Optimal Central Composite Design for Manufacturing Simulation of 0.50 Caliber Projectile

2011 ◽  
Author(s):  
Raghu Echempati ◽  
Bernadetta Kwintiana Ane ◽  
Mark E. Krueger ◽  
Dieter Roller
Keyword(s):  
Central Composite Design ◽  
Polynomial Function ◽  
Friction Coefficients ◽  
Response Surface Plot ◽  
Surface Plot ◽  
Design And Manufacturing ◽  
Order Polynomial ◽  
Critical Components ◽  
Engineering Projects ◽  
Central Composite

Design and manufacturing simulations of critical components such as bullets are considered crucial, particularly, when it is associated with the expense and time constraint of the engineering projects. During the manufacturing, the projectile jacket is the component that faces the greatest strain or stress. In order to find an optimal manufacturing operation for the .50 caliber projectile, an experiment is performed using the Box-Wilson Central Composite Design (CCD) using a combination of two controlled factors, i.e., friction coefficients and hardening exponents, with three-levels of each. The sensitivity of the plastic strain to the hardening exponent and friction coefficients is analyzed. The response surface plot fits well to the second-order polynomial function and is able to provide relative the same plots when the model is extended up to the fourth-order. Furthermore, it is found that the greatest plasticity likely to occur in the jacket walls as the ironing process is performed. Based on the residual strain and stresses analysis, it is evident that the selected material used in the production of projectile is viable. Finally, the ductile fracture analysis confirms that the jacket design is considered safe for the selected manufacturing processes.

scholarly journals Optimization of parameters affecting dealcoholization of anthocyanin extract by liquid emulsion membrane using response surface methodology

2021 ◽  
Vol 19 (6) ◽  
pp. 562-574
Author(s):  
Prakash Binnal ◽  
Rajashekhara S. ◽  
Jagadish Patil
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Suitable Model ◽  
Central Composite Rotatable Design ◽  
Design Expert ◽  
Optimum Parameters ◽  
Response Surface Plot ◽  
Surface Plot ◽  
Liquid Emulsion ◽  
Central Composite

Colour is one of most important properties of foods and beverages and is a basis for their identification and acceptability. Anthocyanin from red cabbage was extracted using 50 % ethanol. The extract was dealcoholized by Liquid Emlusion Membrane technology (LEM). Parafin oil was used as a solvent, lecithin was used as a surfactant and water as stripping medium. Response surface methodology (RSM) was used to design the experiments. A total of 30 experiments were conducted in accordance with central composite rotatable design. Design expert 8 was used to design the experiments. % extraction of alcohol in each case was determined. A suitable model was fitted to experimental data by regression analysis (R-square=0.93). Response surface plot were analysed and optimum parameters for dealcoholization were found to be speed=365.44 rpm, time=18.62 min, concentration of lecithin=2.84 %, feed to emulsion ratio=3.05. A maximum dealcoholisation of 18.63 % was observed under these conditions

Use of central composite design to optimize working conditions of Streptomyces griseus enzymatic method in estimating in vitro rumen undegraded crude protein of feedstuffs

2018 ◽  
Vol 156 (1) ◽  
pp. 100-109
Author(s):  
A. Gallo ◽  
P. Fortunati ◽  
S. Bruschi ◽  
G. Giuberti ◽  
F. Masoero
Keyword(s):  
Central Composite Design ◽  
Wheat Bran ◽  
Crude Protein ◽  
Streptomyces Griseus ◽  
Second Order ◽  
Polynomial Equations ◽  
Distillers Dried Grains ◽  
Order Polynomial ◽  
Central Composite

AbstractThe aim was to identify optimized combinations of Streptomyces griseus protease concentration (CONC), incubation length (TIME), or amount of crude protein (CP) incubated in buffered enzymatic solution (CPW) to predict the in vitro rumen-undegraded feed CP (RUP) of 26 different feeds (soybean, rapeseed or sunflower meals, wheat bran, distillers dried grains with solubles, maize co-products and alfalfa hay). Different levels of CONC (0.08, 0.19, 0.44, 0.69 and 0.80 enzymatic units [U] of S. griseus protease/ml), TIME (6, 10, 18, 26 and 30 h) and CPW (69, 118, 235, 353 and 401 mg CP) were tested in agreement with a central composite design (CCD) with four replications of the central point to calculate second-order polynomial equations of main tested effects. The RUP was estimated by incubating samples in a buffered rumen fluid for 16 h or by adopting different enzymatic approaches as planned a priori in CCD. Differences between rumen and enzymatic RUP (ΔRUP) were estimated and regression terms of second-order polynomial equations for estimating ΔRUP were calculated between and within feeds. These equations were optimized using the non-linear generalized reduced gradient method with the objective set at ΔRUP equal to 0. The adoption of CCD permitted identification of optimized enzymatic combinations of CONC (0.12 U of S. griseus protease/ml), TIME (18 h) and CPW (from 233 to 458 mg CP for distillers dried grains with solubles and soft white wheat bran, respectively) to predict RUP accurately in all feed categories except for soybean meal, where optimized combinations were 0.47 U of S. griseus protease/ml, 18 h and 435 mg CP.

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

2018 ◽  
Vol 11 (6) ◽  
pp. 4337-4348
Author(s):  
Bhikshapathi D. V. R. N. ◽  
Srinivas I
Keyword(s):  
Central Composite Design ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Release Mechanism ◽  
Solvent Evaporation Method ◽  
Onset Of Action ◽  
Evaporation Method ◽  
Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

Formulation and Optimization of 5-Fluorouracil Loaded Chitosan Nanoparticles Employing Central Composite Design

2012 ◽  
Vol 2 (4) ◽  
pp. 281-289
Author(s):  
Rattan Lal ◽  
Rakesh Kumar Marwaha ◽  
Deepti Pandita ◽  
Harish Dureja
Keyword(s):  
Central Composite Design ◽  
Chitosan Nanoparticles ◽  
Central Composite
Sign in / Sign up

Export Citation Format

Share Document