Acute Responses of Inflammatory Markers of Cardiovascular Disease Risk to a Single Walking Session

2005 ◽  
Vol 2 (3) ◽  
pp. 324-332 ◽  
Author(s):  
Elaine M. Murtagh ◽  
Colin Boreham ◽  
Alan Nevill ◽  
Gareth Davison ◽  
Tom Trinick ◽  
...  
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Physical Activity Promotion ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Post Exercise ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Activity Promotion ◽  
Acute Responses

Background:Markers of inflammation are emerging as novel indices of cardiovascular risk. These markers have been shown to alter acutely after intense exercise; however, the effects of more moderate intensity exercise in healthy individuals is not known. Walking forms a cornerstone of physical activity promotion, so the inflammatory response to this exercise merits investigation. This study evaluated the effects of a 45-min walk on C-reactive protein (CRP) and interleukin 6 (IL-6), in sedentary, overweight men.Methods:Fifteen men (49.7 ± 5.9 y) walked for 45 min at 60 to 70% of predicted maximum heart rate. Fasted blood samples were taken prior to and immediately 1 hr and 24 h post-walk.Results:IL-6 decreased from 1 h post-walk to 24 h post-walk (P < 0.01). No significant changes were observed in CRP.Conclusions:These findings suggest that 45 min walking at 60 to 70% HRmax-p causes a decrease in IL-6 24 h post-exercise, but does not evoke a significant response in CRP levels.

scholarly journals Acute Exercise and Postprandial Lipemia in Young People

2014 ◽  
Vol 26 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Keith Tolfrey ◽  
Alice Emily Thackray ◽  
Laura Ann Barrett
Keyword(s):  
Young People ◽  
Acute Exercise ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Postprandial Lipemia ◽  
Exercise Duration ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Healthy Young People ◽  
High Intensity Interval

Exaggerated postprandial triacylglycerol concentrations (TAG) independently predict future cardiovascular events. Acute exercise and diet interventions attenuate postprandial TAG in adults. This paper aims to examine the exercise postprandial lipemia studies published to date in young people. Nine studies satisfied the inclusion criteria adopted for this summary. The majority of studies are in boys (22% girls) and have shown a single ~60-min session of moderate-intensity exercise, performed 12-18 hours before a standardized meal, reduces postprandial TAG. Manipulations of exercise duration and intensity suggest an exercise energy expenditure dose-dependent response is not supported directly in healthy young people. Studies investigating alternative exercise bouts have reported lower postprandial TAG after simulated intermittent games activity, high-intensity interval running and cumulative 10-min blocks over several hours, which may appeal to the spontaneous physical activity habits of young people. Although extension of these initial findings is warranted, exercise may be an effective strategy to promote regular benefits in TAG metabolism in children and adolescents; this may contribute to an improved cardiovascular disease risk profile early in life.

Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats

2021 ◽  
pp. 1-5
Author(s):  
Douglas Lopes Almeida ◽  
Gabriel Sergio Fabricio ◽  
Laize Peron Tófolo ◽  
Tatiane Aparecida Ribeiro ◽  
Camila Cristina Ianoni Matiusso ◽  
...  
Keyword(s):  
Early Life ◽  
Male Rats ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Moderate Intensity Exercise ◽  
Post Exercise ◽  
Reduced Body ◽  
Male Wistar Rats ◽  
The Impact ◽  
Adaptation To Exercise

Abstract Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals’ adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals’ adaptation to exercise.

scholarly journals Assessment of the Efficacy of Lowering LDL Cholesterol with Rosuvastatin 10 mg in Four Korean Statin Benefit Groups as per ACC/AHA Guidelines (NewStaR4G)

2020 ◽  
Vol 9 (4) ◽  
pp. 916
Author(s):  
Kyung-Jin Kim ◽  
Junghan Yoon ◽  
Kyung Heon Won ◽  
Sang-Wook Lim ◽  
In-Ho Chae ◽  
...  
Keyword(s):  
Statin Therapy ◽  
Ldl Cholesterol ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Heart Association ◽  
Korean Population ◽  
Moderate Intensity ◽  
Atherosclerotic Cardiovascular Disease ◽  
Percentage Reduction

The American College of Cardiology and American Heart Association (ACC/AHA) guidelines identified four statin benefit groups on the basis of atherosclerotic cardiovascular disease risk reduction and proposed statin therapy by evidence-based intensity. Although these guidelines used randomized controlled trials with hard outcomes as exclusive evidence for its recommendations, a limited number of studies conducted in Asian countries makes its application of treatment strategy, intensity, and statin doses uncertain in these population. This prospective, multicenter study aimed to evaluate the efficacy of rosuvastatin 10 mg in the four statin benefit groups requiring high- or moderate-intensity statin therapy according to the ACC/AHA guidelines in the Korean population. The primary endpoint was percentage reduction in low-density lipoprotein (LDL) cholesterol. Secondary endpoints were percentage reduction in other lipids and achievement of ≥50% reduction in LDL cholesterol. Rosuvastatin 10 mg lowered LDL cholesterol by 61.4 mg/dL, a 44.9% decrease from baseline after eight weeks. Reduction of LDL cholesterol ≥50% was achieved in 46.3% of patients. Rosuvastatin 10 mg was generally well tolerated. In the Korean population, rosuvastatin 10 mg was favorable and tolerant in lowering LDL cholesterol in the four statin benefit groups requiring high- or moderate-intensity statin therapy according to the ACC/AHA guidelines.

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