scholarly journals Determinants of Heart Rate Recovery and Heart Rate Variability in Lung Cancer Survivors Eligible for Long-Term Cure

2018 ◽  
Author(s):  
Duc Ha ◽  
Atul Malhotra ◽  
Andrew L. Ries ◽  
Wesley T. O’Neal ◽  
Mark M. Fuster
Keyword(s):  
Lung Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
Cancer Survivors ◽  
Parasympathetic Nervous System ◽  
Heart Rate Recovery ◽  
Increased Risk ◽  
The Mean

AbstractBackgroundLung cancer survivors are at increased risk for autonomic dysfunction. We aimed to identify determinants of parasympathetic nervous system (PNS) function as reflected by heart rate recovery (HRR) and heart rate variability (HRV) in lung cancer survivors eligible for long-term cure.MethodsWe performed a cross-sectional study of consecutive lung cancer survivors who completed curative-intent therapy for stage I-IIIA ≥1 month previously. We tested a comprehensive list of variables related to baseline demographics, comorbidities, lung cancer characteristics, and physiological/functional measures using univariable and multivariable (MVA) linear regression analyses. We defined HRR as the difference in heart rate (HR) at 1-minute following and the end of the six-minute walk test (6MWT), and HRV the standard deviation of normal-to-normal R-R intervals (SDNN) and root-mean-square-of-successive-differences (rMSSD) from routine single 10-s electrocardiographs (ECGs).ResultsIn 69 participants, the mean (standard deviation, SD) HRR was -10.6 (6.7) beats. In MVAs, significant independent determinants of HRR [β (95% confidence interval)] were: age [0.17 (0.04, 0,30) for each year] and HR change associated with the 6MWT [0.01 (0.007, 0.02) for each beats/min. In 41 participants who had ECGs available for HRV measurements, the mean (SD) SDNN and rMSSD were 19.1 (15.6) and rMSSD 18.2 (14.6) ms, respectively. In MVAs, significant determinants of HRV were: total lung capacity [0.01 (0.00, 0.02), p=0.047 for each % predicted] and HRR [-0.04 (-0.07, -0.003) for each beat] for natural logarithm (Ln-)SDNN; and [0.01 (0.00, 0.02)] and [-0.04 (-0.07, -0.01)] for Ln-rMSSD, respectively.ConclusionsWe measured determinants of HRR and HRV in lung cancer survivors eligible for long-term cure. HRR and/or HRV may be useful as indicators to stratify patients in interventional studies aimed at improving PNS function in lung cancer survivors, including through exercise training.

scholarly journals Heart rate variability and heart rate recovery in lung cancer survivors eligible for long-term cure

2019 ◽  
Vol 269 ◽  
pp. 103264 ◽  
Author(s):  
Duc Ha ◽  
Atul Malhotra ◽  
Andrew L. Ries ◽  
Wesley T. O’Neal ◽  
Mark M. Fuster
Keyword(s):  
Lung Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Heart Rate Recovery

scholarly journals Heart Rate Variability Assessment by the Entropy Parameters during Sleep

2020 ◽  
Vol 9 (9) ◽  
pp. 468-472
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Eye Movement ◽  
Discrimination Performance ◽  
Conditional Entropy ◽  
Approximate Entropy ◽  
Mean Value ◽  
Sleep Stages ◽  
The Mean

The nonlinear heart rate variability (HRV) parameter quantifies autonomic nervous system (ANS) activity based on the complexity or irregularity of an HRV dataset. At present, among various entropy-related parameters during sleep, approximate entropy (ApEn) and sample entropy (SampEn) are not as well understood as other entropy parameters such as Shannon entropy (SE) and conditional entropy (CE). Therefore, in this study, we investigated the characteristics of ApEn and SampEn to differentiate a rapid eye movement (REM) and nonrapid eye movement (NREM) for sleep stages. For nonlinear sleep HRV analysis, two target 10-minute, long-term HRV segments were obtained from each REM and NREM for 16 individual subjects. The target HRV segment was analyzed by moving the 2-minute window forward by 2 s, resulting in 240 results of each ApEn and SampEn. The ApEn and SampEn were averaged to obtain the mean value and standard deviation (SD) of all the results. SampEn provides excellent discrimination performance between REM and NREM in terms of the mean and SD (p<0.0001 and p=0.1989, respectively; 95% CI), but ApEn was inferior to SampEn (p=0.1980 and p=0.9931). The results indicate that SampEn, but not ApEn could be used to discriminate REM from NREM and detect various sleep-related incidents.

Depression and anxiety as predictors of heart rate variability after myocardial infarction

2007 ◽  
Vol 38 (3) ◽  
pp. 375-383 ◽  
Author(s):  
E. J. Martens ◽  
I. Nyklíček ◽  
B. M. Szabó ◽  
N. Kupper
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
Anxiety Disorder ◽  
Depressive Disorder ◽  
Anxiety Symptoms ◽  
Adverse Outcomes ◽  
Depression And Anxiety ◽  
Increased Risk

BackgroundReduced heart rate variability (HRV) is a prognostic factor for cardiac mortality. Both depression and anxiety have been associated with increased risk for mortality in cardiac patients. Low HRV may act as an intermediary in this association. The present study examined to what extent depression and anxiety differently predict 24-h HRV indices recorded post-myocardial infarction (MI).MethodNinety-three patients were recruited during hospitalization for MI and assessed on self-reported symptoms of depression and anxiety. Two months post-MI, patients were assessed on clinical diagnoses of lifetime depressive and anxiety disorder. Adequate 24-h ambulatory electrocardiography data were obtained from 82 patients on average 78 days post-MI.ResultsIn unadjusted analyses, lifetime diagnoses of major depressive disorder was predictive of lower SDNN [standard deviation of all normal-to-normal (NN) intervals; β=−0.26, p=0.022] and SDANN (standard deviation of all 5-min mean NN intervals; β=0.25, p=0.023), and lifetime anxiety disorder of lower RMSSD (root mean square of successive differences; β=−0.23, p=0.039). Depression and anxiety symptoms did not significantly predict HRV. After adjustment for age, sex, cardiac history and multi-vessel disease, lifetime depressive disorder was no longer predictive of HRV. Lifetime anxiety disorder predicted reduced high-frequency spectral power (β=−0.22, p=0.039) and RMSSD (β=−0.25, p=0.019), even after additional adjustment of anxiety symptoms.ConclusionsClinical anxiety, but not depression, negatively influenced parasympathetic modulation of heart rate in post-MI patients. These findings elucidate the physiological mechanisms underlying anxiety as a risk factor for adverse outcomes, but also raise questions about the potential role of HRV as an intermediary between depression and post-MI prognosis.

scholarly journals Effect of Ice Massage to Head and Spine on Blood Pressure and Heart Rate Variability in Patients with Hypertension: a Pilot Study

2021 ◽  
Vol 14 (3) ◽  
pp. 22-26
Author(s):  
Mooventhan A, MD ◽  
Sneha Bharati, BNYS ◽  
Nivethitha L, PhD ◽  
Manjunath NK, PhD
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
Pilot Study ◽  
Systolic Blood Pressure ◽  
Reduce Blood Pressure ◽  
Clinical Impact ◽  
The Common ◽  
The Mean

Background: Ice massage is one of the common hydrotherapeutic procedures. The current study is first of its kind, conducted to evaluate the effect of ice massage to head and spine on blood pressure and heart rate variability in patients with hypertension. Materials and Methods: Fifteen hypertensive subjects with the mean ± standard deviation (SD) age of 48.87 ± 11.17 yrs were recruited and underwent only one session of ice massage to head and spine for 20 min. Blood pressure and heart rate variability were assessed before and immediately after the intervention. Results: Results of this study showed a significant reduction in systolic blood pressure (p = <.001), diastolic blood pressure (p < .001) and heart rate (p = .012), and a significant increase in R-R Interval (the intervals between adjacent R waves in the electro cardiogram) (p = .001) in the posttest assessments compared to its respective pre-test assessments. Conclusion: Results suggest that 20 min of ice massage to head and spine may reduce blood pressure and heart rate in patients with hypertension. However, there is no evidence that this provides any significant clinical impact for the patient.

scholarly journals Intrinsic heart rate recovery after dynamic exercise is improved with an increased omega-3 index in healthy males

2014 ◽  
Vol 112 (12) ◽  
pp. 1984-1992 ◽  
Author(s):  
Michael J. Macartney ◽  
Lachlan Hingley ◽  
Marc A. Brown ◽  
Gregory E. Peoples ◽  
Peter L. McLennan
Keyword(s):  
Heart Rate ◽  
Standard Deviation ◽  
Heart Rate Recovery ◽  
Control Group ◽  
Omega 3 ◽  
Intense Exercise ◽  
Double Blind ◽  
Dietary Fish ◽  
Group 3 ◽  
The Mean

Dietary fish consumption contributes to a reduced risk of cardiac mortality. In the present study, the effect of low-dose fish oil (FO) supplementation on heart rate (HR) response to intense exercise and recovery was investigated in physically fit males. The subjects (n 26) were supplemented (double-blind, parallel design) with (2 × 1 g/d) soya bean oil (control) or tuna FO providing the long-chain n-3 PUFA DHA (560 mg) and EPA (140 mg). Erythrocyte omega-3 index (%EPA+DHA), HR, HR variability and HR recovery were analysed during rest, intense exercise and recovery at baseline and after 8 weeks of supplementation. The mean erythrocyte omega-3 index, which did not differ between the groups at baseline (control 4·2 (sem 0·2), n 13; FO 4·7 (sem 0·2), n 13), remained unchanged in the control group (3·9 (sem 0·2)), but increased in the FO group (6·3 (sem 0·3); P< 0·01). The mean HR during supine resting conditions (control 56 (sem 10); FO 59 (sem 9)) was not affected by FO supplementation. Poincaré analysis of HR variability at rest exhibited a decreasing trend in parasympathetic activity in the FO group (SD1 (standard deviation of points perpendicular to the axis of line of identity)/SD2 (standard deviation of points along the axis of line of identity): control 0·02 (sem 0·01); FO − 0·05 (sem 0·02); P= 0·18). Peak HR was not affected by supplementation. However, during submaximal exercise over 5 min, fewer total heart beats were recorded in the FO group ( − 22 (sem 6) ( = − 4·5 beats/min)), but not in the control group (+1 (sem 4)) (P< 0·05). Supine HR recovery (half-time) after cycling was significantly faster after FO supplementation (control − 0·4 (sem 1·2) s; FO − 8·0 (sem 1·7) s; P< 0·05). A low intake of FO increased the omega-3 index and reduced the mean exercise HR and improved HR recovery without compromising the peak HR. A direct influence of DHA via reductions in the cardiac intrinsic beat rate was balanced by a reciprocal decrease in vagal tone.

scholarly journals Long-Term Influence of Concussion on Cardio-Autonomic Function in Adolescent Hockey Players

2021 ◽  
Author(s):  
Allyssa K. Memmini ◽  
Michael F. La Fountaine ◽  
Steven P. Broglio ◽  
Robert D. Moore
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Root Mean Square ◽  
Autonomic Function ◽  
Heart Rate Recovery ◽  
Adolescent Male ◽  
Mean Square ◽  
Target Heart Rate ◽  
Concussion History

Context Concussion may negatively influence cardiovascular function and the autonomic nervous system, defined by alteration in heart rate variability (HRV). Differences in HRV most commonly emerge during a physical challenge, such as the final steps of the return-to-sport progression. Objective To assess the effect of concussion history on aspects of cardio-autonomic function during recovery from a bout of submaximal exercise in adolescent male hockey athletes. Design Case-control study. Setting Research laboratory. Patients or Other Participants Thirty-three male athletes participating in Midget-AAA hockey were divided into those with (n = 15; age = 16 ± 1 years, height = 1.78 ± 0.06 m, mass = 73.9 ± 7.4 kg, 10.5 ± 1.6 years of sport experience, 25.2 ± 18.3 months since last injury) or without (n = 18; age = 16 ± 1 years, height = 1.78 ± 0.05 m, mass = 74.8 ± 7.6 kg, 10.6 ± 1.9 years of sport experience) a concussion history. Those with a concussion history were binned on total count: concussion) or 2 or more concussions. Intervention(s) All athletes underwent 5 minutes of resting HRV assessment, followed by 20 minutes of aerobic exercise at 60% to 70% of their maximal target heart rate and a 9-minute, postexercise HRV assessment. Main Outcome Measure(s) Heart rate variability measures of mean NN interval, root mean square of successive differences, and standard deviation of NN interval (SDNN). Results Group demographic characteristics were not different. When the control and concussed groups were compared, group and time main effects for heart rate recovery, root mean square of successive differences, and SDNN (P values &lt; .01), and an interaction effect for SDNN (P &lt; .05) were demonstrated. Recovery trends for each group indicated that a history of 2 or more concussions may negatively affect cardio-autonomic recovery postexercise. Conclusions Our findings suggest that those with more than 1 previous concussion may be associated with a greater risk for long-term dysautonomia. Future use of HRV may provide clinicians with objective guidelines for concussion-management and safe return-to-participation protocols.

Longitudinal assessment of cognitive impairment among lung cancer survivors

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9609-9609
Author(s):  
S. Kohli ◽  
D. W. Szydlo ◽  
P. J. Novotny ◽  
P. Yang ◽  
P. D. Brown ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cognitive Function ◽  
Cancer Survivors ◽  
Longitudinal Assessment ◽  
Cancer Treatments ◽  
Long Term Follow Up ◽  
Patients At Risk ◽  
The Mean

9609 Background: Patients undergoing treatment for cancer often report problems with their cognitive function (CF), which is an essential component in maintaining Quality of Life (QoL). We conducted a longitudinal study of lung cancer (LC) patients to systematically evaluate changes in QOL including changes in CF, over time. Methods: Between 2005–2008, we followed 1757 primary LC patients who responded to CF questions at least once within 8 years of diagnosis. Overall QoL measured by LCSS and LASA (scores 0–100 from worst to best) were assessed among 1,604 of 1,757 (91%) who completed the questionnaire at one or both of two time periods: short-term (T1-within 3 years of diagnosis) and long-term follow-up (T2-beyond 5 years of diagnosis). Questions rated overall CF and problems in thinking clearly. Results: The median age at the time of LC diagnosis was 68 years in men (n=834) and 65 years in women (n=770), p<0.0001. At T1, the mean score of patients reporting problems with CF was 63.2 (±22.45) vs 74.4 (±20.38) who reported no problems (p<0.0001). At T2, the mean score was 62.2 (±24.18) for patients who reported CF problems and 78.1 (±18.28) who reported no changes with their CF (p<0.0001). At T1, the mean score of patients reporting problems thinking clearly was 66.1 (±21.65) vs 75.6 (±20.21) reporting no problems with their thinking (p<0.0001). At T2, the mean score was 70.4 (±20.95) for patients reporting problems thinking clearly vs 82.6 (±17.76) who reported no problems (p<0.0001). Conclusions: Self-reported QoL of lung cancer survivors showed substantial deficits with their cognitive function. Prospective and objective assessments are needed to determine if cancer treatments are positively associated with cognitive decline, to identify the patients at risk, and to test appropriate interventions. Funding Source: NIH grants: CA 115857, CA 84354, CA 80127 and CA 77118. No significant financial relationships to disclose.

Effects of Qi-Training on Heart Rate Variability

2002 ◽  
Vol 30 (04) ◽  
pp. 463-470 ◽  
Author(s):  
Myeong Soo Lee ◽  
Hwa Jeong Huh ◽  
Byung Gi Kim ◽  
Hoon Ryu ◽  
Ho-Sub Lee ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
High Frequency ◽  
Parasympathetic Nervous System ◽  
Low Frequency ◽  
Autonomic Nervous ◽  
Nervous Function ◽  
Young Subjects

This study investigates changes in autonomic nervous function through Qi-training. The power spectrum of heart rate variability (HRV) was examined in 20 sedentary healthy subjects and 20 Qi-trainees. It was found that Qi-training in healthy young subjects during controlled respiration increases the high frequency (HF) power and decreases the low frequency / high frequency (LF/HF) power ratio of HRV. These results support the hypothesis that Qi-training increases cardiac parasympathetic tone. In addition, Qi-trainees were found to have higher parasympathetic heart modulation compared with their age-matched, sedentary counterparts. This augmented HRV in Qi-trainees provides further support for long-term Qi-training as a possible non-pharmacological cardio-protective maneuver. In conclusion, Qi-training may stabilize the autonomic nervous system by modulating the parasympathetic nervous system.

scholarly journals Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial

2021 ◽  
Vol 126 (1) ◽  
Author(s):  
Michael Eklund ◽  
Olof Hellberg ◽  
Hans Furuland ◽  
Yang Cao ◽  
Erik Nilsson
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
Primary Outcome ◽  
Crossover Trial ◽  
Autonomic Function ◽  
Electric Activity ◽  
Cardiac Autonomic Function ◽  
Secondary Outcomes

Background: Spironolactone treatment reduces mortality in haemodialysis (HD) patients. The objective of this study was to evaluate if spironolactone affects cardiac electric activity in this population. Methods: Participants were randomised to start with spironolactone 50 mg daily or observation (12 weeks) with subsequent washout (6 weeks) and crossover to the other intervention (12 weeks). Long-term electrocardiograms were recorded and assessed with blinding to treatment. The primary outcome was premature ventricular complexes (PVC), and secondary outcomes were atrial premature contractions (APC) and heart rate variability (HRV). Results: Thirty participants were recruited, and data for 16 participants were included in the analysis. Treatment was associated with an increase in PVCs by 9.7 [95% confidence interval (CI): 1.5 to 18] h−1. HRV time-domain variables increased during treatment, the standard deviation of all beat-to-beat intervals by 18 (95% CI: 3.3 to 32) milliseconds (ms) and the standard deviation of the averages of beat-to-beat intervals in all 5-min segments of the entire recording by 16 (95% CI: 1.5 to 30) ms. There were no significant differences in other variables. Conclusion: Spironolactone treatment increases PVCs in HD, indicating a possible proarrhythmic effect. However, improved cardiac autonomic function, as indicated by an increased HRV, may contribute to the survival benefit from spironolactone treatment in HD patients.

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