scholarly journals FGF21 Response Varies by Sugar Type and is Associated with Body Weight, Dietary Added Sugar, and Neural Signaling in Humans

2021 ◽  
Author(s):  
Alexandra G Yunker ◽  
Jasmin M Alves ◽  
Shan Luo ◽  
Brendan Angelo ◽  
Alexis DeFendis ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Homeostasis ◽  
Overweight And Obesity ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Healthy Weight ◽  
Added Sugar ◽  
Sugar Intake ◽  
Brain Responses ◽  
Neural Signaling

Fibroblast growth factor 21 (FGF21) is a liver-derived hormone that regulates energy homeostasis. In humans, few studies have investigated whether FGF21 may act to suppress sugar intake and influence eating behavior, and the effects of adiposity on post-ingestive FGF21 regulation of appetite are unknown. Here, we demonstrate among two cohorts of healthy, young adults that acute oral fructose and sucrose compared to glucose lead to greater circulating FGF21. Moreover, high compared to low dietary added sugar intake is associated with greater sucrose-stimulated FGF21 among participants with healthy weight but attenuated in people with overweight and obesity. In addition, our study is the first to demonstrate associations between circulating FGF21 and neural signaling following an acute sucrose load among humans with healthy weight. Collectively, our results suggest that these potential compensatory relationships between sucrose-stimulated circulating FGF21, habitual sugar intake, and post-ingestive brain responses may be altered among adults with overweight and obesity.

scholarly journals Patterns and demographic predictors of 5-year weight change in a multi-ethnic cohort of men and women in Australia

2003 ◽  
Vol 6 (3) ◽  
pp. 269-280 ◽  
Author(s):  
Kylie Ball ◽  
David Crawford ◽  
Paul Ireland ◽  
Allison Hodge
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Population Study ◽  
Weight Change ◽  
Community Sample ◽  
Population Sample ◽  
Critical Time ◽  
Overweight And Obesity ◽  
Entire Population ◽  
Healthy Weight

AbstractObjective:This study investigated 5-year trends in body weight, overweight and obesity and their association with sociodemographic variables in a large, multi-ethnic community sample of Australian adults.Design:This prospective population study used baseline and 5-year follow-up data from participants in the Melbourne Collaborative Cohort Study (MCCS).Setting:Population study in Melbourne, Australia.Subjects:In total, 12 125 men and 17 674 women aged 35–69 years at baseline.Results:Mean 5-year weight change in this sample was +1.58 (standard deviation (SD) 4.82) kg for men and +2.42 (SD 5.17) kg for women. Younger (35–44 years) men and, in particular, women gained more weight than older adults and were at highest risk of major weight gain (≥5 kg) and becoming overweight. Risk of major weight gain and associations between demographic variables and weight change did not vary greatly by ethnicity. Education level showed complex associations with weight outcomes that differed by sex and ethnicity. Multivariate analyses showed that, among men, higher initial body weight was associated with decreased likelihood of major weight gain, whereas among women, those initially overweight or obese were about 20% more likely to experience major weight gain than underweight or healthy weight women.Conclusions:Findings of widespread weight gain across this entire population sample, and particularly among younger women and women who were already overweight, are a cause for alarm. The prevention of weight gain and obesity across the entire population should be an urgent public health priority. Young-to-mid adulthood appears to be a critical time to intervene to prevent future weight gain.

scholarly journals Oxytocin Secretion Is Related to Measures of Energy Homeostasis in Young Amenorrheic Athletes

2014 ◽  
Vol 99 (5) ◽  
pp. E881-E885 ◽  
Author(s):  
Elizabeth A. Lawson ◽  
Kathryn E. Ackerman ◽  
Meghan Slattery ◽  
Dean A. Marengi ◽  
Hannah Clarke ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Growth Factor ◽  
Food Intake ◽  
Energy Expenditure ◽  
Energy Homeostasis ◽  
Female Athletes ◽  
Young Female ◽  
Fibroblast Growth Factor 21 ◽  
Energy Availability ◽  
Fibroblast Growth

Context: Oxytocin has been implicated in the modulation of energy metabolism in animals. Oxytocin knockout mice develop obesity without a change in food intake, suggesting that a lack of oxytocin may reduce metabolic rate. Furthermore, administration of oxytocin centrally reduces food intake in rats, an effect reversed by an oxytocin antagonist, implying that oxytocin may regulate appetite and energy intake. We have previously demonstrated that young female athletes (in a higher energy expenditure state than nonathletes) have low nocturnal oxytocin compared with nonathletes. Whether oxytocin is associated with measures of energy homeostasis in athletes is unknown. Objective: We hypothesized that oxytocin, a signal for energy availability, would be associated with other measures of energy homeostasis in young female athletes. Design and Setting: We performed a cross-sectional study of 45 females, aged 14–21 years [15 amenorrheic athletes (AA), 15 eumenorrheic athletes, and 15 nonathletes] of comparable body mass index. Methods: Dual x-ray absorptiometry was performed to assess body composition. Indirect calorimetry was used to measure resting energy expenditure (REE). Fasting levels of oxytocin, energy homeostasis hormones irisin and fibroblast growth factor-21, and appetite-regulating hormone peptide YY were obtained. Results: In AA, oxytocin secretion was positively correlated with surrogate measures of energy availability, including weight (r = 0.65, P = .009) and body mass index (r = 0.61, P = .016). Furthermore, oxytocin was associated with REE (r = 0.80, P = .0003), independent of lean mass, and with irisin (r = 0.74, P = .002) and fibroblast growth factor-21 (r = 0.58, P = .024). In eumenorrheic athletes, oxytocin was associated with REE (r = 0.59, P = .021), independent of lean mass. In nonathletes, oxytocin secretion was not significantly associated with measures of energy homeostasis. Conclusions: In AA, oxytocin secretion is associated with measures of energy availability and expenditure, suggesting that oxytocin may be involved in regulation of energy balance in energy deficient states. Further studies determining the role of oxytocin in appetite and energy homeostasis in athletes are warranted.

scholarly journals Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1504
Author(s):  
Susanna C. Larsson ◽  
Dipender Gill
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Energy Homeostasis ◽  
Disease Risk ◽  
Fibroblast Growth Factor 21 ◽  
Clinical Effects ◽  
Fibroblast Growth ◽  
Beneficial Effects

Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer’s disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the FGF21 gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The FGF21 G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer’s disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.

Red raspberry (poly)phenolic extract improves diet-induced obesity, hepatic steatosis and insulin resistance in obese mice

2021 ◽  
pp. 1-14
Author(s):  
Haizhao Song ◽  
Xinchun Shen ◽  
Qiang Chu ◽  
Xiaodong Zheng
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Red Raspberry ◽  
Diet Induced Obesity ◽  
Phenolic Extract

BACKGROUND: Red raspberry (Rubus idaeus L.), a natural dietary source of (poly)phenols, has been used as medicine for centuries. OBJECTIVE: The purpose of this study is to determine the effect of a red raspberry (poly)phenolic extract (RPE) on diet-induced obesity, hepatic steatosis and insulin resistance, and elucidate the underlying molecular mechanisms. METHODS: Male specific pathogen-free C57BL/6J mice were randomly divided into three groups (n = 12 per group), and fed with low-fat diet (10% fat energy), high-fat diet (HFD, 45% fat energy), or HFD supplemented with RPE of 150 mg/kg body weight by intragastric administration for 14 weeks. Obesity-related biochemical indexes and hepatic gene expression levels were determined. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test. RESULTS: The body weight gain, steatosis grade scores and insulin resistance index in the RPE group decreased by 34.48% (P = 0.00), 58.82% (P = 0.00), and 53.77% (P = 0.00), respectively, compared to those in the HFD group. Moreover, RPE supplement significantly changed the expression profile of the genes involved in lipid metabolism and fibroblast growth factor 21 signaling pathway. CONCLUSIONS: This study demonstrated that RPE protected from diet-induced obesity and related metabolic disorders by improving the lipid metabolism and fibroblast growth factor 21 resistance.

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