scholarly journals Antimicrobial Resistance in Typhoidal Salmonella: Around the World in 3 Days

2020 ◽  
Vol 71 (Supplement_2) ◽  
pp. S91-S95
Author(s):  
Senjuti Saha ◽  
Mohammad Saiful Islam Sajib ◽  
Denise Garrett ◽  
Farah N Qamar
Keyword(s):  
Antimicrobial Resistance ◽  
Enteric Fever ◽  
Morbidity And Mortality ◽  
Antibacterial Resistance ◽  
The World ◽  
Genotypic Characteristics

Abstract With the increasing antibacterial resistance in typhoidal Salmonella and the dearth of novel antimicrobials on the horizon, we risk losing our primary defense against widespread morbidity and mortality from enteric fever. During 26–28 March 2019, researchers from around the world came together in Hanoi, Vietnam, and shared some of their latest findings on antimicrobial resistance. From the 258 abstracts presented at the conference, at least 50 discussed phenotypic and genotypic characteristics of antimicrobial resistance in typhoidal Salmonella, covering data of at least 24 different countries, spanning 5 continents. Here, we summarize the key findings, focusing on our global journey ahead.

scholarly journals The impact of the COVID-19 pandemic on antimicrobial resistance: a debate

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
David van Duin ◽  
Gavin Barlow ◽  
Dilip Nathwani
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
The Other ◽  
Morbidity And Mortality ◽  
Social Distancing ◽  
Other Hand ◽  
The World ◽  
Potential Impact ◽  
The Impact

Abstract The coronavirus disease 2019 (COVID-19) pandemic is having an enormous impact on public health. Infection with SARS-CoV-2 has become a leading cause of morbidity and mortality in many regions around the world. As many COVID-19 patients are treated with antibiotics, there is concern regarding an associated rise in rates of antimicrobial resistance (AMR). On the other hand, social distancing, isolation and reduced travel may result in decreased spread of AMR. In this issue of JAC-Antimicrobial Resistance, we present a PRO/CON debate on the question of the potential impact of COVID-19 on AMR rates.

scholarly journals Making sense of “superbugs” on YouTube: A storytelling approach

2021 ◽  
pp. 096366252198925
Author(s):  
Monika Djerf-Pierre ◽  
Mia Lindgren
Keyword(s):  
Social Media ◽  
Antimicrobial Resistance ◽  
Health Knowledge ◽  
Social Media Platform ◽  
Making Sense ◽  
New Knowledge ◽  
The World ◽  
Media Platform ◽  
Youtube Videos ◽  
Health Experts

Antimicrobial resistance is one of the greatest challenges facing the world. With the rapid growth of social media, YouTube has become an influential social media platform providing publics with expert health knowledge. This article explores how antimicrobial resistance is communicated on YouTube. Drawing on qualitative media analyses of the most viewed YouTube videos 2016–2020, we identify seven different genres and two main storytelling approaches, personalized and fictionalized storytelling, used to make sense of antimicrobial resistance and its complexities. The study contributes new knowledge about YouTube as a platform for health communication and the types of videos about antimicrobial resistance that gets most traffic. This is useful, not the least for public health experts working to improve communication strategies that target hard-to-reach media publics.

Venous Thromboembolism: Genetics and Thrombophilias

2021 ◽  
Vol 42 (02) ◽  
pp. 271-283
Author(s):  
Manila Gaddh ◽  
Rachel P. Rosovsky
Keyword(s):  
Clinical Practice ◽  
Venous Thromboembolism ◽  
Family History ◽  
Morbidity And Mortality ◽  
Inherited Thrombophilia ◽  
Risks And Benefits ◽  
Hereditary Thrombophilia ◽  
The World ◽  
The Future ◽  
History Of

AbstractVenous thromboembolism (VTE) is a major cause of morbidity and mortality throughout the world. Up to one half of patients who present with VTE will have an underlying thrombophilic defect. This knowledge has led to a widespread practice of testing for such defects in patients who develop VTE. However, identifying a hereditary thrombophilia by itself does not necessarily change outcomes or dictate therapy. Furthermore, family history of VTE by itself can increase an asymptomatic person's VTE risk several-fold, independent of detecting a known inherited thrombophilia. In this article, we will describe the current validated hereditary thrombophilias including their history, prevalence, and association with VTE. With a focus on evaluating both risks and benefits of testing, we will also explore the controversies of why, who, and when to test as well as discuss contemporary societal guidelines. Lastly, we will share how these tests have been integrated into clinical practice and how to best utilize them in the future.

scholarly journals Taming the Elephant: Salmonella Biology, Pathogenesis, and Prevention

2010 ◽  
Vol 78 (6) ◽  
pp. 2356-2369 ◽  
Author(s):  
Helene L. Andrews-Polymenis ◽  
Andreas J. Bäumler ◽  
Beth A. McCormick ◽  
Ferric C. Fang
Keyword(s):  
Morbidity And Mortality ◽  
The World ◽  
Oral Presentations ◽  
Substantial Morbidity

ABSTRACT Salmonella infections continue to cause substantial morbidity and mortality throughout the world. However, recent discoveries and new paradigms promise to lead to novel strategies to diagnose, treat, and prevent Salmonella infections. This review provides an update of the Salmonella field based on oral presentations given at the recent 3rd ASM Conference on Salmonella: Biology, Pathogenesis and Prevention.

scholarly journals Is Antimicrobial Resistance Pattern of Enteric Fever Changing in Kathmandu Valley?

2013 ◽  
Vol 32 (3) ◽  
pp. 221-228
Author(s):  
Ganesh Kumar Rai ◽  
Subhana Karki ◽  
Bina Prajapati
Keyword(s):  
Antimicrobial Resistance ◽  
Nalidixic Acid ◽  
Enteric Fever ◽  
Public Health Problem ◽  
Salmonella Typhi ◽  
Resistance Pattern ◽  
Kathmandu Valley ◽  
Sensitivity Testing ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern

Introduction: Enteric fever is a public health problem in developing countries including Nepal. Antimicrobial sensitivity pattern of Salmonella sp causing enteric fever is changing over time and also differs according to geographical location. Periodic surveillance of antimicrobial resistance of Salmonella sp is mandatory for management of enteric fever rationally. The objective of this study was to analyze the resistance pattern of Salmonella sp to commonly used antimicrobials. Materials and Methods: This was a retrospective study undertaken reviewing the records of blood isolates of Salmonella sp over one year period at Kanti Children’s Hospital, Nepal. Antimicrobial sensitivity testing was done following Kirby Bauer’s disk diffusion technique using Muller Hinton agar. Results: Salmonella typhi was found to be 100% resistance to ampicillin and resistance to nalidixic acid and ciprofloxacin was also high. The resistance to chloramphenicol and ofloxacin was low. No resistance was found to amoxicillin, ceftriaxone, cefotaxime and amikacin. However, among the sensitive isolates of Salmonella typhi intermediate sensitivity to ceftriaxone and ceftazidime was reported to be high. Among the isolates of S paratyphi A, the resistance to nalidixic acid was 100% followed by 75% to ciprofloxacin. No resistance was found to chloramphenicol, ceftriaxone, cefixime, amikacin and low resistance to amoxicillin and ofloxacin. Among the sensitive isolates of S paratyphi A, majority of them were only moderately sensitive to cefotaxime and ceftazidime and about 1/3 of the organisms had only intermediate sensitivity to ceftriaxone. Conclusiion: Commonly used parenteral third generation cephalosporins, first line drugs like chloramphenicol and amoxicillin and ofloxacin among fluoroquinolones were found to be effective in vitro in treating enteric fever. However, Salmonella typhi was found to be highly resistant to the most frequently used drugs like ciprofloxacin and cefixime and Salmonella paratyphi A to ciprofloxacin. A comparative chart of antimicrobial sensitivity of enteric fever in children over 10 year period from different hospitals of Kathmandu valley is also presented in the study. DOI: http://dx.doi.org/10.3126/jnps.v32i3.6625 J. Nepal Paediatr. SocVol.32(3) 2012 221-228

scholarly journals A Comprehensive Review on Current Progressions in Combating The Antimicrobial Resistance

2020 ◽  
Vol 11 (2) ◽  
pp. 1493-1504
Author(s):  
Bharatlal Sain ◽  
Manohar M ◽  
Gowda D V
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Biofilm Formation ◽  
Susceptibility Testing ◽  
Persister Cells ◽  
Comprehensive Review ◽  
Obligate Intracellular ◽  
Competitive Inhibitors ◽  
The World

Anti-microbial resistance (AMR) is the ability of a microbe to resist the effect of antibiotics. It has become the most important cause of concern throughout the world. AMR may develop a variety of mechanisms, including resistance, weakness or due to a certain therapeutic failure. The three major causes of resistance were identified to be over usage of anti-microbials, over-prescription, increased agricultural usage. The mechanism which leads to the development of AMR were found to be Metabolic Inactive Persister cells biofilm formation, Swarming, Obligate intracellular microbes, Reduced uptake and efflux pumps, Modification of the antibiotic binding site, Production of competitive inhibitors. Research is still being carried out and few methods successfully  delay or inhibit the progress of Resistance namely: Photodynamic therapy, which works on the principle of photosensitization, results in formation of ROS which destroy pathogenic cells, Vaccines, which strengthen the defence system to fight against foreign microorganisms efficiently, Antibiotic adjuvants, work by inhibiting any kind of mechanism related to the resistance increasing the drug’s antibacterial efficiency, Nano antibiotics which acts by interfering with the mechanisms for the development of the resistance and microfluidics give a better understanding of the bacteria and its superior antimicrobial susceptibility testing. Hence, in this review the above mechanisms of antimicrobial resistance as well the latest AMR combating strategies are been discussed.

scholarly journals Preventing and managing antimicrobial resistance in the African region: A scoping review protocol

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254737
Author(s):  
Chinwe Juliana Iwu-Jaja ◽  
Anelisa Jaca ◽  
Ishmael Festus Jaja ◽  
Portia Jordan ◽  
Phelele Bhengu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Scoping Review ◽  
Health Care Systems ◽  
Grey Literature ◽  
Antibiotic Consumption ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
African Region ◽  
Care Systems

Introduction Antimicrobial resistance (AMR) constitutes a significant threat to global health and food security, typically associated with high morbidity and mortality rate. The high burden of infectious diseases coupled with the weak health systems in most countries of Africa magnifies the risk of increasing AMR and its consequences thereof. This scoping review will be aimed at mapping the evidence on interventions used to prevent and manage antimicrobial resistance in Africa, guided by the “One Health” concept. Methods We will consider interventions targeting multiple sectors such as health care systems, the agricultural and veterinary sectors. The outcomes to be considered include reduction of AMR decreased morbidity and mortality due to infectious diseases, increased awareness for rational use of antimicrobials and reduced antibiotic consumption. We will include all types of studies regardless of study designs conducted within the context of the WHO African region. Studies will be excluded if they are not conducted in Africa and if they are literature reviews, only describing the concept of AMR without mentioning interventions. We will include studies identified through a comprehensive search of peer-reviewed and grey literature databases. In addition, we will search the reference lists of included studies and relevant reviews. Finally, we plan to do a citation search for included studies. Findings of this review will be narratively synthesized.

Traditional Medicine

2021 ◽  
pp. 118-129
Author(s):  
Pavitra Solanki ◽  
Yasmin Sultana ◽  
Satyavir Singh
Keyword(s):  
At Risk ◽  
Antimicrobial Resistance ◽  
Traditional Medicine ◽  
Volatile Oil ◽  
World Health ◽  
Antibiotic Resistant ◽  
Life Saving ◽  
The World ◽  
History Of ◽  
Health Organization

Everybody is at risk of being infected by drug-resistant microscopic organisms. Managing with sickness has never been less demanding within the history of our species. At the current rate of antimicrobial resistance (AMR) in microbes, specialists foresee that battling infections tuberculosis, HIV, and intestinal sickness will become more complicated. Antimicrobial resistance is rendering numerous life-saving drugs useless. Antibiotic-resistant microbes, known as “superbugs,” are getting to be more various and more harmful, thanks to the proceeding abuse of anti-microbials. Natural medication offers an alternative to these progressively ineffectual drugs. According to the World Health Organization (WHO), traditional medicine is a holistic term enclosing diverse health practices. Concurring to a report by the College of Maryland Therapeutic Center, turmeric's volatile oil serves as a common anti-microbial.

Global impact of antimicrobial resistance

2019 ◽  
pp. 569-576
Author(s):  
Catherine Berry
Keyword(s):  
Antimicrobial Resistance ◽  
World Health ◽  
Health Providers ◽  
Security Threat ◽  
Health Security ◽  
Global Impact ◽  
The World ◽  
Resistant Infection ◽  
Health Organization ◽  
The Impact

This chapter describes the worrisome trend of resistance development in antibacterial agents with exponential increases in resistance to the most effective classes of antibiotics. Described by the World Health Organization as a major global health security threat, the annual deaths from drug-resistant infection are projected to increase from 700,000 to 10 million by 2050. This chapter outlines the impact of antimicrobial resistance in humanitarian settings and provides practical approaches which can be used by organizations and health providers.

The global unmet need of congenital cardiac care: a quantitative analysis of the global burden of disease

2020 ◽  
Vol 30 (11) ◽  
pp. 1688-1693 ◽  
Author(s):  
Dominique Vervoort ◽  
Marcelo Cardarelli
Keyword(s):  
Burden Of Disease ◽  
Unmet Need ◽  
Morbidity And Mortality ◽  
Global Burden Of Disease ◽  
Cardiac Care ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The World

AbstractBackground:CHDs are one of the most frequent congenital malformations, affecting one in hundred live births. In total, 70% will require treatment in the first year of life, but over 90% of cases in low- and middle-income countries receive no treatment or suboptimal treatment. As a result, CHDs are responsible for 66% of preventable deaths due to congenital malformations in low- and middle-income countries. This study examines the unmet need of congenital cardiac care around the world based on the global burden of disease.Materials and methods:CHD morbidity and mortality data for 2006, 2011, and 2016 were collected from the Institute for Health Metrics and Evaluation Global Burden of Disease Results Tool and analysed longitudinally to assess trends in excess morbidity and mortality.Results:Between 2006 and 2016, a 20.7% reduction in excess disability-adjusted life years and 20.6% reduction in excess deaths due to CHDs were observed for children under 15. In 2016, excess global morbidity and mortality due to CHDs remained high with 14,788,418.7 disability-adjusted life years and 171,761.8 paediatric deaths, respectively. In total, 90.2% of disability-adjusted life years and 91.2% of deaths were considered excess.Conclusion:This study illustrates the unmet need of congenital cardiac care around the world. Progress has been made to reduce morbidity and mortality due to CHDs but remains high and largely treatable around the world. Limited academic attention for global paediatric cardiac care magnifies the lack of progress in this area.

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