scholarly journals Vaccines against COVID-19 – Catching the Rays of Hope

2021 ◽  
pp. 469-488
Author(s):  
Suresh Kumar Srinivasamurthy ◽  
Laxminarayana Kurady Bairy
Keyword(s):  
Herd Immunity ◽  
Clinical Impact ◽  
Morbidity And Mortality ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Practical Possibility ◽  
Efficacy Trials ◽  
The World ◽  
The Status ◽  
Early Phase Clinical Trials

COVID-19 pandemic has affected the world in all its dimensions. With herd immunity being a distant and non-practical possibility, vaccination remains most tractable approach to reduce morbidity and mortality. Several early phase clinical trials have proved the immunogenicity of vaccines. The efficacy trials have shown reduction in chance of acquiring COVID-19 disease after vaccination. The vaccines approved for emergency use have reported efficacy above 50% thus making them important public health tool in controlling the pandemic. Nevertheless, several questions remain elusive such as whether these approved vaccines are effective against newer variants of the virus; whether vaccination prevents transmission of the virus in the community; clinical impact of vaccination on morbidity and mortality. This review aims to elucidate the status of vaccine candidates in advanced trials along with the vaccines, which have been granted emergency approvals. Further, we collate the data on vaccines efficacy phase 3 trials and their probability of efficacy against newer variants.

scholarly journals SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Nikolaos C. Kyriakidis ◽  
Andrés López-Cortés ◽  
Eduardo Vásconez González ◽  
Alejandra Barreto Grimaldos ◽  
Esteban Ortiz Prado
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Vaccine Development ◽  
Rna Virus ◽  
Protein S ◽  
Effective Vaccine ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Advantages And Disadvantages ◽  
The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

scholarly journals Calibration of two validated SARS-CoV-2 pseudovirus neutralization assays for COVID-19 vaccine evaluation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yunda Huang ◽  
Oleg Borisov ◽  
Jia Jin Kee ◽  
Lindsay N. Carpp ◽  
Terri Wrin ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
World Health ◽  
United States Government ◽  
Phase 3 ◽  
Efficacy Trials ◽  
Combining Data ◽  
The World ◽  
States Government ◽  
Common Scale ◽  
Aid Decision

AbstractVaccine-induced neutralizing antibodies (nAbs) are key biomarkers considered to be associated with vaccine efficacy. In United States government-sponsored phase 3 efficacy trials of COVID-19 vaccines, nAbs are measured by two different validated pseudovirus-based SARS-CoV-2 neutralization assays, with each trial using one of the two assays. Here we describe and compare the nAb titers obtained in the two assays. We observe that one assay consistently yielded higher nAb titers than the other when both assays were performed on the World Health Organization’s anti-SARS-CoV-2 immunoglobulin International Standard, COVID-19 convalescent sera, and mRNA-1273 vaccinee sera. To overcome the challenge this difference in readout poses in comparing/combining data from the two assays, we evaluate three calibration approaches and show that readouts from the two assays can be calibrated to a common scale. These results may aid decision-making based on data from these assays for the evaluation and licensure of new or adapted COVID-19 vaccines.

scholarly journals Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation

2021 ◽  
Author(s):  
Yunda Huang ◽  
Oleg Borisov ◽  
Jia Jin Kee ◽  
Lindsay Carpp ◽  
Terri Wrin ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
World Health ◽  
United States Government ◽  
Phase 3 ◽  
Efficacy Trials ◽  
Combining Data ◽  
The World ◽  
States Government ◽  
Common Scale ◽  
Aid Decision

Abstract Vaccine-induced neutralizing antibodies (nAbs) are key biomarkers considered to be associated with vaccine efficacy. In United States Government-sponsored phase 3 efficacy trials of COVID-19 vaccines, nAbs are measured by two different validated pseudovirus-based SARS-CoV-2 neutralization assays, with each trial using one of the two assays. Here we describe and compare the nAb titers obtained in the two assays. We observe that one assay consistently yielded higher nAb titers than the other when both assays were performed on the World Health Organization’s anti-SARS-CoV-2 immunoglobulin International Standard, COVID-19 convalescent sera, and mRNA-1273 vaccinee sera. To overcome the challenge this difference in readout poses in comparing/combining data from the two assays, we evaluate three calibration approaches and show that readouts from the two assays can be calibrated to a common scale. These results may aid decision-making based on data from these assays for the evaluation and licensure of new or adapted COVID-19 vaccines.

scholarly journals Nano COVID-19 Vaccines: the firsts RNA lipid nanoparticle vaccines being approved from history - Review

2020 ◽  
Vol 9 (12) ◽  
pp. e20191211123
Author(s):  
Thyago José Arruda Pacheco ◽  
Victor Carlos Mello da Silva ◽  
Danielle Galdino de Souza
Keyword(s):  
World Health ◽  
World Population ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
The Third ◽  
The World ◽  
Proven Efficacy ◽  
Pros And Cons ◽  
Health Organization ◽  
Collaborative Efforts

A new coronavirus, identified in Wuhan, China, has spread globally, infecting millions of people and causing significant morbidity and mortality. The pandemic state, declared by the World Health Organization on March 11, 2020, transformed the world and made people adapt to social distance to control the spread of the virus. The race against time in search of therapeutic solutions has become essential, and nanotechnology may be able to make vaccines available in record time to stimulate the immunization of individuals. Since the beginning of 2020, scientists and companies are rapidly advancing to make vaccine candidates available at a different rate compared to other pandemics that have existed. This review briefly presents the pros and cons of the third generation vaccines, Moderna / NIAID and Pfizer - BioNTech, which are in phase 3 tests, based on lipid RNA nanoparticles. Great collaborative efforts are being invested so that soon the world population will receive doses of vaccines with proven efficacy and enable increased survival, since the pandemic has already caused many irreversible losses.

scholarly journals Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation

2021 ◽  
Author(s):  
Yunda Huang ◽  
Oleg Borisov ◽  
Jia Jin Kee ◽  
Lindsay N. Carpp ◽  
Terri Wrin ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
World Health ◽  
United States Government ◽  
Phase 3 ◽  
Efficacy Trials ◽  
Combining Data ◽  
The World ◽  
States Government ◽  
Common Scale ◽  
Aid Decision

Vaccine-induced neutralizing antibodies (nAbs) are key biomarkers considered to be associated with vaccine efficacy. In United States Government-sponsored phase 3 efficacy trials of COVID-19 vaccines, nAbs are measured by two different validated pseudovirus-based SARS-CoV-2 neutralization assays, with each trial using one of the two assays. Here we describe and compare the nAb titers obtained in the two assays. We observe that one assay consistently yielded higher nAb titers than the other when both assays were performed on the World Health Organization's anti-SARS-CoV-2 immunoglobulin International Standard, COVID-19 convalescent sera, and mRNA-1273 vaccinee sera. To overcome the challenge this difference in readout poses in comparing/combining data from the two assays, we evaluate three calibration approaches and show that readouts from the two assays can be calibrated to a common scale. These results may aid decision-making based on data from these assays for the evaluation and licensure of new or adapted COVID-19 vaccines.

scholarly journals Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Pengfei Jin ◽  
Jingxin Li ◽  
Hongxing Pan ◽  
Yanfei Wu ◽  
Fengcai Zhu
Keyword(s):  
Large Scale ◽  
Current Knowledge ◽  
Surrogate Endpoints ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Correlates Of Protection ◽  
Immune Correlates ◽  
Efficacy Trials ◽  
Review Current

AbstractIn response to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, over 200 vaccine candidates against coronavirus disease 2019 (COVID-2019) are under development and currently moving forward at an unparalleled speed. The availability of surrogate endpoints would help to avoid large-scale filed efficacy trials and facilitate the approval of vaccine candidates, which is crucial to control COVID-19 pandemic. Several phase 3 efficacy trials of COVID-19 vaccine candidates are under way, which provide opportunities for the determination of COVID-19 correlates of protection. In this paper, we review current knowledge for existence of COVID-19 correlates of protection, methods for assessment of immune correlates of protection and issues related to COVID-19 correlates of protection.

ADDRESSING THE ISSUE OF СOVID-19, SARS-COV-2 VIRUS AND THE DISEASE

2020 ◽  
Vol 99 (6) ◽  
pp. 15-31
Author(s):  
A.A. Korenkova ◽  
◽  
E.M. Mayorova ◽  
V.V. Bahmetjev ◽  
M.V. Tretyak ◽  
...  
Keyword(s):  
Public Health ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Herd Immunity ◽  
Significant Problem ◽  
Prevention Measures ◽  
Optimal Therapy ◽  
The World ◽  
Public Health Challenge ◽  
Coronavirus Infection

The new coronavirus infection has posed a major public health challenge around the world, but new data on the disease raises more questions than answers. The lack of optimal therapy is a significant problem. The article examines the molecular mechanisms of SARS-CoV-2 infection and the pathogenesis of COVID-19, special attention is paid to features of pathological processes and immune responses in children. COVID-19 leads to a wide diversity of negative outcomes, many of which can persist for at least months. Many of the consequences have yet to be identified. SARS-CoV-2 may provoke autoimmune reactions. Reinfection, herd immunity, vaccines and other prevention measures are also discussed in this review.

Impact of Social Media on English Language: A Review

2015 ◽  
Vol 3 (3) ◽  
pp. 5
Author(s):  
Dr. Neha Sharma
Keyword(s):  
Social Media ◽  
Cultural Values ◽  
English Language ◽  
Major Influence ◽  
International Level ◽  
Class Society ◽  
The World ◽  
The Status ◽  
The Media ◽  
Subsequent Rise

Language being a potent vehicle of transmitting cultural values, norms and beliefs remains a central factor in determining the status of any nation. India is a multilingual country which tends to encourage people to use English at national and international level. Basically English in India owes its presence to the British but its subsequent rise is not fully attributable to the British. It has now become the language of wider communication which is now spoken by large number of people all over the world. It is influenced by many factors such as class, society, developments in science and technology etc. However the major influence on English language is and has been the media.

MANAGING INFORMATION TECHNOLOGY APPLICATION IN TEACHING AT HIGH SCHOOLS IN VINH YEN CITY, VINH PHUC PROVINCE MEETS INDUSTRIAL REVOLUTION 4.0

2018 ◽  
Author(s):  
Vu Kha Thap
Keyword(s):  
Information Technology ◽  
Social Life ◽  
Industrial Revolution ◽  
Strong Impact ◽  
Surface Strength ◽  
Technology Application ◽  
Management Measures ◽  
The World ◽  
The Status ◽  
Information Technology Application

Entering the XXI century and especially in the period of the industrial revolution has entered the era of IT with the knowledge economy in the trend of globalization. The 4.0 mankind development of ICT, especially the Internet has had a strong impact and make changes to all activities profound social life of every country in the world. Through surveys in six high School, interviewed 85 managers and teachers on the status of the management of information technology application in teaching, author of the article used the SWOT method to distribute surface strength, weaknesses, opportunities and challenges from which to export 7 management measures consistent with reality. 7 measures have been conducting trials and the results showed that 07 measures of necessary and feasible.

FAMILY TRADITIONS: REFLECTION OF SOME FAMILY TRADITIONS IN THE LINGUISTIC PICTURE OF THE WORLD (ON THE BASIS OF ENGLISH AND UZBEK PROVERBS AND IDIOMS)

2020 ◽  
Vol 1 (3) ◽  
pp. 49-56
Author(s):  
Feruza Mamatova ◽  
Keyword(s):  
Cross Cultural ◽  
Cultural Communication ◽  
Cross Cultural Communication ◽  
The World ◽  
Marriage Partner ◽  
The Status ◽  
The Subject

The present paper aims to compare the principles of choosing a marriage partner and analyse the status of being in the marrriage in the frame of family traditions that are totally inherent to the both of the nations: English and Uzbek. It is known that interconnection and cross-cultural communication between the countries of these two nationalities have been recently developed. The purpose to give an idea about these types of family traditions and prevent any misunderstanding that might occur in the communications makes our investigation topical one. The research used phraseological units as an object and the marriage aspects as the subject

Sign in / Sign up

Export Citation Format

Share Document