Long term measurements of the UV irradiance of inclined surfaces and visualization of UV exposure of the human body

2005 ◽  
Vol 14 (2) ◽  
pp. 285-290 ◽  
Author(s):  
Andreas Oppenrieder ◽  
Peter Höppe ◽  
Peter Koepke ◽  
Jochen Reuder
Nanoscale ◽  
2021 ◽  
Author(s):  
Srijan Acharya ◽  
Satyam Suwas ◽  
Kaushik Chatterjee

Metallic materials are widely used to prepare implants for both short-term and long-term use in the human body. The performance of these implants is greatly influenced by their surface characteristics,...


2016 ◽  
Vol 144 ◽  
pp. 44-50 ◽  
Author(s):  
Liisa Nevalainen ◽  
Marttiina V. Rantala ◽  
Tomi P. Luoto ◽  
Antti E.K. Ojala ◽  
Milla Rautio

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Aleksandra Słojewska ◽  
Izabela Gutowska

Introduction: Food is a carrier of many pollutants nowadays. For cadmium and dioxins, it is the main source of these compounds in the general population. Hence, the aim of this work was to collect data on the health effects associated with exposure to cadmium and dioxins which get into the human body through food.Materials and methods: A literature review was conducted by searching the scientific Medline database (PubMed) and Google Scholar.Results: Health effects associated with a long-term exposure to low doses of cadmium and dioxins may be nonspecific and are rarely attributed to food sources. These may cause disorders affecting hormonal balance, kidney function, lipid metabolism, fertility, cognitive function, bone mineralization, and susceptibility to diseases and allergies. These compounds may also lead to cancer development.Conclusions: The general population faces the problem of longterm exposure to small doses of these substances due to their accumulation in the body, even if their amounts do not exceed the relevant standards. The health effects of this type of exposure may be significantly delayed and are not likely to be attributed to the consumption of contaminated food. Consumers wishing to reduce the amounts of these compounds delivered to the body should limit the consumption of grilled and smoked products, and should also opt for organic food.


2021 ◽  
Vol 9 (Suppl 3) ◽  
pp. A980-A980
Author(s):  
Domenico Mallardo ◽  
Giosuè Scognamiglio ◽  
Khrystyna North ◽  
Mariaelena Capone ◽  
Michael Bailey ◽  
...  

BackgroundMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer with neuroendocrine features, and it is associated with elevated mortality. The pathogenesis is associated with presence of clonally integrated Merkel cell polyomavirus (MCPyV) or ultraviolet light (UV) exposure.1 The MCPyV causes up to 80% of MCC tumors in North America and Europe.2–4 Recently immunotherapy is having good results,5 the phase 2 trial JAVELIN Merkel 200 indicated that treatment with Avelumab (PDL1 inhibitor) in patients with metastatic MCC pre-treated have a meaningful long-term survival outcomes respect chemotherapy. Moreover, ORRs were highest in patients with high TMB that were also MCPyV−, PD-L1+ or had a greater CD8+ T cell density at the invasive margin.6 In this study, we investigated the biological signatures in patients with MCPyV or not.MethodsFrom April 2011 to June 2018, we collected retrospectively 50 FFPE (Formalin-Fixed Paraffin-Embed) from 37 patients with metastatic MCC and 13 tissues from a secondary metastatic site. All patients have appropriately signed informed consent. We performed an immunohistochemistry assays (IHC) for MCPyV and PDL1. In addition, through the NanoString GeoMx DSP (Digital Spatial Profiling), we analysed 11 patients (6 MCPyV+; 5 MCPyV-) with cutaneous metastasis using a 44-plex antibody cocktail. For each slide we selected three different areas: Intratumoral, extratumoral and tumour border, in each area we selected CD4+ and CD8+ cells in 4 different ROIs (Region of Interest). Statistical analysis was performed via Bonferroni correction, P< 0.05 was considered statistically significant for median stratification.ResultsThe DSP analysis showed that the tumour border cells have an overexpression of IDO respect intratumoral area (adj. p<0.01). Instead, extratumoral area of MCPyV- patients have a higher expression of B7-H3 respect MCPyV+ as well as FOXP3 is higher in the tumour border of MCPyV+ patients and EpCAM in the intratumoral area (p<0.05). PDL1 is overexpressed in MCPyV+ CD4+ cells respect CD8+ (p<0.05). The IHC assay shown that viral status does not change in multiple metastases and PDL1 is elevated in the tumour border (p<0.05).ConclusionsIn this retrospective study, our preliminary data shown that tumour edge have an important role in the modulations of immune infiltrate and patients with Merkel cell polyomavirus could have a different pathway of immunosuppression compared to patients with non-virus related etiology. Further investigations are needed to get additional information.AcknowledgementsThe study was supported by the Institutional Project ”Ricerca Corrente” of Istituto Nazionale Tumori IRCCS Fondazione ”G. Pascale” of Napoli, Italy.ReferencesKaae J, Hansen AV, Biggar RJ, et al. Merkel cell carcinoma: incidence, mortality, and risk of other cancers. J Natl Cancer Inst 2010 June 2;102(11):793–801.Feng H, Shuda M, Chang Y, et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008 February 22;319(5866):1096–100.Garneski KM, Warcola AH, Feng Q, et al. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol 2009 January;129(1):246–8.Goh G, Walradt T, Markarov V, et al. Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy. Oncotarget 2016 January 19;7(3):3403–15.Bichakjian CK, Olencki T, Aasi SZ, et al. Merkel cell carcinoma, version 1.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2018 June;16(6):742–774.D’Angelo SP, Bhatia S, Brohl AS, et al. Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial. J Immunother Cancer 2020 May;8(1):e000674.Ethics ApprovalThe study was approved by internal ethics board of the Istituto Nazionale Tumori IRCCS Fondazione ”G. Pascale” of Napoli Italy, approval number of registry 33/17 OSS.ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.


2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Binaya Wasti ◽  
Zhifeng Chen ◽  
Yi Ke ◽  
Wen Tao Duan ◽  
Shao-Kun Liu ◽  
...  

Sex hormone has become a “hot topic” to evaluate the hormonal therapeutic potential in severe asthma. Th17 cell is one of the main influencing factors involved in the pathogenesis of severe asthma, hence also called as kernel of severe asthma, and Th17 subtype of non-T2 asthma is less responsive (resistance) to inhaled corticosteroid (ICS), so severe in nature. Methyl-CpG binding domain protein 2 (MBD2) is overexpressed and regulates the Th17 differentiation, showing the possibility of therapeutic target in treating Th17 mediated severe asthma. Sex hormone fluctuates at the different physiobiological conditions of the human body and affects the asthma pathobiology showing its role in asthma prevalence, severity, remission, and therapy. This review briefly overviews the sex hormones, their influence in asthma at the different physiobiological conditions of human body, and MBD2 severe asthma connection with the possible therapeutic potential of sex steroids in MBD2 mediated Th17 predominant severe asthma. Male sex hormone tends to show a beneficial effect and possibly downregulates the expression of Th17 cells via regulating MBD2 through a mechanism distinct from corticosteroid treatment and guides us towards discovery of new therapeutic agent, reduces the asthma-related complications, and promotes long-term survival by lowering the risk of therapy-resistant issues of old age severe asthma.


2020 ◽  
Vol 645 ◽  
pp. A2
Author(s):  
M. Meftah ◽  
M. Snow ◽  
L. Damé ◽  
D. Bolseé ◽  
N. Pereira ◽  
...  

Context. Solar spectral irradiance (SSI) is the wavelength-dependent energy input to the top of the Earth’s atmosphere. Solar ultraviolet (UV) irradiance represents the primary forcing mechanism for the photochemistry, heating, and dynamics of the Earth’s atmosphere. Hence, both temporal and spectral variations in solar UV irradiance represent crucial inputs to the modeling and understanding of the behavior of the Earth’s atmosphere. Therefore, measuring the long-term solar UV irradiance variations over the 11-year solar activity cycle (and over longer timescales) is fundamental. Thus, each new solar spectral irradiance dataset based on long-term observations represents a major interest and can be used for further investigations of the long-term trend of solar activity and the construction of a homogeneous solar spectral irradiance record. Aims. The main objective of this article is to present a new solar spectral irradiance database (SOLAR-v) with the associated uncertainties. This dataset is based on solar UV irradiance observations (165−300 nm) of the SOLAR/SOLSPEC space-based instrument, which provides measurements of the full-disk SSI during solar cycle 24. Methods. SOLAR/SOLSPEC made solar acquisitions between April 5, 2008 and February 10, 2017. During this period, the instrument was affected by the harsh space environment that introduces instrumental trends (degradation) in the SSI measurements. A new method based on an adaptation of the Multiple Same-Irradiance-Level (MuSIL) technique was used to separate solar variability and any uncorrected instrumental trends in the SOLAR/SOLSPEC UV irradiance measurements. Results. A new method for correcting degradation has been applied to the SOLAR/SOLSPEC UV irradiance records to provide new solar cycle variability results during solar cycle 24. Irradiances are reported at a mean solar distance of 1 astronomical unit (AU). In the 165−242 nm spectral region, the SOLAR/SOLSPEC data agrees with the observations (SORCE/SOLSTICE) and models (SATIRE-S, NRLSSI 2) to within the 1-sigma error envelope. Between 242 and 300 nm, SOLAR/SOLSPEC agrees only with the models.


Author(s):  
Yuanzhi Fu ◽  
Liuliu Wu ◽  
V.I. Trotsenko ◽  
H.O. Zhatova

Cadmium pollution in soil is a long-term and urgent problem, which directly affects the edible value of sunflower and winter wheat and may cause harm to human health. Breeding new varieties with low cadmium accumulation can effectively reduce the content of this element in seeds and fundamentally solve the risk of cadmium entering the human body through seeds and oil. In this paper, the method and significance of breeding sunflower and winter wheat with low cadmium accumulation  were discussed.


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