An advanced 3D/2.5D integration packaging approach using double-self-assembly method with complex topography, and micropin-fin heat sink interposer for pressure sensing system

Polyaniline (PANI) nanotubes were synthesized separately using amino acetic acid (AA), ethylenediamine tetraacetic acid (EDTA), oxalic acid (OA) as dopant and ammonium persulfate (APS) as oxidant by a self-assembly method. SEM, TEM,FTIR and X-ray diffraction (XRD) and applying the 4 probes method characterized the morphology, structure and property of the product. It was found that nanotubes morphology were synthesized when the [Aci/[A ratio is 1:2.The room template conductivity of the products were studied.

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Novel Application of a Multiscale Entropy Index as a Sensitive Tool for Detecting Subtle Vascular Abnormalities in the Aged and Diabetic

Computational and Mathematical Methods in Medicine ◽

10.1155/2013/645702 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Hsien-Tsai Wu ◽

Men-Tzung Lo ◽

Guan-Hong Chen ◽

Cheuk-Kwan Sun ◽

Jian-Jung Chen

Keyword(s):

Glycosylated Hemoglobin ◽

Reactive Hyperemia ◽

Multiscale Entropy ◽

Arterial Pulse ◽

Vascular Changes ◽

Entropy Index ◽

Pressure Sensing ◽

Vascular Abnormalities ◽

Sensing System ◽

Sensitive Tool

Although previous studies have shown the successful use of pressure-induced reactive hyperemia as a tool for the assessment of endothelial function, its sensitivity remains questionable. This study aims to investigate the feasibility and sensitivity of a novel multiscale entropy index (MEI) in detecting subtle vascular abnormalities in healthy and diabetic subjects. Basic anthropometric and hemodynamic parameters, serum lipid profiles, and glycosylated hemoglobin levels were recorded. Arterial pulse wave signals were acquired from the wrist with an air pressure sensing system (APSS), followed by MEI and dilatation index (DI) analyses. MEI succeeded in detecting significant differences among the four groups of subjects: healthy young individuals, healthy middle-aged or elderly individuals, well-controlled diabetic individuals, and poorly controlled diabetic individuals. A reduction in multiscale entropy reflected age- and diabetes-related vascular changes and may serve as a more sensitive indicator of subtle vascular abnormalities compared with DI in the setting of diabetes.

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Chemically Responsive Polymer Inverse-Opal Photonic Crystal Films Created by a Self-Assembly Method

The Journal of Physical Chemistry C ◽

10.1021/acs.jpcc.6b01987 ◽

2016 ◽

Vol 120 (22) ◽

pp. 11938-11946 ◽

Cited By ~ 15

Author(s):

Huilin Zhao ◽

Jianping Gao ◽

Zeng Pan ◽

Guanbo Huang ◽

Xiaoyang Xu ◽

...

Keyword(s):

Photonic Crystal ◽

Self Assembly ◽

Inverse Opal ◽

Assembly Method ◽

Responsive Polymer ◽

Crystal Films

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Hydrogen-Bonding Layer Protecting Polyelectrolyte Capsules and Its Mechanical Property Study with Atomic Force Microscope

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2008.156 ◽

2008 ◽

Vol 8 (6) ◽

pp. 2996-3002 ◽

Cited By ~ 4

Author(s):

Liqin Ge ◽

Xing Wang ◽

Long Ba ◽

Zhongze Gu

Keyword(s):

Hydrogen Bonding ◽

Atomic Force Microscope ◽

Elastic Deformation ◽

Self Assembly ◽

Laser Scanning ◽

Confocal Laser ◽

Bonding Layer ◽

Layer By Layer ◽

Assembly Method ◽

Atomic Force

The hydrogen-bonding multilayered polyelectrolyte capsules with sizes around 6 μm were fabricated by layer-by-layer self-assembly method. The morphology of the obtained capsules was observed with Scanning Electron Microscope (SEM), Confocal Laser Scanning Microscope (CLSM) and Atomic Force Microscope (AFM), respectively. The elastic properties of the capsules were studied with AFM. The capsule was pressed by cantilever with different lengths, a glass bead glued at the end of the cantilever. The force curves were measured on the capsule in air. The Young's modulus of the capsule was obtained (E = 170 MPa for the loading). Results show that this model can predict the elastic deformation of the microcapsule. The accuracy of the elastic deformation of polymer capsule can be ensured using a cantilever of mediate stiffness. Our results show that the existence of the hydrogen-bonding layer makes the multilayered polyelectrolyte harder in comparison with the pure multilayered polyelectrolyte capsules.

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An automated setup for production of nanodimensional coatings by the polyelectrolyte self-assembly method

Instruments and Experimental Techniques ◽

10.1134/s0020441206060157 ◽

2006 ◽

Vol 49 (6) ◽

pp. 849-854 ◽

Cited By ~ 13

Author(s):

S. A. Portnov ◽

A. M. Yashchenok ◽

A. S. Gubskii ◽

D. A. Gorin ◽

A. A. Neveshkin ◽

...

Keyword(s):

Self Assembly ◽

Assembly Method

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Regulation of melanoma cell growth by a miR-21 loaded targeted delivery system based on microparticles and nanoparticles targeting phosphatase and tensin homolog (PTEN)

Materials Express ◽

10.1166/mex.2021.2095 ◽

2021 ◽

Vol 11 (11) ◽

pp. 1766-1773

Author(s):

Lei Jin ◽

Tong Yang

Keyword(s):

Delivery System ◽

Self Assembly ◽

Targeted Delivery ◽

Melanoma Cells ◽

Phosphatase And Tensin Homolog ◽

Tensin Homolog ◽

Assembly Method ◽

New Strategy ◽

Low Levels ◽

Phosphatase And Tensin Homologue

The modulatory effect of miR-21 on the proliferation of melanoma cells through stimulation of PTEN (Phosphatase and tensin homologue deleted on chromosome 10) expression was investigated in the current study. PTEN, as a tumor suppressor, is expressed in low levels in melanoma tissues and cell lines. Nevertheless, miR-21 can stimulate cancer development and suppress cell apoptosis. Overexpression of PTEN substantially impaired the proliferation of miR-21-treated melanoma cells. In addition, miR-21 and PTEN were observed to exhibit a combinatorial effect, whereas miR-21 could negatively regulate the expression of PTEN. In conclusion, these findings demonstrate that miR-21 affects melanoma development by targeting PTEN, establishing a new strategy for treating malignant melanoma. Furthermore, in this study, microparticles and nanoparticles were employed as carriers to construct, through the self-assembly method, nanocapsules carrying miR-21 in order to develop an efficient nanocapsule delivery system of miR-21 against melanoma cells.

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Enhanced Entrapment and Improved in Vitro Controlled Release of N-Acetyl Cysteine in Hybrid PLGA/Lecithin Nanoparticles Prepared Using a Nanoprecipitation/Self-Assembly Method

Journal of Cellular Biochemistry ◽

10.1002/jcb.26070 ◽

2017 ◽

Vol 118 (12) ◽

pp. 4203-4209 ◽

Cited By ~ 10

Author(s):

Parvin Ahmaditabar ◽

Amir A. Momtazi-Borojeni ◽

Ali H. Rezayan ◽

Mahboobeh Mahmoodi ◽

Amirhossein Sahebkar ◽

...

Keyword(s):

Controlled Release ◽

Self Assembly ◽

Assembly Method ◽

Acetyl Cysteine

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LifeChair: A Conductive Fabric Sensor-Based Smart Cushion for Actively Shaping Sitting Posture

Sensors ◽

10.3390/s18072261 ◽

2018 ◽

Vol 18 (7) ◽

pp. 2261 ◽

Cited By ~ 9

Author(s):

Karlos Ishac ◽

Kenji Suzuki

Keyword(s):

Detection Accuracy ◽

Upright Posture ◽

Performance Study ◽

Vibrotactile Feedback ◽

Pressure Sensing ◽

Sitting Posture ◽

Conductive Fabric ◽

The Past ◽

Sensing System ◽

Average Accuracy

The LifeChair is a smart cushion that provides vibrotactile feedback by actively sensing and classifying sitting postures to encourage upright posture and reduce slouching. The key component of the LifeChair is our novel conductive fabric pressure sensing array. Fabric sensors have been explored in the past, but a full sensing solution for embedded real world use has not been proposed. We have designed our system with commercial use in mind, and as a result, it has a high focus on manufacturability, cost-effectiveness and adaptiveness. We demonstrate the performance of our fabric sensing system by installing it into the LifeChair and comparing its posture detection accuracy with our previous study that implemented a conventional flexible printed PCB-sensing system. In this study, it is shown that the LifeChair can detect all 11 postures across 20 participants with an improved average accuracy of 98.1%, and it demonstrates significantly lower variance when interfacing with different users. We also conduct a performance study with 10 participants to evaluate the effectiveness of the LifeChair device in improving upright posture and reducing slouching. Our performance study demonstrates that the LifeChair is effective in encouraging users to sit upright with an increase of 68.1% in time spent seated upright when vibrotactile feedback is activated.

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