The Impact of a 12-Month Activity Tracker Intervention on Activity Behavior Across Body Mass Index Subgroups Among Recent Retirees: Post Hoc Analysis of a Randomized Controlled Trial

2021 ◽  
pp. 1-7
Author(s):  
Miika Tuominen ◽  
Kristin Suorsa ◽  
Jaana Pentti ◽  
Pasi Koski ◽  
Sari Stenholm ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Intervention Group ◽  
Intervention Effect ◽  
Post Hoc Analysis ◽  
Activity Tracker ◽  
Activity Behavior ◽  
Post Hoc ◽  
The Impact

Background: This study examined the effectiveness of a 12-month activity tracker-based intervention on activity behavior among recent retirees (Enhancing physical ACTivity and healthy aging among recent REtirees [REACT]) in subgroups based on body mass index. Methods: REACT trial randomized 231 participants (mean age 65.2) into intervention and control groups. Main outcomes were accelerometer-measured moderate-to-vigorous (MVPA) and light physical activity (LPA) and sedentary time (SED) measured at baseline and 3-, 6-, and 12-month follow-ups. As a post hoc analysis, the intervention effect was examined among participants with normal weight (n = 77), overweight (n = 89), and obesity (n = 61). Results: An intervention effect was observed among participants with obesity in LPA (time × group P = .045) mirrored by a similar, albeit nonsignificant, effect in SED (P = .067), but not in MVPA (P = .92). A transient increase of 41 minutes per day (95% confidence interval, 14 to 68) in LPA was observed at 6 months among the intervention group, with a concomitant decrease of 42 minutes per day (−72 to −12) in SED. However, these changes were not maintained at 12 months. No between-group differences in changes over time were observed among participants with normal or overweight. Conclusions: Activity trackers may be particularly suitable for promoting changes in LPA and SED among older adults with obesity. However, their long-term effectiveness might be limited.

Body Mass Index Does Not Impact Clinical Efficacy of Ustekinumab in Crohn’s Disease: A Post Hoc Analysis of the IM-UNITI Trial

2020 ◽  
Author(s):  
Emily C L Wong ◽  
John K Marshall ◽  
Walter Reinisch ◽  
Neeraj Narula
Keyword(s):  
Body Mass Index ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Body Mass ◽  
Clinical Efficacy ◽  
Activity Index ◽  
Linear Trend ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
The Impact

Abstract Background This post hoc analysis aimed to evaluate the impact of BMI on the efficacy of ustekinumab in the IM-UNITI study. Methods The relationship between body mass index (BMI) and efficacy of ustekinumab was evaluated using data from a 44-week maintenance study of ustekinumab in Crohn’s disease (IM-UNITI, NCT01369355, YODA #2019–4105). The primary endpoints of interest were clinical remission (CR), defined as Crohn’s disease activity index <150 and corticosteroid-free CR at week 44. Patients were stratified into the following subgroups according to their BMI at study entry: underweight <18.5 kg/m2, normal 18.5 to 25 kg/m2, overweight 25 to <30 kg/m2, and obese ≥30 kg/m2. The χ 2 test of linear trend was conducted for comparisons of frequencies between the 3 cohorts. Multivariate regression analyses evaluated possible association between BMI and efficacy outcomes of CR and corticosteroid-free CR, with adjustment for variables found significant on univariate analyses. Results are presented as odds ratios with 95% confidence intervals. Data were analyzed using Stata/IC 15. Results A total of 254 patients treated with ustekinumab were included in this analysis. At week 44 of IM-UNITI, rates of CR did not differ among those whose BMI was underweight (67.9%%; 19 of 28 patients), normal (51.3%; 60 of 117), overweight (45.1%; 32 of 71), or obese (55.3%; 21 of 38; P = 0.89). Multivariate logistic analysis did not find BMI to be a significant predictor of CR when adjusted for covariates. Ustekinumab drug level at week 44 was significantly lower in obese patients (median level 2.98 mcg/mL; interquartile range [IQR], 2.86) compared with patients who were overweight (4.84 mcg/mL; IQR, 3.51; P = 0.021) or had underweight or normal BMI (4.43 mcg/m;, IQR, 2.82; P = 0.014). Conclusions Although BMI impacts ustekinumab drug levels, there was no impact of BMI on clinical efficacy. Further studies of the pharmacodynamic effects of ustekinumab in patients with high BMI are needed.

scholarly journals Bone Metabolism Markers and their Correlation with Body Mass Index in Aerobic Physical Activity

2018 ◽  
Vol 49 (2) ◽  
Author(s):  
Zorislava Bajić ◽  
Nela Rašeta ◽  
Nenad Ponorac
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Bone Formation ◽  
Body Mass ◽  
Young Women ◽  
Intervention Group ◽  
Positive Influence ◽  
Control Group ◽  
Bone Resorption Marker

Introduction: Bone formation marker osteocalcin (OC) and bone resorption marker C-terminal telopeptide of type 1 collagen (CTX) can be used to detect or to monitor the early responses of the skeleton to physical activity. Literature suggests that it is likely that higher body mass index (BMI) has positive effect on bones and can postpone onset of osteoporosis.Aim of the Study: The aim of this study is to:1.Determine the effect of aerobic physical acitivity on OC and CTX in young women2.Investigate correlation of OC, CTX and BMI in young women engaged into structured aerobic excerciseMaterial and methods: Study included 64 healthy young women, aged 19 to 25 years, devided into two groups: intervention group (n=32) and control group (n=32). The study duration was six weeks with follow-up period of four weeks. The intervention group underwent structured aerobic physical activity program for six weeks, but the control group did not receive such program. Level of OC, CTX and BMI were measured at baseline, after 6-week aerobic program, and after 4-week follow up (only intervention group).Results: There was significant increase of OC level after 6-week aerobic program, while level of CTX did not changed. OC level was at its maximum immediately after finishing the program in the participants with normal BMI (p<0.001). There was no statistically significant interaction of BMI and CTX level.Conclusion: Aerobic physical activity increases level of osteocalcin, suggesting that it has positive influence on bone formation in young women, primarily in women with normal BMI.

scholarly journals Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model

2018 ◽  
Vol 15 (8) ◽  
pp. 1721 ◽  
Author(s):  
Yangchang Zhang ◽  
Yang Xiong ◽  
Jia Dong ◽  
Tingting Guo ◽  
Xiaoman Tang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Medical Students ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Multiple Mediation ◽  
Depression Anxiety Stress Scale ◽  
Positive Role ◽  
Cross Sectional ◽  
The Impact

Background: This paper investigates the problems regarding caffeinated drinks intake, late chronotype, and increased body mass index (BMI) among medical students at a Chinese university. Methods: This cross-sectional study was conducted in 2018 with 616 medical students from Chongqing Medical University in Chongqing, China, whose information were collected by a self-reported questionnaire that included four sections: Demographic characteristics; Caffeinated drinks intake and physical state; Morningness-Eveningness Questionnaire; Depression Anxiety Stress Scale 21. Multiple mediation analyses were conducted to test the impact of late chronotype on increased BMI through caffeinated drinks consumption through two models. Results: The significantly mediated effect of caffeinated drinks consumption was revealed (estimate: −0.01, SE = 0.01, 95% CI [−0.02, −0.01]), and which played a positive role in linking late chronotype (B = −0.01, SE = 0.01, p < 0.001) and increased BMI (B = 1.37, SE = 0.21, p < 0.01), but their significant association did not be found in reversed model. In addition, physical activity and inactivity times demonstrated significant indirect effects in the two models. Conclusions: Interventions should focus on reducing caffeinated drinks intake and sedentary behavior time, enhancing physical activity among medical students.

scholarly journals The impact of body mass index, central obesity and physical activity on lung function: results of the EpiHealth study

2020 ◽  
Vol 6 (4) ◽  
pp. 00214-2020
Author(s):  
Magnus Svartengren ◽  
Gui-Hong Cai ◽  
Andrei Malinovschi ◽  
Jenny Theorell-Haglöw ◽  
Christer Janson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Lung Function ◽  
Body Mass ◽  
Physical Inactivity ◽  
Central Obesity ◽  
Forced Expiratory Volume ◽  
Normal Weight ◽  
Weight Group ◽  
The Impact

Study objectivesObesity is often associated with lower lung function; however, the interaction of lung function with central obesity and physical inactivity is less clear. As such, we investigated the effect on lung function of body size (body mass index (BMI)), central obesity (waist circumference (WC)) and self-reported physical activity.MethodsLung function, height, weight and WC were measured in 22 743 participants (12 791 women), aged 45–75 years, from the EpiHealth cohort study. Physical activity, gender and educational level were assessed using a questionnaire.ResultsObesity, central obesity and physical inactivity were all associated with lower forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). However, in participants without central obesity there was an increase in both FEV1 and FVC by BMI (% predicted FVC increasing from median 98%, interquartile range (IQR) 89–110% in underweight participants (BMI <20) to 103%, IQR 94–113% in obese participants (BMI ≥30)). In contrast, there was a decrease in % predicted FVC in participants with central obesity (from 98%, IQR 89–109% in the normal weight group to 95%, IQR 85–105% in the obese weight group). We further found a negative association between physical activity and lung function among those with low and high levels of physical activity (% predicted FEV1 97%, IQR 86–107% versus 103%, IQR 94–113%, respectively and % predicted FVC 96%, IQR 85–106% versus 103%, IQR 94–113%, respectively). All results remained when calculated by z-scores.ConclusionsThe association between BMI and lung function is dependent on the presence of central obesity. Independent of obesity, there is an association between physical activity and lung function.

scholarly journals Feasibility of Social-Network-Based eHealth Intervention on the Improvement of Healthy Habits among Children

Sensors ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 1404 ◽  
Author(s):  
José Alberto Benítez-Andrades ◽  
Natalia Arias ◽  
María Teresa García-Ordás ◽  
Marta Martínez-Martínez ◽  
Isaías García-Rodríguez
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Eating Habits ◽  
Intervention Group ◽  
Group Versus ◽  
Daily Basis ◽  
Control Group ◽  
Healthy Habits ◽  
Ehealth Intervention

This study shows the feasibility of an eHealth solution for tackling eating habits and physical activity in the adolescent population. The participants were children from 11 to 15 years old. An intervention was carried out on 139 students in the intervention group and 91 students in the control group, in two schools during 14 weeks. The intervention group had access to the web through a user account and a password. They were able to create friendship relationships, post comments, give likes and interact with other users, as well as receive notifications and information about nutrition and physical activity on a daily basis and get (virtual) rewards for improving their habits. The control group did not have access to any of these features. The homogeneity of the samples in terms of gender, age, body mass index and initial health-related habits was demonstrated. Pre- and post-measurements were collected through self-reports on the application website. After applying multivariate analysis of variance, a significant alteration in the age-adjusted body mass index percentile was observed in the intervention group versus the control group, as well as in the PAQ-A score and the KIDMED score. It can be concluded that eHealth interventions can help to obtain healthy habits. More research is needed to examine the effectiveness in achieving adherence to these new habits.

Impact of Adulthood Stage and Social-Environmental Context on Body Mass Index and Physical Activity of Individuals With Intellectual Disability

2015 ◽  
Vol 53 (2) ◽  
pp. 100-113 ◽  
Author(s):  
Kelly Hsieh ◽  
Tamar Heller ◽  
Julie Bershadsky ◽  
Sarah Taub
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Intellectual Disability ◽  
Community Participation ◽  
Body Mass ◽  
Environmental Context ◽  
Individual Characteristics ◽  
Social Environmental ◽  
The Impact ◽  
The Relationship

Abstract Individuals with intellectual disability (ID) are at risk for obesity and physical inactivity. We analyzed a subset of 2009–2010 National Core Indicators (NCI) database to examine (1) the impact of three adulthood stages– younger (20–39 years), middle (40–59 years), and older (60 years and older) on Body Mass Index (BMI) and physical activity (PA); and (2) the relationship between social-environmental context (i.e., residence type, everyday choices, and community participation) and BMI and PA, with adjustment for individual characteristics of the adults with ID. Findings highlight the need to pay more attention to obesity by providing health education and emphasizing healthy choices. Results also suggest the importance of community participation as a way of promoting more physical activity.

scholarly journals Preconception Micronutrient Supplementation Affects Maternal Body Mass Index Post-Partum: A Randomized Controlled Trial in Vietnam

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 892-892
Author(s):  
Usha Ramakrishnan ◽  
Melissa Young ◽  
Long Khuong ◽  
Lan Mai Tran ◽  
Thai Hong Duong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Randomized Controlled Trial ◽  
Body Mass ◽  
Post Partum ◽  
Controlled Trial ◽  
Intervention Group ◽  
Anthropometric Measurements ◽  
Maternal Body Mass Index ◽  
Randomized Controlled ◽  
The Impact

Abstract Objectives While there is growing evidence on the role of preconception nutrition for birth outcomes, very few studies have evaluated the effects of nutrition interventions during the preconception period on maternal health. This study evaluates the impact of preconception weekly multiple micronutrients (MM) or iron and folic acid (IFA) supplementation compared to FA alone on maternal nutritional status through 6–7y post-partum (PP). Methods We followed women who participated in a randomized controlled trial of preconception supplementation in Vietnam and delivered live offspring (n = 1599). Women received weekly supplements containing either 2800 μg FA only, 60 mg iron and 2800 μg FA, or MM (15 micronutrients including IFA), from baseline until conception; followed by daily prenatal IFA supplements until delivery. Anthropometric measurements were obtained at recruitment and at 2 and 6–7 y PP. Group comparisons were done using ANOVA or chi-square tests. Results The groups were similar for baseline (preconception) maternal and offspring birth characteristics. Mean (SD) Body Mass Index (BMI; kg/m2) increased from 19.6 (2.1) at baseline, to 20.4 (2.4) and 21.6 (2.8) at 2 and 6–7 y PP (n = 931). The prevalence of overweight (BMI ≥ 23.5 kg/m2) also increased from 4.7% to 9% and 21%, at baseline, 2, and 6–7 years PP respectively, while underweight (BMI &lt; 18.5 kg/m2) declined from 31.4% to 21.4% and 10%, respectively. At 6–7 y PP, we found significant differences (P &lt; 0.01) by intervention group for mean BMI (MM: 22.0 (2.4), IFA: 21.6 (2.7); FA:21.4 (2.9)), and the prevalence of underweight (MM: 5.1%, IFA: 10.1%; FA:14.4%), but no differences in overweight (MM: 21.3%, IFA:20.3%; FA:21.3%), or other anthropometric measurements (weight to hip ratio, arm circumference and skinfold thickness). Conclusions Preconception supplementation with MM resulted in higher BMI and greater reductions in maternal underweight when compared to IFA and FA only. The prevalence of overweight increased dramatically over time but there with no differences by intervention group at 6–7 y PP. These findings suggest that preconception micronutrient interventions may have long term effects on maternal BMI that need to be further examined. Funding Sources The Nestle Foundation, the Mathile Institute, and the Micronutrient Initiative.

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