scholarly journals Survival of Xiphinema index in Vineyard Soil and Retention of Grapevine fanleaf virus Over Extended Time in the Absence of Host Plants

2005 ◽  
Vol 95 (10) ◽  
pp. 1151-1156 ◽  
Author(s):  
Gérard Demangeat ◽  
Roger Voisin ◽  
Jean-Claude Minot ◽  
Nathalie Bosselut ◽  
Marc Fuchs ◽  
...  
Keyword(s):  
Host Plants ◽  
Control Strategies ◽  
Limited Information ◽  
Grapevine Fanleaf Virus ◽  
Term Survival ◽  
Adverse Conditions ◽  
Xiphinema Index ◽  
Vineyard Soil ◽  
Viral Genomic Rna

Grapevine fanleaf virus (GFLV) is transmitted specifically from grapevine to grapevine by the ectoparasitic root-feeding nematode Xiphinema index. Limited information is available on the survival of X. index in vineyard soil and on the retention of GFLV by X. index over extended periods of time. We addressed these two issues by quantifying the numbers of living X. index recovered from soil samples that were collected in three naturally GFLV-infected vineyards in France and subsequently stored at 7 or 20°C in the absence of host plants. Our data indicated a two- to eightfold decrease in X. index numbers but the recovery of 8 to 10 living fourth-stage juveniles (J4) and adults per kilogram of soil after 4 years of storage regardless of temperature. In addition, GFLV was detected readily in all groups of 20 isolated X. index adults and J4 (except for J4 that were kept 4 years at 20°C) by reverse transcription-polymerase chain reaction using total nematode RNAs and a primer set located in conserved regions at the 3′ end of viral genomic RNA 2. Our findings on the long-term survival of viruliferous X. index under adverse conditions emphasize the need for new control strategies against GFLV.

scholarly journals Bronchiectasis and increased mortality in patients with corticosteroid-dependent severe asthma: a nationwide population study

2020 ◽  
Vol 14 ◽  
pp. 175346662096303
Author(s):  
Hayoung Choi ◽  
Hyun Lee ◽  
Jiin Ryu ◽  
Sung Jun Chung ◽  
Dong Won Park ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Respiratory Diseases ◽  
Chronic Obstructive ◽  
Study Cohort ◽  
Limited Information ◽  
Term Survival ◽  
Obstructive Pulmonary Disease ◽  
All Cause Mortality ◽  
The Impact

Background: Long-term corticosteroid (CS) use is associated with increased mortality in patients with asthma, and comorbid bronchiectasis is also associated with frequent asthma exacerbation and increased healthcare use. However, there is limited information on whether bronchiectasis further increases mortality in patients with CS-dependent asthma. This study examined the impact of bronchiectasis on mortality in patients with CS-dependent asthma. Methods: A retrospective cohort of patients with CS-dependent asthma ⩾18 years old was established using records from the Korean National Health Insurance Service database from 2005 to 2015. Patients with CS-dependent asthma with and without bronchiectasis were matched by age, sex, type of insurance, and Charlson comorbidity index. We evaluated the hazard ratio (HR) for all-cause mortality in patients with bronchiectasis compared with those without bronchiectasis. Results: The study cohort included 754 patients with CS-dependent asthma with bronchiectasis and 3016 patients with CS-dependent asthma without bronchiectasis. Patients with CS-dependent asthma with bronchiectasis had a higher all-cause mortality than those without bronchiectasis (8429/100,000 versus 6962/100,000 person-years, p < 0.001). The adjusted HR for mortality in patients with CS-dependent asthma with bronchiectasis relative to those without bronchiectasis was 1.33 (95% confidence interval, 1.18–1.50), and the association was primarily significant for respiratory diseases (subdistribution HR = 1.65, 95% confidence interval, 1.42–1.92). Conclusions: Bronchiectasis further increases all-cause mortality in patients with CS-dependent asthma, a trend that was especially associated with respiratory diseases including chronic obstructive pulmonary disease. Strategies to improve treatment outcomes in patients with CS-dependent asthma with bronchiectasis are urgently needed to improve long-term survival. The reviews of this paper are available via the supplemental material section.

A new endemic psyllid genus, Stevekenia gen. nov. (Hemiptera: Psylloidea, Triozidae), from the Hawaiian Islands with two new and rare species on threatened host plants in the endemic genus Nothocestrum (Solanaceae)

Zootaxa ◽  
2017 ◽  
Vol 4286 (3) ◽  
pp. 370 ◽  
Author(s):  
DIANA M. PERCY
Keyword(s):  
New Species ◽  
Host Plants ◽  
Plant Density ◽  
Hawaiian Islands ◽  
Morphological Characters ◽  
Iucn Red List ◽  
Term Survival ◽  
Endemic Genus ◽  
Endangered Status

A new endemic psyllid genus from the Hawaiian Islands, Stevekenia gen. nov., is described. Two new species, both single island endemics, feed on host plants in the endemic genus Nothocestrum (Solanaceae). Stevekenia nothocestri sp. nov. is found on Nothocestrum longifolium on the island of Oahu and Stevekenia aiea sp. nov. is found on N. peltatum on the island of Kauai. The host plants are montane rainforest species and both are on the IUCN Red List of Threatened Species. In particular, N. peltatum, which is endemic to the island of Kauai, is considered critically endangered, and therefore a similarly endangered status for these host-specific insects is likely. Only a few specimens of each Stevekenia species have been found, suggesting occurrence at low abundance. The host plants survive either as isolated individuals or small fragmented populations, which may already constitute less than the required critical host plant density for the long term survival of this psyllid genus. Unique morphological characters distinguish Stevekenia from other Hawaiian genera, and the placement of this genus within Triozidae is discussed. Mitochondrial DNA barcodes for the new species are provided. 

Long-term survival of an introduced red alga in adverse conditions

2009 ◽  
Vol 5 (3) ◽  
pp. 304-308 ◽  
Author(s):  
Cecilia D. Nyberg ◽  
Inger Wallentinus
Keyword(s):  
Red Alga ◽  
Term Survival ◽  
Long Term Survival ◽  
Adverse Conditions

scholarly journals Focal Midbrain Glioma: Long Term Survival in a Cohort of 16 Patients and the Implications for Management

1996 ◽  
Vol 23 (3) ◽  
pp. 204-207 ◽  
Author(s):  
Mark G. Hamilton ◽  
Carl Lauryssen ◽  
Neil Hagen
Keyword(s):  
Radiation Therapy ◽  
Treatment Effectiveness ◽  
Symptom Control ◽  
Mass Effect ◽  
Tumor Location ◽  
Limited Information ◽  
Term Outcome ◽  
Term Survival ◽  
Long Term Outcome

AbstractBackground: Focal gliomas involving the midbrain tectum and tegmentum have been identified as having a better prognosis than diffuse tumors affecting the brain stem. However, only limited information is available concerning treatment effectiveness and long term outcome for these patients. Methods: A retrospective, population-based cancer registry survey was performed to assess the clinical features and treatment courses of patients with focal midbrain tumors. Results: Sixteen patients with midbrain gliomas were identified; eight had tectal gliomas and eight tegmental gliomas. Thirteen patients presented with symptoms related to hydrocephalus, and 12 required a ventriculoperitoneal shunt. Seven patients underwent surgery directed at the tumor. Eight patients underwent initial radiation therapy and none had initial chemotherapy. One patient diagnosed at age 18 months had a rapidly growing tumor after 14 months of follow up which has responded to chemotherapy. The mean survival of this patient population was 84 months (range 3-280 months) after diagnosis, with only one tumor related death occurring (280 months after diagnosis). Survival was not affected by tumor location within the midbrain (tegmental or tectal) or by whether radiation therapy was or was not administered. Conclusions: Patients with focal midbrain gliomas require symptom control aimed at treatment of hydrocephalus, or mass effect from the tumor. However the extended survival of this population suggests that routine aggressive surgical debulking is often not required. Furthermore, the routine use of radiation therapy or chemotherapy for all such patients is questioned.

Novel molecular classification of colorectal cancer and correlation with long-term survival.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15514-e15514
Author(s):  
Fayaz Hussain Mangi ◽  
Tanweer Ahmed Shaikh ◽  
Daniel Soria ◽  
Jawaid Naeem Qureshi ◽  
Ikram Uddin Ujjan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Median Survival ◽  
Clinical Information ◽  
Molecular Classification ◽  
Limited Information ◽  
Ki 67 ◽  
Term Survival ◽  
Long Term Survival

e15514 Background: Colorectal cancer (CRC) is a heterogeneous disease, however there is limited information available regarding molecular classification and correlation with long term clinical outcome. Methods: Over the period of 11 years (2008 to 2018) totals 435 patients of colorectal cancer were reported and their tumour blocks and complete set of clinical information was available for 201 patients. Immunohistochemistry was done for ER, PR, HER 2-neu, Ki-67, Bcl-2, E-Cadherin, P53, CEA, EGFR, and VEGF. PDL1, CDX-2 and CK 20. The biological pattern characterized by partitioned clustering method as described using R software. Survival analysis was done by using Kaplan Meier method. Results: There were 201 patients including 54.7% male and females were 45.3 %. Median survival was 28 months. Cluster analysis showed four novel clusters (Table), with major difference based on Ki67, CDX2 and p53. These classes showed difference in median survival, where common class 1 showed higher survival while common cluster 4 showed poor survival. Conclusions: There are at least four distinct molecular classes of colorectal cancer which can be potentially utilized in clinical practice. Pattern of Novel molecular classification of colorectal cancer and correlation with long term survival.[Table: see text]

Biology, Ecology and Control of Soldier Flies Inopus Spp (Diptera, Stratiomyidae) - a Review

1988 ◽  
Vol 36 (6) ◽  
pp. 627 ◽  
Author(s):  
PG Allsopp ◽  
LN Robertson
Keyword(s):  
Sugar Cane ◽  
Population Biology ◽  
Host Plants ◽  
Control Strategies ◽  
Cultural Control ◽  
Important Species ◽  
Sampling Plans ◽  
Development Processes ◽  
And Control

The taxonomy and identification of the soldier flies, Inopus spp., their distribution, host plants, population biology and dynamics, and their chemical and cultural control are reviewed. Previous work has concentrated on I. rubriceps (Macquart), the most economically important species and a pest of sugar cane in Australia and pastures in New Zealand. Areas where further study is desirable include: the taxonomy and distribution of the genus; effects of host plants on development; processes involved in the inhibition of ratooning of sugar cane; detailed life-table studies on different host plants and different cultivars of sugar cane; damage and intervention thresholds and statistically based sampling plans for sugar cane; factors influencing pupation; the contribution of predation, parasitism and disease to mortality; control with insecticides other than organochlorines; the long-term need for insecticides; and control strategies other than insecticide treatments.

scholarly journals Infection of Acanthamoeba polyphagawith Simkania negevensis and S. negevensis Survival within Amoebal Cysts

2001 ◽  
Vol 67 (10) ◽  
pp. 4789-4795 ◽  
Author(s):  
Simona Kahane ◽  
Bella Dvoskin ◽  
Mazit Mathias ◽  
Maureen G. Friedman
Keyword(s):  
Electron Microscopy ◽  
Inclusion Bodies ◽  
Respiratory Illness ◽  
Developmental Cycle ◽  
Term Survival ◽  
Adverse Conditions ◽  
The Family ◽  
Simkania Negevensis ◽  
First Time

ABSTRACT Simkania negevensis, a novel microorganism belonging to the family Simkaniaceae in the orderChlamydiales, has an intracellular developmental cycle during which two morphological entities, elementary bodies (EB) and reticulate bodies (RB), are seen by electron microscopy. Rates of seropositivity to the organism are high in certain population groups, and S. negevensis has been associated with respiratory illness in humans. This study reports for the first time the ability ofS. negevensis to survive and grow insideAcanthamoeba polyphaga in addition to its known ability to grow in cell cultures of human or simian origin. Infectivity ofS. negevensis and growth in amoebae were monitored by immunoperoxidase assays. Long-term persistence and exponential growth of S. negevensis in amoebal trophozoites were demonstrated by infectivity assays and by electron microscopy. EB and dividing RB of S. negevensis were observed within inclusion bodies inside A. polyphaga. When S. negevensis-infected A. polyphaga amoebae were exposed to adverse conditions resulting in encystation of the amoebae, several possible outcomes were observed: cysts containing both normal amoebic cytoplasm and S. negevensis; cysts in whichS. negevensis cells were relegated to the space between cyst walls; and cysts containing S. negevensis, but apparently lacking amoebal cytoplasm. S. negevensiswithin dried amoebal cysts was capable of long-term survival. The possibility that amoebae may have a role in natural transmission ofS. negevensis needs to be investigated.

scholarly journals Transmission Competency of Single-Female Xiphinema index Lines for Grapevine fanleaf virus

2010 ◽  
Vol 100 (4) ◽  
pp. 384-389 ◽  
Author(s):  
Gérard Demangeat ◽  
Véronique Komar ◽  
Cyril Van-Ghelder ◽  
Roger Voisin ◽  
Olivier Lemaire ◽  
...  
Keyword(s):  
Fold Increase ◽  
Reproductive Rate ◽  
Initial Population ◽  
Limited Information ◽  
Grapevine Fanleaf Virus ◽  
Single Female ◽  
Xiphinema Index ◽  
Rate Analysis ◽  
Amino Acid Divergence ◽  
Vector Competency

Grapevine fanleaf virus (GFLV) is vectored specifically from grapevine to grapevine by the ectoparasitic nematode Xiphinema index. Limited information is available on the vector competency of X. index populations from diverse geographical origins. We determined the transmissibility of two GFLV strains showing 4.6% amino acid divergence within their coat protein (e.g., strains F13 and GHu) by seven clonal lines of X. index developed from seven distinct populations from the Mediterranean basin (Cyprus, southern France, Israel, Italy, and Spain), northern France, and California. X. index lines derived from single adult females were produced on fig (Ficus carica) plants to obtain genetically homogenous aviruliferous clones. A comparative reproductive rate analysis on Vitis rupestris du Lot and V. vinifera cv. Cabernet Sauvignon showed significant differences among clones, with the single-female Cyprus line showing the highest rate (30-fold the initial population) and the Spain and California lines showing the lowest rate (10-fold increase), regardless of the grapevine genotype. However, there was no differential vector competency among the seven X. index lines for GFLV strains F13 and GHu. The implications of our findings for the dynamic of GFLV transmission in vineyards and screening of Vitis spp. for resistance to GFLV are discussed.

Long-term survival of patients with metastatic melanoma (MM) treated with dacarbazine (DTIC) or temozolomide (TMZ)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9054-9054
Author(s):  
C. Kim ◽  
C. W. Lee ◽  
R. Klasa ◽  
A. Shah ◽  
K. J. Savage
Keyword(s):  
Metastatic Melanoma ◽  
Tumor Biology ◽  
Survival Rates ◽  
Progression Free Survival ◽  
Complete Response ◽  
Similar Efficacy ◽  
Limited Information ◽  
Term Survival ◽  
Long Term Survival

9054 Background: Patients with metastatic melanoma (MM) generally have a poor prognosis, with a median survival of 6 to 9 months. There is a small proportion of patients who achieve long term survival (LTS), however, it is unclear whether LTS reflects sensitivity to systemic therapy, indolent tumor biology or host immune factors. Dacarbazine (DTIC) is the only approved chemotherapy for the treatment of MM, although temozolomide (TMZ) has similar efficacy. There is limited information as to the frequency of complete response (CR) following DTIC or TMZ, duration of response and whether LTS occurs only in patients who achieve a CR. We sought to identify all patients with MM treated with either DTIC (alone or in combinations) or TMZ at the BC Cancer Agency (BCCA) who achieved LTS defined as survival ≥ 18 months from the time of administration of chemotherapy. Methods: All patients with MM treated with either DTIC or TMZ from January 1, 1988 to February 1, 2006 were identified in the BCCA pharmacy database. The BCCA surveillance and outcomes unit (SAO) was utilized to identify cases of LTS. CR was defined as disappearance of all disease by diagnostic imaging. Given the retrospective nature of the analysis, progressive disease (PD) was defined as any tumor growth, and partial response or stable disease (PR/SD) were combined. Results: In the 18-year period reviewed, 397 patients with MM were treated with DTIC (n= 349) or TMZ (n=48). Of these, 45 patients met the criterion of LTS and had the following characteristics: median age 53 (range 22–86); male 67 %; ocular primary 7%; non-pulmonary visceral metastases 38%; DTIC 11.7% (41/349), TMZ 8.3% (4/48). The best response to DTIC or TMZ documented was: CR 18%, PR/SD 67%, PD 13%. The 5-year overall and progression-free survival rates were 33% and 12%, respectively. Eleven patients survived > 5 years (range 5–27.5), and 6 patients remain in remission (5 CR, 1 PR). Disease progression occurred in 5 patients in < 1 year however, they remain alive for at least 5 years (range 5.2–17.9). Conclusions: LTS occurs in patients with MM treated with either DTIC or TMZ. However, a minority have a sustained response following chemotherapy, and most cases of LTS are likely the result of indolent disease or host biology. No significant financial relationships to disclose.

Caspases and apoptosis

2002 ◽  
Vol 38 ◽  
pp. 9-19 ◽  
Author(s):  
Guy S Salvesen
Keyword(s):  
Cysteine Proteases ◽  
Signalling Pathways ◽  
Term Survival ◽  
Mature Adult ◽  
Intracellular Signalling Pathways ◽  
Adult Cell ◽  
Caspase Family ◽  
Cell Fragments ◽  
Pro Inflammatory Cytokines

The ability of metazoan cells to undergo programmed cell death is vital to both the precise development and long-term survival of the mature adult. Cell deaths that result from engagement of this programme end in apoptosis, the ordered dismantling of the cell that results in its 'silent' demise, in which packaged cell fragments are removed by phagocytosis. This co-ordinated demise is mediated by members of a family of cysteine proteases known as caspases, whose activation follows characteristic apoptotic stimuli, and whose substrates include many proteins, the limited cleavage of which causes the characteristic morphology of apoptosis. In vertebrates, a subset of caspases has evolved to participate in the activation of pro-inflammatory cytokines, and thus members of the caspase family participate in one of two very distinct intracellular signalling pathways.

Sign in / Sign up

Export Citation Format

Share Document