scholarly journals Phenotypic Noise and the Cost of Complexity

2020 ◽  
Author(s):  
Charles Rocabert ◽  
Guillaume Beslon ◽  
Carole Knibbe ◽  
Samuel Bernard

Experimental studies demonstrate the existence of phenotypic diversity despite constant genotype and environment. Theoretical models based on a single phenotypic character predict that during an adaptation event, phenotypic noise should be positively selected far from the fitness optimum because it increases the fitness of the genotype, and then be selected against when the population reaches the optimum. It is suggested that because of this fitness gain, phenotypic noise should promote adaptive evolution. However, it is unclear how the selective advantage of phenotypic noise is linked to the rate of evolution, and whether any advantage would hold for more realistic, multi-dimensional phenotypes. Indeed, complex organisms suffer a cost of complexity, where beneficial mutations become rarer as the number of phenotypic characters increases. By using a quantitative genetics approach, we first show that for a one-dimensional phenotype, phenotypic noise promotes adaptive evolution on plateaus of positive fitness, independently from the direct selective advantage on fitness. Second, we show that for multi-dimensional phenotypes, phenotypic noise evolves to a low-dimensional configuration, with elevated noise in the direction of the fitness optimum. Such a dimensionality reduction of the phenotypic noise promotes adaptive evolution and numerical simulations show that it reduces the cost of complexity.

2011 ◽  
Vol 2011 ◽  
pp. 1-21 ◽  
Author(s):  
Ali Mostofizadeh ◽  
Yanwei Li ◽  
Bo Song ◽  
Yudong Huang

In recent years, many theoretical and experimental studies have been carried out to develop one of the most interesting aspects of the science and nanotechnology which is called carbon-related nanomaterials. The goal of this paper is to provide a review of some of the most exciting and important developments in the synthesis, properties, and applications of low-dimensional carbon nanomaterials. Carbon nanomaterials are formed in various structural features using several different processing methods. The synthesis techniques used to produce specific kinds of low-dimensional carbon nanomaterials such as zero-dimensional carbon nanomaterials (including fullerene, carbon-encapsulated metal nanoparticles, nanodiamond, and onion-like carbons), one-dimensional carbon nanomaterials (including carbon nanofibers and carbon nanotubes), and two-dimensional carbon nanomaterials (including graphene and carbon nanowalls) are discussed in this paper. Subsequently, the paper deals with an overview of the properties of the mainly important products as well as some important applications and the future outlooks of these advanced nanomaterials.


1995 ◽  
Vol 23 (2) ◽  
pp. 116-135 ◽  
Author(s):  
H. Shiobara ◽  
T. Akasaka ◽  
S. Kagami ◽  
S. Tsutsumi

Abstract The contact pressure distribution and the rolling resistance of a running radial tire under load are fundamental properties of the tire construction, important to the steering performance of automobiles, as is well known. Many theoretical and experimental studies have been previously published on these tire properties. However, the relationships between tire performances in service and tire structural properties have not been clarified sufficiently due to analytical and experimental difficulties. In this paper, establishing a spring support ring model made of a composite belt ring and a Voigt type viscoelastic spring system of the sidewall and the tread rubber, we analyze the one-dimensional contact pressure distribution of a running tire at speeds of up to 60 km/h. The predicted distribution of the contact pressure under appropriate values of damping coefficients of rubber is shown to be in good agreement with experimental results. It is confirmed by this study that increasing velocity causes the pressure to rise at the leading edge of the contact patch, accompanied by the lowered pressure at the trailing edge, and further a slight movement of the contact area in the forward direction.


2014 ◽  
Vol 6 (1) ◽  
pp. 1032-1035 ◽  
Author(s):  
Ramzi Suleiman

The research on quasi-luminal neutrinos has sparked several experimental studies for testing the "speed of light limit" hypothesis. Until today, the overall evidence favors the "null" hypothesis, stating that there is no significant difference between the observed velocities of light and neutrinos. Despite numerous theoretical models proposed to explain the neutrinos behavior, no attempt has been undertaken to predict the experimentally produced results. This paper presents a simple novel extension of Newton's mechanics to the domain of relativistic velocities. For a typical neutrino-velocity experiment, the proposed model is utilized to derive a general expression for . Comparison of the model's prediction with results of six neutrino-velocity experiments, conducted by five collaborations, reveals that the model predicts all the reported results with striking accuracy. Because in the proposed model, the direction of the neutrino flight matters, the model's impressive success in accounting for all the tested data, indicates a complete collapse of the Lorentz symmetry principle in situation involving quasi-luminal particles, moving in two opposite directions. This conclusion is support by previous findings, showing that an identical Sagnac effect to the one documented for radial motion, occurs also in linear motion.


Author(s):  
Parviz Enany ◽  
Oleksandr Shevchenko ◽  
Carsten Drebenstedt

AbstractThis paper presents experimental studies on the optimization of air–water flow in an airlift pump. Airlift pumps use compressed gas to verticall transport liquids and slurries. Due to the lack of theoretical equations for designing and predicting flow regimes, experimental investigations must be carried out to find the best condition to operate an airlift pump at high efficiency. We used a new air injection system and different submergence ratios to evaluate the output of a simple pump for vertical displacement of water in an underground mine. The tests were carried out in a new device with 5.64 m height and 10.2 cm circular riser pipe. Three air-jacket pipes, at different gas flows in the range of 0.002–0.09 m3/s were investigated with eight submergence ratios. It was found that with the same air flow rate, the most efficient flow of water was achieved when an air jacket with 3 mm diameter holes was used with a submergence ratio between 0.6 and 0.75. In addition, a comparison of practical results with two theoretical models proposed by other investigators showed that neither was able to accurately predict airlift performance in air–water flow mode.


2011 ◽  
Vol 41 (11) ◽  
pp. 2155-2167 ◽  
Author(s):  
Xavier Sanchez ◽  
Elena Roget ◽  
Jesus Planella ◽  
Francesc Forcat

Abstract The theoretical models of Batchelor and Kraichnan, which account for the smallest scales of a scalar field passively advected by a turbulent fluid (Prandtl > 1), have been validated using shear and temperature profiles measured with a microstructure profiler in a lake. The value of the rate of dissipation of turbulent kinetic energy ɛ has been computed by fitting the shear spectra to the Panchev and Kesich theoretical model and the one-dimensional spectra of the temperature gradient, once ɛ is known, to the Batchelor and Kraichnan models and from it determining the value of the turbulent parameter q. The goodness of the fit between the spectra corresponding to these models and the measured data shows a very clear dependence on the degree of isotropy, which is estimated by the Cox number. The Kraichnan model adjusts better to the measured data than the Batchelor model, and the values of the turbulent parameter that better fit the experimental data are qB = 4.4 ± 0.8 and qK = 7.9 ± 2.5 for Batchelor and Kraichnan, respectively, when Cox ≥ 50. Once the turbulent parameter is fixed, a comparison of the value of ɛ determined from fitting the thermal gradient spectra to the value obtained after fitting the shear spectra shows that the Kraichnan model gives a very good estimate of the dissipation, which the Batchelor model underestimates.


2021 ◽  
Vol 1038 ◽  
pp. 336-344
Author(s):  
Olena Pinchevska ◽  
Andriy Spirochkin ◽  
Denys Zavialov ◽  
Rostislav Oliynyk

The reasons of white spots appearance in the middle of oak timber are determined. These white spots reduce the cost of the lamina made of oak timbers - the front covering of floorboards. It is proposed to intensify the drying process by using oscillating drying schedules to avoid this defect. A method for calculating the duration of such drying is proposed. This method includes the peculiarities of heating and cooling periods kinetics of oak timbers with 25 mm and 30 mm thickness. The inexpediency of using the oscillation of the drying agent parameters in the range of wood moisture content below 20% has been established. An adequate model for calculating wood temperature and air humidity during wood heating and cooling periods has been developed using heat and mass transfer criteria and experimentally determined oak wood moisture conductivity coefficient. Based on the results of theoretical and experimental studies oscillating drying schedules of different thickness oak timbers are offered. Tests of the proposed schedules in industrial conditions showed no discoloration of the central layers of European oak (Quercus robur) timbers. The drying process duration was reduced by 1.5–2.4 times and energy consumption were reduced by 1.53 times.


Energies ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 2428 ◽  
Author(s):  
Fei Shen ◽  
Linsong Cheng ◽  
Qiang Sun ◽  
Shijun Huang

Recently, commingling production has been widely used for the development of offshore heavy oil reservoirs with multilayers. However, the differences between layers in terms of reservoir physical properties, oil properties and pressure have always resulted in interlayer interference, which makes it more difficult to evaluate the producing degree of commingled production. Based on the Buckley–Leverett theory, this paper presents two theoretical models, a one-dimensional linear flow model and a planar radial flow model, for water-flooded multilayer reservoirs. Through the models, this paper establishes a dynamic method to evaluate seepage resistance, sweep efficiency and recovery percent and then conducts an analysis with field data. The result indicates the following: (1) the dynamic difference in seepage resistance is an important form of interlayer interference during the commingled production of an offshore multilayer reservoir; (2) the difference between commingled production and separated production is small within a certain range of permeability ratio or viscosity ratio, but separated production should be adopted when the ratio exceeds a certain value.


Author(s):  
C. Stuart Daw ◽  
K. Dean Edwards ◽  
Robert M. Wagner ◽  
Johney B. Green

Spark assist appears to offer considerable potential for increasing the speed and load range over which homogeneous charge compression ignition (HCCI) is possible in gasoline engines. Numerous experimental studies of the transition between conventional spark-ignited (SI) propagating-flame combustion and HCCI combustion in gasoline engines with spark assist have demonstrated a high degree of deterministic coupling between successive combustion events. Analysis of this coupling suggests that the transition between SI and HCCI can be described as a sequence of bifurcations in a low-dimensional dynamic map. In this paper, we describe methods for utilizing the deterministic relationship between cycles to extract global kinetic rate parameters that can be used to discriminate multiple distinct combustion states and develop a more quantitative understanding of the SI-HCCI transition. We demonstrate the application of these methods for indolene-containing fuels and point out an apparent HCCI mode switching not previously reported. Our results have specific implications for developing dynamic combustion models and feedback control strategies that utilize spark assist to expand the operating range of HCCI combustion.


Since blood transfusion is linked to the magnitude of the surgical procedure, comparing transfused patients to untransfused patients will always be confounded by infection risks due to factors related to the procedure. To control for these factors one must compare patients transfused with red cells from different sources or prepared in a manner which minimize infection risk. Patients transfused with homologous blood have infection rates several fold higher than recipients of equal values of autologous blood undergoing the same operative procedure (20-23). Homologous blood recipients have significantly longer hospital stays attributed to treating infections. The cost of a blood transfusion exceeds the cost of collection, storage and administration because of transfusion's association with length of stay. In this era of cost-containment the association with prolonged stay may ultimately curtail the use of blood. Homologous blood can be filtered to remove donor leukocytes which may be contributing to immune suppression and infection risk. A prospective randomized trial comparing the infection rates among colorectal cancer patients receiving filtered and unfiltered blood has been conducted (9). There were 17 infectious complications among the 56 recipients of whole blood and one infectious complication among the 48 recipients of filtered blood. Infections were prevented by the seemingly simplistic addition of a $25/filter to every bag of blood transfused. These clinical studies are very convincing: homologous blood transfusion is associated with increased risk of infection in every clinical situation examined. In multivariate analyses transfusion was a significant predictor of infection after consideration of other variables measured and in the majority of those studies transfusion was the single most significant factor. Patients receiving homologous blood exhibited an incidence of infectious complications that was approximately four times higher than patients receiving autologous blood. The association of transfusion with infection is found among patients undergoing surgery for cardiac, orthopedic and gastrointestinal disorders and for trauma as well as among unoperated patients transfused for bums and gastrointestinal bleeding. The observation that nosocomial infections are increased in these studies argues strongly that the association of transfusion with infection is not simply a reflection of transfusion as a marker of tissue destruction and contamination. Infections that develop in transfused patients away from the site of trauma or in the absence of trauma, cannot be attributed to the quantity of tissue destroyed or to the degree of bacterial contamination. Filtered blood can remove leukocytes and prevent postoperative infections. Since filtering blood can significantly reduce the incidence of infection among transfused patients, all transfused blood will be passing through filters in the very near future. EXPERIMENTAL STUDIES RELATING BLOOD TRANSFUSION TO INCREASED RISK OF INFECTION Patients are extremely heterogeneous and even in prospective randomized trials, factors which influence patients' participation affect the outcome despite double-blinding and randomization. In animal studies using syngeneic strains with identical housing, lighting, access to food and water, control over the extent of injury, use of antibiotics and exposure to other variables the influence of a single variable such as blood transfusion can be measured. Dr. Waymack's laboratory has intensively studied parameters which interact with transfusion in

1995 ◽  
pp. 296-296

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