Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study

2001 ◽  
Vol 19 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Pasquale Strazzullo ◽  
Roberto Iacone ◽  
Alfonso Siani ◽  
Francesco P. Cappuccio ◽  
Ornella Russo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Central Adiposity ◽  
Cross Sectional ◽  
Trp64arg Polymorphism ◽  
Heart Study ◽  
Interaction With Age ◽  
Relationship Of

scholarly journals Adiposity and blood pressure among 55 000 relatively lean rural adults in southwest of China

2015 ◽  
Vol 29 (9) ◽  
pp. 522-529 ◽  
Author(s):  
X Chen ◽  
H Du ◽  
J Zhang ◽  
X Chen ◽  
G Luo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rural China ◽  
Central Adiposity ◽  
Regression Analyses ◽  
Chinese Adults ◽  
Rural County ◽  
Cross Sectional ◽  
Mean Values ◽  
Relationship Of ◽  
General Adiposity

Abstract Obesity is a strong determinant of blood pressure. Uncertainty remains, however, about which indices of adiposity most strongly predict blood pressure, particularly among those who were relatively lean, such as those from rural China. We analyzed cross-sectional data on 55 687 (38.3% men) participants aged 30–79 years who were enrolled into the China Kadoorie Biobank from a rural county in southwest of China during 2004–2008. Measured body mass index (BMI) and waist circumference (WC) were related to blood pressure in multivariable linear regression analyses. The overall mean values of BMI, WC, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 23.3 kg m−2, 78.0 cm, 129.2 mm Hg and 77.2 mm Hg, respectively. There was a strongly positive, and apparently linear, relationship of BMI and WC with blood pressure, with 1 s.d. higher BMI associated with 4.3/2.3 mm Hg higher SBP/DBP and 1 s.d. WC associated with 3.8/2.1 mm Hg (P<0.0001). Additional adjustment for WC only slightly attenuated the association of BMI with blood pressure, whereas additional adjustment for BMI almost completely eliminated the association of WC with blood pressure. Our findings suggest that in relatively lean Chinese adults, general adiposity is more strongly assciated with blood pressure than central adiposity.

scholarly journals Hypertension Related Knowledge and Its Relationship with Control of High Blood Pressure in Pakistan

2021 ◽  
pp. 183-186
Author(s):  
Bilal Younas ◽  
Muhammad Fahad ◽  
Muhammad Arslan
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Compliance Level ◽  
Significant Difference ◽  
Level Of Knowledge ◽  
Relationship Of ◽  
The Relationship

Introduction: High blood pressure (HBP) is a leading major risk factor for chronic diseases such as CKD, CADx, and deaths. The prevalence of patients with hypertension (HT) has risen from 600 million in 1980 to one billion in 2008. Aims and Objectives: The basic aim of the study is to find the relationship of knowledge about hypertension with the control of blood pressure. Methodology of the Study: This cross sectional study was conducted in Mayo hospital Lahore from January 2021 to July 2021. The data was collected from 100 patients with high blood pressure who visited the OPD of our hospital. A questionnaire was prepared by the researchers in accordance with the literature to measure the level of knowledge about HT. Results: The data was collected from 100 patients of both genders. On comparison of questions related to knowledge, there was a statistically significant difference in; meaning of hypertension (p <0.001), target SBP (p0.001), target DBP (p 0.001), importance of SBP versus DBP, improvement of health with lowering of blood pressure (p 0.002), high blood pressure being asymptomatic (p <0.001), changing lifestyle improves blood pressure (p 0.003), hypertension being a lifelong disease (<0.001), lifelong treatment with anti-hypertensives (<0.001) and high blood pressure being part of aging (<0.001). Conclusion: It is concluded that patients who were aware that elevated BP levels lead to reductions in life expectancy had a higher compliance level with medication use and follow-up visits than patients without this awareness.

scholarly journals Sustained high blood pressure and 24-h ambulatory blood pressure monitoring in Tanzanian adolescents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mussa K. Nsanya ◽  
Philip Ayieko ◽  
Ramadhan Hashim ◽  
Ezekiel Mgema ◽  
Daniel Fitzgerald ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Cross Sectional Study ◽  
Screening Strategy ◽  
Cross Sectional ◽  
School Settings ◽  
Education And Health ◽  
Screening Algorithm ◽  
Estimate Prevalence

AbstractEstimates for prevalence of high blood pressure (BP) among adolescents in Africa vary widely and few studies, if any, have documented the results of the recommended stepwise BP screening. In this cross-sectional study in Tanzania, we aimed to estimate prevalence of sustained high BP in 3 public secondary schools using the American Academy of Pediatrics BP screening strategy. On Day 1, one screening automated office BP (AOBP) measurement (Step 1) was followed by two more AOBP measurements (Step 2). Repeat AOBP measurements were obtained after about one month on adolescents with high AOBP measurements on Day 1 (Step 3). Participants with sustained high BP underwent 24-h ambulatory BP monitoring (step 4). Of all 500 enrolled participants, the prevalence of high blood pressure at each step in the process was 36.6% (183), 25.6% (128), 10.2% (51), and 2.6%(13) respectively for Steps 1–4. All except 6 students completed all 4 steps of the BP screening algorithm as indicated. We conclude that diagnosis of hypertension in African adolescents should use multiple AOBP measurements over multiple days followed by 24-h ABPM. Screening for high BP in school settings appears to be feasible and could provide a platform for cardiovascular disease education and health promotion.

The effects of household income distribution on stroke prevalence and its risk factors of high blood pressure and smoking: a cross-sectional study in Saskatchewan, Canada

2016 ◽  
Vol 137 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Yelena Bird ◽  
Mark Lemstra ◽  
Marla Rogers
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Risk Factor ◽  
Income Distribution ◽  
High Blood Pressure ◽  
Household Income ◽  
Lower Income ◽  
Cross Sectional ◽  
Statistical Adjustment ◽  
Stroke Prevalence

Background: Stroke is a major chronic disease and a common cause of adult disability and mortality. Although there are many known risk factors for stroke, lower income is not one that is often discussed. Aims: To determine the unadjusted and adjusted association of income distribution on the prevalence of stroke in Saskatchewan, Canada. Methods: Information was collected from the Canadian Community Health Survey conducted by Statistics Canada for 2000–2008. In total, 178 variables were analysed for their association with stroke. Results: Prior to statistical adjustment, stroke was seven times more common for lower income residents than higher income residents. After statistical adjustment, only four covariates were independently associated with stroke prevalence, including having high blood pressure (odds ratio (OR) = 2.62; 95% confidence interval (CI) = 2.12–3.24), having a household income below CAD$30,000 per year (OR = 2.49; 95% CI = 1.88–3.29), being a daily smoker (OR = 1.36; 95% CI = 1.16–1.58) and being physically inactive (OR = 1.27; 95% CI = 1.13–1.43). After statistical adjustment, there were five covariates independently associated with high blood pressure prevalence, including having a household income below CAD$30,000 per year (OR = 1.52; 95% CI = 1.41–1.63). After statistical adjustment, there were five covariates independently associated with daily smoking prevalence, including having a household income below CAD$30,000 per year (OR = 1.29; 95% CI = 1.25–1.33). Conclusions: Knowledge of disparities in the prevalence, severity, disability and mortality of stroke is critically important to medical and public health professionals. Our study found that income distribution was strongly associated with stroke, its main disease intermediary – high blood pressure – and its main risk factor – smoking. As such, income is an important variable worthy of public debate as a modifiable risk factor for stroke.

scholarly journals Use of physical activity and cardiorespiratory fitness in identifying cardiovascular risk factors in male brazilian adolescents

2016 ◽  
Vol 18 (6) ◽  
pp. 678
Author(s):  
Lilian Messias Sampaio Brito ◽  
Luis Paulo Gomes Mascarenhas ◽  
Deise Cristiane Moser ◽  
Ana Cláudia Kapp Titski ◽  
Monica Nunes Lima Cat ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
High Blood Pressure ◽  
Abdominal Obesity ◽  
Age Groups ◽  
Cross Sectional ◽  
The Impact

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n6p678 The aim of this study was to investigate the impact of physical activity (PA) and cardiorespiratory fitness (CRF) levels on the prevalence of overweight and high blood pressure levels in adolescents. In this observational, cross-sectional study, 614 boys aged 10-14 years were assessed for height, body mass, body mass index (BMI), waist circumference (WC) and blood pressure (BP). CRF was assessed using a run test (Léger Test) and subjects were then grouped according to their CRF level. PA level was assessed through a questionnaire (The Three Day Physical Activity Recall) and classified into two groups, namely > 300 minutes of PA/week and < 300 minutes of PA/week. Maturational stage was evaluated according to the development of pubic hair (self-assessment) as proposed by Tanner. We used statistical descriptive analysis, univariate and multivariate analyses in the total participants and subjects were divided by age. Fifty percent of the sample performed < 300 minutes of PA/week and 67.6% had unsatisfactory CRF levels. There was a higher prevalence of unsatisfactory CRF levels among subjects with altered BMI (overweight), WC (abdominal obesity) or BP (high blood pressure) for all age groups. PA history, however, did not show any significance. A total of 31% of participants were overweight, 24.8% had abdominal obesity and 15.4% had increased BP. Unsatisfactory CRF levels were found to be a better predictor for the diagnosis of cardiovascular diseases (CV) risk factors than PA history, regardless of age group. 

scholarly journals HUBUNGAN INDEKSMASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH LAKI-LAKI DEWASA

2018 ◽  
Vol 9 (2) ◽  
pp. 193-199
Author(s):  
Tamariani Manullang
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Study Design ◽  
Computer Software ◽  
Adult Males ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

Prevalence of hypertension in adult males was highest in PuskesmasBasuki Rahmat (16.2%) as many as 648 cases of hypertension patients which hasincreased compared to 2012 by 12% in cases of hypertension totaled 482 patients((Dinkes Kota, 2013). This study aims to determine the relationship of body massindex (BMI) and waist circumference (WC) with systolic blood pressure (BP) in adultmales in Puskesmas Basuki Rahmat Bengkulu City in 2015. The study design wasdescriptive analytic with cross sectional approach. Study location was in PuskesmasBasuki Rahmat City of Bengkulu. Samples were selected using purposive samplingtotalling 68 people. Criterias sample were being adult males who occupied inPuskesmas Basuki Rahmat City of Bengkulu, aged ≥ 18 years, agreed to beinterviewed,and able to communicate actively. Data were obtained include BMI, WCand systolic BP adult males and processed using computer software with pearsoncorrelation analysis.The results showed that there was relationship between BMI andsystolic BP (p = 0.0005; r = 0.395); between WC and systolic BP (p = 0.004 and r =0.347) in adult males. This study concluded that there was relationship between BMIand WC with systolic BP in adult males in Puskesmas Basuki Rahmat Bengkulu Cityin 2015.

scholarly journals Optimization of Droplet Digital Polymerase Chain Reaction (Ddpcr) For Dna Copy Number Variation Analysis of Cnv Esv27061 in Young Adults with Higher Blood Pressure

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Siti Radziah Shaik Alaudeen ◽  
Aszrin Abdullah ◽  
Azarisman Shah Mohd Shah ◽  
Norlelawati Abdul Talib
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Copy Number Variation ◽  
High Blood Pressure ◽  
Dna Sequences ◽  
Copy Number ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Dna Concentration ◽  
Number Variation

Introduction: Copy number variation (CNV) caused by changes in DNA sequences of 1000 or more bases is implicated with susceptibility to common diseases. A study on CNV esv27061 among hypertensive Australian adults reported association with high blood pressure (BP). In Malaysia, no study on CNV among hypertensive young adults is available. Thus, this investigation aimed to assess the CNV esv27061 of young Malaysian adults with high blood pressure using optimized ddPCR. Materials and method: Ten samples each from hypertensive and healthy controls were randomly selected from samples collected for an on-going comparative cross-sectional research project among young adults living in Kuantan. The DNAs were purified using Maxwell RSC Buffy Coat DNA Kit and the concentration was measured using SimpliNano spectrophotometer. Subsequently, restriction digestion of DNAs by EcoRV was performed prior to ddPCR. The products were later subjected to droplet generation (QX100 Droplet Generator), PCR amplification and finally CNV was read by QX100 Droplet reader. Unfortunately, the above method did not yield any result. Thus, an alternative method in which purified DNA concentration was determined by QuantiFluor ONE dsDNA System (Quantus fluorometer). The DNAs (60 ng) and Alu1 were added in master mix during ddPCR and CNV esv27061 analysis was performed as stated above. Results: Optimization of method in this study showed that the detection of CNV esv27061 was possible by the use of more sensitive measurement of DNA concentration, Alu1 restriction enzyme instead of EcoRV and digestion in ddPCR reaction method rather than prior digestion. The finalized protocol run on selected hypertensive and healthy controls has shown to be reproducible and easily interpretable discrimination of gene's copy numbers. Conclusion: This optimized protocol for CNV esv27061 analysis proved useful in identifying CNV and will allow a reproducible assay evaluation and the application of this method to a bigger sample size.

scholarly journals Relationship of Time-Activity-Adjusted Particle Number Concentration with Blood Pressure

2018 ◽  
Vol 15 (9) ◽  
pp. 2036 ◽  
Author(s):  
Laura Corlin ◽  
Shannon Ball ◽  
Mark Woodin ◽  
Allison Patton ◽  
Kevin Lane ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Particle Number ◽  
Linear Models ◽  
Number Concentration ◽  
Particle Number Concentration ◽  
Cross Sectional ◽  
Time Activity ◽  
Sufficient Set ◽  
Ultrafine Particulate Matter ◽  
Relationship Of

Emerging evidence suggests long-term exposure to ultrafine particulate matter (UFP, aerodynamic diameter < 0.1 µm) is associated with adverse cardiovascular outcomes. We investigated whether annual average UFP exposure was associated with measured systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and hypertension prevalence among 409 adults participating in the cross-sectional Community Assessment of Freeway Exposure and Health (CAFEH) study. We used measurements of particle number concentration (PNC, a proxy for UFP) obtained from mobile monitoring campaigns in three near-highway and three urban background areas in and near Boston, Massachusetts to develop PNC regression models (20-m spatial and hourly temporal resolution). Individual modeled estimates were adjusted for time spent in different micro-environments (time-activity-adjusted PNC, TAA-PNC). Mean TAA-PNC was 22,000 particles/cm3 (sd = 6500). In linear models (logistic for hypertension) adjusted for the minimally sufficient set of covariates indicated by a directed acyclic graph (DAG), we found positive, non-significant associations between natural log-transformed TAA-PNC and SBP (β = 5.23, 95%CI: −0.68, 11.14 mmHg), PP (β = 4.27, 95%CI: −0.79, 9.32 mmHg), and hypertension (OR = 1.81, 95%CI: 0.94, 3.48), but not DBP (β = 0.96, 95%CI: −2.08, 4.00 mmHg). Associations were stronger among non-Hispanic white participants and among diabetics in analyses stratified by race/ethnicity and, separately, by health status.

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