scholarly journals Evaluation of Quinone Outside and Succinate Dehydrogenase Inhibitors for Effectiveness Against Eastern Filbert Blight of Hazelnut

Plant Disease ◽  
2017 ◽  
Vol 101 (11) ◽  
pp. 1868-1873 ◽  
Author(s):  
J. W. Pscheidt ◽  
S. Heckert ◽  
S. A. Cluskey
Keyword(s):  
Succinate Dehydrogenase ◽  
Shoot Growth ◽  
Meta Analysis ◽  
Bud Break ◽  
Qoi Fungicides ◽  
Significant Control ◽  
A Value ◽  
Dmi Fungicides ◽  
Group 3 ◽  
Eastern Filbert Blight

Most of the hazelnut production in Oregon, a value of $130 million in 2014, was based on eastern filbert blight (EFB) susceptible cultivars. On these cultivars, EFB management involves, among other tactics, fungicide treatment during bud break and early shoot growth. Many active ingredients have been shown to be effective against EFB. This report summarizes the evaluation of quinone outside (QoI, FRAC group 11) and succinate dehydrogenase (SDHI, FRAC group 7) inhibitors alone and in combination with each other or with demethylation-inhibiting (DMI, FRAC group 3) fungicides for management of EFB. Based on a meta-analysis, picoxystrobin, pyraclostrobin, or trifloxystrobin alone resulted in significant control over nontreated trees ranging between 64 and 74%. Fluoxastrobin was not as effective as other QoI fungicides with an average of 44% control and high variability. SDHI fungicides as a group were less useful for management of EFB with boscalid, fluopyram, and penthiopyrad ineffective while fluxapyroxad averaged 83% control against EFB. Prepackaged mixes of QoI materials with either SDHI or DMI fungicides were also significantly effective against EFB. Use of QoI fungicides and the SDHI material fluxapyroxad offers added flexibility and complexity within EFB management programs. Growers can incorporate any of five different modes of action in EFB management programs including FRAC groups M1, M5, 3, 7, and 11.

scholarly journals Tank Mixing Fungicides for Effectiveness Against Eastern Filbert Blight of Hazelnut

Plant Disease ◽  
2018 ◽  
Vol 102 (5) ◽  
pp. 919-924 ◽  
Author(s):  
J. W. Pscheidt ◽  
S. Heckert ◽  
S. A. Cluskey
Keyword(s):  
Corylus Avellana ◽  
Resistance Development ◽  
Qoi Fungicides ◽  
Quinone Outside Inhibitor ◽  
Action Committee ◽  
Anisogramma Anomala ◽  
Dmi Fungicides ◽  
Group 3 ◽  
Eastern Filbert Blight ◽  
Control Tank

Hazelnut (Corylus avellana) production in Oregon primarily occurs on cultivars susceptible to Anisogramma anomala, the causal agent of eastern filbert blight (EFB). Management of EFB involves planting resistant cultivars, removal of cankered limbs, and the application of fungicides. Tank mixes of demethylation-inhibiting (DMI; Fungicide Resistance Action Committee [FRAC] group 3) or quinone outside inhibitor (QoI; FRAC group 11) fungicides with chlorothalonil (FRAC group M5) at full or reduced rates were evaluated for effectiveness against A. anomala. The use of chlorothalonil in a mix with a DMI or QoI fungicide was an effective treatment for EFB even if each component of the mix was at half the labeled rate. Different liquid or dry formulations of chlorothalonil were equally effective in a tank mix for EFB control. The combination of propiconazole (FRAC group 3) tank mixed with trifloxystrobin (FRAC group 11) was not effective, whereas trees treated with propiconazole tank mixed with pyraclostrobin (FRAC group 11) resulted in significantly fewer EFB cankers compared with nontreated trees. When using tank mixes for EFB management, DMI fungicides should remain at full rates while mixing with a half-rate of chlorothalonil. In contrast, QoI fungicides and chlorothalonil could both be used at half-rates and still maintain acceptable EFB control. Tank mixing chlorothalonil with fungicides at risk of resistance development can help maintain consistent EFB control and should help prevent or delay the emergence of fungicide-resistant A. anomala isolates.

Are DMI+QoI Fungicide Premixes During flowering Worthwhile for Fusarium head blight Control in Wheat? A Meta-analysis

Plant Disease ◽  
2020 ◽  
Author(s):  
Jhonatan Barro ◽  
Flávio Martins Santana ◽  
Franklin Jackson Machado ◽  
Maíra Rodrigues Duffeck ◽  
Douglas Lau ◽  
...  
Keyword(s):  
Fusarium Head Blight ◽  
Field Experiments ◽  
Meta Analysis ◽  
Field Trials ◽  
Yield Response ◽  
Cooperative Network ◽  
Head Blight ◽  
Qoi Fungicides ◽  
Quinone Outside Inhibitor ◽  
Dmi Fungicides

Fusarium head blight (FHB), caused mainly by Fusarium graminearum, is best controlled with demethylation inhibitor (DMI) fungicides during flowering. However, the use of premixes of DMI and quinone outside inhibitor (QoI) fungicides to control FHB has increased in Brazil. Data on FHB severity and wheat yields measured in field experiments conducted in Brazil were gathered from both peer- and non-peer-reviewed sources published from 2000 to 2018. After applying selection criteria, 73 field trials from 35 bibliographic sources were identified, among which 50% of the data were obtained from cooperative network trials conducted after 2011. To be included in the analysis, a DMI+QoI premixes or tebuconazole (TEB) were tested in at least 14 trials and three years. Four premixes met the criteria. Estimates of percent control (and respective 95% confidence interval) by a network model fitted to the log of the treatment means ranged from 44.1% (pyraclostrobin + metconazole applied once; 32.4 to 53.7) to 64.3% (pyraclostrobin + metconazole; 58.4 to 69.3); the latter not differing from TEB (59.9%, 53.6 to 65.3). Yield response was statistically similar for pyraclostrobin + metconazole (532.1 kg/ha, 441 to 623) and trifloxystrobin + prothioconazole (494.9 kg/ha, 385 to 551), and both differed statistically from a group composed of TEB (448.2 kg/ha, 342 to 554), trifloxystrobin + TEB (468.2 kg/ha, 385 to 551), azoxystrobin + TEB (462.4 kg/ha, 366 to 558) and pyraclostrobin + metconazole applied once (413.7 kg/ha, 308 to 518). The two categories of FHB index (7% cut off) and yield (3,000 kg/ha cut off), both in the non-treated check, did not explain the heterogeneity in the estimates. Two sequential sprays of TEB or one spray of pyraclostrobin + metconazole as management choices are likely more profitable than DIM+QoI premixes sprayed twice during flowering considering only the fungicide effects on yield.

scholarly journals Is Routine Preoperative Esophagogastroduodenoscopy Prior to Bariatric Surgery Mandatory? Systematic Review and Meta-analysis of 10,685 Patients

2020 ◽  
Vol 30 (8) ◽  
pp. 3073-3083 ◽  
Author(s):  
Walid El Ansari ◽  
Ayman El-Menyar ◽  
Brijesh Sathian ◽  
Hassan Al-Thani ◽  
Mohammed Al-Kuwari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Publication Bias ◽  
Surgical Approach ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background This systematic review and meta-analysis searched, retrieved and synthesized the evidence as to whether preoperative esophagogastroduodenoscopy (p-EGD) should be routine before bariatric surgery (BS). Methods Databases searched for retrospective, prospective, and randomized (RCT) or quasi-RCT studies (01 January 2000–30 April 2019) of outcomes of routine p-EGD before BS. STROBE checklist assessed the quality of the studies. P-EGD findings were categorized: Group 0 (no abnormal findings); Group 1 (abnormal findings that do not necessitate changing the surgical approach or postponing surgery); Group 2 (abnormal findings that change the surgical approach or postpone surgery); and Group 3 (findings that signify absolute contraindications to surgery). We assessed data heterogeneity and publication bias. Random effect model was used. Results Twenty-five eligible studies were included (10,685 patients). Studies were heterogeneous, and there was publication bias. Group 0 comprised 5424 patients (56%, 95% CI: 45–67%); Group 1, 2064 patients (26%, 95% CI: 23–50%); Group 2, 1351 patients (16%, 95% CI: 11–21%); and Group 3 included 31 patients (0.4%, 95% CI: 0–1%). Conclusion For 82% of patients, routine p-EGD did not change surgical plan/ postpone surgery. For 16% of patients, p-EGD findings necessitated changing the surgical approach/ postponing surgery, but the proportion of postponements due to medical treatment of H Pylori as opposed to “necessary” substantial change in surgical approach is unclear. For 0.4% patients, p-EGD findings signified absolute contraindication to surgery. These findings invite a revisit to whether p-EGD should be routine before BS, and whether it is judicious to expose many obese patients to an invasive procedure that has potential risk and insufficient evidence of effectiveness. Further justification is required.

A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases

2017 ◽  
Vol 474 (16) ◽  
pp. 2713-2731 ◽  
Author(s):  
Athinoula L. Petrou ◽  
Athina Terzidaki
Keyword(s):  
Oxidative Stress ◽  
Excited State ◽  
Singlet Oxygen ◽  
Ground State ◽  
Meta Analysis ◽  
Common Mechanism ◽  
High Electron ◽  
A Value ◽  
First Excited State

From kinetic data (k, T) we calculated the thermodynamic parameters for various processes (nucleation, elongation, fibrillization, etc.) of proteinaceous diseases that are related to the β-amyloid protein (Alzheimer's), to tau protein (Alzheimer's, Pick's), to α-synuclein (Parkinson's), prion, amylin (type II diabetes), and to α-crystallin (cataract). Our calculations led to ΔG≠ values that vary in the range 92.8–127 kJ mol−1 at 310 K. A value of ∼10–30 kJ mol−1 is the activation energy for the diffusion of reactants, depending on the reaction and the medium. The energy needed for the excitation of O2 from the ground to the first excited state (1Δg, singlet oxygen) is equal to 92 kJ mol−1. So, the ΔG≠ is equal to the energy needed for the excitation of ground state oxygen to the singlet oxygen (1Δg first excited) state. The similarity of the ΔG≠ values is an indication that a common mechanism in the above disorders may be taking place. We attribute this common mechanism to the (same) role of the oxidative stress and specifically of singlet oxygen, (1Δg), to the above-mentioned processes: excitation of ground state oxygen to the singlet oxygen, 1Δg, state (92 kJ mol−1), and reaction of the empty π* orbital with high electron density regions of biomolecules (∼10–30 kJ mol−1 for their diffusion). The ΔG≠ for cases of heat-induced cell killing (cancer) lie also in the above range at 310 K. The present paper is a review and meta-analysis of literature data referring to neurodegenerative and other disorders.

Sensitivity of C. fructicola and C. siamense of peach in China to multiple classes of fungicides and characterization of pyraclostrobin-resistant isolates

Plant Disease ◽  
2021 ◽  
Author(s):  
Hafiz Muhammad Usman ◽  
Qin Tan ◽  
Mohammad Mazharul Karim ◽  
Muhammad Adnan ◽  
Weixiao Yin ◽  
...  
Keyword(s):  
High Resistance ◽  
Mycelial Growth ◽  
Management Strategies ◽  
Cross Resistance ◽  
Qoi Fungicides ◽  
Quinone Outside Inhibitor ◽  
Dmi Fungicides ◽  
Colletotrichum Gloeosporioides Species Complex ◽  
Cyt B Gene

Anthracnose, mainly caused by Colletotrichum gloeosporioides species complex including C. fructicola and C. siamense, is a devastating disease of peach. The chemical control has been widely used for years and management failures have increased towards commonly used fungicides. Therefore, screening of sensitivity of Colletotrichum spp. to fungicides with different modes of action is needed to make proper management strategies for peach anthracnose. In this study, sensitivity of 80 isolates of C. fructicola and C. siamense was screened for pyraclostrobin, procymidone, prochloraz and fludioxonil based on mycelial growth inhibition at discriminatory doses. Results showed that C. fructicola and C. siamense isolates were highly resistant to procymidone and fludioxonil with 100% resistance frequencies to both fungicides, but sensitive to prochloraz, i.e., no resistant isolates were found. For pyraclostrobin, 74% of C. fructicola isolates showed high resistance and 26 % were low resistant, all of the C. siamense isolates were low resistant. No positive cross-resistance was observed between pyraclostrobin and azoxystrobin, even they are members of the same quinone outside inhibitor (QoI) fungicide group, and between pyraclostrobin and non-QoIs. Resistant isolates to QoI fungicides were evaluated for the fitness penalty. Results showed that no significant differences except for mycelial growth rates were detected between highly resistant and low-resistant isolates of C. fructicola. Molecular characterization of Cyt b gene revealed that the G143A point mutation was the determinant of the high resistance in C. fructicola. This study demonstrated the current resistance status of C. fructicola and C. siamense to different fungicides and their future perspectives. Demethylation inhibitor (DMI) fungicides are the best option among different chemicals to control peach anthracnose in China.

scholarly journals Cross-talk between active DNA demethylation, resetting of cellular metabolism and shoot apical growth in poplar bud break

2017 ◽  
Author(s):  
Daniel Conde ◽  
Mariano Perales ◽  
Anne-Laure Le Gac ◽  
Christopher Dervinis ◽  
Matias Kirst ◽  
...  
Keyword(s):  
Boreal Forests ◽  
Shoot Growth ◽  
Growth Cycle ◽  
Dna Demethylation ◽  
Bud Break ◽  
Winter Dormancy ◽  
Environmental Signals ◽  
Woody Perennials ◽  
Active Dna Demethylation ◽  
Dna Demethylase

AbstractAnnual dormancy-growth cycle is a developmental and physiological process essential for the survival of temperate and boreal forests. Seasonal control of shoot growth in woody perennials requires specific genetic programs integrated with the environmental signals. The environmental-controlled mechanisms that regulate the shift between winter dormancy to growth promoting genetic program are still unknown. Here, we show that dynamics in genomic DNA methylation (gDNA) levels regulate dormancy-growth cycle in poplar. We proved that the reactivation of cell division in the apical shoot that lead bud break process in spring, is preceded by a progressive reduction of gDNA methylation in apex tissue. We also identified that the induction in apex tissue of a chilling-dependent poplar DEMETER-LIKE 10 (PtaDML10) DNA demethylase precedes shoot growth reactivation. Transgenic poplars showing down-regulation of PtaDML8/10 caused delayed bud break. Genome wide transcriptome and methylome analysis and data mining revealed the gene targets of active DML-dependent DNA demethylation genetically associated to bud break. These data point to a chilling dependent-DEMETER-like DNA demethylase controlling the genetic shift from winter dormancy to a condition that promotes shoot apical vegetative growth in poplar.

EFFECTIVE HYDROGEN CYANAMIDE (DORMEX®) APPLICATION FOR BUD BREAK, FLOWERING AND NUT YIELD OF PISTACHIO TREES CV. MATEUR IN WARM GROWING AREAS

2013 ◽  
Vol 50 (3) ◽  
pp. 398-406 ◽  
Author(s):  
MOHAMED GHRAB ◽  
MEHDI BEN MIMOUN
Keyword(s):  
Global Warming ◽  
Shoot Growth ◽  
Starch Content ◽  
Optimal Dose ◽  
Fruit Trees ◽  
Bud Break ◽  
Northern Tunisia ◽  
Hydrogen Cyanamide ◽  
Effective Hydrogen ◽  
Pistachio Trees

SUMMARYClimate change characterized by global warming is expected to have an incidence on fruit trees’ development and production. The severity of these effects depends on lack of chilling. The current study focused on the research of an optimal dose of hydrogen cyanamide (Dormex®) treatment which can advance the bud break of female pistachio trees (Pistacia veraL.) to ensure better blooming synchronization with pollinators. A field experiment was conducted in northern Tunisia (36°49′N, 9°48′E) on mature pistachio trees. Two hydrogen cyanamide treatments at 2% and 4% Dormex® were applied with reference to the control untreated trees. The flowering time, vegetative growth, starch content, productivity and nut characters were followed. Results show that 4% Dormex® advanced the normal bud break by 15 days and flowering by 11 days and improved natural pollination by synchronization of male and female flowers. Consequently, fresh yield and nut quality as split and blank rates and nut weight were improved. However, shoot growth, leaf area and starch content in current shoot seemed unaffected by hydrogen cyanamide applications. In conclusion, hydrogen cyanamide could be used as 4% Dormex® and sprayed 45 days before bud break to improve pistachio productivity and prevent anomalies of lack of chilling due to global warming that could be more frequent in the Mediterranean areas.

scholarly journals Is psychotherapy effective? A re-analysis of treatments for depression

2018 ◽  
Vol 28 (03) ◽  
pp. 268-274 ◽  
Author(s):  
T. Munder ◽  
C. Flückiger ◽  
F. Leichsenring ◽  
A. A. Abbass ◽  
M. J. Hilsenroth ◽  
...  
Keyword(s):  
Natural History ◽  
Publication Bias ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Wait List ◽  
Control Groups ◽  
Data Set ◽  
A Value ◽  
History Of ◽  
History Of Depression

AbstractAimsThe aim of this study was to reanalyse the data from Cuijpers et al.'s (2018) meta-analysis, to examine Eysenck's claim that psychotherapy is not effective. Cuijpers et al., after correcting for bias, concluded that the effect of psychotherapy for depression was small (standardised mean difference, SMD, between 0.20 and 0.30), providing evidence that psychotherapy is not as effective as generally accepted.MethodsThe data for this study were the effect sizes included in Cuijpers et al. (2018). We removed outliers from the data set of effects, corrected for publication bias and segregated psychotherapy from other interventions. In our study, we considered wait-list (WL) controls as the most appropriate estimate of the natural history of depression without intervention.ResultsThe SMD for all interventions and for psychotherapy compared to WL controls was approximately 0.70, a value consistent with past estimates of the effectiveness of psychotherapy. Psychotherapy was also more effective than care-as-usual (SMD = 0.31) and other control groups (SMD = 0.43).ConclusionsThe re-analysis reveals that psychotherapy for adult patients diagnosed with depression is effective.

scholarly journals Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

2019 ◽  
Vol 138 (2) ◽  
pp. 309-326 ◽  
Author(s):  
Tanvi Sharma ◽  
Edward C. Schwalbe ◽  
Daniel Williamson ◽  
Martin Sill ◽  
Volker Hovestadt ◽  
...  
Keyword(s):  
Second Generation ◽  
Meta Analysis ◽  
Group 4 ◽  
Group 3

scholarly journals Investigation of the Effect of Comorbidity on Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 (4) ◽  
pp. 5579-5590
Keyword(s):  
Effect Size ◽  
Meta Analysis ◽  
Kappa Statistics ◽  
Chronic Respiratory Diseases ◽  
Cardiovascular Comorbidities ◽  
A Value ◽  
Patient Groups ◽  
Main Determinants ◽  
Poor Outcomes ◽  
Related Mortality

Comorbidity is the coexistence of two or more diseases in a certain period. Severe COVID-19 can occur in healthy individuals of any age but predominantly in adults of advanced age or with underlying medical comorbidity. Comorbidities are identified as the main determinants of poor outcomes. This meta-analysis aims to examine the effect of comorbidity on mortality in patients with a diagnosis of COVID-19. Materials and Methods: The studies published between 2019-2020 from Google Scholar, Pub Med, Medline, Scopus, Science Direct, and Web of Science databases were scanned. Inter-rater agreement was calculated with Kappa statistics, effect size "Odds Ratio", heterogeneity between studies with Cochran's Q statistics. The study's effect size and publication bias included in the meta-analysis were calculated using the CMA 3 (Comprehensive Meta-Analysis) program. Results: A total of 24 studies were included in the study. According to the random-effects model, the overall effect size of comorbid factors on mortality development in patients diagnosed with COVID-19 was found to be statistically significant with a value of 2.537 (G.A; 2.078-2.098; p <0.05). In conclusion, cancers, chronic respiratory diseases, diabetes, hypertension, and especially cardiovascular comorbidities are important risk factors for COVID-19 related mortality for COVID-19. There are controversial results in the literature; Further studies involving larger patient groups and examining the specific impact of certain comorbid conditions are needed in order to reach more precise conclusions.

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