A Multifunctional Microfluidic Device Based on Bifurcation Geometry

2010 ◽  
Author(s):  
Ahmed Fadl ◽  
Stefanie Demming ◽  
Zongqin Zhang ◽  
Bjo¨rn Hoxhold ◽  
Stephanus Bu¨ttgenbach ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Optical Lithography ◽  
Working Fluid ◽  
The Novel ◽  
Flow Rates ◽  
Single Function ◽  
Fluidic Device ◽  
Bifurcation Structures ◽  
Novel Design

Developing multifunctional devices are essential to realize more efficient Microsystems. With miniaturization processes taking place in many different applications, the rooms for single function microfluidic devices are limited. In this study, we introduce a multifunctional micro fluidic device based on bifurcation geometry which is capable of performing pumping and mixing at the same time. Optical lithography is used to fabricate the designed microfluidic device. The microfluidic device is tested at low actuator frequencies, and ethanol is employed as a working fluid. The operational principles are based on rectifying the oscillatory flows by using bifurcation structures for flow rectification. The results prove the feasibility of the novel design, and results are presented in terms of flow rates and maximum back pressures.

scholarly journals Modular pumps as programmable hydraulic batteries for microfluidic devices

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 21-30 ◽  
Author(s):  
Brian M. Cummins ◽  
Rukesh Chinthapatla ◽  
Balaji Lenin ◽  
Frances S. Ligler ◽  
Glenn M. Walker
Keyword(s):  
Microfluidic Device ◽  
Microfluidic Channel ◽  
Microfluidic Devices ◽  
Complex Flow ◽  
Oscillating Flows ◽  
Flow Rates ◽  
Simple Fluid ◽  
Flow Profiles ◽  
Over Time

Simple fluid pumps have been developed to improve microfluidic device portability, but they cannot be easily programmed, produce repeatable pumping performance, or generate complex flow profiles — key requirements for increasing the functionality of portable microdevices. We present a detachable, paper-based, “hydraulic battery” that can be connected to the outlet of a microfluidic channel to pump fluid at varying flow rates over time, including step changes, ramping flows, and oscillating flows.

scholarly journals A Passive Microfluidic Device for Chemotaxis Studies

Micromachines ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 551 ◽  
Author(s):  
Maria Laura Coluccio ◽  
Maria Antonia D’Attimo ◽  
Costanza Maria Cristiani ◽  
Patrizio Candeloro ◽  
Elvira Parrotta ◽  
...  
Keyword(s):  
Cell Migration ◽  
Microfluidic Device ◽  
Cell Biology ◽  
Scientific Literature ◽  
Microfluidic Devices ◽  
Microfluidic System ◽  
Micro Milling ◽  
Flow Rates ◽  
Free Environment ◽  
Liquid Flows

This work presents a disposable passive microfluidic system, allowing chemotaxis studies, through the generation of a concentration gradient. The device can handle liquid flows without an external supply of pressure or electric gradients, but simply using gravity force. It is able to ensure flow rates of 10 µL/h decreasing linearly with 2.5% in 24 h. The device is made of poly(methylmethacrylate) (PMMA), a biocompatible material, and it is fabricated by micro-milling and solvent assisted bonding. It is assembled into a mini incubator, designed properly for cell biology studies in passive microfluidic devices, which provides control of temperature and humidity levels, a contamination-free environment for cells with air and 5% of CO2. Furthermore, the mini incubator can be mounted on standard inverted optical microscopes. By using our microfluidic device integrated into the mini incubator, we are able to evaluate and follow in real-time the migration of any cell line to a chemotactic agent. The device is validated by showing cell migration at a rate of 0.36 µm/min, comparable with the rates present in scientific literature.

Experimental study of thermohydraulic characteristics and irreversibility analysis of novel axial corrugated tube with spring tape inserts

2020 ◽  
Vol 92 (3) ◽  
pp. 30901
Author(s):  
Suvanjan Bhattacharyya ◽  
Debraj Sarkar ◽  
Ulavathi Shettar Mahabaleshwar ◽  
Manoj K. Soni ◽  
M. Mohanraj
Keyword(s):  
Heat Transfer ◽  
Experimental Study ◽  
Thermal Performance ◽  
Working Fluid ◽  
The Novel ◽  
Heat Exchanger Tube ◽  
Heat Transfer Augmentation ◽  
Corrugated Tube ◽  
The Impact ◽  
Exchanger Tube

The current study experimentally investigates the heat transfer augmentation on the novel axial corrugated heat exchanger tube in which the spring tape is introduced. Air (Pr = 0.707) is used as a working fluid. In order to augment the thermohydraulic performance, a corrugated tube with inserts is offered. The experimental study is further extended by varying the important parameters like spring ratio (y = 1.5, 2.0, 2.5) and Reynolds number (Re = 10 000–52 000). The angular pitch between the two neighboring corrugations and the angle of the corrugation is kept constant through the experiments at β = 1200 and α = 600 respectively, while two different corrugations heights (h) are analyzed. While increasing the corrugation height and decreasing the spring ratio, the impact of the swirling effect improves the thermal performance of the system. The maximum thermal performance is obtained when the corrugation height is h = 0.2 and spring ratio y = 1.5. Eventually, correlations for predicting friction factor (f) and Nusselt number (Nu) are developed.

Calculation and Measurement of the Stiffness and Damping Coefficients for a Low Impedance Hydrodynamic Bearing

1997 ◽  
Vol 119 (1) ◽  
pp. 57-63 ◽  
Author(s):  
M. J. Goodwin ◽  
P. J. Ogrodnik ◽  
M. P. Roach ◽  
Y. Fang
Keyword(s):  
Experimental Data ◽  
Dynamic Stiffness ◽  
Perturbation Technique ◽  
The Novel ◽  
Oil Film ◽  
Hydrodynamic Bearing ◽  
Damping Coefficients ◽  
Stiffness And Damping ◽  
Film Stiffness ◽  
Novel Design

This paper describes a combined theoretical and experimental investigation of the eight oil film stiffness and damping coefficients for a novel low impedance hydrodynamic bearing. The novel design incorporates a recess in the bearing surface which is connected to a standard commercial gas bag accumulator; this arrangement reduces the oil film dynamic stiffness and leads to improved machine response and stability. A finite difference method was used to solve Reynolds equation and yield the pressure distribution in the bearing oil film. Integration of the pressure profile then enabled the fluid film forces to be evaluated. A perturbation technique was used to determine the dynamic pressure components, and hence to determine the eight oil film stiffness and damping coefficients. Experimental data was obtained from a laboratory test rig in which a test bearing, floating on a rotating shaft, was excited by a multi-frequency force signal. Measurements of the resulting relative movement between bearing and journal enabled the oil film coefficients to be measured. The results of the work show good agreement between theoretical and experimental data, and indicate that the oil film impedance of the novel design is considerably lower than that of a conventional bearing.

scholarly journals A novel flexible tool with rotary ultrasonic spindle for fine grinding of tungsten carbide

2018 ◽  
Vol 185 ◽  
pp. 00018
Author(s):  
Albert Wen-Jeng Hsue ◽  
Yi-Zhong Zheng
Keyword(s):  
Tungsten Carbide ◽  
The Novel ◽  
Machining Processes ◽  
Flexible Tool ◽  
Operational Conditions ◽  
Cnc Grinding ◽  
Grinding Conditions ◽  
Novel Design ◽  
Conventional Machining ◽  
Tungsten Steel

Tungsten carbide is a typical difficult-to-cut material by conventional machining processes. In this paper, a novel design of flexible abrasives tool combined with a rotary ultrasonic machining (RUM) spindle is conducted to reduce the labor force significantly. The newly designed flexibility of tool-tip is aimed at preventing overcutting from the CNC grinding. The grinding conditions with resulted surface morphology of the tungsten steel were investigated through Taguchi design of experiment and ANOVA analysis. The machining capability of the novel flexible tool is compared with conventional tools through specific grinding paths under proper operational conditions.

Why Do So Few Consumers Use Health Care Quality Report Cards? A Framework for Understanding the Limited Consumer Impact of Comparative Quality Information

2018 ◽  
Vol 76 (5) ◽  
pp. 515-537 ◽  
Author(s):  
Neeraj Bhandari ◽  
Dennis P. Scanlon ◽  
Yunfeng Shi ◽  
Rachel A. Smith
Keyword(s):  
Health Care Quality ◽  
Care Quality ◽  
Report Cards ◽  
Quality Information ◽  
The Novel ◽  
Cognitive Limitations ◽  
Provider Quality ◽  
The Media ◽  
New Generation ◽  
Novel Design

Despite growing investment in producing and releasing comparative provider quality information (CQI), consumer use of CQI has remained poor. We offer a framework to interpret and synthesize the existing literature’s diverse approaches to explaining the CQI’s low appeal for consumers. Our framework cautions CQI stakeholders against forming unrealistic expectations of pervasive consumer use and suggests that they focus their efforts more narrowly on consumers who may find CQI more salient for choosing providers. We review the consumer impact of stakeholder efforts to apply the burgeoning knowledge of consumers’ cognitive limitations to the design and dissemination of the new generation of report cards; we conclude that while it is too limited to draw firm conclusions, early evidence suggests consumers are responding to the novel design and dissemination strategies. We find that consumers continue to have difficulty accessing reliable report cards, while the media remains underused in the dissemination of report cards.

scholarly journals Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 387
Author(s):  
Carlos Toshiyuki Matsumi ◽  
Wilson José da Silva ◽  
Fábio Kurt Schneider ◽  
Joaquim Miguel Maia ◽  
Rigoberto E. M. Morales ◽  
...  
Keyword(s):  
Electric Fields ◽  
Microfluidic Device ◽  
Soft Lithography ◽  
Low Cost ◽  
Characteristic Curve ◽  
Microfluidic Devices ◽  
Average Diameter ◽  
Internal Diameter ◽  
Medical Diagnostic ◽  
Average Size

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e.g., CEHDA) or soft lithography equipment for the production of microfluidic devices. This study presents a hybrid manufacturing process using micropipettes and 3D printing for the construction of a T-Junction microfluidic device resulting in simple and low cost generation of monodisperse microbubbles. In this work, microbubbles with an average size of 16.6 to 57.7 μm and a polydispersity index (PDI) between 0.47% and 1.06% were generated. When the device is used at higher bubble production rate, the average diameter was 42.8 μm with increased PDI of 3.13%. In addition, a second-order polynomial characteristic curve useful to estimate micropipette internal diameter necessary to generate a desired microbubble size is presented and a linear relationship between the ratio of gaseous and liquid phases flows and the ratio of microbubble and micropipette diameters (i.e., Qg/Ql and Db/Dp) was found.

scholarly journals Manufacturing of Microfluidic Devices with Interchangeable Commercial Fiber Optic Sensors

Sensors ◽  
2021 ◽  
Vol 21 (22) ◽  
pp. 7493
Author(s):  
Krystian L. Wlodarczyk ◽  
William N. MacPherson ◽  
Duncan P. Hand ◽  
M. Mercedes Maroto-Valer
Keyword(s):  
Porous Structure ◽  
Steady Flow ◽  
Microfluidic Device ◽  
Fiber Optic ◽  
Dynamic Pressure ◽  
Pressure Sensors ◽  
Microfluidic Devices ◽  
Fiber Optic Sensors ◽  
Valuable Insight ◽  
Local Pressure

In situ measurements are highly desirable in many microfluidic applications because they enable real-time, local monitoring of physical and chemical parameters, providing valuable insight into microscopic events and processes that occur in microfluidic devices. Unfortunately, the manufacturing of microfluidic devices with integrated sensors can be time-consuming, expensive, and “know-how” demanding. In this article, we describe an easy-to-implement method developed to integrate various “off-the-shelf” fiber optic sensors within microfluidic devices. To demonstrate this, we used commercial pH and pressure sensors (“pH SensorPlugs” and “FOP-MIV”, respectively), which were “reversibly” attached to a glass microfluidic device using custom 3D-printed connectors. The microfluidic device, which serves here as a demonstrator, incorporates a uniform porous structure and was manufactured using a picosecond pulsed laser. The sensors were attached to the inlet and outlet channels of the microfluidic pattern to perform simple experiments, the aim of which was to evaluate the performance of both the connectors and the sensors in a practical microfluidic environment. The bespoke connectors ensured robust and watertight connection, allowing the sensors to be safely disconnected if necessary, without damaging the microfluidic device. The pH SensorPlugs were tested with a pH 7.01 buffer solution. They measured the correct pH values with an accuracy of ±0.05 pH once sufficient contact between the injected fluid and the measuring element (optode) was established. In turn, the FOP-MIV sensors were used to measure local pressure in the inlet and outlet channels during injection and the steady flow of deionized water at different rates. These sensors were calibrated up to 140 mbar and provided pressure measurements with an uncertainty that was less than ±1.5 mbar. Readouts at a rate of 4 Hz allowed us to observe dynamic pressure changes in the device during the displacement of air by water. In the case of steady flow of water, the pressure difference between the two measuring points increased linearly with increasing flow rate, complying with Darcy’s law for incompressible fluids. These data can be used to determine the permeability of the porous structure within the device.

scholarly journals Translucent Answer Predictions in Multi-Hop Reading Comprehension

2020 ◽  
Vol 34 (05) ◽  
pp. 7700-7707
Author(s):  
G P Shrivatsa Bhargav ◽  
Michael Glass ◽  
Dinesh Garg ◽  
Shirish Shevade ◽  
Saswati Dana ◽  
...  
Keyword(s):  
Reading Comprehension ◽  
Question Answering ◽  
State Of The Art ◽  
Local Context ◽  
The Novel ◽  
Loose Coupling ◽  
Loosely Coupled ◽  
Neural Architecture ◽  
Coupled Networks ◽  
Novel Design

Research on the task of Reading Comprehension style Question Answering (RCQA) has gained momentum in recent years due to the emergence of human annotated datasets and associated leaderboards, for example CoQA, HotpotQA, SQuAD, TriviaQA, etc. While state-of-the-art has advanced considerably, there is still ample opportunity to advance it further on some important variants of the RCQA task. In this paper, we propose a novel deep neural architecture, called TAP (Translucent Answer Prediction), to identify answers and evidence (in the form of supporting facts) in an RCQA task requiring multi-hop reasoning. TAP comprises two loosely coupled networks – Local and Global Interaction eXtractor (LoGIX) and Answer Predictor (AP). LoGIX predicts supporting facts, whereas AP consumes these predicted supporting facts to predict the answer span. The novel design of LoGIX is inspired by two key design desiderata – local context and global interaction– that we identified by analyzing examples of multi-hop RCQA task. The loose coupling between LoGIX and the AP reveals the set of sentences used by the AP in predicting an answer. Therefore, answer predictions of TAP can be interpreted in a translucent manner. TAP offers state-of-the-art performance on the HotpotQA (Yang et al. 2018) dataset – an apt dataset for multi-hop RCQA task – as it occupies Rank-1 on its leaderboard (https://hotpotqa.github.io/) at the time of submission.

scholarly journals An Enhanced FPGA Based Asynchronous Microprocessor Design Using VIVADO and ISIM

2018 ◽  
Vol 7 (2) ◽  
pp. 199-208
Author(s):  
Archana Rani ◽  
Naresh Grover
Keyword(s):  
The Novel ◽  
Design And Implementation ◽  
Microprocessor Design ◽  
Novel Design

This paper deals with the novel design and implementation of asynchronous microprocessor by using HDL on Vivado tool wherein it has the capability of handling even I-Type, R-Type and Jump instructions with multiplier instruction packet. Moreover, it uses separate memory for instructions and data read-write that can be changed at any time. The complete design has been synthesized and simulated using Vivado. The complete design is targeted on Xilinx Virtex-7 FPGA. This paper more focuses on the use of Vivado Tool for advanced FPGA device. By using Vivado we get enhaced analysis result for better view of properly Route Placed design.

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