Extraction for profiling free and bound phenolic compounds in tea seed oil by deep eutectic solvents

The present study aimed at evaluating the effectiveness of different natural deep eutectic solvents (NADES) on the extraction of phenolic compounds from Lavandula pedunculata subsp. lusitanica (Chaytor) Franco, on the antioxidant activity, and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (Tyr) inhibitory capacities. Ten different NADES were used in this research and compared with conventional solvents. Ultrasound-assisted extraction (UAE) for 60 min proved to be the best extraction condition, and proline:lactic acid (1:1) and choline chloride:urea (1:2) extracts showed the highest total phenolic contents (56.00 ± 0.77 mgGAE/gdw) and antioxidant activity [64.35 ± 1.74 mgTE/gdw and 72.13 ± 0.97 mgTE/gdw in 2.2-diphenyl-1-picrylhydrazyl (DPPH) and 2.2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods, respectively]. These extracts also exhibited enzymes inhibitory capacity particularly against Tyr and AChE. Even so, organic acid-based NADES showed to be the best extractants producing extracts with considerable ability to inhibit enzymes. Twenty-four phenolic compounds were identified by HPLC-HRMS, being rosmarinic acid, ferulic acid and salvianolic acid B the major compounds. The results confirmed that the combination of UAE and NADES provide an excellent alternative to organic solvents for sustainable and green extraction, and have huge potential for use in industrial applications involving the extraction of bioactive compounds from plants.

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Review on Extraction of Phenolic Compounds from Natural Sources Using Green Deep Eutectic Solvents

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.0c06641 ◽

2021 ◽

Vol 69 (3) ◽

pp. 878-912 ◽

Cited By ~ 1

Author(s):

Ali Ali Redha

Keyword(s):

Phenolic Compounds ◽

Deep Eutectic Solvents ◽

Natural Sources

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Separation of phenols from oils using deep eutectic solvents and ionic liquids

Pure and Applied Chemistry ◽

10.1515/pac-2019-1119 ◽

2020 ◽

Vol 92 (10) ◽

pp. 1717-1731

Author(s):

Yucui Hou ◽

Zhi Feng ◽

Jaime Ruben Sossa Cuellar ◽

Weize Wu

Keyword(s):

Ionic Liquids ◽

Phenolic Compounds ◽

High Efficiency ◽

Deep Eutectic Solvents ◽

Environmentally Benign ◽

Organic Chemical ◽

Environmental Friendliness ◽

Oil Mixtures ◽

Organic Chemical Industry

AbstractPhenolic compounds are important basic materials for the organic chemical industry, such as pesticides, medicines and preservatives. Phenolic compounds can be obtained from biomass, coal and petroleum via pyrolysis and liquefaction, but they are mixtures in oil. The traditional methods to separate phenols from oil using alkaline washing are not environmentally benign. To solve the problems, deep eutectic solvents (DESs) and ionic liquids (ILs) have been developed to separate phenols from oil, which shows high efficiency and environmental friendliness. In this article, we summarized the properties of DESs and ILs and the applications of DESs and ILs in the separation of phenols and oil. There are two ways in which DESs and ILs are used in these applications: (1) DESs formed in situ using different hydrogen bonding acceptors including quaternary ammonium salts, zwitterions, imidazoles and amides; (2) DESs and ILs used as extractants. The effect of water on the separation, mass transfer dynamics in the separation process, removal of neutral oil entrained in DESs, phase diagrams of phenol + oil + extractant during extraction, are also discussed. In the last, we analyze general trends for the separation and evaluate the problematic or challenging aspects in the separation of phenols from oil mixtures.

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