scholarly journals Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation

2020 ◽  
Vol 6 (30) ◽  
pp. eaba2987 ◽  
Author(s):  
Geng Dou ◽  
Ran Tian ◽  
Xuemei Liu ◽  
Pingyun Yuan ◽  
Qianwen Ye ◽  
...  
Keyword(s):  
Mesoporous Silica Nanoparticles ◽  
Apoptotic Bodies ◽  
Stimuli Responsive ◽  
Synthetic Materials ◽  
Intracellular Release ◽  
Optimal Functions ◽  
Therapeutic Molecules ◽  
Engineering Strategy ◽  
Regulatory Effects ◽  
Selection Of

Engineered extracellular vesicles (EVs) carrying therapeutic molecules are promising candidates for disease therapies. Yet, engineering EVs with optimal functions is a challenge that requires careful selection of functionally specific vesicles and a proper engineering strategy. Here, we constructed chimeric apoptotic bodies (cABs) for on-demand inflammation modulation by combining pure membrane from apoptotic bodies (ABs) as a bioconjugation/regulation module and mesoporous silica nanoparticles (MSNs) as a carrier module. MSNs were preloaded with anti-inflammatory agents (microRNA-21 or curcumin) and modified with stimuli-responsive molecules to achieve accurate cargo release at designated locations. The resulting cABs actively target macrophages in the inflammatory region and effectively promote M2 polarization of these macrophages to modulate inflammation due to the synergistic regulatory effects of AB membranes and the intracellular release of preloaded cargos. This work provides strategies to arbitrarily engineer modular EVs that integrate the advantages of natural EVs and synthetic materials for various applications.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

From Biomedical to Oil Industry: Promising Mesoporous Materials for Oil Field Applications

2021 ◽  
Author(s):  
Ahmed Wasel Alsmaeil ◽  
Mohamed Amen Hammami ◽  
Amr Ismail Abdel-Fattah ◽  
Mazin Yousef Kanj ◽  
Emmanuel P Giannelis
Keyword(s):  
Mesoporous Silica ◽  
Interfacial Tension ◽  
Mesoporous Materials ◽  
Oil Recovery ◽  
Oil And Gas ◽  
Mesoporous Silica Nanoparticles ◽  
Exchange Process ◽  
Oil Field ◽  
Stimuli Responsive ◽  
High Salinity Water

Abstract Developing nanocarriers deliver molecules to targeted locations has received widespread attention in different fields ranging from biomedical to oil and gas industries. Mesoporous Silica Nanoparticles (MSNs), where the pore size diameter ranges from 2-50 nm, have become attractive in many fields including biomedicine. One advantage is the ability to control the size, morphology of the particles, and the internal and external surfaces properties which enable encapsulating molecules of different size and charges. Moreover, it is possible to functionalize the pores and the surface of the MSNs, which make them suitable to host different molecules and release them in situ in a controlled manner. Despite the numerous studies of MSNs, little has been devoted to subsurface applications. This review will highlight some of the interesting characteristics of MSNs that make them promising carriers of molecules for slow and/or stimuli-responsive delivery for oil field applications. For example, they could be utilized for the controlled release of surfactants for enhanced oil recovery applications to minimize surfactant losses near the well-bore area. The mesoporous materials can be designed to harvest the ions normally present in oil field water, and the high temperatures encountered when travelling deep in the reservoir to release the surfactant. The ion exchange process makes it possible to engineer the MSNs to release their cargo for efficient and stimuli responsive delivery applications. The ion-responsive release was analyzed by the interfacial tension behavior between crude oil and high salinity water (HSW). It is concluded that the interfacial tension could be reduced up to 0.0045 mN/m when the mesoporous silica particles are suspended in HSW in comparison to 0.9 mN/m when suspended in DI water.

Near-Infrared Emitting Dual-Stimuli-Responsive Carbon Dots from Endogenous Bile Pigments

Nanoscale ◽  
2021 ◽  
Author(s):  
Parinaz Fathi ◽  
Parikshit Moitra ◽  
Madeleine M. McDonald ◽  
Mandy Brigitte Esch ◽  
Dipanjan Pan
Keyword(s):  
Surface Modification ◽  
Carbon Dots ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Bile Pigments ◽  
Careful Selection ◽  
Stimuli Responsive ◽  
Carbon Dot ◽  
Surface Modification Techniques ◽  
Selection Of

Carbon dots are biocompatible nanoparticles suitable for a variety of biomedical applications. Careful selection of carbon dot precursors and surface modification techniques has allowed for the development of carbon dots...

Vesicle Trafficking, Autophagy and Nanoparticles: A Brief Review

2020 ◽  
Vol 10 (1) ◽  
pp. 3-19
Author(s):  
Tianzhong Li ◽  
Mengsu Yang
Keyword(s):  
Clinical Trials ◽  
Signaling Pathways ◽  
Cellular Uptake ◽  
Vesicle Trafficking ◽  
Endocytic Pathway ◽  
Proton Sponge ◽  
Intracellular Release ◽  
Molecular Machinery ◽  
Delivery Vehicles ◽  
Selection Of

Background: Nanomedicine shows a huge promise for incurable diseases. So far, more than 50 nanoparticles have been approved by FDA and around 80 nanoformulations are currently in clinical trials. Nanoparticles possess several advantages over traditional drugs, including higher biocompatibility and bioavailability. One of the challenges for their wide application is insufficient understanding of the molecular network related to internalization of particles and intracellular release of cargos. Objective: This article aims to review the interactions between nanoparticles, vesicle transportation and autophagy pathways. The underlying molecular machinery is also discussed. Methods: For each step of the vesicle trafficking and autophagy, details of signaling pathways are described for a better understanding of the interactions between delivery vehicles and biomolecules within the cell. Conclusion: The selection of cellular uptake route mainly depends on physical characteristics of nanoparticles. For nanoparticles modified with ligands, they undergo receptormediated endocytic pathway. Once residing within the cells, cargos are released after disruption of endosomes, a mechanism called ‘proton sponge effect’. Besides, internalized nanoparticles either can be exocytosized, or they initiate the autophagy response, affecting the intracellular distribution of drugs.

Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging

2020 ◽  
Vol 56 (44) ◽  
pp. 5981-5984
Author(s):  
Nicole E. Arsenault ◽  
Kathleen T. Downey ◽  
Michael O. Wolf
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Water Concentration ◽  
Stimuli Responsive ◽  
Biologically Relevant

Environment-responsive fluorophores are attached to mesoporous silica nanoparticles that can be used for sensing water concentration around biologically-relevant substrates.

scholarly journals Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

2019 ◽  
Vol 16 (4) ◽  
pp. 415-439 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
Blanca González ◽  
Miguel Manzano ◽  
Isabel Izquierdo-Barba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

2016 ◽  
Vol 1 (6) ◽  
pp. 480-487 ◽  
Author(s):  
Ye Tian ◽  
Ranran Guo ◽  
Yunfeng Jiao ◽  
Yangfei Sun ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Disulfide Linkages ◽  
Targeting Delivery ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica

Transferrin-capped hollow mesoporous silica nanoparticles through disulfide linkages realize tumor-targeting delivery and glutathione-induced drug release.

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