methods towards better therapeutic strategies. However, current era of gene-based research may influence the treatment outcome particularly as an adjunct to diagnostics by exploring the role of non-invasive liquid biopsies or circulating markers. The characterization of tumor milieu for physiological fluids has been central to identifying the role of exosomes or small extracellular vesicles (sEVs). These exosomes provide necessary communication between tumor cells in the tumor microenvironment (TME). The manipulation of exosomes in TME may provide promising diagnostic/therapeutic strategies, particularly in triple-negative breast cancer patients. This review has described and highlighted the role of exosomes in breast carcinogenesis and how they could be used or targeted by recent immunotherapeutics to achieve promising intervention strategies.

Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences

2017 ◽  
Vol 474 (17) ◽  
pp. 2903-2924 ◽  
Author(s):  
Matthias Dedobbeleer ◽  
Estelle Willems ◽  
Stephen Freeman ◽  
Arnaud Lombard ◽  
Nicolas Goffart ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Solid Tumors ◽  
Primary Cancer ◽  
Key Factors ◽  
Cellular Functions ◽  
The Central Nervous System ◽  
Differentiation And Proliferation ◽  
Shed Light

Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonstrated to be key factors for oncogenesis. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

scholarly journals An Update on the Role of the Actin Cytoskeleton in Plasmodesmata: A Focus on Formins

2021 ◽  
Vol 12 ◽  
Author(s):  
Min Diao ◽  
Shanjin Huang
Keyword(s):  
Plant Growth ◽  
Actin Cytoskeleton ◽  
Growth And Development ◽  
Cell Communication ◽  
Underlying Mechanism ◽  
Review Article ◽  
Plant Growth And Development ◽  
Shed Light

Cell-to-cell communication in plants is mediated by plasmodesmata (PD) whose permeability is tightly regulated during plant growth and development. The actin cytoskeleton has been implicated in regulating the permeability of PD, but the underlying mechanism remains largely unknown. Recent characterization of PD-localized formin proteins has shed light on the role and mechanism of action of actin in regulating PD-mediated intercellular trafficking. In this mini-review article, we will describe the progress in this area.

scholarly journals Changing the NHS a day at a time: The role of enactment in the mobilisation and prefiguration of change

2016 ◽  
Vol 4 (1) ◽  
pp. 196-219 ◽  
Author(s):  
Liora Moskovitz ◽  
Lucia Garcia-Lorenzo
Keyword(s):  
Collective Action ◽  
Social Movement ◽  
Collective Efficacy ◽  
Organisational Change ◽  
Small Scale ◽  
Group Setting ◽  
Top Down ◽  
Frontline Staff ◽  
Identity Processes

This paper aims to contribute to our understanding of the unique role of enactment in the dynamics of motivation and participation in prefigurative social movements, with the intention of providing a deeper understanding of the mechanisms, inherent to prefiguration, driving change through collective action. We achieve this through examining what motivates people to participate as activists in a social movement trying to enact changes within the National Health Service (NHS) in the United Kingdom. To do so, we explore the narratives of 23 activists working to develop the NHS Change Day movement. The narratives describe how NHS frontline staff engage in daily grassroots change activities while having to navigate top-down, planned, organisational change interventions. We analyse our findings in light of recent developments in the understanding of group identity processes in the mobilisation of collective action, and highlight the role of enactment in these dynamics. The findings indicate that it is not the overall top-down managerial strategies, but rather the daily participation and enactment of self-initiated small-scale change actions that gives meaning and direction to the activists’ participation in the social movement – a meaning which is constructed through the encapsulation of a sense of personal agency and collective efficacy, contributing to a sense of the affirmation of vocational and organisational identity. We contend that the relationship between the experience of the daily enactment of self-initiated activities within a supportive group setting and the motivation to participate in collective action is mutually constructed, and as such, inextricable.

When a Social Movement Quarantines: The Power of Urban Memory in the 2019 Chilean Anti-neoliberal Uprising

2020 ◽  
Vol 23 (3) ◽  
pp. 286-292
Author(s):  
Manuela Badilla Rajevic
Keyword(s):  
Social Movements ◽  
Collective Action ◽  
Social Movement ◽  
Social Interactions ◽  
Spatial Dimension ◽  
Hygienic Measures ◽  
Alternative Spaces ◽  
The City

This article reflects on the connections between space, social movements, and urban memory by analyzing the effects of quarantine on the massive Chilean anti-neoliberal movement. It explores two aspects of the quarantine that have unsettled and challenged the spatial dimension of collective action: restrictions on transit through the city and the imposition of hygienic measures on infrastructure and social interactions. The article suggests that these aspects represent a concrete threat to social movements, while at the same time push to strengthen alternative spaces and repertoires of action. It concludes by illustrating the role of urban memories on the potential continuity of the mobilizations and their demands.

Characterization of tumor-induced platelet aggregation: The role of immunorelated GPIb and expression by MCF-7 breast cancer cells

1995 ◽  
Vol 79 (3) ◽  
pp. 261-274 ◽  
Author(s):  
Leslie Oleksowicz ◽  
Zbigniew Mrowiec ◽  
Edward Schwartz ◽  
Manoochehr Khorshidi ◽  
Janice P. Dutcher ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Platelet Aggregation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

scholarly journals Metformin and Probiotics in the Crosstalk between Colitis-Associated Colorectal Cancer and Diabetes in Mice

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1857
Author(s):  
Sahar Al Kattar ◽  
Rosalyn Jurjus ◽  
Aline Pinon ◽  
David Yannick Leger ◽  
Abdo Jurjus ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Process ◽  
Colorectal Carcinogenesis ◽  
Treatment Modalities ◽  
Downstream Signaling ◽  
Diabetes In Mice ◽  
Tnf Α ◽  
Shed Light

The co-occurrence of colorectal cancer (CRC) and diabetes mellitus along with inflammation and dismicrobism has been frequently reported. Several studies shed light on the antioncogenic potential of metformin on colorectal carcinogenesis. This study aimed to demonstrate that metformin in association with probiotics acts in a synergic effect in breaking the crosstalk, thus inhibiting CRC progression, improving diabetes, and reducing inflammation. Ninety-six male Balb/c mice, 6–8 weeks old, were divided into 16 control and experimental groups to assess the effect of the different treatments and combinations at the clinical, histological, and molecular levels. Metformin and probiotics showed beneficial outcomes on CRC and diabetes, alone and most importantly in combination. Their effects were exerted by inhibiting the inflammatory process whereby a downregulation of IL-6 and TNF-α as well as oxidative stress were depicted. The characterization of the effects of probiotics and metformin on CRC and diabetes sheds light on the role of inflammation and microbiota in this crosstalk. Deciphering the downstream signaling pathways elicited by these compounds will help in developing new effective targeted treatment modalities.

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