scholarly journals Virome-wide serological profiling reveals association of herpesviruses with obesity

2020 ◽  
Author(s):  
Mohammad Rubayet Hasan ◽  
Mahbuba Rahman ◽  
Taushif Khan ◽  
Amira Saeed ◽  
Sathyavathi Sundaraju ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Adult Population ◽  
Epidemiological Data ◽  
Multivariate Regression Analysis ◽  
Antibody Responses ◽  
Viral Pathogens ◽  
Age And Gender ◽  
Wide Range ◽  
And Gender ◽  
Hsv 1

AbstractThe relationship between viral infection and obesity has been known for several decades but epidemiological data related to obesity is limited to only a few viral pathogens. To identify associations between viral infections and obesity, a high-throughput virome-wide serological profiling tool, VirScan, was used to measure antibody responses to a wide range of viruses. Serum specimens from 457 Qatari adults (lean=184;obese=273) and 231 Qatari children (lean=111;obese=120) were assessed by VirScan. Pediatric specimens were simultaneously tested by conventional serology for several herpesviruses to validate VirScan results. Viral association with obesity was determined by calculation of odds ratio (OR) and p-values from Fisher test, and by multivariate regression analysis to adjust for age and gender, with Bonferroni correction for multiple testing. Comprehensive serological profiling of Qatari adult population with VirScan revealed positive and negative associations (p<0.05) of antibody responses to members of Herpesviridae and Picornaviridae families, respectively, with obesity. After adjusting p-values for multiple comparisons, only herpes simplex virus 1 (HSV-1) and Rhinovirus A were positively (OR=3.3; 95%CI 2.15-4.99; p=2.787E-08) and negatively (OR=0.4; 95%CI 0.26-0.65; p=1.175E-03) associated with obesity. At the peptide level, higher prevalence of antibodies against several peptide epitopes of HSV-1/2 was positively (OR=2.35-3.82; p≤3.981E-05) associated with obesity. No such associations were seen at the species or peptide levels in the pediatric population. By multivariate regression analysis, HSV-1 was independently associated with obesity irrespective of age and gender. These findings are in agreement with limited data on the adipogenic properties of HSV-1 observed in vitro.ImportanceThe state of Qatar has one of the highest rates of obesity and associated morbidities in the world. Although obesity is predominantly caused by the intake of high calorie diet and reduced physical activities, other factors including infections with certain viruses have been reported. Among these viruses, human adenoviruses were widely studied but epidemiological data for other viruses in relation to human obesity are limited. Here, we studied the association of obesity in Qatari adults and children with a wide range of viral pathogens using VirScan, a virome-wide serological profiling tool. Our results indicate significant association HSV-1 with obesity in the adult population only. Furthermore, we have identified a set of HSV peptides as candidate obesogenic factors for future studies.

scholarly journals Virome-wide serological profiling reveals association of herpesviruses with obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohammad Rubayet Hasan ◽  
Mahbuba Rahman ◽  
Taushif Khan ◽  
Amira Saeed ◽  
Sathyavathi Sundararaju ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Multivariate Regression ◽  
Pediatric Population ◽  
Adult Population ◽  
Multivariate Regression Analysis ◽  
Age And Gender ◽  
Peptide Epitopes ◽  
Wide Range ◽  
And Gender ◽  
Hsv 1

AbstractThe relationship between viral infection and obesity has been known for several decades but epidemiological data is limited to only a few viral pathogens. The association between obesity and a wide range of viruses was assessed using VirScan, a pan-viral serological profiling tool. Serum specimens from 457 Qatari adults (lean = 184; obese = 273) and 231 Qatari children (lean = 111; obese = 120) were analyzed by VirScan. Associations with obesity were determined by odds ratio (OR) and Fisher’s test (p values), and by multivariate regression analysis to adjust for age and gender. Although there was no association of viral infections with obesity in the pediatric population, a nominal association of obesity with seropositivity to members of the Herpesviridae family is observed for the adult population (OR = 1.5–3.3; p < 0.05). After adjusting p values for multiple comparisons (Bonferroni correction) the odds of being obese is significantly higher in herpes simplex virus 1 (HSV-1) seropositive Qatari adults (OR = 3.3; 95% CI 2.15–4.99; p = 2.787E − 08). By VirScan, the sero-prevalence of HSV1 is 81.3% and 57.1% among Qatari obese and lean adult populations, respectively. Higher prevalence of antibodies against several peptide epitopes of HSV-1/2 is positively associated with obesity (OR = 2.35–3.82; p ≤ 3.981E − 05). By multivariate regression analysis, HSV-1 was independently associated with obesity irrespective of age and gender. Our results suggest that obesity among Qataris may be associated with a higher prevalence of herpesvirus infections, in particular HSV-1. Furthermore, the high prevalence of antibodies against peptide antigens specific to HSV-1 and -2 in the obese population suggests that these viral peptides may play a role in adipogenesis. Further studies with these candidate peptides in cell culture or animal models may confirm their adipogenic roles.

scholarly journals Information and information resources in COVID-19: Awareness, control, and prevention

2021 ◽  
pp. 096100062110165
Author(s):  
Mohammadhiwa Abdekhoda ◽  
Fatemeh Ranjbaran ◽  
Asghar Sattari
Keyword(s):  
Low Cost ◽  
Information Resources ◽  
Age And Gender ◽  
Use Of Resources ◽  
Strategic Approach ◽  
Wide Range ◽  
Data Collection Instrument ◽  
Control And Prevention ◽  
And Gender ◽  
And Control

This study was conducted with the aim of evaluating the role of information and information resources in the awareness, control, and prevention of COVID-19. This study was a descriptive-analytical survey in which 450 participants were selected for the study. The data collection instrument was a researcher-made questionnaire. Descriptive and inferential statistics were used to analyze the data through SPSS. The findings show that a wide range of mass media has become well known as information resources for COVID-19. Other findings indicate a significant statistical difference in the rate of using information resources during COVID-19 based on age and gender; however, this difference is not significant regarding the reliability of information resources with regard to age and gender. Health information has an undisputable role in the prevention and control of pandemic diseases such as COVID-19. Providing accurate, reliable, and evidence-based information in a timely manner for the use of resources and information channels related to COVID-19 can be a fast and low-cost strategic approach in confronting this disease.

scholarly journals Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 Units.

2020 ◽  
Author(s):  
Francesco Carubbi ◽  
Lia Salvati ◽  
Alessia Alunno ◽  
Fabio Maggi ◽  
Erika Borghi ◽  
...  
Keyword(s):  
Ct Scan ◽  
Time Course ◽  
Mediastinal Lymph Node ◽  
Clinical Signs ◽  
Pulmonary Involvement ◽  
Imaging Data ◽  
Age And Gender ◽  
Disease Outcomes ◽  
Wide Range ◽  
And Gender

Abstract The coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of imaging findings, depending on disease severity and time course. We conducted a retrospective evaluation of hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement, in order to identify relationships between clinical, serological, imaging data and disease outcomes in patients with COVID-19. Clinical and serological records of patients admitted to two COVID-19 Units of the Abruzzo region in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively evaluated.Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR=14.5, 95% CI=2.3-90.9, p=0.004), the presence of septal thickening (OR=8.2, 95% CI=1.6-40.9, p=0.011) and the presence of mediastinal lymph node enlargement (OR=12.0, 95% CI=1.1-127.5, p=0.039) independently of age and gender.We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease outcomes. The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

Reference interval by the indirect approach of serum thyrotropin (TSH) in a Mediterranean adult population and the association with age and gender

2019 ◽  
Vol 57 (10) ◽  
pp. 1587-1594 ◽  
Author(s):  
Bruna Lo Sasso ◽  
Matteo Vidali ◽  
Concetta Scazzone ◽  
Luisa Agnello ◽  
Marcello Ciaccio
Keyword(s):  
Healthy Subjects ◽  
Indirect Method ◽  
Adult Population ◽  
Reference Interval ◽  
University Hospital ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
Age And Gender ◽  
And Gender ◽  
Effect Of Age

Abstract Background The serum concentration of thyrotropin (TSH) represents a first-line test in diagnostic algorithms. The estimation of TSH reference intervals (RIs) is still a matter of debate due to the high prevalence of subclinical disease making difficult the definition of truly healthy subjects. The aim of this study was to estimate TSH RIs in healthy subjects and to evaluate the effect of age and gender on TSH concentration. Methods Forty-four thousand one hundred and fifty-six TSH data were collected between July 2012 and April 2018 at the Department of Laboratory Medicine, University-Hospital, Palermo. Common and sex-specific RIs were estimated by Arzideh’s indirect method after exclusion of individuals younger than 15 years, subjects with repeated TSH tests and with abnormal free thyroxine (fT4), free triiodothyronine (fT3) or anti-thyroid-peroxidase antibodies. The combined effect of age and gender on TSH values was evaluated. Results RIs estimated in the selected individuals (n = 22602) were, respectively, 0.18–3.54 mIU/L (general), 0.19–3.23 mIU/L (men) and 0.18–3.94 mIU/L (women). Women showed significantly higher median TSH than men (1.46 vs. 1.39 mIU/L; p < 0.0001). Both in men and in women, median TSH decreased along with age; however, although up to 60 years in both men and women showed similar values, afterwards women showed constantly higher TSH than men. Accordingly, statistical analysis showed a significant interaction between gender and age (p = 0.001), suggesting that the effect of age on TSH is different between genders. Conclusions Our findings suggest that the indirect method, with appropriate cleaning of data, could be useful to define TSH RIs.

Basal serum pancreatic polypeptide is dependent on age and gender in an adult population

1997 ◽  
Vol 57 (8) ◽  
pp. 695-702 ◽  
Author(s):  
M. Brimnes Damholt ◽  
B. K. Rasmussen ◽  
L. Hilsted ◽  
R. Jensen ◽  
J. Hilsted
Keyword(s):  
Pancreatic Polypeptide ◽  
Adult Population ◽  
Age And Gender ◽  
Basal Serum ◽  
And Gender

Temporal trends in incidence of heart failure in relation to age and gender in western Sweden 2008–2017

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Wideqvist ◽  
A Rosengren ◽  
M Schaufelberger ◽  
A Pivodic ◽  
M Fu
Keyword(s):  
Heart Failure ◽  
Adult Population ◽  
Temporal Trends ◽  
Administrative Database ◽  
Funding Source ◽  
Age And Gender ◽  
Development Fund ◽  
The Government ◽  
And Gender ◽  
Incident Cases

Abstract Background During the last decades we have witnessed gradually improved cardiovascular primary and secondary prevention, while life expectancy is increasing, with a growing population of elderly people. Heart failure is a disease of the elderly and end stage of other cardiac diseases. Accordingly, trends in incidence of heart failure are dynamic and may differ by age and gender Purpose To investigate overall trends in incidence for HF over the last decades in Western Sweden. Additionally we wanted to study incidence in relation to age and gender. Method The VEGA database is an administrative database of all patients managed in hospital care (through direct linkage to the Swedish nationwide patient registry) and/or in primary care facilities (private and public) living in Western Sweden. All patients with a main or contributory diagnosis of HF (I50) &gt;18 years of age between 2008 and 2017 were included in our cohort. HF incidence was calculated based on the entire population of Vastra Gotaland (a region of Western Sweden). Results The adult population in Western Sweden increased by 8% from 2008 (n=1,234,609) to 2017 (n=1,338,906), with 69% &lt;60 years of age and 50% female, both constant over time. In total, 62,229 incident cases of HF were identified during 2008–2017. In 2008 we identified 6464 cases with a mean age of 78.7 (11.5) and 49.8% (n=3222) male patients, while in 2017 5,727 cases were identified with a mean age of 78.3 (11.8) and 52.5% (n=3006) male cases. The yearly incidence rate of HF remained constant over the 10-year period but with large variations by age and gender. A constantly higher incidence of HF was seen for men compared to women in all age categories. Although overall incidence remained constant in the last decade, we did observe decreasing incidence among those &gt;80 years of age with incidence rates dropping from 4.4% to 3.0% between 2008–2017 (80–90 years) and from 7.8 to 5.5% in the same period (&gt;90 years of age). A similar pattern was seen in both men and women in these age groups with incidence decreasing over the last ten years. Conclusion The overall incidence of HF remained unchanged over the last decade. However a declining trend in incidence was observed in the oldest part of the population, who, however, constitutes only approximately 5% of the population. Our findings emphasize the need for implementation of effective preventive strategies for HF. Trends in HF incidence 2007-2018 Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): The Swedish agreement between the government and the county councils concerning economic support for providing an infrastructure for research and education of doctors (ALF), and the Regional Development Fund, Västra Götaland County, Sweden (FOU-VGR)

scholarly journals Heavy burden of non-communicable diseases at early age and gender disparities in an adult population of Burkina Faso: world health survey

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Malgorzata Miszkurka ◽  
Slim Haddad ◽  
Étienne V Langlois ◽  
Ellen E Freeman ◽  
Seni Kouanda ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Health Survey ◽  
Adult Population ◽  
Gender Disparities ◽  
World Health ◽  
Early Age ◽  
World Health Survey ◽  
Age And Gender ◽  
Heavy Burden ◽  
And Gender

scholarly journals Method of Measuring Psychological Defense

2020 ◽  
Vol 13 (2) ◽  
pp. 194-209
Author(s):  
E.R. Pilyugin ◽  
R.F. Suleimanov
Keyword(s):  
Defense Mechanisms ◽  
Research Process ◽  
Psychometric Characteristics ◽  
Age And Gender ◽  
Psychological Defense ◽  
Wide Range ◽  
And Gender

The authors suggests a psychodiagnostic method for measuring 20 defense mechanisms. The advantages of this method are the simplicity of the research process, the independence of the result from the researcher personality, and the wide range of measured defense mechanisms. The psychometric characteristics of the method are given: validity, discriminativity, reliability, represenativeness. The age and gender statistical limits of norms are determined.

Dynamics of the incidence of sexually transmitted infections in different groups of the adult population in the Russian Federation in 2011–2019

2020 ◽  
Vol 18 (4) ◽  
pp. 58-73
Author(s):  
A.A. Kubanov ◽  
◽  
E.V. Bogdanova ◽  
Keyword(s):  
Sexually Transmitted Infections ◽  
Russian Federation ◽  
Adult Population ◽  
Male Population ◽  
Age And Gender ◽  
Female Population ◽  
Sexually Transmitted ◽  
The Russian Federation ◽  
And Gender ◽  
Gender Groups

Objective. To describe the dynamics of the incidence of six sexually transmitted infections among different age and gender groups of the adult population in the Russian Federation. Materials and methods. The analysis of data from the federal statistical observation of the incidence of sexually transmitted infections in the Russian Federation in 2011–2019. Results. In the Russian Federation, in all age and gender groups of the adult population during the period 2011–2019, there was a decrease in the incidence of early forms of syphilis, trichomoniasis, gonococcal and chlamydia infections. There were changes in the age structure of the number of cases of sexually transmitted infections with an increase in the proportion of cases detected among people aged 40 or over. The increase in the incidence of late and other unspecified forms of syphilis was noted among the male population aged 30 years or over and the female population aged 40 years or over. In 2019, compared to 2011, the increase in the incidence of anogenital warts and anogenital herpes virus infection was recorded among the male population aged 40 or over. Key words: age and gender groups, incidence, sexually transmitted infections, the Russian Federation

Sign in / Sign up

Export Citation Format

Share Document