scholarly journals Taming the Elephant: Salmonella Biology, Pathogenesis, and Prevention

2010 ◽  
Vol 78 (6) ◽  
pp. 2356-2369 ◽  
Author(s):  
Helene L. Andrews-Polymenis ◽  
Andreas J. Bäumler ◽  
Beth A. McCormick ◽  
Ferric C. Fang

ABSTRACT Salmonella infections continue to cause substantial morbidity and mortality throughout the world. However, recent discoveries and new paradigms promise to lead to novel strategies to diagnose, treat, and prevent Salmonella infections. This review provides an update of the Salmonella field based on oral presentations given at the recent 3rd ASM Conference on Salmonella: Biology, Pathogenesis and Prevention.

2021 ◽  
Vol 42 (02) ◽  
pp. 271-283
Author(s):  
Manila Gaddh ◽  
Rachel P. Rosovsky

AbstractVenous thromboembolism (VTE) is a major cause of morbidity and mortality throughout the world. Up to one half of patients who present with VTE will have an underlying thrombophilic defect. This knowledge has led to a widespread practice of testing for such defects in patients who develop VTE. However, identifying a hereditary thrombophilia by itself does not necessarily change outcomes or dictate therapy. Furthermore, family history of VTE by itself can increase an asymptomatic person's VTE risk several-fold, independent of detecting a known inherited thrombophilia. In this article, we will describe the current validated hereditary thrombophilias including their history, prevalence, and association with VTE. With a focus on evaluating both risks and benefits of testing, we will also explore the controversies of why, who, and when to test as well as discuss contemporary societal guidelines. Lastly, we will share how these tests have been integrated into clinical practice and how to best utilize them in the future.


2021 ◽  
Vol 2125 (1) ◽  
pp. 011001

We are glad to introduce you that the 2021 4th International Conference on Mechanical, Electrical and Material Application (MEMA 2021) was successfully held on October 29-31, 2021. In light of worldwide travel restriction and the impact of COVID-19, MEMA 2021 was carried out in the form of virtual conference to avoid personnel gatherings. Because most participants were still highly enthusiastic about participating in this conference, we chose to carry out MEMA 2021 via online platform according to the original schedule instead of postponing it. MEMA 2021 is to bring together innovative academics and industrial experts in the field of Mechanical, Electrical and Material Application to a common forum. The primary goal of the conference is to promote research and developmental activities in Mechanical, Electrical and Material Application and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world. The conference will be held every year to make it an ideal platform for people to share views and experiences in Mechanical, Electrical and Material Application and related areas. We were greatly honored to invited Prof. Kun Li, from Chongqing University, China and Assoc. Prof. Wei Wei, from Xi’an University of Technology, China as our Conference Chairmen. This scientific event brings together more than 100 national and international researchers in mechanical, electrical and material application. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and online Q&A discussion. In the first part, some scholars, whose submissions were selected as the excellent papers, were given about 5-10 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-45 minutes to hold their speeches. We were pleased to invite four distinguished experts to present their insightful speeches. Our first keynote speaker, Prof. Shahid Hussain, Jiangsu University, China. His research interests include MOS-MOF-MXene Nanomaterials, Gas-Sensors, Electrochemical Supercapacitors, Li-S batteries. And then we had Prof. Jie Huang, from Southwest University, China. His research includes RF/Microwave circuits and sensors. Prof. Qiyan Xu, Anhui University of Technology, China. His main research directions are: New process and technology of low cost steel making, Direct reduction and melting reduction, Development of new metallurgical technology - comprehensive utilization of waste resources. Lastly, we were glad to invite Prof. Kun Li, Chongqing University, China. He mainly engaged in additive manufacturing, intelligent 3D net forming, high performance materials and phase transformation, material computing and other research. In the last part of the conference, all participants were invited to join in a WeChat group to discuss and explore the academic issues after the presentations. The online discussion was lasted for about 30-60 minutes. We are glad to share with you that we still received lots of submissions from the conference during this special period. Hence, we selected a bunch of high-quality papers and compiled them into the proceedings after rigorously reviewed them. These papers feature following topics but are not limited to: Mechanical Dynamics and its Applications, Material Physics, Electrical and Electronic Systems and other related topics. All the papers have been through rigorous review and process to meet the requirements of International publication standard. Lastly, we would like to express our sincere gratitude to the Chairman, the distinguished keynote speakers, as well as all the participants. We also want to thank the publisher for publishing the proceedings. May the readers could enjoy the gain some valuable knowledge from the proceedings. We are expecting more and more experts and scholars from all over the world to join this international event next year. The Committee of MEMA 2021 List of Committee member is available in this pdf.


2020 ◽  
Vol 30 (11) ◽  
pp. 1688-1693 ◽  
Author(s):  
Dominique Vervoort ◽  
Marcelo Cardarelli

AbstractBackground:CHDs are one of the most frequent congenital malformations, affecting one in hundred live births. In total, 70% will require treatment in the first year of life, but over 90% of cases in low- and middle-income countries receive no treatment or suboptimal treatment. As a result, CHDs are responsible for 66% of preventable deaths due to congenital malformations in low- and middle-income countries. This study examines the unmet need of congenital cardiac care around the world based on the global burden of disease.Materials and methods:CHD morbidity and mortality data for 2006, 2011, and 2016 were collected from the Institute for Health Metrics and Evaluation Global Burden of Disease Results Tool and analysed longitudinally to assess trends in excess morbidity and mortality.Results:Between 2006 and 2016, a 20.7% reduction in excess disability-adjusted life years and 20.6% reduction in excess deaths due to CHDs were observed for children under 15. In 2016, excess global morbidity and mortality due to CHDs remained high with 14,788,418.7 disability-adjusted life years and 171,761.8 paediatric deaths, respectively. In total, 90.2% of disability-adjusted life years and 91.2% of deaths were considered excess.Conclusion:This study illustrates the unmet need of congenital cardiac care around the world. Progress has been made to reduce morbidity and mortality due to CHDs but remains high and largely treatable around the world. Limited academic attention for global paediatric cardiac care magnifies the lack of progress in this area.


2020 ◽  
Vol 71 (Supplement_2) ◽  
pp. S91-S95
Author(s):  
Senjuti Saha ◽  
Mohammad Saiful Islam Sajib ◽  
Denise Garrett ◽  
Farah N Qamar

Abstract With the increasing antibacterial resistance in typhoidal Salmonella and the dearth of novel antimicrobials on the horizon, we risk losing our primary defense against widespread morbidity and mortality from enteric fever. During 26–28 March 2019, researchers from around the world came together in Hanoi, Vietnam, and shared some of their latest findings on antimicrobial resistance. From the 258 abstracts presented at the conference, at least 50 discussed phenotypic and genotypic characteristics of antimicrobial resistance in typhoidal Salmonella, covering data of at least 24 different countries, spanning 5 continents. Here, we summarize the key findings, focusing on our global journey ahead.


Author(s):  
Jing Wang ◽  
Wen Meng

Abstract Coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2 infection has now evolved into a worldwide crisis that triggers substantial morbidity and mortality. COVID-19 occurs more frequently and has more serious complications in patients with diabetes mellitus, but the underlying mechanisms remain largely elusive. Here, we summarize current and evolving concepts on the detrimental effect of hyperglycemia on SARS-CoV-2 infection and consequences, focusing on several key mechanisms underlying the link between diabetes and COVID-19. A better understanding of the mechanisms by which hyperglycemia worsens the prognosis of COVID-19 is critical for reducing the risk of SARS-CoV-2 infection and its associated mortality.


2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Alex Lara Jácome ◽  
Luis Mogrovejo Freire ◽  
Guillermo Freire Castro ◽  
Rosaura Bravo Pita ◽  
Omar Barragán Cabezas ◽  
...  

Tuberculosis is one of the most serious infectious problems in the world, it represents one of the main causes of global morbidity and mortality. Primary tuberculosis of the oral cavity and oropharynx is quite rare. In this article, we describe a case of a 38-year-old woman who has been HIV positive for two years with a diagnosis of tonsillar tuberculosis with an active pulmonary focus. Clinical manifestations, difficulty of diagnosis, differential diagnoses are considered. A detailed review of the literature on tonsillar tuberculosis is also included. Palabras claves: amígdala, tuberculosis, VHI


2014 ◽  
Vol 41 (6) ◽  
pp. 1200-1205 ◽  
Author(s):  
Agnes Szentpetery ◽  
Mary Ann N. Johnson ◽  
Christopher T. Ritchlin

At the 2013 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Toronto, Ontario, Canada, 26 dermatology and rheumatology fellows engaged in psoriasis or psoriatic arthritis research were invited to present their work at the Trainees Symposium, which preceded the annual meeting and was also attended by GRAPPA members from around the world. Herein, we provide a brief overview of the 6 oral presentations and 25 posters presented, which reflect the focus and diversity of current basic and clinical research in psoriatic disease.


2021 ◽  
Vol 2078 (1) ◽  
pp. 011001

We are glad to introduce you that the 2021 3rd International Conference on Artificial Intelligence Technologies and Applications (ICAITA 2021) was successfully held on September 10-12, 2021. In light of worldwide travel restriction and the impact of COVID-19, ICAITA 2021 was carried out in the form of virtual conference to avoid personnel gatherings. Because most participants were still highly enthusiastic about participating in this conference, we chose to carry out ICAITA 2021 via online platform according to the original schedule instead of postponing it. ICAITA 2021 is to bring together innovative academics and industrial experts in the field of Artificial Intelligence Technologies and Applications to a common forum. The primary goal of the conference is to promote research and developmental activities in Artificial Intelligence Technologies and Applications and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world. The conference will be held every year to make it an ideal platform for people to share views and experiences in Artificial Intelligence Technologies and Applications and related areas. This scientific event brings together more than 100 national and international researchers in artificial intelligence technologies and applications. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and online Q&A discussion. In the first part, some scholars, whose submissions were selected as the excellent papers, were given about 5-10 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-45 minutes to hold their speeches. We were pleased to invite three distinguished experts to present their insightful speeches. Our first keynote speaker, Prof. Yau Kok Lim, from Sunway University, Malaysia. His research interests include Applied artificial intelligence, 5G networks, Cognitiveradio networks, Routing and clustering, Trust and reputation, Intelligent transportation system. And then we had Prof. Peter Sincak, from Technical University of Kosice, Slovakia. His research includes Artificial Intelligence and Intelligent Systems. Lastly, we were glad to invite Chinthaka Premachandra, from Shibaura Institute of Technology, Sri Lanka. His research interests include Artificial Intelligence, image processing and robotics. In the last part of the conference, all participants were invited to join in a WeChat group to discuss and explore the academic issues after the presentations. The online discussion was lasted for about 30-60 minutes. The first two parts were conducted via online collaboration tool, Zoom, while the online discussion was carried out through instant communication tool, WeChat. The online platform enabled all participants to join this grand academic event from their own home. We are glad to share with you that we still received lots of submissions from the conference during this special period. Hence, we selected a bunch of high-quality papers and compiled them into the proceedings after rigorously reviewed them. These papers feature following topics but are not limited to: Artificial Intelligence Applications & Technologies, Computing and the Mind, Foundations of Artificial Intelligence and other related topics. All the papers have been through rigorous review and process to meet the requirements of international publication standard. Lastly, we would like to express our sincere gratitude to the Chairman, the distinguished keynote speakers, as well as all the participants. We also want to thank the publisher for publishing the proceedings. May the readers could enjoy the gain some valuable knowledge from the proceedings. We are expecting more and more experts and scholars from all over the world to join this international event next year. The Committee of ICAITA 2021 List of titles Committee member, General Conference Chair, Technical Program Committee Chair, Academic Committee Chair, Technical Program Committee Member, Academic Committee Member are available in this Pdf.


Author(s):  
Suresh Kumar Srinivasamurthy ◽  
Laxminarayana Kurady Bairy

COVID-19 pandemic has affected the world in all its dimensions. With herd immunity being a distant and non-practical possibility, vaccination remains most tractable approach to reduce morbidity and mortality. Several early phase clinical trials have proved the immunogenicity of vaccines. The efficacy trials have shown reduction in chance of acquiring COVID-19 disease after vaccination. The vaccines approved for emergency use have reported efficacy above 50% thus making them important public health tool in controlling the pandemic. Nevertheless, several questions remain elusive such as whether these approved vaccines are effective against newer variants of the virus; whether vaccination prevents transmission of the virus in the community; clinical impact of vaccination on morbidity and mortality. This review aims to elucidate the status of vaccine candidates in advanced trials along with the vaccines, which have been granted emergency approvals. Further, we collate the data on vaccines efficacy phase 3 trials and their probability of efficacy against newer variants.


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