3D Reconstruction of the Left Ventricle From Four Echocardiographic Projections

2014 ◽  
Author(s):  
Navaneetha Krishnan Rajan ◽  
Zeying Song ◽  
Kenneth R. Hoffmann ◽  
Marek Belohlavek ◽  
Eileen M. McMahon ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Three Dimensional ◽  
Image Data ◽  
Left Ventricular ◽  
The Body ◽  
Patient Specific ◽  
Immersed Boundary ◽  
Cross Sectional ◽  
Standard Format ◽  
Automated Method

The left ventricle (LV) of a human heart receives oxygenated blood from the lungs and pumps it throughout the body via the aortic valve. Characterizing the LV geometry, its motion, and the ventricular flow is critical in assessing the heart’s health. An automated method has been developed in this work to generate a three-dimensional (3D) model of the LV from multiple-axis echocardiography (echo). Image data from three long-axis sections and a basal section is processed to compute spatial nodes on the LV surface. The generated surfaces are output in a standard format such that it can be imported into the curvilinear-immersed boundary (CURVIB) framework for numerical simulation of the flow inside the LV. The 3D LV model can be used for better understanding of the ventricular motion and the simulation framework provides a powerful tool for studying left ventricular flows on a patient specific basis. Future work would incorporate data from additional cross-sectional images.

Evaluation of the left ventricle longitudinal deformity using myocardial-tracking signals in severely obese adolescents

2015 ◽  
Vol 26 (4) ◽  
pp. 749-753 ◽  
Author(s):  
Norma Balderrábano ◽  
Blanca Del Rio ◽  
Elsy Navarrete ◽  
Arturo Berber ◽  
Nancy Méndez
Keyword(s):  
Left Ventricle ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
The Body ◽  
School Age Children ◽  
Left Ventricular Ejection ◽  
Cross Sectional ◽  
Ventricular Ejection Fraction ◽  
Obese Adolescents ◽  
Severely Obese

AbstractBackgroundThe global prevalence of obesity in school-age children and adolescents has increased in recent decades. Obesity modifies some aspects of the cardiovascular system in order to preserve the body homoeostasis. Echocardiography to study ventricular function plays an important role in the evaluation of pathological re-modelling associated with left ventricular dysfunction. The aim of this study was to evaluate the left ventricle function and structure with conventional echocardiography and to analyse the longitudinal deformity of the left ventricle using myocardial-tracking signals in a group of severely obese adolescents.Methods and resultsWe carried out a descriptive cross-sectional study. We describe the evaluation of the left ventricle using conventional bi-dimensional echocardiography and the myocardial-tracking signals in severely obese adolescents. There were 34 severely obese adolescents included in our study; 52% had a left ventricular ejection fraction<55%, the left ventricular end-diastolic diameter was increased in 70.5% of patients, and 32.3% had an increase in left ventricular mass. On average, 78.9% had abnormal values of left ventricle longitudinal deformations. The number of segments affected per patient was, on average, 5.8, with the anterior apical segment being the most commonly affected. There was a decrease in global longitudinal deformity in 79.4% of the cases.ConclusionMore than half of this group of asymptomatic severely obese adolescents showed abnormalities in left ventricular structure and function evaluated using traditional echocardiographic methods, but 100% of the cases showed abnormalities in longitudinal deformation in at least one of the 17 left ventricle segments evaluated using myocardial-tracking signals.

scholarly journals Interactive prostate shape reconstruction from 3D TRUS images

2014 ◽  
Vol 1 (4) ◽  
pp. 272-288 ◽  
Author(s):  
Tomotake Furuhata ◽  
Inho Song ◽  
Hong Zhang ◽  
Yoed Rabin ◽  
Kenji Shimada
Keyword(s):  
Transrectal Ultrasound ◽  
Three Dimensional ◽  
Shape Reconstruction ◽  
The Body ◽  
Surface Model ◽  
Cross Sectional ◽  
Automated Method ◽  
3D Surface ◽  
High Level ◽  
Trus Image

Abstract This paper presents a two-step, semi-automated method for reconstructing a three-dimensional (3D) shape of the prostate from a 3D transrectal ultrasound (TRUS) image. While the method has been developed for prostate ultrasound imaging, it can potentially be applicable to any other organ of the body and other imaging modalities. The proposed method takes as input a 3D TRUS image and generates a watertight 3D surface model of the prostate. In the first step, the system lets the user visualize and navigate through the input volumetric image by displaying cross sectional views oriented in arbitrary directions. The user then draws partial/full contours on selected cross sectional views. In the second step, the method automatically generates a watertight 3D surface of the prostate by fitting a deformable spherical template to the set of user-specified contours. Since the method allows the user to select the best cross-sectional directions and draw only clearly recognizable partial or full contours, the user can avoid time-consuming and inaccurate guesswork on where prostate contours are located. By avoiding the usage of noisy, incomprehensible portions of the TRUS image, the proposed method yields more accurate prostate shapes than conventional methods that demand complete cross-sectional contours selected manually, or automatically using an image processing tool. Our experiments confirmed that a 3D watertight surface of the prostate can be generated within five minutes even from a volumetric image with a high level of speckles and shadow noises.

scholarly journals Visualization and simulated surgery of the left ventricle in the virtual pathological heart of the Virtual Physiological Human

2011 ◽  
Vol 1 (3) ◽  
pp. 374-383 ◽  
Author(s):  
N. J. B. McFarlane ◽  
X. Lin ◽  
Y. Zhao ◽  
G. J. Clapworthy ◽  
F. Dong ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Economic Problem ◽  
Patient Specific ◽  
Integrated Medicine ◽  
Quantitative Measurements ◽  
Specific Prediction ◽  
User Friendly ◽  
Significant Health

Ischaemic heart failure remains a significant health and economic problem worldwide. This paper presents a user-friendly software system that will form a part of the virtual pathological heart of the Virtual Physiological Human (VPH2) project, currently being developed under the European Commission Virtual Physiological Human (VPH) programme. VPH2 is an integrated medicine project, which will create a suite of modelling, simulation and visualization tools for patient-specific prediction and planning in cases of post-ischaemic left ventricular dysfunction. The work presented here describes a three-dimensional interactive visualization for simulating left ventricle restoration surgery, comprising the operations of cutting, stitching and patching, and for simulating the elastic deformation of the ventricle to its post-operative shape. This will supply the quantitative measurements required for the post-operative prediction tools being developed in parallel in the same project.

scholarly journals Petiole-Lamina Transition Zone: A Functionally Crucial but Often Overlooked Leaf Trait

Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 774
Author(s):  
Max Langer ◽  
Thomas Speck ◽  
Olga Speck
Keyword(s):  
Transition Zone ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Body Plan ◽  
The Body ◽  
Vascular Bundles ◽  
Cross Sectional ◽  
Thin Sections ◽  
Transition Zones ◽  
The Cross

Although both the petiole and lamina of foliage leaves have been thoroughly studied, the transition zone between them has often been overlooked. We aimed to identify objectively measurable morphological and anatomical criteria for a generally valid definition of the petiole–lamina transition zone by comparing foliage leaves with various body plans (monocotyledons vs. dicotyledons) and spatial arrangements of petiole and lamina (two-dimensional vs. three-dimensional configurations). Cross-sectional geometry and tissue arrangement of petioles and transition zones were investigated via serial thin-sections and µCT. The changes in the cross-sectional geometries from the petiole to the transition zone and the course of the vascular bundles in the transition zone apparently depend on the spatial arrangement, while the arrangement of the vascular bundles in the petioles depends on the body plan. We found an exponential acropetal increase in the cross-sectional area and axial and polar second moments of area to be the defining characteristic of all transition zones studied, regardless of body plan or spatial arrangement. In conclusion, a variety of terms is used in the literature for describing the region between petiole and lamina. We prefer the term “petiole–lamina transition zone” to underline its three-dimensional nature and the integration of multiple gradients of geometry, shape, and size.

scholarly journals Deep learning-based estimation of Flory–Huggins parameter of A–B block copolymers from cross-sectional images of phase-separated structures

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Katsumi Hagita ◽  
Takeshi Aoyagi ◽  
Yuto Abe ◽  
Shinya Genda ◽  
Takashi Honda
Keyword(s):  
Deep Learning ◽  
Diblock Copolymers ◽  
Three Dimensional ◽  
Image Data ◽  
Real Space ◽  
Cross Sectional ◽  
Regression Problem ◽  
Self Consistent Field ◽  
Experimental Image ◽  
Chain Lengths

AbstractIn this study, deep learning (DL)-based estimation of the Flory–Huggins χ parameter of A-B diblock copolymers from two-dimensional cross-sectional images of three-dimensional (3D) phase-separated structures were investigated. 3D structures with random networks of phase-separated domains were generated from real-space self-consistent field simulations in the 25–40 χN range for chain lengths (N) of 20 and 40. To confirm that the prepared data can be discriminated using DL, image classification was performed using the VGG-16 network. We comprehensively investigated the performances of the learned networks in the regression problem. The generalization ability was evaluated from independent images with the unlearned χN. We found that, except for large χN values, the standard deviation values were approximately 0.1 and 0.5 for A-component fractions of 0.2 and 0.35, respectively. The images for larger χN values were more difficult to distinguish. In addition, the learning performances for the 4-class problem were comparable to those for the 8-class problem, except when the χN values were large. This information is useful for the analysis of real experimental image data, where the variation of samples is limited.

Abstract 248: Aberrant TGFβ Signaling as an Etiology of Left Ventricular Non-compaction Cardiomyopathy

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Kazuki Kodo ◽  
Sang-Ging Ong ◽  
Fereshteh Jahanbani ◽  
Vittavat Termglinchan ◽  
Kolsoum InanlooRahatloo ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Induced Pluripotent Stem Cell ◽  
Left Ventricular ◽  
Patient Specific ◽  
Developmental Defect ◽  
Tgfβ Signaling ◽  
Growth Factor Beta ◽  
Induced Pluripotent

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in children and has a unique phenotype with characteristically extensive hypertrabeculation of the left ventricle, similar to the embryonic left ventricle, suggesting a developmental defect of the embryonic myocardium. However, studying this disease has been challenging due to the lack of an animal model that can faithfully recapitulate the clinical phenotype of LVNC. To address this, we showed that patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) generated from a family with LVNC history recapitulated a developmental defect consistent with the LVNC phenotype at the single-cell level. We then utilized hiPSC-CMs to show that increased transforming growth factor beta (TGFβ) signaling is one of the central mechanisms underlying the pathogenesis of LVNC. LVNC hiPSC-CMs demonstrated decreased proliferative capacity due to abnormal activation of TGFβ signaling (Figs A-B). Exome sequencing demonstrated a mutation in TBX20, which regulates TGFβ signaling through upregulation of ITGAV, contributing to the LVNC phenotype. Inhibition of abnormal TGFβ signaling or genetic correction of the TBX20 mutation (Figs C-D) using TALEN reversed the proliferation defects seen in LVNC hiPSC-CMs. Our results demonstrate that hiPSC-CMs are a useful tool for the exploration of novel mechanisms underlying poorly understood cardiomyopathies such as LVNC. Here we provide the first evidence of activation of TGFβ signaling as playing a role in the pathogenesis of LVNC.

Automated Three-Dimensional Reconstruction of the Left Ventricle From Multiple-Axis Echocardiography

2015 ◽  
Vol 138 (1) ◽  
Author(s):  
Navaneetha Krishnan Rajan ◽  
Zeying Song ◽  
Kenneth R. Hoffmann ◽  
Marek Belohlavek ◽  
Eileen M. McMahon ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Cross Sections ◽  
Low Cost ◽  
Software Tool ◽  
Acquisition Time ◽  
Lv Function ◽  
High Temporal Resolution ◽  
Standard Format ◽  
Flow Simulations ◽  
Automated Method

Two-dimensional echocardiography (echo) is the method of choice for noninvasive evaluation of the left ventricle (LV) function owing to its low cost, fast acquisition time, and high temporal resolution. However, it only provides the LV boundaries in discrete 2D planes, and the 3D LV geometry needs to be reconstructed from those planes to quantify LV wall motion, acceleration, and strain, or to carry out flow simulations. An automated method is developed for the reconstruction of the 3D LV endocardial surface using echo from a few standard cross sections, in contrast with the previous work that has used a series of 2D scans in a linear or rotational manner for 3D reconstruction. The concept is based on a generalized approach so that the number or type (long-axis (LA) or short-axis (SA)) of sectional data is not constrained. The location of the cross sections is optimized to minimize the difference between the reconstructed and measured cross sections, and the reconstructed LV surface is meshed in a standard format. Temporal smoothing is implemented to smooth the motion of the LV and the flow rate. This software tool can be used with existing clinical 2D echo systems to reconstruct the 3D LV geometry and motion to quantify the regional akinesis/dyskinesis, 3D strain, acceleration, and velocities, or to be used in ventricular flow simulations.

scholarly journals “A CROSS SECTIONAL, DESCRIPTIVE STUDY ON SYSTEMIC ILLNESSES AND CARDIAC FUNCTION ABNORMALITIES IN CHILDREN”

2021 ◽  
pp. 75-79
Author(s):  
Munesh Tomar ◽  
Tanvi goel ◽  
Raza Faizan ◽  
Vijay Jaiswal
Keyword(s):  
Cardiac Output ◽  
Cardiac Function ◽  
Ventricular Dysfunction ◽  
Significant Proportion ◽  
Descriptive Study ◽  
Left Ventricular ◽  
The Body ◽  
Cross Sectional ◽  
Pr Interval ◽  
Ecg Abnormalities

Background:There are wide number of diseases of almost every system in the body which can affect heart in a number of different ways including increasing demands on the heart ,ventricular dysfunction ,rhythm abnormalities ,valve abnormalities ,pulmonary pressures and lot more.Cardiac involvement in systemic diseases is usually silent or oligosymptomatic and includes different pathophysiological mechanisms such as myocardial inflammation, infarction ,subendocardial vasculitis,valvular disease and different patterns of fibrosis. Objective : To study association between systemic illnesses (hematological, endocrinal , renal) and cardiac function abnormalities as ventricular function,cardiac dimensions ,pulmonary artery pressure and pericardial effusion,for early diagnosis and treatment to decrease morbidity and mortality in patient with systemic illness. Design/Method:It was a cross sectional,descriptive study The present study was conducted in the Department of Pediatrics, LLRM Medical College,Meerut,Uttar Pradesh over a period of 1 year (June 2019-June 2020) Results: Cardiac findings in all three groups show ECG abnormalities and echocardiographic changes compared to general population. ECG abnormalities were prolonged PR interval and sinus tachycardia while echocardiographic changes mainly left ventricular(LV) dilatation and hypertrophy ,increased cardiac output ,ventricular dysfunction and pulmonary arterial hypertension(PAH),were noted in a significant proportion of patients. Conclusion:Systemic illnesses affect cardiac parameters in various ways including prolonged PR interval,cardiac dilatation,chamber hypertrophy ,high cardiac output,high cardiac index ,PAH and ventricular dysfunction.

scholarly journals MRI Study on Tibial Nerve of the Ankle Canal and Its Branches: A method of multiplanar reconstruction with 3D-FIESTA-C sequences

2020 ◽  
Author(s):  
Yan Zhang ◽  
Xucheng He ◽  
Juan Li ◽  
Ju Ye ◽  
Wenjuan Han ◽  
...  
Keyword(s):  
Tibial Nerve ◽  
Three Dimensional ◽  
The Body ◽  
Multiplanar Reconstruction ◽  
Medial Malleolus ◽  
Cross Sectional ◽  
Medial Plantar Nerve ◽  
Lateral Plantar Nerve ◽  
Good Imaging ◽  
Starting Point

Abstract Background The display of tibial nerve and its branches in the ankle canal is helpful for the diagnosis of local lesions and compression, and also for clinical observation and surgical planning.The aim of this study was to investigate the feasibility of three-dimensional dual-excitation balanced steady-state free precession sequence (3D-FIESTA-C) multiplanar reconstruction (MPR) display of tibial nerve and its branches of the ankle canal. Methods The subjects were 20 healthy volunteers (40 ankles), aged 22–50, with no history of ankle joint desease. 3D-FIESTA-C sequence was used in the 3.0t magnetic resonance equipment for imaging. During the scanning, each foot was at a 90-degree angle to the tibia.The tibial nerve of the ankle canal and its branches were displayed and measured at the same level through multiplanar reconstruction. Results Most of the tibial nerve bifurcation points were located in the ankle canal (57.5%), few (42.5%) were located at the proximal end of the ankle canal, and none was found away from the distal end. The bifurcation between the medial plantar nerve and the lateral plantar nerve is on the line between the tip of the medial malleolus and the calcaneus, and it’s angle is between 6° and 35°.The average cross-sectional diameter of the medial plantar nerve is about mm, and the lateral plantar nerve about mm. In MPR images, the display rates of both the medial calcaneal nerve and the subcalcaneal nerve were 100%, and the starting point of the subcalcaneal nerve was always at the distal end of the starting point of the medial calcaneal nerve. In 55% of cases, there were more than 2 medial calcaneal nerve innervations. Conclusion The 3D-FIESTA-C MPR can display the morphological features and positions of tibial nerve and its branches and the bifurcation point’s projection position on the body surface can be marked. This method not only benefited the imaging diagnosis of tibial nerve and branch-related lesions of the ankle canal, but also provided a good imaging basis to plan the clinical operation of the ankle canal and avoid surgical injury.

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