Design of a Multifunctional Porous Coaxial Electrospun Mesh Using Polycaprolactone (PCL) and Poly Butylene Adipate-CO-Terephthalate (PBAT)

2016 ◽  
Author(s):  
Hussain R. Rizvi ◽  
Nandika D'Souza
Keyword(s):  
Tensile Testing ◽  
Supercritical Co2 ◽  
Fiber Diameter ◽  
Three Dimensional ◽  
Thermal Characteristics ◽  
Mechanical Analysis ◽  
Delivery Vehicle ◽  
Foaming Agent ◽  
Sem Image ◽  
Coaxial Fibers

In this paper, we formulate a method to create a potential drug delivery vehicle and scaffold architecture of coaxial electrospun fibers. Having the capability to introduce porosity either in core or sheath of the fiber using supercritical CO2 as a foaming agent is utilized. Polycaprolactone (PCL) and Poly butylene adipate-co-terephthalate (PBAT) were used because of their biodegradable and biocompatible nature. Physical morphology of the porous coaxial fibers was studied using Scanning Electron Microscopy (SEM), Image J software was used to quantify the pore size and fiber diameter. Dynamic Mechanical Analysis (DMA) and Tensile Testing of the three-dimensional fibrous mesh was done to determine the mechanical properties of the porous structure. Differential Scanning Calorimeter (DSC) was used to study the thermal characteristics of the mesh.

scholarly journals Conductive GelMA–Collagen–AgNW Blended Hydrogel for Smart Actuator

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1217
Author(s):  
Jang Ho Ha ◽  
Jae Hyun Lim ◽  
Ji Woon Kim ◽  
Hyeon-Yeol Cho ◽  
Seok Geun Jo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Umbilical Vein ◽  
Three Dimensional ◽  
Silver Nanowire ◽  
Structural Deformation ◽  
Rheological Analysis ◽  
Sem Image ◽  
Smart Actuator ◽  
Umbilical Vein Endothelial Cells ◽  
Electrical Stimuli

Blended hydrogels play an important role in enhancing the properties (e.g., mechanical properties and conductivity) of hydrogels. In this study, we generated a conductive blended hydrogel, which was achieved by mixing gelatin methacrylate (GelMA) with collagen, and silver nanowire (AgNW). The ratio of GelMA, collagen and AgNW was optimized and was subsequently gelated by ultraviolet light (UV) and heat. The scanning electron microscope (SEM) image of the conductive blended hydrogels showed that collagen and AgNW were present in the GelMA hydrogel. Additionally, rheological analysis indicated that the mechanical properties of the conductive GelMA–collagen–AgNW blended hydrogels improved. Biocompatibility analysis confirmed that the human umbilical vein endothelial cells (HUVECs) encapsulated within the three-dimensional (3D), conductive blended hydrogels were highly viable. Furthermore, we confirmed that the molecule in the conductive blended hydrogel was released by electrical stimuli-mediated structural deformation. Therefore, this conductive GelMA–collagen–AgNW blended hydrogel could be potentially used as a smart actuator for drug delivery applications.

scholarly journals Porous PLAs with Controllable Density by FDM 3D Printing and Chemical Foaming Agent

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 866
Author(s):  
A. R. Damanpack ◽  
André Sousa ◽  
M. Bodaghi
Keyword(s):  
3D Printing ◽  
Flow Rate ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Layer By Layer ◽  
Printing Technology ◽  
Material Density ◽  
Foaming Agent ◽  
3D Printing Technology ◽  
Fabrication Parameters

This paper shows how fused decomposition modeling (FDM), as a three-dimensional (3D) printing technology, can engineer lightweight porous foams with controllable density. The tactic is based on the 3D printing of Poly Lactic Acid filaments with a chemical blowing agent, as well as experiments to explore how FDM parameters can control material density. Foam porosity is investigated in terms of fabrication parameters such as printing temperature and flow rate, which affect the size of bubbles produced during the layer-by-layer fabrication process. It is experimentally shown that printing temperature and flow rate have significant effects on the bubbles’ size, micro-scale material connections, stiffness and strength. An analytical equation is introduced to accurately simulate the experimental results on flow rate, density, and mechanical properties in terms of printing temperature. Due to the absence of a similar concept, mathematical model and results in the specialized literature, this paper is likely to advance the state-of-the-art lightweight foams with controllable porosity and density fabricated by FDM 3D printing technology.

scholarly journals Numerical aspects for efficient welding computational mechanics

2014 ◽  
Vol 18 (suppl.1) ◽  
pp. 139-148
Author(s):  
Tarek Aburuga ◽  
Aleksandar Sedmak ◽  
Zoran Radakovic
Keyword(s):  
Residual Stresses ◽  
Three Dimensional ◽  
Shell Element ◽  
Element Model ◽  
Mechanical Analysis ◽  
Tensile Test Specimen ◽  
Integrity Assessment ◽  
Mass Scaling ◽  
Three Dimensional Models ◽  
Thermal Mechanical Analysis

The effect of the residual stresses and strains is one of the most important parameter in the structure integrity assessment. A finite element model is constructed in order to simulate the multi passes mismatched submerged arc welding SAW which used in the welded tensile test specimen. Sequentially coupled thermal mechanical analysis is done by using ABAQUS software for calculating the residual stresses and distortion due to welding. In this work, three main issues were studied in order to reduce the time consuming during welding simulation which is the major problem in the computational welding mechanics (CWM). The first issue is dimensionality of the problem. Both two- and three-dimensional models are constructed for the same analysis type, shell element for two dimension simulation shows good performance comparing with brick element. The conventional method to calculate residual stress is by using implicit scheme that because of the welding and cooling time is relatively high. In this work, the author shows that it could use the explicit scheme with the mass scaling technique, and time consuming during the analysis will be reduced very efficiently. By using this new technique, it will be possible to simulate relatively large three dimensional structures.

Electrochemical and thermal characteristics of prismatic lithium-ion battery based on a three-dimensional electrochemical-thermal coupled model

2021 ◽  
Vol 42 ◽  
pp. 102976
Author(s):  
Huanhuan Li ◽  
Ashwani Saini ◽  
Chengyang Liu ◽  
Jufeng Yang ◽  
Yaping Wang ◽  
...  
Keyword(s):  
Lithium Ion Battery ◽  
Three Dimensional ◽  
Thermal Characteristics ◽  
Coupled Model ◽  
Lithium Ion

Development and Mechanical Characterization of a Collagen/Hydroxyapatite Bilayered Scaffold for Ostechondral Defect Replacement

2011 ◽  
Vol 493-494 ◽  
pp. 890-895 ◽  
Author(s):  
Francesca Gervaso ◽  
Francesca Scalera ◽  
Sanosh Kunjalukkal Padmanabhan ◽  
Antonio Licciulli ◽  
Daniela Deponti ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Sol Gel ◽  
Three Dimensional ◽  
Collagen Scaffold ◽  
Mechanical Analysis ◽  
Design Parameters ◽  
Compression Tests ◽  
Templating Method ◽  
Organic Part ◽  
Hydroxyapatite Scaffold

In this work a novel three-dimensional ostechondral substitute is proposed that is made of an inorganic/organic hybrid material, namely collagen/hydroxyapatite. The two components of the substitute have been characterized separately. The inorganic part, a hydroxyapatite scaffold, was fabricated by a polymer sponge templating method using a reactive sub-micron powder synthesized in our laboratory by hydroxide precipitation sol-gel route. The organic part, a collagen scaffold, was fabricated by a freeze-dying technique varying design parameters. Both the parts were analysed by scanning electron microscopy and their mechanical properties assessed by compression tests. The hydroxyapatite scaffold showed a high and highly interconnected porosity and a mechanical strength equal to 0.55 MPa, higher than those reported in literature. The collagen scaffolds were seeded by chondrocytes, processed for histology analysis and tested in compression. The biological tests proved the ability of the scaffolds to be positively populated by chondrocytes and the mechanical analysis showed that the mechanical strength of the scaffolds significantly increased after 3 weeks of culture.

scholarly journals The Effect of Implant Length and Diameter on Stress Distribution around Single Implant Placement in 3D Posterior Mandibular FE Model Directly Constructed Form In Vivo CT

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7344
Author(s):  
Akikazu Shinya ◽  
Yoshiki Ishida ◽  
Daisuke Miura ◽  
Akiyoshi Shinya
Keyword(s):  
High Stress ◽  
Three Dimensional ◽  
Clinical Situation ◽  
Mechanical Analysis ◽  
Fe Model ◽  
High Stress Concentration ◽  
Implant Placement ◽  
Implant Therapy ◽  
Mandibular First Molar

A three-dimensional (3D) finite element (FE) model of the mandibular bone was created from 3D X-ray CT scan images of a live human subject. Simulating the clinical situation of implant therapy at the mandibular first molar, virtual extraction of the tooth was performed at the 3D FE mandibular model, and 12 different implant diameters and lengths were virtually inserted in order to carry out a mechanical analysis. (1) High stress concentration was found at the surfaces of the buccal and lingual peri-implant bone adjacent to the sides of the neck in all the implants. (2) The greatest stress value was approximately 6.0 MPa with implant diameter of 3.8 mm, approx. 4.5 MPa with implant diameter of 4.3 mm, and approx. 3.2 MPa with implant diameter of 6.0 mm. (3) The stress on the peri-implant bone was found to decrease with increasing length and mainly in diameter of the implant.

scholarly journals Reconstruction Technique of Three-Dimensional Shape by SEM Image

1989 ◽  
Vol 32 (2) ◽  
pp. 263-268
Author(s):  
Kenjiro KOMAI ◽  
Kohji MINOSHIMA ◽  
Jun KIKUCHI ◽  
Masatoshi NOGUCHI ◽  
Guisik KIM
Keyword(s):  
Three Dimensional ◽  
Reconstruction Technique ◽  
Sem Image ◽  
Dimensional Shape ◽  
Three Dimensional Shape
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