scholarly journals Clinical and laboratory evaluation of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma: a prospective study

2020 ◽  
Author(s):  
Michele Donato ◽  
Steven Park ◽  
Melissa Baker ◽  
Robert Korngold ◽  
Alison Morawski ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Prospective Study ◽  
Antiviral Therapy ◽  
High Titer ◽  
Laboratory Evaluation ◽  
Respiratory Syndrome Virus ◽  
Clinical Parameters ◽  
A Prospective Study

Background Effective antiviral therapy against the severe acute respiratory syndrome virus 2 (SARS-CoV-2) remains elusive. Convalescent plasma is an anti-viral approach currently under investigation. We aimed to assess the laboratory and clinical parameters of patients with COVID-19 pneumonia treated with convalescent plasma containing high levels of neutralizing anti-SARS-CoV-2 antibodies.

scholarly journals Epistaxis as a marker for severe acute respiratory syndrome coronavirus-2 status – a prospective study

2020 ◽  
Vol 134 (8) ◽  
pp. 717-720 ◽  
Author(s):  
MH Hussain ◽  
M Mair ◽  
P Rea
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Prospective Study ◽  
Control Group ◽  
Study Group ◽  
Chain Reaction ◽  
Polymerase Chain Reaction Testing ◽  
The Mean ◽  
Polymerase Chain ◽  
The Difference ◽  
A Prospective Study

AbstractObjectiveTo evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.MethodsA prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.ResultsThe mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).ConclusionEpistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.

Hepatocellular carcinoma following direct acting antiviral therapy does not display an aggressive pattern: a prospective study

2020 ◽  
Vol 73 ◽  
pp. S622-S623
Author(s):  
Reham Soliman ◽  
Nabiel Mikhail ◽  
ayman hassan ◽  
Talal Amer ◽  
Mohammed Eslam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prospective Study ◽  
Antiviral Therapy ◽  
Direct Acting Antiviral ◽  
Direct Acting ◽  
A Prospective Study

scholarly journals ROLE OF LUNG ULTRASOUND FOR THE ETIOLOGICAL DIAGNOSIS OF COMMUNITY- ACQUIRED PNEUMONIA IN CHILDREN: A PROSPECTIVE STUDY

2020 ◽  
Author(s):  
Danilo Buonsenso ◽  
Annamaria Musolino ◽  
Valentina Ferro ◽  
Cristina De Rose ◽  
Rosa Morello ◽  
...  
Keyword(s):  
Prospective Study ◽  
Lung Ultrasound ◽  
Community Acquired Pneumonia ◽  
Clinical Parameters ◽  
Etiological Diagnosis ◽  
Size Number ◽  
Ultrasound Findings ◽  
Personalized Approach ◽  
A Prospective Study

ABSTRACTObjective and designOur prospective study is one of the largest prospective study assessing the role of detailed lung ultrasound features to discriminate the etiological diagnosis of Community acquired pneumonia (CAP) in children.MethodologyWe prospectively analysed patients aged from 1 month to 17 years admitted between March 2018 and April 2020 who were hospitalized for CAP. For all patients included in the study, history, clinical parameters, microbiological data, and lung ultrasound data were collected.Patients were stratified into three main groups (“bacterial”, “viral”, “atypical”) according to the presumed microbial aetiology and lung ultrasound findings evaluated according to the aetiological group.ResultsWe found that some ultrasound findings as size, number and distribution of consolidations, the position and motion of air bronchograms, pleural effusions and distribution of vertical artifacts significantly differ (p < 0.05) in children with bacterial, viral and atypical CAP. Conversely, clinical parameters and laboratory were not able to significantly distinguish between these groups. Chest x-ray, despite being still widely used, was the less useful tool in this discrimination.ConclusionOur study provides a detailed analysis of LUS features able to predict the etiology CAP in children. These findings may help the physicians to better manage a child with CAP and to offer personalized approach, from diagnosis to treatment and follow-up.

scholarly journals Surgery Safety Protocol for Patients and Staff During the COVID-19 Global Pandemic – A Prospective Study of 78 Consecutive, Open and Laparoscopic Surgical Procedures

2020 ◽  
pp. 1-6
Author(s):  
Gianluca Matteo Sampietro ◽  
Gianluca Matteo Sampietro ◽  
Carlo Corbellini ◽  
Caterina Baldi ◽  
Salvatore Barberi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Severe Acute Respiratory Syndrome ◽  
Prospective Study ◽  
Older Men ◽  
Northern Italy ◽  
Gas Filtration ◽  
Global Pandemic ◽  
Laparoscopic Surgical Procedures ◽  
A Prospective Study ◽  
Surgical Pathway

Background: To evaluate safety, for patients and staff, and efficacy of a protocol for the surgical treatment of patients during COVID-19 pandemic (50 days period) in a hospital located in the northern Italy. Methods: Two different pathways were adopted (non-COVID-19 and COVID-19), with dedicated OR and ICU, and PPE for personnel. A monitoring of patients and staff for COVID-19 was carried out. Results: 78 patients were included. Laparoscopy was used in 33.4% without gas filtration. COVID-19- positive patients (11.5%) were older men (0.04%), with elevated ASA score (0.002), and two or more comorbidities (0.02). They experienced longer hospitalization (0.003), more complications and more deaths (0.0001). All COVID-19 related deaths were due to severe acute respiratory syndrome. None of the patients included resulted infected, but one out of 47 staff personnel (<2%). Conclusion: COVID-19 is largely unknown, but a safe and effective surgical pathway is feasible.

scholarly journals Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0253072
Author(s):  
Ozguc Takmaz ◽  
Eren Kaya ◽  
Burak Erdi ◽  
Gozde Unsal ◽  
Pari Sharifli ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Prospective Study ◽  
Study Design ◽  
Vaginal Swab ◽  
Reproductive Age ◽  
Inpatient Service ◽  
Women Of Reproductive Age ◽  
Vaginal Swabs ◽  
A Prospective Study ◽  
Pcr Test

Objective To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed with coronavirus disease-19 (COVID-19) pneumonia. Study design The study was conducted prospectively in a university affiliated hospital. Forty-one women of reproductive age whose nasopharyngeal PCR test were positive for SARS-CoV-2 and clinically diagnosed with pneumonia were included in the study. Vaginal swabs were obtained for SARS-CoV-2 PCR tests when the patients were admitted to the inpatient service before pneumonia treatment was initiated. Results Vaginal swab samples of 38 patients were analysed with SARS-CoV-2 PCR tests. None of the vaginal swabs were positive for SARS-CoV-2. Conclusions SARS-CoV-2 does not infect the vagina of women diagnosed with SARS-CoV-2 pneumonia.

scholarly journals A study of hypertensive disorders of pregnancy and the fetal outcome in a tertiary care hospital: a prospective study

2020 ◽  
Vol 9 (8) ◽  
pp. 3275
Author(s):  
Sangamesh S. Mathapati ◽  
Aruna M. Biradar ◽  
Laxmi S. Sangolli ◽  
Nidhi A. Mangalwadi ◽  
Gamini B. S. ◽  
...  
Keyword(s):  
Prospective Study ◽  
Laboratory Evaluation ◽  
Research Centre ◽  
Hypertensive Disorder ◽  
Care Hospital ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
A Prospective Study ◽  
In Pregnancy

Background: Pregnancy induced hypertension is one of the major causes of feto maternal morbidity and mortality in pregnancy. The exact cause of PIH is unknown certain factors are known to increase the risk of PIH such as risk factor includes that young women with first pregnancy.Methods: The objective of this study was to assess the socio-demographic and clinico-pathological profile of the patients with hypertensive disorders of pregnancy and its associated fetal outcomes. A prospective study was conducted in department of obstetrics and gynecology Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura Karnataka from 15th July to 15th December 2018. All women admitted to labour ward with diagnosis of hypertensive disorders of pregnancy were included in the study after ruling out the exclusion criteria and thorough history, examination and laboratory evaluation were done and followed till delivery.Results: A total of 123 pregnant women with hypertensive disorder of pregnancy were enrolled in the study. Most of the participants were in the age group of 20 to 30 years. The PIH was seen mostly in primigravida, lower socioeconomic status and with lower educational levels. Emergency LSCS is the most common mode of delivery.Conclusions: The hypertensive disorder in pregnancy affects the majorly younger age group. It is most commonly seen in low socio-economic and uneducated population. Hence, there should be provided with proper antenatal care, early detection of hypertensive disorders for better feto-maternal outcome.

FETOMATERNAL OUTCOME IN COVID 19 POSITIVE PREGNANCIES-A PROSPECTIVE STUDY

2020 ◽  
Vol 4 (12) ◽  
Author(s):  
Dhanya Prabhu ◽  
Kanaklatta. D. Nakum ◽  
Aditi Vitthal
Keyword(s):  
Prospective Study ◽  
Pregnant Women ◽  
Antiviral Therapy ◽  
Gestational Age ◽  
Clinical Characteristics ◽  
Severe Pneumonia ◽  
History Of ◽  
Preliminary Study ◽  
A Prospective Study ◽  
Rule Out

Background: WHO has declared COVID-19 infection as a health emergency of international   concern on 11thMarch, 2020. It is not clear whether clinical characteristics of pregnant women with COVID-19 differ from those of nonpregnant women and whether it aggravates COVID-19 symptoms and whether antiviral therapy is necessary for COVID-19 infected pregnant women. Methods: This is a prospective study of 47 cases based on the compiled clinical data for pregnant women with COVID-19 from April 2020 to October 2020. A laboratory confirmed positive case of COVID-19 infection in pregnant women were included. Results: In the study involving 47 pregnant patients with covid-19 infection, 38(81%) had cough, 20(42.5%) reported fever, 12(25.5%) had diarrhea, followed by 10(21%), 8(17%) and 3(6%) experienced sore throat,myalgia and dyspnea,respectively. 9(19%) out of 47 were asymptomatic and were tested in view of strong history of contact with covid infected patients. With 32 of 47 (68%) delivered through LSCS for obstetric indication and 15(32%) delivered vaginally.40 (85%) patients were of term gestation and 7(15%) were from preterm gestational age.  Conclusions: At present, there is no evidence regarding the greater risk of pregnant women to succumb to COVID-19 infection and experience severe pneumonia. This preliminary study however does not rule out the possibility of vertical transmission of SARS-CoV- 2 when it manifests towards the end of pregnancy. Keywords: COVID-19, Pregnancy, Pandemic.

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