Cross-sectional associations of cortical β-amyloid with erythrocyte membrane long-chain polyunsaturated fatty acids in older adults with subjective memory complaints

Subjective memory complaints (SMCs) and social capital were known to be related to self-rated health (SRH). Despite this, no studies have examined the potential interaction of SMC and social capital on SRH. Using data from a cross-sectional health survey of men and women aged 56 years and above (n = 6,421), we examined how SMCs and social capital explained SRH in a population of community-dwelling older adults in a semirural area in Malaysia. We also evaluated whether SRH’s relationship with SMCs is moderated by social capital. The association of SMC and social capital with poor SRH was investigated using multivariable logistic regression. Social capital (OR = 0.86, 95% CI = 0.82–0.89), mild SMC (OR = 1.70, 95% CI = 1.50–1.94), and moderate SMC (OR = 1.90, 95% CI = 1.63–2.20) were found to be associated with poor SRH after adjustment for sociodemographic factors and depression in the initial regression model. SMC was found to have partial interaction effects with social capital which was included in the subsequent regression model. Unlike individuals with no SMC and mild SMC, those who reported moderate SMC did not show decreasing probabilities of poor SRH despite increasing levels of social capital. Nevertheless, this analysis suggests that social capital and SMC are independent predictors of poor SRH. Further research needs to be targeted at improving the understanding on how social capital and SMC moderate and interact with the perception of health in older adults.

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Chronically raised C-reactive protein is inversely associated with cortical β-amyloid in older adults with subjective memory complaints

Experimental Gerontology ◽

10.1016/j.exger.2018.04.014 ◽

2018 ◽

Vol 108 ◽

pp. 226-230 ◽

Cited By ~ 2

Author(s):

Claudie Hooper ◽

Philipe De Souto Barreto ◽

Christelle Cantet ◽

Matteo Cesari ◽

Pierre Payoux ◽

...

Keyword(s):

Older Adults ◽

Subjective Memory Complaints ◽

C Reactive Protein ◽

Subjective Memory ◽

Reactive Protein ◽

Memory Complaints ◽

Β Amyloid

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Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study

Nutrients ◽

10.3390/nu13072453 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2453

Author(s):

Ana M Pinto ◽

Helen L MacLaughlin ◽

Wendy L Hall

Keyword(s):

Chronic Kidney Disease ◽

Fatty Acids ◽

Heart Rate ◽

Heart Rate Variability ◽

Kidney Disease ◽

Polyunsaturated Fatty Acids ◽

Cardiac Death ◽

Cross Sectional ◽

Ckd Stage ◽

Long Chain

Low heart rate variability (HRV) is independently associated with increased risk of sudden cardiac death (SCD) and all cardiac death in haemodialysis patients. Long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) may exert anti-arrhythmic effects. This study aimed to investigate relationships between dialysis, sleep and 24 h HRV and LC n-3 PUFA status in patients who have recently commenced haemodialysis. A cross-sectional study was conducted in adults aged 40–80 with chronic kidney disease (CKD) stage 5 (n = 45, mean age 58, SD 9, 20 females and 25 males, 39% with type 2 diabetes). Pre-dialysis blood samples were taken to measure erythrocyte and plasma fatty acid composition (wt % fatty acids). Mean erythrocyte omega-3 index was not associated with HRV following adjustment for age, BMI and use of β-blocker medication. Higher ratios of erythrocyte eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) were associated with lower 24 h vagally-mediated beat-to-beat HRV parameters. Higher plasma EPA and docosapentaenoic acid (DPAn-3) were also associated with lower sleep-time and 24 h beat-to-beat variability. In contrast, higher plasma EPA was significantly related to higher overall and longer phase components of 24 h HRV. Further investigation is required to investigate whether patients commencing haemodialysis may have compromised conversion of EPA to DHA, which may impair vagally-mediated regulation of cardiac autonomic function, increasing risk of SCD.

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Subjective memory complaints in an elderly sample: a cross-sectional study

International Journal of Geriatric Psychiatry ◽

10.1002/gps.1836 ◽

2007 ◽

Vol 23 (1) ◽

pp. 49-54 ◽

Cited By ~ 97

Author(s):

Thaís Soares Cianciarullo Minett ◽

Rosimeire Vieira Da Silva ◽

Karin Zazo Ortiz ◽

Paulo Henrique Ferreira Bertolucci

Keyword(s):

Cross Sectional Study ◽

Sectional Study ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Cross Sectional ◽

Memory Complaints

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Fear of falling, but not gait impairment, predicts subjective memory complaints in cognitively intact older adults

Geriatrics and Gerontology International ◽

10.1111/ggi.12829 ◽

2016 ◽

Vol 17 (7) ◽

pp. 1125-1131 ◽

Cited By ~ 11

Author(s):

Ryota Sakurai ◽

Hiroyuki Suzuki ◽

Susumu Ogawa ◽

Hisashi Kawai ◽

Hideyo Yoshida ◽

...

Keyword(s):

Older Adults ◽

Fear Of Falling ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Gait Impairment ◽

Memory Complaints ◽

Cognitively Intact

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The impact of subjective memory complaints on quality of life in community-dwelling older adults

Psychogeriatrics ◽

10.1111/psyg.12056 ◽

2014 ◽

Vol 14 (3) ◽

pp. 175-181 ◽

Cited By ~ 24

Author(s):

Yohko Maki ◽

Tomoharu Yamaguchi ◽

Tetsuya Yamagami ◽

Tatsuhiko Murai ◽

Kenji Hachisuka ◽

...

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Community Dwelling ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

The Impact ◽

Community Dwelling Older Adults

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Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.05.014 ◽

2018 ◽

Vol 14 (9) ◽

pp. 1204-1215 ◽

Cited By ~ 27

Author(s):

Enrica Cavedo ◽

Patrizia A. Chiesa ◽

Marion Houot ◽

Maria Teresa Ferretti ◽

Michel J. Grothe ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Sex Differences ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Cognitively Normal ◽

Memory Complaints ◽

Neuroimaging Biomarkers

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Memory Strategy Training in Older Adults with Subjective Memory Complaints: A Randomized Controlled Trial

Journal of the International Neuropsychological Society ◽

10.1017/s1355617718000619 ◽

2018 ◽

Vol 24 (10) ◽

pp. 1110-1120 ◽

Cited By ~ 5

Author(s):

Nikita L. Frankenmolen ◽

Eduard J. Overdorp ◽

Luciano Fasotti ◽

Jurgen A.H.R. Claassen ◽

Roy P.C. Kessels ◽

...

Keyword(s):

Older Adults ◽

Daily Life ◽

Controlled Trial ◽

Strategy Training ◽

Memory Training ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Memory Strategy ◽

Memory Functioning

AbstractObjectives: Subjective memory complaints (SMC) in older adults are associated with a decline in everyday functioning and an increased risk for future cognitive decline. This study examines the effect of a memory strategy training compared to a control memory training on memory functioning in daily life. Methods: This was a randomized controlled trial with baseline, post-treatment, and 6-month follow-up assessments conducted in 60 older adults (50–87 years) with SMC. Participants were randomly assigned to either seven sessions of memory strategy training or seven sessions of control memory training. Both interventions were given in small groups and included psycho-education. Primary outcome measure was memory functioning in daily life. Objective measures of memory performance and self-reported measures of strategy use were included as secondary outcome measures. Results: Participants in each intervention group reported an improvement in personal memory goals (p<.0005), up to 6 months after training. An interaction effect showed that participants following memory strategy training reported a larger improvement in personal memory goals (p=.002). Both intervention groups improved on two memory tests (p<.001 and p<.01). In the memory strategy training group, an increase in strategy use in daily life was the strongest predictor (p<.05) of improvement in subjective memory functioning. Conclusions: Older adults with subjective memory complaints benefit from memory strategy training, especially in their memory functioning in daily life. (JINS, 2018, 24, 1110–1120)

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Association between childhood socioeconomic status and subjective memory complaints among older adults: results from the Japan Gerontological Evaluation Study 2010

International Psychogeriatrics ◽

10.1017/s1041610219000814 ◽

2019 ◽

Vol 31 (12) ◽

pp. 1699-1707 ◽

Cited By ~ 3

Author(s):

Toshinori Nishizawa ◽

Ayako Morita ◽

Takeo Fujiwara ◽

Katsunori Kondo

Keyword(s):

Older Adults ◽

Socioeconomic Status ◽

Evaluation Study ◽

Community Dwelling ◽

Self Report ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Childhood Socioeconomic Status ◽

Community Dwelling Older Adults

ABSTRACTBackground:Subjective memory complaints (SMC) have been suggested as an early marker of mild cognitive impairment and dementia. However, there is a paucity of evidence on the effects of early life conditions on the development of SMC in old age. This study is aimed at investigating the association between childhood socioeconomic status (SES) and SMC in community-dwelling older adults.Methods:We used the data of the Japan Gerontological Evaluation Study, a population-based cohort study of people aged 65 years or older enrolled from 28 municipalities across Japan. Childhood SES and SMC in everyday life were assessed from the self-report questionnaire administered in 2010 (n = 16,184). Poisson regression was performed to determine their association, adjusted for potential confounders and life-course mediators and examined cohort effects.Results:We identified SMC in 47.4% of the participants. After adjusting for sex, age, and number of siblings, low and middle childhood SES were associated with 29% (prevalence ratio [PR]: 1.29, 95% confidence interval [CI]: 1.22, 1.36) and 10% higher prevalence of SMC (PR: 1.10, 95%CI: 1.04, 1.17), respectively, compared with high childhood SES (p for trend <.001). The interaction terms between childhood SES and age groups were not statistically significant.Conclusion:Childhood SES is significantly associated with SMC among community-dwelling older adults. Efforts to minimize childhood poverty may diminish or delay the onset of SMC and dementia in later life.

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Executive Function Predicts the Validity of Subjective Memory Complaints in Older Adults beyond Demographic, Emotional, and Clinical Factors

Journal of Prevention of Alzheimer's Disease ◽

10.14283/jpad.2020.61 ◽

2020 ◽

pp. 1-8

Author(s):

R.-Y. Chao ◽

T.-F. Chen ◽

Y.-L. Chang

Keyword(s):

Older Adults ◽

Executive Function ◽

Group Membership ◽

Memory Performance ◽

Objective Measures ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Old Adults ◽

Symptoms Of Depression ◽

Memory Complaints

Background: Although evidence suggests that subjective memory complaints (SMCs) could be a risk factor for dementia, the relationship between SMCs and objective memory performance remains controversial. Old adults with or without mild cognitive impairment (MCI) may represent a highly heterogeneous group, based partly on the demonstrated variability in the level of executive function among those individuals. It is reasonable to speculate that the accuracy of the memory-monitoring ability could be affected by the level of executive function in old adults. Objective: This study investigated the effects of executive function level on the consistency between SMCs and objective memory performance while simultaneously considering demographic and clinical variables in nondemented older adults. Setting: Participants were recruited from both the memory clinics and local communities. Participants: Participants comprised 65 cognitively normal (CN) older adults and 54 patients with MCI. Measurements: Discrepancy scores between subjective memory evaluation and objective memory performance were calculated to determine the degree and directionality of the concordance between subjective and objective measures. Demographic, emotional, genetic, and clinical information as well as several executive function measurements were collected. Results: The CN and MCI groups exhibited similar degrees of SMC; however, the patients with MCI were more likely to overestimate their objective memory ability, whereas the CN adults were more likely to underestimate their objective memory ability. The results also revealed that symptoms of depression, group membership, and the executive function level together predicted the discrepancy between the subjective and objective measures of memory function; however, the executive function level retained its unique predictive ability even after the symptoms of depression, group membership, and other factors were controlled for. Conclusion: Although both noncognitive and cognitive factors were necessary for consideration, the level of executive function may play a unique role in understanding the equivocal relationship of the concurrence between subjective complaints and objective function measures. Through a comprehensive evaluation, high-risk individuals (i.e., CN individuals heightened self-awareness of memory changes) may possibly be identified or provided with the necessary intervention during stages at which objective cognitive impairment remains clinically unapparent.

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