scholarly journals SARS-CoV-2 waves in Europe: A 2-stratum SEIRS model solution

Author(s):  
Levan Djaparidze ◽  
Federico Lois

AbstractIn order to design actionable SARS-CoV-2 strategies, we extended the SEIRS model to support stratified isolation levels for healthy <60 and vulnerable individuals. At first, we forced isolation levels to be uniform, showing that daily deaths curves of all metropolitan areas in the analysis can be fitted using homogeneous Ro=3.3. In the process, we established the possibility that an extremely short infectiousness period of 2 days coupled with 5 days exposure may be responsible for the multiple deaths valleys observed during the weeks following lockdowns. Regardless of the infectiousness period, we realized that is possible to infer non-uniform isolation levels for healthy <60 and vulnerable by forcing the model to match the <60 to >60 age serology ratio reported in seroprevalence studies. Since the serology ratio is more robust than absolute values, we argue immunity level estimations made in this way (Madrid 41%; Catalonia 23%; Brussels 49%; and Stockholm 62%) are closer to reality. In locations where we didn’t find reliable serology, we performed immunity estimations assuming Spain’s serology ratio (Paris: 23%; London: 33%). We predict that no location can return to normal life without having a second wave (albeit in Stockholm a smaller one). We searched what isolation values allow to return to normal life in 90 days minimizing final deaths, shockingly all found isolations for healthy <60 were negative (i.e. coronavirus parties minimize final deaths). Then, assuming an ideal 1-day long vaccination campaign with a 77% efficacy vaccine, we compared predicted final deaths of those 90-day strategies for all possible vaccination dates with a 180-day long vaccine waiting strategy that imposes 0.40 mandatory isolation to healthy <60 and results in 0.65 isolation to vulnerable. We found that 180-day of mandatory isolations to healthy <60 (i.e. schools and workplaces closed) produces more final deaths if the vaccination date is later than (Madrid: Feb 23 2021; Catalonia: Dec 28 2020; Brussels Apr 25 2021; Paris: Jan 14 2021; London: Jan 22 2021). We also modeled how average isolation levels change the probability of getting infected for a single individual that isolates differently than average. That led us to realize disease damages to third parties due to virus spreading can be calculated and to postulate that an individual has the right to avoid mandatory isolation during epidemics (SARS-CoV-2 or any other) if these damages can be covered with a novel proposed isolation exemption insurance policy. As secondary findings in Appendix III we hypothesize that an early D614 like strain wave might be the cause of low mortality in Asia, and show the negligible reduction of HIT due to heterogeneity. Finally we conclude that our 2-stratum SEIRS model is suitable to predict SARS-CoV-2 epidemic behavior and can be used to minimize covid-19 disease and isolations related damages. To the sole effect of understanding and verifying its content the same model used through this paper has been made available online at www.sars2seir.com/paper-12-2020/

2019 ◽  
Vol 25 (2) ◽  
pp. 197-201
Author(s):  
Tudor-Vlad Sfârlog

Abstract The present study offers the doctrine of the right of intellectual creation new perspectives on the study of the institution of termination of the assignment contract for the patrimonial rights resulting from the intellectual creation. We believe that the present study is rich in doctrinal contributions, formulating new theses and opening the prospect for new perspectives of scientific research. Last but not least, we appreciate that the proposals made in the present study contribute not only to the activity of opinionated in the field, but also to the work of practitioners and direct beneficiaries of the legal provisions on the assignment of patrimonial rights of authors.


2021 ◽  
pp. 1-27
Author(s):  
Markus Knell

Abstract This paper studies how the rates of deduction for early retirement have to be determined in pay-as-you-go (PAYG) systems in order to keep their budget stable. The derivation of these deductions requires the use of a multiperiod intertemporal budget constraint that involves assumptions about the retirement behavior of past, present, and future cohorts. In general, it is not possible to calculate budget-neutral deductions from the budget constraint of a single individual who retires before the target retirement age—an approach that dominates the related literature. Only for specific cases one can use this second approach but then one has to adjust the discount rate to the assumption about collective retirement. If there is only one deviating individual, then the right choice is the market interest rate while for a stationary retirement distribution it is the internal rate of return of the PAYG system. In this case, the necessary deductions are lower than under the standard approach. This is also true for retirement ages that fluctuate randomly around a stationary distribution. Various long-run developments (e.g., increases in life expectancy or permanent changes in the average retirement age) might cause challenges for the sustainability of the pension system. These developments, however, can only be dealt with by adequate adjustments to the basic pension formulas and not by the use of deduction rates.


1996 ◽  
Vol 3 (1) ◽  
pp. 49-74
Author(s):  
Alan Meisel

AbstractIn the 20 years that have passed since the Karen Quinlan case exposed a simmering clinical issue to the light of day — more precisely, to the press and to judicial process — a consensus has developed in American law about how end-of-life decisionmaking should occur. To be sure, there are dissenting voices from this consensus, but they are often (though not always) about minor issues. By illustrating how this consensus has evolved, this paper explores how law is made in the American legal system and the roles that different legal and extra-legal institutions play in lawmaking.


2021 ◽  
Vol 138 (1) ◽  
pp. 88-114
Author(s):  
Thino Bekker

The summary judgment procedure in South African law provides for a speedy judgment in favour of a deserving plaintiff where it can be shown that the defendant does not have a triable defence. In 2019 the Rules Board made certain drastic amendments to the procedure of summary judgment in the high court. In this article the historical development of the procedure of summary judgment will be discussed, and the new amendments to rule 32 of the Uniform Rules of Court critically evaluated. It will be argued that the amendments to rule 32 were unnecessary and that it may diminish the right to access to justice in civil disputes. It will, however, also be argued that there are some merits in the critique raised by the Rules Board in relation to rule 32 and that the Rules Board missed a golden opportunity to overhaul the entire summary judgment procedure in a more sensible manner and in line with the core constitutional values of s 34 of the Constitution. It will be argued that rule 32 should be replaced in its entirety by a new, more streamlined procedure, and some recommendations for legal reform will be made in this regard.


1765 ◽  
Vol 55 ◽  
pp. 326-344 ◽  

The observations of the late transit of Venus, though made with all possible care and accuracy, have not enabled us to determine with certainty the real quantity of the sun's parallax; since, by a comparison of the observations made in several parts of the globe, the sun's parallax is not less than 8" 1/2, nor does it seem to exceed 10". From the labours of those gentlemen, who have attempted to deduce this quantity from the theory of gravity, it should seem that the earth performs its annual revolution round the sun at a greater distance than is generally imagined: since Mr. Professor Stewart has determined the sun's parallax to be only 6', 9, and Mr. Mayer, the late celebrated Professor at Gottingen, who hath brought the lunar tables to a degree of perfection almost unexpected, is of opinion that it cannot exceed 8".


2011 ◽  
Vol 473 ◽  
pp. 209-216
Author(s):  
Eugen Oswald ◽  
Mathias Liewald ◽  
Oliver Stephan

In the automotive industry, current design and dimensioning of forming tools and bearing tool components occurs according to guidelines. Possible interactions between arising loads as well as dimensioning are empirically estimated. Simulative computations, which are based on CAE-methods, are only realized in special cases. Therefore, most often current standards lead to oversized tools. In consequence, new studies based on CAE-analyses are supposed to investigate new possibilities to design forming tools and components optimized in their structure corresponding to the right distribution of forces and stress. This is made in order to increase reliability during the manufacturing process, as well as the tools’ stiffness and contribute to decrease of investment costs.


1939 ◽  
Vol 16 (1) ◽  
pp. 96-120
Author(s):  
O. M. HELFF

(1) Opercular integument, homoplastically transplanted to the back and side of R. temporaria larvae, underwent a process of partial degeneration. The histolysis was not confined to any localized region of the transplant. (2) Autoplastic transplantation of opercular integument to the back and side produced a variety of results. Normal histological structure was maintained in certain transplants, generalized degeneration was observed in others, while in several instances localized histolysis resulting in perforation formation occurred. (3) Homoplastic and autoplastic transplantation of back and side skin to the opercular region resulted in histolysis and perforation formation in such transplants during larval involution. (4) The right forelimbs (in early stages of development) with attached portions of the shoulder girdle were extirpated in R. temporaria and B. bufo. During subsequent metamorphosis, normal opercular histolysis followed by perforation formation in many cases was observed. In most instances, serial sections of the peribranchial cavity revealed the absence of cutaneous glands. (5) Extirpation of the right forelimb only was made in the same two species. Opercular histolysis subsequently occurred in all instances, resulting in perforation formation in the great majority of cases during larval involution. In many of the B. bufo animals two separate perforations developed, one filled with limb stump and the other with gill tissue. (6) It is concluded that in R. temporaria a particular area of the operculum may in some individuals possess self-degenerative potentialities conducive to histolysis and perforation formation during metamorphosis. In both R. temporaria and B. bufo histolytic influences emanating from the atrophying gill tissue and the cutaneous glands of the forelimb are probably also responsible for opercular histolysis and perforation formation. Limb pressure must be considered a supplemental factor. (7) The results are discussed in general and attention called to the fact that opercular histolysis and perforation formation are "doubly assured" in some species and possibly even "triply assured" in others. Emphasis is placed on the evidently wide divergence between species as regards the particular combination of factors responsible for opercular histolysis and perforation formation. Apparently, no one explanation can serve to account for the phenomenon as it occurs in various species of anurans.


2018 ◽  
pp. 19-27
Author(s):  
Grażyna STRNAD

The history of American women fighting for equal rights dates back to the 18th century, when in Boston, in 1770, they voiced the demand that the status of women be changed. Abigail Adams, Sarah Grimke, Angelina Grimke and Frances Wright are considered to have pioneered American feminism. An organized suffrage movement is assumed to have originated at the convention Elizabeth Stanton organized in Seneca Falls in 1848. This convention passed a Declaration of Sentiments, which criticized the American Declaration of Independence as it excluded women. The most prominent success achieved in this period was the US Congress passing the Nineteenth Amendment to the Constitution granting women the right to vote. The 1960s saw the second wave of feminism, resulting from disappointment with the hitherto promotion of equality. The second-wave feminists claimed that the legal reforms did not provide women with the changes they expected. As feminists voiced the need to feminize the world, they struggled for social customs to change and gender stereotypes to be abandoned. They criticized the patriarchal model of American society, blaming this model for reducing the social role of women to that of a mother, wife and housewife. They pointed to patriarchal ideology, rather than nature, as the source of the inequality of sexes. The leading representatives of the second wave of feminism were Betty Friedan (who founded the National Organization for Women), Kate Millet (who wrote Sexual Politics), and Shulamith Firestone (the author of The Dialectic of Sex: The Case for Feminist Revolution). The 1990s came to be called the third wave of feminism, characterized by multiple cultures, ethnic identities, races and religions, thereby becoming a heterogenic movement. The third-wave feminists, Rebecca Walker and Bell Hooks, represented groups of women who had formerly been denied the right to join the movement, for example due to racial discrimination. They believed that there was not one ‘common interest of all women’ but called for leaving no group out in the fight for the equality of women’s rights. They asked that the process of women’s emancipation that began with the first wave embrace and approve of the diversity of the multiethnic American society.


2020 ◽  
Vol 29 (1) ◽  
pp. 129
Author(s):  
Dominik J. Kościuk ◽  
Justyna Kulikowska-Kulesza

<p>The provisions of the Act on Access to Public Information regulate, among others, the subjective and objective scope of the right to public information, reasons for restricting access to information, procedure and form of disclosure, rules for creating and publishing information in the Public Information Bulletin, costs of activities leading to the disclosure of information and the establishment of complaint proceedings in the event of refusal to provide the public information requested. Therefore, it is worth to pay attention to several problems arising from the analysis of statutory provisions and the practical consequences of applying the Act of 6 September 2001 on Access to Public Information. The current, extremely extensive, output of doctrine and jurisprudence allows for a fairly “efficient” summary of the considerations made in both literature and judicial and administrative case law.</p>


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