COVID-19 Fatality and Comorbidity Risk Factors among Diagnosed Patients in Mexico

AbstractAs of April 18, 2020, 2.16 million patients in the world had been tested positive with Coronavirus (COVID-19) and 146,088 had died, which accounts for a case fatality rate of 6.76%. In Mexico, according to official statistics (April 18), 7,497 cases have been confirmed with 650 deaths, for a case fatality rate of 8.67%. These estimates, however, may not reflect the final fatality risk among COVID-19 confirmed patients, because they are based on cross-sectional counts of diagnosed and deceased patients, and therefore are not adjusted by time of exposure and right-censorship. In this paper we estimate fatality risks based on survival analysis methods, calculated from individual-level data on symptomatic patients confirmed with COVID-19 recently released by the Mexican Ministry of Health. The estimated fatality risk after 35 days of onset of symptoms is 12.38% (95% CI: 11.37-13.47). Fatality risks sharply rise with age, and significantly increase for males (59%) and individuals with comorbidities (38%-168%, depending on the disease). Two reasons may explain the high COVID-19 related fatality risk observed in Mexico, despite its younger age structure: the high selectivity and self-selectivity in testing and the high prevalence of chronic-degenerative diseases.

Download Full-text

Sebaran Infeksi Leptospira Patogenik pada Tikus dan Cecurut di Daerah Pasca Banjir Kabupaten Pati dan Endemis Boyolali

BALABA JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA ◽

10.22435/blb.v13i2.279 ◽

2018 ◽

pp. 173-182

Author(s):

Zumrotus Sholichah ◽

Rahmawati Rahmawati

Keyword(s):

Case Fatality Rate ◽

Endemic Area ◽

Case Fatality ◽

Google Earth ◽

Transmission Risk ◽

Random Pattern ◽

Fatality Rate ◽

Pathogenic Leptospira ◽

Cross Sectional ◽

Cross Sectional Design

Until March 2014 leptospirosis cases and its Case Fatality Rate increased in Pati and Boyolali. This study aims to describe distribution of infected rats and shrews in flood area in Pati and endemic area in Boyolali. Research carried out by the cross sectional design on March-April 2014. Coordinate of Leptospira infected rats and shrews were mapped using google earth with home range buffer. Data analyzed descriptively to describe distribution of infected rats and shrews. Pathogenic Leptospira sp. infected rats and shrews spread with random pattern. This results could be an explanation of higher transmission risk. of leptospirosis in the area of study

Download Full-text

Global epidemiology of septic shock: a protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2019-032289 ◽

2019 ◽

Vol 9 (11) ◽

pp. e032289

Author(s):

Frank Leonel Tianyi ◽

Joel Noutakdie Tochie ◽

Celestin Danwang ◽

Aime Mbonda ◽

Mazou N Temgoua ◽

...

Keyword(s):

Systematic Review ◽

Septic Shock ◽

Case Fatality Rate ◽

Hospital Admissions ◽

Meta Analysis ◽

Case Fatality ◽

Primary Study ◽

Fatality Rate ◽

Cross Sectional ◽

Global Epidemiology

BackgroundSeptic shock is a life-threatening infection frequently responsible for hospital admissions or may be acquired as nosocomial infection in hospitalized patients with resultant significant morbidity and mortality . There is a dearth of data on a résumé and meta-analysis on the global epidemiology of this potentially deadly condition. Therefore, we propose the first systematic review to synthesize existing data on the global incidence, prevalence and case fatality rate of septic shock worldwide.MethodsWe will include cross-sectional, case-control and cohort studies reporting on the incidence, and case fatality rate of septic shock. Electronic databases including PubMed, Embase, WHO Global Health Library and Web of Science will be searched for relevant records published between 1 January 2000 and 31 August 2019. Independents reviewers will perform study selection and data extraction, as well as assessment of methodological quality of included studies. Appropriate meta-analysis will then be used to pool studies judged to be clinically homogenous. Egger’s test and funnel plots will be used to detect publication bias. Findings will be reported and compared by human development level of countries.Ethics and disseminationBeing a review, ethical approval is not required as it was obtained in the primary study which will make up the review. This review is expected to provide relevant data to help in evaluating the burden of septic shock in the general population. The overall findings of this research will be published in a peer-reviewed journal.PROSPERO registration numberCRD42019129783.

Download Full-text

Road Traffic Collisions—Case Fatality Rate, Crash Injury Rate, and Number of Motor Vehicles: Time Trends between a Developed and Developing Country

The American Surgeon ◽

10.1177/000313481007600933 ◽

2010 ◽

Vol 76 (9) ◽

pp. 977-981 ◽

Cited By ~ 3

Author(s):

Sanchia S. Goonewardene ◽

Khalid Baloch ◽

Keith Porter ◽

Ian Sargeant ◽

Gamini Punchihewa

Keyword(s):

Visual Impairment ◽

Case Fatality Rate ◽

Road Traffic ◽

Case Fatality ◽

Injury Rate ◽

Cross Sectional Study ◽

Motor Vehicles ◽

Fatality Rate ◽

Cross Sectional ◽

The Uk

Road traffic collisions (RTCs) are one of the most common preventable causes of death and disability worldwide. We investigated changes in numbers of motor vehicles, case fatality rate, and crash injury rate for the most present recorded year (2002) 5 and 10 years before that in the United Kingdom (UK) and Sri Lanka (SL). We also investigated environmental and individual factors impacting patients at South Birmingham Trauma Unit, UK and Colombo General Hospital, SL. We conducted a descriptive cross-sectional study (both quantitative and qualitative). Over the 10-year period, numbers of motor vehicles have risen in both countries; the crash injury remained stable in both countries. Case fatality rate (far higher) in SL has decreased, as in the UK. Three hundred and twenty-five patients took part in the survey in SL, with 83 in the UK. In the categories investigated, including patient demographics, RTC environment, visual impairment, pedestrian and driver factors, the majority of results were significantly different between the two countries. Target factors such as inadequate street lighting, visual impairment, speeding, and not wearing seatbelts at time of accident were identified, and recommendations developed as a result.

Download Full-text

Regional Differences in Epidemiological and Clinical Characteristics, Treatment, and Clinical Outcomes of COVID-19 in Wuhan and Remote Areas of Hubei Province

Frontiers in Medicine ◽

10.3389/fmed.2021.667623 ◽

2021 ◽

Vol 8 ◽

Author(s):

Honggang Ren ◽

Xingyi Guo ◽

Antonio Palazón-Bru ◽

Pengcheng Yang ◽

Nan Huo ◽

...

Keyword(s):

Regional Differences ◽

Case Fatality Rate ◽

Clinical Characteristics ◽

Case Fatality ◽

Cross Sectional Study ◽

Hubei Province ◽

Fatality Rate ◽

Cross Sectional ◽

Suburban Areas

Background: The Coronavirus disease 2019 (COVID-19) pandemic has been a major threat to global health. Regional differences in epidemiological and clinical characteristics, treatment and outcomes of patients have not yet been investigated. This study was conducted to investigate these differences amongCOVID-19 patients in Hubei Province, China.Methods: This retrospective cross-sectional study analyzed data on 289 COVID-19 patients from designated hospitals in three regions:Urban (Wuhan Union West Hospital), Suburban areas of Wuhan (Hannan Hospital) and Enshi city, between February 8 and 20, 2020. The final date of follow-up was December 14th, 2020. The outcomes were case fatality rate and epidemiological and clinical data.Results: Urban Wuhan experienced a significantly higher case fatality rate (21.5%) than suburban Wuhan (5.23%) and rural area of Enshi (3.51%). Urban Wuhan had a higher proportion of patients on mechanical ventilation (24.05%) than suburban Wuhan (0%) and rural Enshi (3.57%). Treatment with glucocorticoids was equivalent in urban and suburban Wuhan (46.84 and 45.75%, respectively) and higher than Enshi (25.00%). Urban Wuhan had a higher proportion of patients with abnormal tests including liver function and serum electrolytes and a higher rate of pneumonia (p < 0.01 for all). Urban Wuhan also had a higher incidence of respiratory failure, heart disease, liver disease and shock, compared with the other two regions (all p < 0.05).Conclusions: Our findings revealed that there are regional differences in COVID-19. These findings provide novel insights into the distribution of appropriate resources for the prevention, control and treatment of COVID-19 for the global community.

Download Full-text

Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: a Cross-Sectional Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx162.054 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S22-S22

Author(s):

Igor Thiago Queiroz ◽

Jessika Thais Da Silva Maia ◽

Gleysson Rosa ◽

Tatyana Vidal Mendes ◽

S Jayne Alves Vidal ◽

...

Keyword(s):

Case Fatality Rate ◽

Case Fatality ◽

Rio Grande ◽

Cross Sectional Study ◽

High Rate ◽

Fatality Rate ◽

Sectional Study ◽

Zikv Infection ◽

Cross Sectional ◽

Congenital Zika Syndrome

Abstract Background Many studies have demonstrated a causal link between Zika virus (ZIKV) infection, microcephaly (MCP), and other congenital abnormalities (CA). This study aimed to determine perinatal case fatality rate in cases of Congenital Zika Syndrome (CZS) in the Rio Grande do Norte State (RN), a Brazilian Northeast State highly impacted by the Zika virus outbreak. Methods A cross-sectional study was conducted using data obtained through the State Health Department (SHD) for cases of MCP and CA in Rio Grande do Norte from April 2015 to February 5, 2016. Definition of perinatal period: commences at 22 completed weeks (154 days) of gestation and ends seven completed days after birth. Results During the study period, there were 486 cases of MCP and others CA notified in RN, of which 142 were confirmed and 108 remain under investigation. The remaining 236 cases have been ruled out by presenting normal examinations or due to presenting microcephaly by noninfectious causes. Of the total confirmed cases, 26.7% (38/142) died after birth or during pregnancy. 15.78% (06/38) of confirmed deaths had ZIKV infection during pregnancy and 2.63% (01/38) had a positive TORCH blood test. The six cases related to ZIKV were confirmed by RT–PCR and/or IgM/IgG antibodies against ZIKV. The remaining cases of deaths remain either under investigation or have been ruled out. Conclusion This study highlights a high rate of perinatal lethality (15.78%) in cases of CZS. Despite the growing number of CZS cases, the real incidence and prevalence might be higher due to the underreporting and lack of resources for confirmatory diagnostic tests (laboratory and imaging). Due to the high rate of lethality and the ongoing uncontrolled ZIKV outbreak, this study predicts an increase in the infant mortality rate in Brazil and highlights the need for developing public health programs to control the ZIKV outbreak. Disclosures All authors: No reported disclosures.

Download Full-text

Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: A Cross-Sectional Study

Pediatric Neurology ◽

10.1016/j.pediatrneurol.2017.11.012 ◽

2018 ◽

Vol 81 ◽

pp. 47-48 ◽

Cited By ~ 2

Author(s):

Nilson N. Mendes Neto ◽

Jessika Thais da Silva Maia ◽

Marcelo Rodrigues Zacarkim ◽

Igor Queiroz ◽

Angelle Desiree Labeaud ◽

...

Keyword(s):

Case Fatality Rate ◽

Case Fatality ◽

Cross Sectional Study ◽

Fatality Rate ◽

Sectional Study ◽

Cross Sectional ◽

Congenital Zika Syndrome

Download Full-text

Case Fatality Rate of COVID-19 and Association With Sociodemographic Characteristics of Populations in Ecuador, 2020

10.21203/rs.3.rs-444898/v1 ◽

2021 ◽

Author(s):

Karla Flores Sacoto ◽

Galo Sánchez Del Hierro ◽

Xavier Jarrín Estupiñan ◽

Felipe Moreno-Piedrahita Hernandez

Keyword(s):

Death Rate ◽

Case Fatality Rate ◽

Case Fatality ◽

Sociodemographic Factors ◽

Cross Sectional Study ◽

Secondary Outcome ◽

Morbidity Rate ◽

Fatality Rate ◽

Cross Sectional ◽

The Impact

Abstract Background COVID-19 has caused deaths worldwide affecting the most vulnerable population with different case fatality rates. Socioeconomic conditions have demonstrated a role regarding the spread of infections and mortality. Socioeconomic characteristics of Ecuador related to poverty, ethnicity and demographic characteristics increase the impact of COVID-19 in certain populations. Methods Objective To analyze the influence of demographic factors on the COVID-19 case fatality rate (CFR) in Ecuador. Design: cross sectional study. Setting 24 provinces in Ecuador-221 cantons. Population: data including 233.277 confirmed COVID-19 cases of Ecuador. Primary and secondary outcome measures COVID-19 CFR and crude cause-specific death rate weight calculated using province-country level data from health ministry of Ecuador in data website. Results Ecuadors CFR is 4,03%, analyzed by cantons the CFR increases to a median of 5,75%, with cantons like Playas with a CFR of 32,39%. The morbidity rate has a median of 795,31 per 100 000 hab. with the highest rate in Isabela-Galápagos (10185,49), Aguarico-Orellana (9506,75) and Baños-Tungurahua (4156,85). And the crude COVID-19 death rate has a median of 39,73 per 100 000 hab. with the highest rate in Penipe-Chimborazo (201,29), 24 de Mayo-Manabí (143,79) and San Pedro de Huaca-Carchi (134,36). The correlations show relations with sociodemographic factors like poverty, ethnicity and scholarity. Conclusion The CFR is the proxy indicator of COVID-19 impact in Ecuador and the analysis made by location give us new information about the specific impact of this disease.

Download Full-text

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI OUTCOME TERAPI PASIEN PNEUMONIA DI RUMAH SAKIT UMUM PUSAT FATMAWATI JAKARTA

Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) ◽

10.22487/j25020749.2019.v5.i3.14049 ◽

2019 ◽

Vol 5 (3) ◽

pp. 18

Author(s):

Feri Setiadi ◽

Shirly Kumala ◽

Hesty Utami R ◽

Ahmad Subhan

Keyword(s):

Case Fatality Rate ◽

Case Fatality ◽

Community Acquired Pneumonia ◽

Fatality Rate ◽

Chi Square ◽

Cross Sectional ◽

Hospital Acquired Pneumonia ◽

Hospital Acquired

Berdasarkan data Riset Kesehatan Dasar (Riskesdas)2018 prevalensi pneumonia di jakarta 2.3 %. Pneumoni mempunyai case fatality rate (CFR) yang tinggi yaitu 7.6% sehingga beresiko mempunyai outcome terapi yang tidak baik. Oleh karena itu penelitian ini bertujuan menganalisis faktor-faktor yang mempengaruhi outcome terapi pasien pneumonia di RSUP Fatmawati. Penelitian ini dilakukan secara retrospektif dengan metode cross sectional pada pasien pneumonia (hospital acquired pneumonia/HAP dan community-acquired pneumonia/CAP) yang memenuhi kriteria inklusi selama periode januari-september 2018. Penelitian ini dilakukan dengan pengkajian data rekam medis pasien. Ada dua jenis outcome terapi yang digunakan yaitu pasien pulang/sembuh dan pasien meninggal. Analisis faktor yang mempengaruhi outcome dilakukan dengan uji chi square menggunakan SPSS. Selama penelitian didapatkan 40 pasien memenuhi kriteria inklusi terdiri dari 22 HAP dan 18 CAP. Hasil umur pasien (65.0%) berada pada kelompok usia 17-65 tahun. Lebih banyak pasien laki-laki (57.5%) dibandingkan pasien perempuan (42.5%). Sebagian besar pasien (37.5%) di rawat selama 8-14 hari. Penggunaan antibiotik (35.0%) terbanyak digunakan antibiotik ceftriaxone golongan sefalosporin. Proporsi pasien dengan outcome sembuh/pulang sebanyak (52.5%) dan pasien meninggal ( 47.5%). Hasil analisis statistik menunjukkan faktor yang signifikan mempengaruhi outcome adalah penyakit penyerta (P=0.022) Adapun faktor yang tidak ada hubungan bermakna terhadap outcome pasien pneumonia yaitu: usia pasien, lama perawatan dan kerasionalan antibiotik.

Download Full-text

Pengetahuan Dan Sikap Masyarakat Dalam Mencegah Leptospirosis di Desa Pabelan Kabupaten Sukoharjo

Talenta Conference Series Tropical Medicine (TM) ◽

10.32734/tm.v1i1.34 ◽

2018 ◽

Vol 1 (1) ◽

pp. 13-17

Author(s):

Agus Sudaryanto ◽

Fatkhurrohman Ilham Fuadi ◽

Endang Zulaicha Susilaningsih

Keyword(s):

Quantitative Research ◽

Case Fatality Rate ◽

Case Fatality ◽

Preventive Measure ◽

Fatality Rate ◽

Cross Sectional ◽

Positive Attitudes ◽

Cross Sectional Design ◽

Severe Leptospirosis ◽

The Relationship

Leptospirosis merupakan penyakit zoonosis yang mempunyai dampak signifikan terhadap kesehatan di banyak belahan dunia beriklim sub tropis dan tropis. Bakteri Leptospira merupakan penyebab leptospirosis yang dapat menyerang hewan dan manusia. Infeksi pada manusia merupakan kejadian yang bersifat insidental, karena reservoir atau penyebar utama Leptospira adalah tikus. Air kencing tikus yang terinfeksi Leptospira terbawa banjir dan dapat masuk ke tubuh manusia melalui kulit yang terluka dan selaput mukosa. Semua kasus leptospirosis ringan (anikterik) dapat sembuh sempurna, berbeda dengan leptospirosis berat (ikterik) yang mempunyai angka Case Fatality Rate tinggi, antara 5%-40%. Upaya pencegahan merupakan salah satu cara untuk menekan angka kejadian leptospirosis, diantaranya ialah dengan menumbuhkan sikap dan pengetahuan yang baik tentang leptospirosis. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan dengan sikap masyarakat dalam mencegah leptospirosis di Desa Pabelan, Kecamatan Kartasura, Kabupaten Sukoharjo. Jenis penelitian ini adalah kuantitatif dengan menggunakan rancangan cross sectional. Sampel dalam penelitian ini adalah masyarakat Desa Pabelan sejumlah 212 responden dengan menggunakan accidental sampling. Mayoritas responden mempunyai pengetahuan yang kurang (53,3%). Sebaliknya, 80,7% dari responden mempunyai skor sikap yang baik. Leptospirosis is a zoonotic disease which has a significant effect on human health most commonly found in tropical or sub-tropical countries. Leptospira bacteria is the cause of leptospirosis which can attack animals and humans. Infection in humans is accidental, because the main reservoir or spreader of leptospira is rodents. The urine of infected rodents carried away by floodwaters can enter the human body through broken skin and mucous membranes. All patients with mild leptospirosis (anicteric) can recover completely. It is very different from patients with severe leptospirosis (jaundice) who have a high case fatality rate from 5% to 40%. Preventive measure is one way to reduce the incidence of leptospirosis by developing positive attitudes and improving good knowledge about leptospirosis. The objective of this study was to determine the relationship between knowledge and attitudes of the community concerning on the prevention of leptospirosis in Pabelan village, Sukoharjo Regency. This study employed quantitative research with a cross sectional design in a sample of 212 respondents from Pabelan village selected by using accidental sampling. Majority of respondents demonstrated moderate knowledge (53.3%). However, 80.7% of the them demonstrated good attitude scores.

Download Full-text

Estimates of COVID-19 case-fatality risk from individual-level data

10.1101/2020.04.16.20067751 ◽

2020 ◽

Cited By ~ 2

Author(s):

Simona Bignami-Van Assche ◽

Daniela Ghio ◽

Ari Van Assche

Keyword(s):

Case Fatality ◽

Event History ◽

Canadian Province ◽

Fatality Risk ◽

Individual Level ◽

Level Data ◽

The World ◽

Simple Ratio ◽

Case Fatality Risk ◽

True Measure

ABSTRACTWhen calculated from aggregate data on confirmed cases and deaths, the case-fatality risk (CFR) is a simple ratio between the former and the latter, which is prone to numerous biases. With individual-level data, the CFR can be estimated as a true measure of risk as the proportion of incidence for the disease. We present the first estimates of the CFR for COVID-19 by age and sex based on event history modelling of the risk of dying among confirmed positive individuals in the Canadian province of Ontario, which maintains one of the few individual-level datasets on COVID-19 in the world.

Download Full-text