Iron Transport and Metabolism in Escherichia, Shigella, and Salmonella

EcoSal Plus ◽  
2021 ◽  
Author(s):  
Alexandra R. Mey ◽  
Camilo Gómez-Garzón ◽  
Shelley M. Payne
Keyword(s):  
Iron Transport ◽  
Intestinal Tract ◽  
Essential Element ◽  
Content Type

Iron is an essential element for Escherichia , Salmonella , and Shigella species. The acquisition of sufficient amounts of iron is difficult in many environments, including the intestinal tract, where these bacteria usually reside.

scholarly journals Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments

2015 ◽  
Vol 80 (1) ◽  
pp. 69-90 ◽  
Author(s):  
Shelley M. Payne ◽  
Alexandra R. Mey ◽  
Elizabeth E. Wyckoff
Keyword(s):  
Regulatory Networks ◽  
Iron Transport ◽  
Horizontal Transmission ◽  
Essential Element ◽  
Transport Systems ◽  
Iron Binding ◽  
Content Type ◽  
High Affinity ◽  
Wide Range ◽  
Genes Encoding

SUMMARYIron is an essential element forVibriospp., but the acquisition of iron is complicated by its tendency to form insoluble ferric complexes in nature and its association with high-affinity iron-binding proteins in the host. Vibrios occupy a variety of different niches, and each of these niches presents particular challenges for acquiring sufficient iron.Vibriospecies have evolved a wide array of iron transport systems that allow the bacteria to compete for this essential element in each of its habitats. These systems include the secretion and uptake of high-affinity iron-binding compounds (siderophores) as well as transport systems for iron bound to host complexes. Transporters for ferric and ferrous iron not complexed to siderophores are also common toVibriospecies. Some of the genes encoding these systems show evidence of horizontal transmission, and the ability to acquire and incorporate additional iron transport systems may have allowedVibriospecies to more rapidly adapt to new environmental niches. While too little iron prevents growth of the bacteria, too much can be lethal. The appropriate balance is maintained in vibrios through complex regulatory networks involving transcriptional repressors and activators and small RNAs (sRNAs) that act posttranscriptionally. Examination of the number and variety of iron transport systems found inVibriospp. offers insights into how this group of bacteria has adapted to such a wide range of habitats.

The effect of supplier development initiatives on purchasing performance: a structural model

2005 ◽  
Vol 10 (4) ◽  
pp. 289-301 ◽  
Author(s):  
Cristóbal Sánchez‐Rodríguez ◽  
David Hemsworth ◽  
Ángel R. Martínez‐Lorente
Keyword(s):  
Supply Chain ◽  
Structural Equation ◽  
Manufacturing Industry ◽  
Structural Model ◽  
Essential Element ◽  
Equation Modeling ◽  
Supplier Development ◽  
Manufacturing Companies ◽  
Content Type ◽  
Different Levels

PurposeSupply chain management is an increasingly important organizational concern, and proper management of supplier relationships constitutes one essential element of supply chain success. However, there is little empirical research that has tested the effect of supplier development on performance. The main objective is to analyze the effect of supplier development practices with different levels of implementation complexity on the firm's purchasing performance.Design/methodology/approachThree supplier development constructs were defined: basic supplier development, moderate supplier development, and advanced supplier development. Three structural models were hypothesized and tested using structural equation modeling through field research on a sample of 306 manufacturing companies in Spain.FindingsIdentified important interrelationships among the various supplier development practices, basic, moderate, and advanced. Also indicated that the implementation of supplier development practices significantly contributes to the prediction of purchasing performance.Research limitations/implicationsThe use of a single key informant could be seen as a potential limitation of the study. The study was a cross‐sectional and descriptive sample of the manufacturing industry at a given point in time. A more stringent test of the relationships between the different levels of supplier development and performance requires a longitudinal study, or field experiment.Practical implicationsThis study focused on supplier development practices and revealed how involving suppliers in supplier development activities is important and may help buyers to increase their purchasing performance. The findings from the structural analysis should provide practicing managers with insights on how these practices and their benefits are related in terms of purchasing performance, thus affecting their ability to make better sourcing decisions.Originality/valueFills an important gap in the purchasing literature with respect to the area of supplier development. While there is much written about supplier development based on conceptual and case study research, this study is unique in that it is the first attempt to empirically model the relationships between different levels of supplier development and their impact on purchasing performance using a comprehensive set of practices.

Low power aware pulse triggered flip flops using modified clock gating approaches

2018 ◽  
Vol 15 (6) ◽  
pp. 792-803
Author(s):  
Sudhakar Jyothula
Keyword(s):  
Power Consumption ◽  
Low Power ◽  
Average Power ◽  
Essential Element ◽  
Battery Life ◽  
Portable Devices ◽  
Clock Gating ◽  
Flip Flop ◽  
Content Type ◽  
Low Leakage

PurposeThe purpose of this paper is to design a low power clock gating technique using Galeor approach by assimilated with replica path pulse triggered flip flop (RP-PTFF).Design/methodology/approachIn the present scenario, the inclination of battery for portable devices has been increasing tremendously. Therefore, battery life has become an essential element for portable devices. To increase the battery life of portable devices such as communication devices, these have to be made with low power requirements. Hence, power consumption is one of the main issues in CMOS design. To reap a low-power battery with optimum delay constraints, a new methodology is proposed by using the advantages of a low leakage GALEOR approach. By integrating the proposed GALEOR technique with conventional PTFFs, a reduction in power consumption is achieved.FindingsThe design was implemented in mentor graphics EDA tools with 130 nm technology, and the proposed technique is compared with existing conventional PTFFs in terms of power consumption. The average power consumed by the proposed technique (RP-PTFF clock gating with the GALEOR technique) is reduced to 47 per cent compared to conventional PTFF for 100 per cent switching activity.Originality/valueThe study demonstrates that RP-PTFF with clock gating using the GALEOR approach is a design that is superior to the conventional PTFFs.

scholarly journals The Ins and Outs of Iron Homeostasis

Physiology ◽  
2006 ◽  
Vol 21 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Adriana Donovan ◽  
Cindy N. Roy ◽  
Nancy C. Andrews
Keyword(s):  
Iron Transport ◽  
Iron Homeostasis ◽  
Essential Element ◽  
Regulatory Mechanisms ◽  
Health And Disease ◽  
And Storage ◽  
Different Tissues

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.

scholarly journals Salmonella -Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut

2018 ◽  
Vol 86 (5) ◽  
Author(s):  
Jikang Wu ◽  
Anice Sabag-Daigle ◽  
Mikayla A. Borton ◽  
Linnea F. M. Kop ◽  
Blake E. Szkoda ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Salmonella Enterica ◽  
Intestinal Tract ◽  
Intestinal Inflammation ◽  
Dry Weight ◽  
Pathogenicity Islands ◽  
Content Type ◽  
Gain Access

ABSTRACT Salmonella enterica elicits intestinal inflammation to gain access to nutrients. One of these nutrients is fructose-asparagine (F-Asn). The availability of F-Asn to Salmonella during infection is dependent upon Salmonella pathogenicity islands 1 and 2, which in turn are required to provoke inflammation. Here, we determined that F-Asn is present in mouse chow at approximately 400 pmol/mg (dry weight). F-Asn is also present in the intestinal tract of germfree mice at 2,700 pmol/mg (dry weight) and in the intestinal tract of conventional mice at 9 to 28 pmol/mg. These findings suggest that the mouse intestinal microbiota consumes F-Asn. We utilized heavy-labeled precursors of F-Asn to monitor its formation in the intestine, in the presence or absence of inflammation, and none was observed. Finally, we determined that some members of the class Clostridia encode F-Asn utilization pathways and that they are eliminated from highly inflamed Salmonella -infected mice. Collectively, our studies identify the source of F-Asn as the diet and that Salmonella -mediated inflammation is required to eliminate competitors and allow the pathogen nearly exclusive access to this nutrient.

Evaluation of perceived benefits and employee satisfaction through knowledge management practices

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Jamini Ranjan Meher ◽  
Rohita Kumar Mishra
Keyword(s):  
Knowledge Management ◽  
Employee Satisfaction ◽  
Management Practices ◽  
Research Study ◽  
Essential Element ◽  
Partial Least Square ◽  
Equation Modeling ◽  
Employee Benefit ◽  
Content Type ◽  
Perceived Benefit

Purpose This study aims to identify the key contributing factors of knowledge management (KM) practices with respect to an employee benefit. The research is designed to gain insight into the KM practices of Indian information technology (IT) firms and evaluate its effects on employee perceived benefit (EPB) and employee satisfaction (ES). Design/methodology/approach This study focuses on the cause and effect relationship between the variables. In this research study, a structured questionnaire is administered and accumulated responses from executives, software developers and knowledge managers from five IT firms with the help of google form. The sample size was 339 for this study. Confirmatory factor analysis and partial least square (PLS)-structural equation modeling have been used to analyze the data with the help of SMART-PLS software. Findings The well-fitted model describes the importance of KM practices with respect to increasing employee benefit and satisfaction. The hypothesized model is empirically investigated and it is also supported by the analysis. The KM practices have significant effects on EPBs. Employee benefits have a significant effect on ES. The result shows that the benefits of KM practices are more intended toward the sources of motivation where they can increase their capability with the help of KM practices. Research limitations/implications Benefit leads to the motivation and satisfaction of employees. The work itself can be a highly motivating dimension with the help of proper KM practices. The managers’ prime responsibility is to focus on collaborative work with regularizing the exchange of knowledge, where new knowledge can be created and, do better for the organization. Originality/value This research study offers a new direction of motivation to work. The employee can be highly motivated if he can be benefited from the work itself. This study gives an approach to satisfy the employee with the help of KM practices. Perceived benefit is considered as an essential element for this study.

Exploring BIM-triggered organisational and professional culture change: a systematic literature review

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sonali Alankarage ◽  
Nicholas Chileshe ◽  
Raufdeen Rameezdeen ◽  
David J. Edwards ◽  
Aparna Samaraweera
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Essential Element ◽  
Future Research ◽  
Content Type ◽  
New Employees ◽  
Body Of Knowledge ◽  
Building Information ◽  
Considerable Impact

Purpose Building information modelling (BIM) has had a considerable impact on the socio-technical aspects of construction organisations. Culture has been considered an essential element in BIM practice. Hence, this paper aims to explore existing research relates to culture in the BIM context. Design/methodology/approach A systematic literature review (SLR) was conducted based on the PRISMA guidelines using 104 articles published between 2011 and 2020 and directed with a descriptive and content analysis. Findings The SLR results give evidence that culture in the BIM context is still an under-researched topic. Culture has been considered as both a dependent and independent factor in the BIM domain. Organisational BIM culture is a collection of fundamental beliefs established in a BIM using organisation and passed to new employees with the use of BIM. BIM using organisations are have either weak or strong BIM cultures. Proper analysis and understanding of the BIM culture of different organisations are necessary to realise the strategies of transformation from a weak BIM culture to a strong BIM culture. Originality/value To the best of the author's knowledge, this is the first SLR in BIM research that investigates the role of culture in the BIM setting. This study contributed to the existing body of knowledge by proposing a conceptual framework to understand and change a weak BIM culture of an organisation to a strong, matured BIM culture. This SLR serves as a future research basis in BIM-triggered culture.

The impact of information security initiatives on supply chain robustness and performance: an empirical study

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sindhuja P.N.
Keyword(s):  
Supply Chain ◽  
Information Security ◽  
Supply Chains ◽  
Structural Equation ◽  
Essential Element ◽  
Equation Modeling ◽  
Content Type ◽  
And Performance ◽  
The Impact ◽  
Supply Chain Robustness

Purpose Information security is an essential element in all business activities. The damage to businesses from information security breaches has become pervasive. The scope of information security has widened as information has become a critical supply chain asset, making it more important to protect the organization’s data. Today’s global supply chains rely upon the speedy and robust dissemination of information among supply chain partners. Hence, processing of accurate supply chain information is quintessential to ensure the robustness and performance of supply chains. An effective information security management (ISM) is deemed to ensure the robustness of supply chains. The purpose of the paper is to examine the impact of information security initiatives on supply chain robustness and performance. Design/methodology/approach Based on extant literature, a research model was developed and validated using a questionnaire survey instrument administered among information systems/information technology managers. Data collected were analyzed using exploratory and confirmatory factor analysis. Further, to test the hypotheses and to fit the theoretical model, Structural equation modeling techniques were used. Findings Results of this study indicated that information security initiatives are positively associated with supply chain robustness and performance. These initiatives are likely to enhance the robustness and performance of the supply chains. Originality/value With the advancements in internet technologies and capabilities as well as considering the dynamic environment of supply chains, this study is relevant in terms of the capability that an organization needs to acquire with regards to ISM. Benefiting from the resource dependency theory, information security initiatives could be considered as a critical resource having an influence on the internal and external environment of supply chains.

scholarly journals Complete High-Quality Genome Sequence of Clostridium limosum (Hathewaya limosa) Isolate 14S0207, Recovered from a Cow with Suspected Blackleg in Germany

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Prasad Thomas ◽  
Mostafa Y. Abdel-Glil ◽  
Anne Busch ◽  
Lothar H. Wieler ◽  
Inga Eichhorn ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Intestinal Tract ◽  
High Quality ◽  
Circular Chromosome ◽  
Content Type ◽  
High Quality Genome

Clostridium limosum can be found in soil and the intestinal tract of animals. In 2014, C. limosum was isolated from a suspected blackleg outbreak in cattle in Schleswig-Holstein, Germany. We present a complete genome sequence of a C. limosum strain represented by a circular chromosome and three plasmids.

scholarly journals Collaborative configurations of tourism development: a Greenlandic example

2019 ◽  
Vol 6 (1) ◽  
pp. 24-39
Author(s):  
Daniela Chimirri
Keyword(s):  
Design Methodology ◽  
Local Community ◽  
Tourism Development ◽  
Essential Element ◽  
Small Scale ◽  
Research Approach ◽  
Content Type ◽  
Study Approach ◽  
Collaborative Activities

Purpose While tourism scholars have increasingly recognized the significance of collaboration as an essential element in tourism development, there is a lack of theoretical and empirical research centering on (trans)local collaboration as a central means for future tourism development in Greenland. The purpose of this paper is to analyze the conceptual and analytic potentials and challenges of collaboration in an explorative case study. Design/methodology/approach The paper applies a case study approach to scrutinize collaboration in the setting of a tourism workshop in South Greenland. This research approach is exploratory in nature and focuses on collaborative activities among participants from different research institutions and countries, from Campus Kujalleq in Qaqortoq, from small-scale enterprises and businesses, managers of destination marketing organizations and local fishermen. Findings Four “collaborative configurations” emerged during the workshop. These inspire and challenge ways of (re)conceptualizing collaborative tourism development in South Greenland and call for the reconsideration of the present approach toward tourism development for shaping new possible future(s) of tourism in the Greenlandic context. Originality/value The relevance of this paper emerges from the crucial significance that tourism actors in Greenland credit collaboration. Moreover, by approaching development issues from within and mutually developing possible practice solutions through collaboration with local tourism actors, the paper aims to give voice to the local community, which currently is lacking in the debate on tourism development in Greenland.

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