Physical properties and biocompatibility of acemannan scaffold for biomedical applications

Polyelectrolytes have been at the center of interdisciplinary research for many decades. In the field of polymer science and soft matter, they have provided the dimensions of electrostatic interactions, which opens a vast variety of opportunities for new physical properties and applications. In biological matter, polyelectrolytes are present in many forms, from extracellular polysaccharides to complex DNA molecules and proteins. This review discusses the recent research on polyelectrolytes covering the fundamental level of their conformations and nanostructures, their molecular interactions with materials that have close relevance to bioapplications and their applications in the biomedical field. This approach is motivated by the fact that the polyelectrolyte research is constantly active in all the aforementioned levels and continually affects many critical scientific areas.

Download Full-text

Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications

Nanoscale ◽

10.1039/c5nr01538c ◽

2015 ◽

Vol 7 (18) ◽

pp. 8209-8232 ◽

Cited By ~ 99

Author(s):

Donglu Shi ◽

M. E. Sadat ◽

Andrew W. Dunn ◽

David B. Mast

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Physical Properties ◽

Iron Oxide Nanoparticles ◽

Basic Science ◽

Biomedical Applications ◽

Oxide Nanoparticles ◽

Nanometer Range

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications.

Download Full-text

Synthetic amorphous calcium phosphates (ACPs):preparation, structure, properties and biomedical applications

Biomaterials Science ◽

10.1039/d1bm01239h ◽

2021 ◽

Author(s):

Sergey V Dorozhkin

Keyword(s):

Physical Properties ◽

Biomedical Applications ◽

Calcium Phosphates ◽

Amorphous State ◽

Calcium Orthophosphates ◽

Structure Properties

Amorphous calcium phosphates (ACPs) represent a metastable amorphous state of other calcium orthophosphates (abbreviated as CaPO4) possessing variable compositional but rather identical glass-like physical properties, in which there are neither...

Download Full-text

Applications of magnetic and multiferroic core/shell nanostructures and their physical properties

DYNA ◽

10.15446/dyna.v85n207.69203 ◽

2018 ◽

Vol 85 (207) ◽

pp. 29-35

Author(s):

Claudia Milena Bedoya-Hincapié ◽

Elisabeth Restrepo-Parra ◽

Luis Demetrio López-Carreño

Keyword(s):

Physical Properties ◽

Biomedical Applications ◽

Magnetic Behavior ◽

Core Shell ◽

Cellular Functions ◽

Shell Nanostructures ◽

Biomedical Field ◽

Core Shell Structure ◽

Significant Attention ◽

Stimulation Of

The potential of nanotechnology in the biomedical field has been crucial for contributing to the possibility of efficiently meeting present necessities with novel materials. Over the last few decades, nanostructures with a core/shell structure have attracted significant attention because of the possibility of changing their physical properties by varying their chemistry and geometry. These structures have become relevant in targeted therapy (drug delivery and treatments to complement chemotherapy and radiotherapy), imaging and in the stimulation of cellular functions. Thus in this paper the current development of core/shell nanostructures is reviewed, emphasizing the physical properties of those that have been proposed as potentially having biomedical applications, which are based in a magnetic behavior or in a mixture of magnetic and electric (multiferroic) phenomena.

Download Full-text

Synthesis and Biological Application of Polylactic Acid

Molecules ◽

10.3390/molecules25215023 ◽

2020 ◽

Vol 25 (21) ◽

pp. 5023

Author(s):

Ge Li ◽

Menghui Zhao ◽

Fei Xu ◽

Bo Yang ◽

Xiangyu Li ◽

...

Keyword(s):

Physical Properties ◽

Polylactic Acid ◽

Biomedical Applications ◽

Raw Materials ◽

Raw Material ◽

Biomedical Materials ◽

Biomedical Material ◽

Sugar Fermentation ◽

Low Toxicity ◽

Good Biocompatibility

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.

Download Full-text

Coarse-Grained Models of RNA Nanotubes for Large Time Scale Studies in Biomedical Applications

Biomedicines ◽

10.3390/biomedicines8070195 ◽

2020 ◽

Vol 8 (7) ◽

pp. 195 ◽

Cited By ~ 1

Author(s):

Shyam Badu ◽

Sanjay Prabhakar ◽

Roderick Melnik

Keyword(s):

Physical Properties ◽

Time Scale ◽

Biomedical Applications ◽

Md Simulation ◽

Large Time ◽

Coarse Grained ◽

Dihedral Angles ◽

Computation Cost ◽

In Series ◽

Large Time Scale

In order to describe the physical properties of large time scale biological systems, coarse-grained models play an increasingly important role. In this paper we develop Coarse-Grained (CG) models for RNA nanotubes and then, by using Molecular Dynamics (MD) simulation, we study their physical properties. Our exemplifications include RNA nanotubes of 40 nm long, equivalent to 10 RNA nanorings connected in series. The developed methodology is based on a coarse-grained representation of RNA nanotubes, where each coarse bead represents a group of atoms. By decreasing computation cost, this allows us to make computations feasible for realistic structures of interest. In particular, for the developed coarse-grained models with three bead approximations, we calculate the histograms for the bond angles and the dihedral angles. From the dihedral angle histograms, we analyze the characteristics of the links used to build the nanotubes. Furthermore, we also calculate the bead distances along the chains of RNA strands in the nanoclusters. The variations in these features with the size of the nanotube are discussed in detail. Finally, we present the results on the calculation of the root mean square deviations for a developed RNA nanotube to demonstrate the equilibration of the systems for drug delivery and other biomedical applications such as medical imaging and tissue engineering.

Download Full-text

Physical Properties of Nanoparticles That Result in Improved Cancer Targeting

Journal of Oncology ◽

10.1155/2020/5194780 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16 ◽

Cited By ~ 3

Author(s):

Randa Zein ◽

Wissam Sharrouf ◽

Kim Selting

Keyword(s):

Adverse Effects ◽

Physical Properties ◽

Therapeutic Efficacy ◽

Biomedical Applications ◽

Cancer Targeting ◽

Drug Penetration ◽

Charge Shape ◽

Tumor Tissues ◽

Chemical Attributes

The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target, and drug penetration into tumors is limited by abnormal vasculature and high interstitial pressure. Chemotherapy is the most common systemic treatment for cancer but can cause undesirable adverse effects, including toxicity to the bone marrow and gastrointestinal system. Therefore, nanotechnology-based drug delivery systems have been developed to reduce the adverse effects of traditional chemotherapy by enhancing the penetration and selective drug retention in tumor tissues. A thorough knowledge of the physical properties (e.g., size, surface charge, shape, and mechanical strength) and chemical attributes of nanoparticles is crucial to facilitate the application of nanotechnology to biomedical applications. This review provides a summary of how the attributes of nanoparticles can be exploited to improve therapeutic efficacy. An ideal nanoparticle is proposed at the end of this review in order to guide future development of nanoparticles for improved drug targeting in vivo.

Download Full-text

Titanium-containing bioactive phosphate glasses

Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences ◽

10.1098/rsta.2011.0276 ◽

2012 ◽

Vol 370 (1963) ◽

pp. 1352-1375 ◽

Cited By ~ 26

Author(s):

A. Kiani ◽

N. J. Lakhkar ◽

V. Salih ◽

M. E. Smith ◽

J. V. Hanna ◽

...

Keyword(s):

Physical Properties ◽

Tissue Regeneration ◽

Biomedical Applications ◽

Review Paper ◽

Phosphate Glasses ◽

Bone Substitute Material ◽

Soft Tissue Regeneration ◽

Recent Developments ◽

Titanium Incorporation ◽

Biomedical Field

The use of biomaterials has revolutionized the biomedical field and has received substantial attention in the last two decades. Among the various types of biomaterials, phosphate glasses have generated great interest on account of their remarkable bioactivity and favourable physical properties for various biomedical applications relating to both hard and soft tissue regeneration. This review paper focuses mainly on the development of titanium-containing phosphate-based glasses and presents an overview of the structural and physical properties. The effect of titanium incorporation on the glassy network is to introduce favourable properties. The biocompatibility of these glasses is described along with recent developments in processing methodologies, and the potential of Ti-containing phosphate-based glasses as a bone substitute material is explored.

Download Full-text

Stimuli-Responsive Polypeptides for Biomedical Applications

Polymers ◽

10.3390/polym10080830 ◽

2018 ◽

Vol 10 (8) ◽

pp. 830 ◽

Cited By ~ 2

Author(s):

DaeYong Lee ◽

N. Rejinold ◽

Seong Jeong ◽

Yeu-Chun Kim

Keyword(s):

Physical Properties ◽

Adenosine Triphosphate ◽

Biomedical Applications ◽

Stimuli Responsive ◽

The Past ◽

Bioactive Properties ◽

Recent Advances ◽

Ph Reduction ◽

Biomedical Fields

Stimuli-responsive polypeptides have gained attention because desirable bioactive properties can be easily imparted to them while keeping their biocompatibility and biodegradability intact. In this review, we summarize the most recent advances in various stimuli-responsive polypeptides (pH, reduction, oxidation, glucose, adenosine triphosphate (ATP), and enzyme) over the past five years. Various synthetic strategies exploited for advanced polypeptide-based materials are introduced, and their applicability in biomedical fields is discussed. The recent polypeptides imparted with new stimuli-responsiveness and their novel chemical and physical properties are explained in this review.

Download Full-text

Synthesis and characterization of photocrosslinkable albumin-based hydrogels for biomedical applications

Soft Matter ◽

10.1039/d0sm00977f ◽

2020 ◽

Vol 16 (40) ◽

pp. 9242-9252

Author(s):

Darlin Lantigua ◽

Michelle A. Nguyen ◽

Xinchen Wu ◽

Sanika Suvarnapathaki ◽

Seongjin Kwon ◽

...

Keyword(s):

Physical Properties ◽

Glycidyl Methacrylate ◽

Biomedical Applications ◽

Synthesis And Characterization

Modulating the levels of glycidyl methacrylate modification in the BSAGMA prepolymer yields hydrogel products with tunable physical properties and enhanced biocompatibility, making BSAGMA hydrogels suitable for a range of biomedical applications.

Download Full-text