Biomedical and social contributions to sustainability

2011 ◽  
Vol 369 (1942) ◽  
pp. 1730-1747 ◽  
Author(s):  
Ian Wilmut ◽  
Tuempong Wongtawan ◽  
Mindy Quigley ◽  
Gareth Sullivan
Keyword(s):  
Stem Cells ◽  
Infectious Diseases ◽  
Physiological Function ◽  
Genetic Diseases ◽  
Human Suffering ◽  
The Past ◽  
Developing Communities ◽  
Social Contributions ◽  
History Of ◽  
Full Benefit

Over the past two or three centuries, biomedical advances have provided methods to prevent and treat infectious diseases. These changes have greatly reduced human suffering and enhanced sustainability by allowing people to live longer and healthier lives. The challenge for the coming centuries will be to ensure that these longer, healthier lives are also more productive lives. We must build on the gains of the past by translating new discoveries in regenerative medicine into therapies for degenerative and genetic diseases. Stem cells may be used to identify drugs that prevent the development of symptoms or to replace cells that have either died or lost their physiological function. In the case of genetic diseases, it may be possible to correct the genetic error. While most conditions that might be treated in these ways are common to all communities, some are more prevalent in specific races. Provision of these and other benefits depends not only on attainment of the research objectives, but also upon our ability to make treatment opportunities available throughout both developed and developing communities. The long history of researching and treating infectious diseases shows that it may take many decades to reap the full benefit of the new biological understanding.

scholarly journals Dermoscopy revealing a case of Tinea Nigra*

2013 ◽  
Vol 88 (1) ◽  
pp. 128-129 ◽  
Author(s):  
Paulo Ricardo Criado ◽  
Lívia Delgado ◽  
Gustavo Alonso Pereira
Keyword(s):  
Infectious Diseases ◽  
Diagnostic Tool ◽  
Glabrous Skin ◽  
Daily Routine ◽  
Brown Patch ◽  
The Past ◽  
History Of ◽  
Tinea Nigra ◽  
Skin Conditions

Dermoscopy has being used over the past twenty years as a noninvasive aid in the diagnosis of innumerable skin conditions, including infectious diseases and infestations (Entodermoscopy).Tinea nigra is a superficial phaeohyfomycosis that affects mainly the glabrous skin of palms and soles. We describe a 14 year-old girl with a three-month history of an enlarging brown patch of her hand diagnosed as Tinea Nigra following clinical and dermoscopy examination.These images emphasize the importance of dermoscopy as a diagnostic tool in the daily routine of dermatologists.

A survey of vaccine history in German cats and owners’ attitudes to vaccination

2018 ◽  
Vol 21 (2) ◽  
pp. 73-83 ◽  
Author(s):  
Anne-Claire Gehrig ◽  
Katrin Hartmann ◽  
Felix Günther ◽  
André Klima ◽  
Gabriele Habacher ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Positive Impact ◽  
Vaccination Status ◽  
Regulatory Requirements ◽  
Online Questionnaire ◽  
The Past ◽  
Vaccination Recommendations ◽  
History Of ◽  
The Uk ◽  
Current Guidelines

Objectives Vaccination is the most important measure for prevention of feline infectious diseases. Cat owner compliance with vaccination recommendations has been investigated in the UK but not in other European countries. The aim of the present study was to determine cat owners’ attitudes towards vaccination in cats in Germany, to identify factors that are associated with the vaccination status of their cats and to compare the results with those of the UK survey. Methods The survey was conducted using an online questionnaire and was aimed at respondents throughout Germany. Respondents under 16 years of age, cats that were less than 9 weeks old and veterinarians were excluded. A total of 920 questionnaires were evaluated, and information about cats and respondents was assessed with respect to the current vaccination status of the cats using a linear logistic regression model. Results The majority of cats (77.9%; n = 717) were vaccinated according to current guidelines; only 5.4% (n = 50; 95% confidence interval [CI] 5.00–9.00) of cats had never received a vaccine. Having visited a cattery, a cat show or travelled abroad in the past 12 months (n = 96/773; odds ratio [OR] 6.95; 95% CI 1.65–52.19) had the highest positive impact on the vaccination status of cats. In addition, detailed veterinary advice about vaccination had a positive impact (n = 275/773; OR 2.09; 95% CI 0.67–6.25) on the attitude of owners towards vaccinating their cats. Conclusions and relevance A history of travelling abroad or visiting cat shows or a cattery, and thus regulatory requirements, had the greatest positive impact on the current vaccination status of the cats. Veterinary consultation on preventive measures, including vaccination, is crucial for protecting the cat population against infectious diseases.

scholarly journals Innovative Approach to Solving Theoretical Issues of the Ecological and Epidemiological Concept of Sapronoses

2018 ◽  
Vol 17 (1) ◽  
pp. 87-94
Author(s):  
A. B. Belov
Keyword(s):  
Veterinary Medicine ◽  
General Theory ◽  
Infectious Diseases ◽  
Biomedical Sciences ◽  
Russian Science ◽  
Research And Practice ◽  
The Past ◽  
The World ◽  
History Of ◽  
Theoretical Issues

The history of the study of infections attributed by the microbiologist and epidemiologist V.I. Tersky in 1958 as the class of human infectious diseases – «Sapronoses» is presented. Over the past 60 years in the world and especially in Russian science the knowledge that allows us to complete the development of an ecological and epidemiological theory of sapronoses infections was accumulated. This knowledge should be extended to the whole complex of biomedical sciences associated with the population pathology of biota. To solve the controversial and complex issues of the theory, terminology and classifications of population infectology, it is necessary to integrate the knowledge of specialists in various fields of research and practice in the medicine, veterinary medicine, parasitology, phytopathology and other disciplines. The ways and prospects of improving the general theory of infectology in the light of new approaches to understanding the essence of sapronoses are discussed. 

scholarly journals Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation

Circulation ◽  
2020 ◽  
Vol 142 (3) ◽  
pp. 275-291
Author(s):  
Lingjuan He ◽  
Ngoc B. Nguyen ◽  
Reza Ardehali ◽  
Bin Zhou
Keyword(s):  
Stem Cells ◽  
Basic Research ◽  
Heart Regeneration ◽  
Cardiomyocyte Proliferation ◽  
Developmental Potential ◽  
The Past ◽  
Injured Myocardium ◽  
Cell Tracing ◽  
History Of ◽  
Adverse Remodeling

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and heart failure. Identifying new sources for cardiomyocytes and promoting their formation represents a goal of cardiac biology and regenerative medicine. Within the past decade, many types of putative cardiac stem cells (CSCs) have been reported to regenerate the injured myocardium by differentiating into new cardiomyocytes. Some of these CSCs have been translated from bench to bed with reported therapeutic effectiveness. However, recent basic research studies on stem cell tracing have begun to question their fundamental biology and mechanisms of action, raising serious concerns over the myogenic potential of CSCs. We review the history of different types of CSCs within the past decade and provide an update of recent cell tracing studies that have challenged the origin and existence of CSCs. In addition to the potential role of CSCs in heart regeneration, proliferation of preexisting cardiomyocytes has recently gained more attention. This review will also evaluate the methodologic and technical aspects of past and current studies on CSCs and cardiomyocyte proliferation, with emphasis on technical strengths, advantages, and potential limitations of research approaches. While our understanding of cardiomyocyte generation and regeneration continues to evolve, it is important to address the shortcomings and inaccuracies in this field. This is best achieved by embracing technological advancements and improved methods to label single cardiomyocytes/progenitors and accurately investigate their developmental potential and fate/lineage commitment.

scholarly journals Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing

2019 ◽  
Vol 221 (Supplement_3) ◽  
pp. S289-S291 ◽  
Author(s):  
Mariana Leguia ◽  
Anton Vila-Sanjurjo ◽  
Patrick S G Chain ◽  
Irina Maljkovic Berry ◽  
Richard G Jarman ◽  
...  
Keyword(s):  
Public Health ◽  
Next Generation Sequencing ◽  
Infectious Diseases ◽  
Next Generation ◽  
The Past ◽  
Infectious Disease Research ◽  
History Of ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Health Applications

Abstract This brief report serves as an introduction to a supplement of the Journal of Infectious Diseases entitled “Next-Generation Sequencing (NGS) Technologies to Advance Global Infectious Disease Research.” We briefly discuss the history of NGS technologies and describe how the techniques developed during the past 40 years have impacted our understanding of infectious diseases. Our focus is on the application of NGS in the context of pathogen genomics. Beyond obvious clinical and public health applications, we also discuss the challenges that still remain within this rapidly evolving field.

scholarly journals COVID-19: One year together

2021 ◽  
Vol 13 (1) ◽  
pp. 5-12
Author(s):  
A. N. Lukashev
Keyword(s):  
Infectious Diseases ◽  
Respiratory Infection ◽  
Medical Science ◽  
Healthcare Systems ◽  
The Past ◽  
Current State ◽  
Significant Events ◽  
History Of ◽  
One Year

The pandemic of COVID-19, a novel respiratory infection, has become one of the most significant events in the history of infectious diseases over the past 100 years. The article reviews the main stages in the development of a pandemic and the fight against it, the most appealing issued faced by medical science, the successes and mistakes of healthcare systems and researchers, the current state of the problem and the nearest prospects.

History of hygiene, microbiology and epidemiology in the art of small forms: the past and the present

2021 ◽  
pp. 74-86
Author(s):  
Roman Aleksandrovich Tolmachev ◽  
Lyudmila Grigorievna Podunova ◽  
Sergey Pavlovich Glyantsev
Keyword(s):  
Infectious Diseases ◽  
Research Methods ◽  
Educational Institution ◽  
Primary Sources ◽  
Educational Institutions ◽  
Medical Specialties ◽  
The Past ◽  
Scientific Disciplines ◽  
History Of ◽  
First Time

For the first time, more than 700 award, anniversary and commemorative badges reflecting the history of hygiene, microbiology and epidemiology were systematized and analyzed. The following directions are identified for studying the history of these medical specialties and educational and scientific disciplines with the help of epigraphy: 1) outstanding figures of hygiene, microbiology and epidemiology; 2) hygienic and epidemiological congresses, congresses and other forums; 3) specialized research institutions; 4) educational institutions and faculties of universities that train specialists in the field of hygiene, microbiology and epidemiology; 5) pathogens and vectors of infectious diseases; 6) methods of detecting microorganisms and treating infections; 7) the COVID-19 pandemic. The study showed that during the XX and XXI centuries a large number of badges (awards and commemorative) were issued, reflecting selected pages of the history of hygiene, microbiology and epidemiology. These faleristic objects related to the art of small forms are full-fledged primary sources for studying the history of these areas of medicine and objects for the collections of state, municipal and departmental museums of medical subjects. Signs with portraits of outstanding hygienists, microbiologists and epidemiologists can be used to study and illustrate their life and activities, contribution to science and perpetuate their memory. Epigraphy on the presented signs can help both in establishing the time of a particular fact or event in the past (for example, the dates of the life and activity of an outstanding scientist; the time, place and subject of the scientific forum, the opening date of the research institute, educational institution, faculty or department, etc.), and the specifics of conducting scientific research in the field of hygiene, microbiology and epidemiology (pathogens and vectors of diseases; concepts, devices and research methods, methods of diagnosis and prevention of infectious diseases, etc.).

scholarly journals From epidemics to terrorism: Infective agents as specific security risk in contemporary world

2016 ◽  
Vol 68 (2-3) ◽  
pp. 242-255
Author(s):  
Elizabeta Ristanovic
Keyword(s):  
Infectious Diseases ◽  
Climate Changes ◽  
Biological Weapons ◽  
Security Risk ◽  
Security Risks ◽  
New Era ◽  
Contemporary World ◽  
Left Behind ◽  
The Past ◽  
History Of

Infectious diseases are recognized as one of the leading security risks in the changing security architecture of the contemporary world, because of the dimensions of the possible consequences that can provoke, as evidenced by the epidemics that changed the history of mankind in the past (plague, smallpox, Spanish influenza) and the consequences that have been left behind the epidemic of Ebola or AIDS as interplanetary plague of the new era. Migrations and climate changes present the risk of emergency of new or increasing the incidence of existing infectious diseases. Misuse of microorganisms and their products for terrorist purposes-bioterrorism, today also represents a major security risk and real danger, especially because of the possibility of misuse of genetic engineering and biotechnology for the improvement of biological weapons. Therefore, it is important to strengthen the resources at the national and international level for an adequate response to the possible epidemics, as well as prevention and response in the event of bioterrorist acts.

On The Possibility of an Autonomous History of Modern Southeast Asia

1961 ◽  
Vol 2 (2) ◽  
pp. 73-105 ◽  
Author(s):  
John R. W. Small
Keyword(s):  
Southeast Asia ◽  
Contemporary History ◽  
The Past ◽  
History Of

It is generally accepted that history is an element of culture and the historian a member of society, thus, in Croce's aphorism, that the only true history is contemporary history. It follows from this that when there occur great changes in the contemporary scene, there must also be great changes in historiography, that the vision not merely of the present but also of the past must change.

Stellar Evolution

1962 ◽  
Vol 11 (02) ◽  
pp. 137-143
Author(s):  
M. Schwarzschild
Keyword(s):  
Solar System ◽  
Stellar Evolution ◽  
Space Craft ◽  
New Techniques ◽  
Substantial Body ◽  
Individual Stars ◽  
The Past ◽  
Evolution Of Galaxies ◽  
History Of ◽  
Fast Flow

It is perhaps one of the most important characteristics of the past decade in astronomy that the evolution of some major classes of astronomical objects has become accessible to detailed research. The theory of the evolution of individual stars has developed into a substantial body of quantitative investigations. The evolution of galaxies, particularly of our own, has clearly become a subject for serious research. Even the history of the solar system, this close-by intriguing puzzle, may soon make the transition from being a subject of speculation to being a subject of detailed study in view of the fast flow of new data obtained with new techniques, including space-craft.

Sign in / Sign up

Export Citation Format

Share Document