scholarly journals “Like a sediment that stays in the body”: Social percep-tion of persistent toxic substances and other synthetic chemical substances in food among pregnant and breastfeeding women in Spain

2019 ◽  
Vol 14 (01) ◽  
Author(s):  
Cristina Larrea-Killinger ◽  
Araceli Muñoz ◽  
Arantza Begueria ◽  
Jaume Mascaró Pons
Keyword(s):  
The Body ◽  
Toxic Substances ◽  
Chemical Substances ◽  
Percep Tion

Perception of the risk of contamination through feeding in pregnant and breastfeeding women

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M Company-Morales ◽  
A Fontalba-Navas ◽  
M F Rubio-Jimenez ◽  
V Gil-Aguilar ◽  
J P Arrebola
Keyword(s):  
Fruits And Vegetables ◽  
Cumulative Effect ◽  
The Body ◽  
Primary Data ◽  
Toxic Substances ◽  
Large Fish ◽  
Structured Interviews ◽  
Chemical Substances ◽  
Synthetic Chemicals ◽  
Harmful Effects

Abstract Introduction Persistent Toxic Substances (PTS) are substances that are characterized by the cumulative effect at low doses inside the body. Exposure to PTS in pregnant and breastfeeding women, through food consumption, shows various harmful effects on the health of the mother, the fetus and the baby. The objective of this article is to analyze how pregnant and breastfeeding women perceive the presence of chemical substances in food and reflect on the accumulation, transmission and elimination of these substances. Methodology Descriptive and interpretive study under the qualitative research paradigm following a phenomenological and ethnographic perspective. As instruments to obtain the primary data we rely on 111 semi-structured interviews with pregnant and breastfeeding women, 4 focused ethnographies, 8 focus groups (63 women), 71 feeding diaries, 71 free listings. To encode the content of the speeches of pregnant and nursing women we rely on the N-Vivo 12 software. Results Pregnant and breastfeeding women are concerned about food quality controls. Women trust on local and seasonal foods such as fresh fruits and vegetables from non-extensive crops and close to their home. Foods that produce distrust in women are processed, packaged foods, red meat and large fish. The latter foods promote in women a perception of risk of contamination by chemical substances, manifesting a defenseless situation to maintain a diet without contaminants. Conclusions Pregnant and breastfeeding women in Spain have no information on the risk and danger of synthetic chemicals or PTS, with the exception of certain toxic substances such as mercury present in large fish. Women maintain a duality in their own care and that of the fetus or child. This circumstance implies that the women interviewed believe that PTS and synthetic chemicals may have different harmful effects on the mother and the degree of growth of the fetus and, subsequently, of the baby. Key messages Future mothers are worried about the type of product they eat, knowing that food influences healthy growth and development of the fetus. Pregnant and breastfeeding women often distrust “processed” or “industrial” foods, which they tend to associate with low quality and large amounts of additives and chemical substances.

Immunological mechanisms of chronic liver lesions under the influence of chemicals

2020 ◽  
pp. 536-537
Author(s):  
G. S. Agzamova ◽  
M. M. Abdullaeva
Keyword(s):  
The Body ◽  
Chronic Liver ◽  
Toxic Substances ◽  
Liver Lesions ◽  
Industrial Chemicals ◽  
Toxic Agent ◽  
Chronic Poisoning ◽  
Immunological Mechanisms ◽  
T System

The immunological profile of chronic liver lesions depending on the toxic agent was studied. It was revealed that chronic poisoning by industrial toxic substances causes changes in the functional state of the T-system of immunity, long-term contact with industrial chemicals leads to increased sensitization to autoantigens of the body.

A Comprehensive Review on Nanotechnology-Based Innovations in Topical Drug Delivery for the Treatment of Skin Cancer

2020 ◽  
Vol 26 (44) ◽  
pp. 5720-5731 ◽  
Author(s):  
Arun Singh Lalotra ◽  
Vishesh Singh ◽  
Bharat Khurana ◽  
Shelly Agrawal ◽  
Shubham Shrestha ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Systemic Exposure ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Toxic Substances ◽  
Abnormal Growth ◽  
Dermal Layer ◽  
Therapeutic Benefits ◽  
Carrier Systems

Background: Skin is the largest organ of the body and helps to regulate several physiological functions. It acts as a barrier that protects the body against UV-radiation, toxic substances, infections, etc. The abnormal growth of the skin cells is called skin cancer. Different types of skin cancer can be classified as Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC); which mainly occur due to chronic exposure to UV- sunlight and pollution. Methods: The conventional topical treatments of skin cancer such as cream, gel, ointment, etc., are more occlusive and thus they do not penetrate deep into the skin (dermal layer) and remain at the upper part of the skin (epidermal layer). The stratum corneum acts as a physiological barrier for the drug-loaded in the conventional formulation. The novel carrier systems have the potential to facilitate the penetration of the drug deep into the skin (dermal layer) because these have less size and higher flexibility than conventional treatment. Conclusion: In the present review, we have discussed various novel carrier systems being investigated for the topical application of chemotherapeutic agents for efficient skin targeting and better dermatological as well as therapeutic benefits with minimal systemic exposure and toxicity.

Toxicology

2017 ◽  
Author(s):  
Robert Laumbach ◽  
Michael Gochfeld
Keyword(s):  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Toxicity Testing ◽  
The Body ◽  
Toxic Substances ◽  
Basic Principles ◽  
Practical Applications ◽  
Mechanisms Of Toxicity ◽  
Body Distribution ◽  
Threshold Doses

This chapter describes the basic principles of toxicology and their application to occupational and environmental health. Topics covered include pathways that toxic substances may take from sources in the environment to molecular targets in the cells of the body where toxic effects occur. These pathways include routes of exposure, absorption into the body, distribution to organs and tissues, metabolism, storage, and excretion. The various types of toxicological endpoints are discussed, along with the concepts of dose-response relationships, threshold doses, and the basis of interindividual differences and interspecies differences in response to exposure to toxic substances. The diversity of cellular and molecular mechanisms of toxicity, including enzyme induction and inhibition, oxidative stress, mutagenesis, carcinogenesis, and teratogenesis, are discussed and the chapter concludes with examples of practical applications in clinical evaluation and in toxicity testing.

Finishing System Based on Ultrasonic Computerized Processes for Textiles

2014 ◽  
Vol 658 ◽  
pp. 666-671
Author(s):  
Florin Pantilimonescu ◽  
Lucian Constantin Hanganu ◽  
Mihaita Peptanariu ◽  
Stefan Grigoras ◽  
Irina Ionescu ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Textile Industry ◽  
Residual Water ◽  
Toxic Substances ◽  
Environment Pollution ◽  
Chemical Substances ◽  
Textile Materials ◽  
Transfer Processes ◽  
Active Chemical ◽  
High Work

During conventional finishing textile processes it is necessary a big consumption both of water and energy. This aspectsare is imposed by the development process of thermo and mass transfer of finishing agents into the textile structure materials applied in dentistry (fibers, yarns, fabric, nonwovens). The intensification of transfer processes into the textile materials is realized in conventional finishing textile industry (washing, cleaning, and coloring) by using high work temperature. The negative result of this intervention and the presence of chemical substances without degradation mean the environment pollution by the pour out residual water with a great quantity of toxic substances. The recently laboratory scientific research showed that the use of ultrasonic systems in finishing textile materials contributes both to the acceleration of thermo and mass transfer and to the decreasing of active chemical substances. In this way the paper presents a finishing system based on ultrasonic processes which is composed by modules and specific hardware components.

scholarly journals THE EFFECTS OF NICOTINE ON THE PERIODONTAL TISSUE

2010 ◽  
Vol 1 (3) ◽  
pp. 151
Author(s):  
Herawati Herawati ◽  
Jenny Sunariani
Keyword(s):  
Significant Role ◽  
Host Response ◽  
Detrimental Effect ◽  
Periodontal Therapy ◽  
The Other ◽  
Toxic Substances ◽  
Periodontal Tissue ◽  
Chemical Substances ◽  
Periodontal Tissues ◽  
Periodontal Destruction

Tobacco contains thousands of chemical substances which known to be harmful to periodontal tissues. Nicotine was considered as the most toxic substances to periodontal tissues. The datas in this review indicate that smoking may have a significant role in the initiation and progression of periodontal destruction. The conclusion of this and the other studies indicate that smokers have a less favorable response to periodontal therapy than non smoker. Nicotine is potentially toxic substances that have a detrimental effect on periodontal tissue, by altering the host response or directly damage the cells of normal periodontium.

scholarly journals Reviewing Effective Factors of Alimentary Deficiency in Animals Reproductive Functions

2021 ◽  
Vol 11 (2) ◽  
pp. 157-169
Author(s):  
Pavlo Skliarov ◽  
Serhiy Fedorenko ◽  
Svitlana Naumenko ◽  
Oleksandr Onyshchenko ◽  
Alina Pasternak ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Optimal Level ◽  
The Body ◽  
Reproductive Capacity ◽  
Toxic Substances ◽  
Prevention Measures ◽  
Animal Reproduction ◽  
Number Of Factors ◽  
Wide Range ◽  
Negative Impacts

Animal reproduction is one of the main factors limiting the efficiency of livestock production. Its optimal level is possibly achieved when certain conditions are created for animals. As reproduction is a complex reflex process depending on neuroendocrine regulatory mechanisms, the character and strength of stimuli, which, in turn, is due to a number of factors. Under normal conditions, the body of animals is affected by many different factors, which are appropriately transformed and specified by positive or negative reactions. Inhibitory factors include air pool, saturated with harmful substances and gases, ionizing radiation, poor water quality along with altered redox properties, hypokinesia combined with poor unbalanced feeding, systematic chronic stress, presence of toxic substances in feed, and the deficiency of vitamins and other bioantioxidants in feed or their excessive spending. Of the wide range of genetic and paratypic factors of negative impacts on reproductive capacity, the most common one is alimentary, which causes impaired reproductive function due to deficiencies in the rules, regulations, and feeding regime of animals. In particular, the alimentary can be associated with both general malnutrition (starvation) and overfeeding (obesity). However, the alimentary form of infertility mostly occurs due to low-quality diets when the diet lacks vital components (mainly vitamins, macro-, and micronutrients) or the quantitative ratios of the ingredients are violated. This is possible even if the total nutritional value of the diet meets the established requirements for the physiological needs of the body. Vitamins, micro-, and macronutrients are ecologically deficient factors of disturbance of animal reproductive function, the influence of which is observed on all processes of reproduction, from fertilization to the postpartum period and the preservation of young animals. The pathogenesis of their insufficiency is associated with the violation of steroido-, gameto-, and embryogenesis and the emergence of ante-, intra-, neo- and postnatal pathologies, respectively. Therefore, treatments and prevention measures should be aimed at providing animals with biologically complete balanced feeding and replenishment of the body with vitamins and minerals. However, all these issues remain incompletely studied and need further research.

scholarly journals Nephrocytes are part of the spectrum of filtration epithelial diversity

2020 ◽  
Vol 382 (3) ◽  
pp. 609-625
Author(s):  
Takayuki Miyaki ◽  
Yuto Kawasaki ◽  
Akira Matsumoto ◽  
Soichiro Kakuta ◽  
Tatsuo Sakai ◽  
...  
Keyword(s):  
Body Fluid ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
Three Dimensional ◽  
Model System ◽  
The Body ◽  
Toxic Substances ◽  
Cellular Architecture ◽  
Animal Phylogeny ◽  
Scanning Electron

AbstractThe excretory system produces urine by ultrafiltration via a filtration epithelium. Podocytes are widely found as filtration epithelial cells in eucoelomates. In some animal taxa, including insects and crustaceans, nephrocytes serve to separate toxic substances from the body fluid, in addition to podocytes. Drosophila nephrocytes have been recently utilized as a model system to study podocyte function and disease. However, functionality and cellular architecture are strikingly different between Drosophila nephrocytes and eucoelomate podocytes, and the phylogenetic relationship between these cells remains enigmatic. In this study, using focused-ion beam-scanning electron microscopy (FIB-SEM) tomography, we revealed three-dimensional architecture of decapod nephrocytes with unprecedented accuracy—they filled an enormous gap, which can be called “missing link,” in the evolutionary diversity of podocytes and nephrocytes. Thus, we concluded that nephrocytes are part of the spectrum of filtration epithelial diversity in animal phylogeny.

scholarly journals Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3

2006 ◽  
Vol 175 (4) ◽  
pp. 661-670 ◽  
Author(s):  
Cristina de Guzman Strong ◽  
Philip W. Wertz ◽  
Chenwei Wang ◽  
Fan Yang ◽  
Paul S. Meltzer ◽  
...  
Keyword(s):  
Developmental Stages ◽  
Genomic Analysis ◽  
Skin Barrier ◽  
The Body ◽  
Toxic Substances ◽  
Innate Immune Responses ◽  
Environment Analysis ◽  
Epidermal Barrier ◽  
Specific Deletion

Skin lies at the interface between the complex physiology of the body and the external environment. This essential epidermal barrier, composed of cornified proteins encased in lipids, prevents both water loss and entry of infectious or toxic substances. We uncover that the transcription factor GATA-3 is required to establish the epidermal barrier and survive in the ex utero environment. Analysis of Gata-3 mutant transcriptional profiles at three critical developmental stages identifies a specific defect in lipid biosynthesis and a delay in differentiation. Genomic analysis identifies highly conserved GATA-3 binding sites bound in vivo by GATA-3 in the first intron of the lipid acyltransferase gene AGPAT5. Skin from both Gata-3−/− and previously characterized barrier-deficient Kruppel-like factor 4−/− newborns up-regulate antimicrobial peptides, effectors of innate immunity. Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis.

scholarly journals PARTIAL CHRONIC TOXICITY TEST OF COPPER (Cu2+), ZINC (Zn2+) and CYANIDE (Cn+) FOR YOUNG COBIA FISH (Rachycentron canadum)

2008 ◽  
Vol 33 (1) ◽  
pp. 49-53
Author(s):  
Le Quang Dung ◽  
Nguyen Duc Cu
Keyword(s):  
Heavy Metals ◽  
Growth Rate ◽  
Statistical Analysis ◽  
Chronic Toxicity ◽  
The Body ◽  
Toxicity Tests ◽  
Fish Length ◽  
Toxic Substances ◽  
Rachycentron Canadum ◽  
Copper Zinc

The partial toxicity tests of copper (Cu2+), zinc (Zn2+) and cyanide (CN-) for young cobia (Rachycentron canadum) fishes 45 days-old were conducted in Doson station during ten days (yr 2005). These three toxic substances affected strongly the growth rate of the Cobia fish (length and weight of the body), even at the lowest treated concentration. The LC50 values of copper, zinc and cyanide were 0.32 mg l-1; over mg l-1 and 0,049 mg l-1, respectively. Based on the statistical analysis of growth rate of cobia by determining 1C25, IC50, NOEC and LOEC values, we have addressed the safe concentrations of these two heavy metals and cyanide in the environmental aquaculture which must be lower than 0.025 mg Cu l-1, 0.5 mg Zn l-1 and 0.005 mg CN l-1, respectively. The result also showed that cyanide was the most toxic to Cobia, followed by copper and zinc.

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