scholarly journals Comparing QuantiFERON-TB Gold Plus with Other Tests To Diagnose Mycobacterium tuberculosis Infection

2019 ◽  
Vol 57 (11) ◽  
Author(s):  
Thara K. Venkatappa ◽  
Rose Punnoose ◽  
Dolly J. Katz ◽  
Michael P. Higgins ◽  
Niaz Banaei ◽  
...  
Keyword(s):  
Latent Tuberculosis ◽  
Epidemiologic Studies ◽  
Tuberculosis Infection ◽  
Fourth Generation ◽  
Rank Test ◽  
Test Results ◽  
Mycobacterium Tuberculosis Infection ◽  
Negative Results ◽  
Signed Rank ◽  
Signed Rank Test

ABSTRACT The fourth-generation QuantiFERON test for tuberculosis infection, QuantiFERON-TB Gold Plus (QFT-Plus) has replaced the earlier version, QuantiFERON-TB Gold In-Tube (QFT-GIT). A clinical need exists for information about agreement between QFT-Plus and other tests. We conducted this study to assess agreement of test results for QFT-Plus with those of QuantiFERON-TB Gold In-Tube (QFT-GIT), T-SPOT.TB (T-SPOT), and the tuberculin skin test (TST). Persons at high risk of latent tuberculosis infection (LTBI) and/or progression to tuberculosis (TB) disease were enrolled at the 10 sites of the Tuberculosis Epidemiologic Studies Consortium from October 2016 through May 2017; each participant received all four tests. Cohen’s kappa (κ) and Wilcoxon signed-rank test compared qualitative and quantitative results of QFT-Plus with the other tests. Test results for 506 participants showed 94% agreement between QFT-Plus and QFT-GIT, with 19% positive and 75% negative results. When the tests disagreed, it was most often in the direction of QFT-GIT negative/QFT-Plus positive. QFT-Plus had similar concordance as QFT-GIT with TST (77% and 77%, respectively) and T-SPOT (92% and 91%, respectively). The study showed high agreement between QFT-GIT and QFT-Plus in a direct comparison. Both tests had similar agreement with TST and T-SPOT.

scholarly journals The effect of 8-week thera-band exercises on male swimmers’ 100 m freestyle swimming performance

2017 ◽  
Vol 14 (4) ◽  
pp. 3950 ◽  
Author(s):  
Ahmet Gönener ◽  
Utku Gönener ◽  
Ozan Yılmaz ◽  
Tuğçe Horoz ◽  
Deniz Demirci
Keyword(s):  
Swimming Performance ◽  
Training Programme ◽  
Rank Test ◽  
Control Group ◽  
Study Group ◽  
Test Results ◽  
Signed Rank ◽  
Post Test ◽  
Signed Rank Test ◽  
And Control

The aim of this study is to investigate 8 weeks Thera-Band trainings' effects on male swimmers' 100 m freestyle swimming performance.The study group is created by 20 (n = 20) licenced male athletes that had trained at least 3 days in a week and have been active in swimming sport at least 3 years in Gebze Genclerbirligi Swimming Club 20 (n = 20). Athletes were divided into experiment group (n = 10) and control group (n = 10) randomly. Training programme was applied to the study group for 55-60 minutes for 3 days on alternate days and times when the club does not have swimming training. 12 different Thera-Band trainings were applied for 40-45 mins and each set was 15 minutes.Mann-Whitney U test was used to analyze differences between groups and Wilcoxon signed rank test was applied for analyzing the differences of intra-groups. SPSS 21.0 Statistics package software was used for statistical analyzes. The results show that there are no significantly differences between experimental group's and control group's post test results. (p>0.05). Statistically significant differences are found as a result of intra-group comparison of the experimental group's pre-test and post-test results (p<0.05).Depending on the results obtained after reviewing the literature, it can be concluded that Thera-Band training is effective on the performance improvement of swimmers aged 13-15 years.

Diagnosis of latent tuberculosis infection among HIV-infected clients in Far North Queensland: use of an interferon-gamma release assay

Sexual Health ◽  
2013 ◽  
Vol 10 (4) ◽  
pp. 389
Author(s):  
Katrina Lyne ◽  
Sandra Downing ◽  
Darren Russell
Keyword(s):  
Interferon Gamma ◽  
Significant Risk ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assay ◽  
Test Results ◽  
Mycobacterium Tuberculosis Infection ◽  
Far North ◽  
Release Assay ◽  
Tuberculosis Risk

Latent Mycobacterium tuberculosis infection is a significant risk for those infected with HIV. We examined the use of an interferon-gamma release assay for the diagnosis of latent tuberculosis among HIV-infected clients attending two sexual health services in Far North Queensland. Of 240 clients tested, 19 returned a positive result (7.9%, 95% confidence interval (CI): 4.5–11.3%) and three were indeterminate (1.3%, 95% CI: –0.2%–2.7%). Low CD4 count was found to be significantly associated with an indeterminate test result (P = 0.004). However, we found no significant association between test results and client demographics, self-reported prior tuberculosis infection, Bacille Calmette-Guérin vaccine status or selected tuberculosis risk factors (P-values = 0.2–0.9).

Efficacy of the “Cooperative Assessment” Diagnostic Procedure to Early Improve Acute Symptoms in a Sample of Adolescents with Anxiety and Mood Disorders

2017 ◽  
Vol 41 (S1) ◽  
pp. S122-S123
Author(s):  
M. Biagiarelli ◽  
M. Curto ◽  
M.P. Andraos ◽  
V. Aprile ◽  
S. Pelaccia ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Repeated Measures ◽  
Poor Mental Health ◽  
Rank Test ◽  
Therapeutic Assessment ◽  
Test Results ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Competing Interest

IntroductionAnxiety and mood disorders are common in adolescence and predict poor mental health outcomes and low quality of life in adulthood. Although early intervention seems to be critical, dropouts in the early stages of treatment are frequent and associated with low insight and severe symptoms. Therefore, a diagnostic assessment phase aimed to increase insight and early reduce symptoms appears to be essential in adolescents.ObjectivesThe objective of this study is to demonstrate that the diagnostic method Cooperative Assessment is able to early reduce symptoms in adolescents with anxiety and mood disorders.MethodsA sample of 88 patients, aged 14–19 years were included. All were recruited at the first visit and evaluated with the Cooperative Assessment. This manualized procedure was created from principles of collaborative and therapeutic assessment and aim to involve the patient in a co-developed diagnosis thorough the collaborative use of test results. Patients were evaluated before (T0), in the middle (T1) and after (T2) the assessment using CGI, GAF, HAM-A, HAM-D and MRS scales.ResultsEighty-eight adolescents, 56.8% females, diagnosed with anxiety (47.7%) and mood disorders (52.3%) completed the protocol. HAM-A, HAM-D, MRS, CGI and GAF significantly improved at T1 and T2 with respect to T0 (T0: HAM-A 17.31 ± 8.22; HAM-D 16.97 ± 8.37; MRS5.78 ± 6.17; GAF 59.3 ± 11.06; CGI 3.63 ± 1.35; T2: HAM-A 11.41 ± 6.82; HAM-D 11.1 ± 6.91; MRS3.82 ± 3.87; GAF 67.5 ± 10.76; CGI 3.03 ± 1.26; P < 0.001; Wilcoxon signed-rank test for repeated measures).ConclusionsCooperative assessment is able to early improve symptoms in adolescents with mood and anxiety disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Effect of Breast Treatment and Oxytocin Massage on the Production of Breast Milk

2020 ◽  
Vol 17 (7) ◽  
pp. 3047-3052
Author(s):  
Ganis Amaliasari ◽  
Harmayetty ◽  
Retnayu Pradanie
Keyword(s):  
Breast Milk ◽  
Milk Production ◽  
Comparison Group ◽  
Post Partum ◽  
Rank Test ◽  
Test Results ◽  
Breast Milk Production ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Breast Care

Breastfeeding is a normal process following childbirth. However, post partum mothers often complain several problems during breastfeeding. A problem that is often complained of by post partum mothers is the lack of breast milk supply. The lack of breast milk production will interfere with the process of breastfeeding, which is one of the causing factors as to why certain mothers do not exclusively breastfeed. To find out the effect of breast care and oxytocin massage on increasing milk production in post partum mothers. This research uses a quasi-experimental design. The population in this study were all primiparous post partum mothers with lactation period of 0-7 days. A total of 20 mothers participated in this study and was divided into two groups namely the treatment group and the comparison group. The samples were obtained using purposive sampling. There are independent variables (breast care and oxytocin massage) and dependent variables (milk production). Data collection was performed using a questionnaire, then analyzed using the test Wilcoxon Signed Rank Test and Mann Whitney Test. Wilcoxon Signed Rank Test Results of breast milk production of (p = 0.003) in the treatment group, while in the comparison group the breast milk production was (p = 0.014). The Mann Whitney Test results show that p = 0.004. It can be concluded that breast care and oxytocin massage effectively increase the milk production of post partum mothers. The therapy is recommended for health professionals to apply breast care and oxytocin massage to increase the milk production of post partum mothers who have less milk production. Combination of breast care and oxytocin massage have more effective benefits in increasing the breast milk production of postpartum mothers.

scholarly journals REDUKSI MISKONSEPSI ASAM BASA MELALUI INKUIRI TERBUKA DAN STRATEGI CONCEPTUAL CHANGE

2017 ◽  
Vol 3 (1) ◽  
pp. 286
Author(s):  
Ahmad Ahmad ◽  
Suyono Suyono ◽  
Leny Yuanita
Keyword(s):  
Critical Thinking ◽  
Conceptual Change ◽  
Inquiry Learning ◽  
T Test ◽  
Rank Test ◽  
Test Results ◽  
Signed Rank ◽  
Significant Difference ◽  
Before And After ◽  
Signed Rank Test

This research aims to study the effect of inquiry learning by critical thinking practice followed by a conceptual change efforts to reduce misconceptions on acid-base learn. The research design using one-group pretest-posttest design with students of SMAN 2 Ngawi as sample research. The student conception  status finding by knowing concept (TK), not knowing concept (TTK), and misconception (MK), whereas intensity of misconception be analized by CRI. Results and analysis of research data found that there is a shift in conception after inquiry learning p rocess. Based on Wilcoxon’s signed rank test, the T value of test TK, TTK, and MK is less than T table at α = 0.05 , so it was concluded that inquiry learning increase TK and decrease TTK and MK. The influence of inquiry learning for understanding the influence was strengthened by the results of the t test tests before and after understanding the concept of inquiry learning that indicate a significant difference.  t-test results on tests of critical thinking before and after the inquiry learning also showed a significant difference. Inquiry learning can not reduce all of misconceptions. Reduction step again is with conceptual change. Based on Wilcoxon’s signed rank test was concluded that conceptual change learning can reduce misconception significantlyPenelitian ini bertujuan mempelajari pengaruh pembelajaran inkuiri terbuka disertai latihan berpikir kritis yang dilanjutkan dengan conceptual change sebagai upaya mereduksi miskonsepsi pada materi asam basa. Penelitian eksperimen semu ini menggunakan metode one group pretest-postest design dengan subyek penelitian  siswa kelas XI SMA Negeri 2 Ngawi. Profil konsepsi siswa dinyatakan dengan status tahu konsep (TK), tidak tahu konsep (TTK), dan miskonsepsi (MK), sedangkan intensitas miskonsepsi diperoleh dari hasil analisis CRI jawaban siswa.  Hasil dan analisis hasil tes pemahaman konsep menemukan bahwa terjadi pergeseran konsepsi setelah proses pembelajaran inkuiri terbuka. Berdasarkan wilcoxon’s signed rank test diperoleh T hitung untuk semua status TK, TTK, dan MK kurang dari nilai T tabel pada α = 0,05 dan n = 25, sehingga   disimpulkan bahwa pembelajaran inkuiri meningkatkan jumlah TK dan menurunkan TTK dan MK.  Pengaruh pembelajaran inkuiri terhadap pemahaman konsep serta kemampuan berpikir kritis diketahui dari uji t hasil tes pemahaman konsep serta tes berpikir kritis sebelum dan setelah pembelajaran. Hasil uji t pada α = 0,05 menunjukkan adanya perbedaan signifikan pemahaman konsep serta kemampuan berpikir kritis antara sebelum dan setelah pembelajaran inkuiri. Miskonsepsi yang masih tersisa setelah pembelajaran inkuiri direduksi kembali dengan strategi   conceptual change. Berdasarkan wilcoxon’s signed rangk test disimpulkan bahwa pembelajaran conceptual change dapat mereduksi miskonsepsi secara signifikan.

scholarly journals Effectiveness of surgical management of malignant glaucoma in phakic eyes

2022 ◽  
Vol 15 (1) ◽  
pp. 65-70
Author(s):  
Qi-Wei Wang ◽  
◽  
Xiao-Shan Lin ◽  
Wan Chen ◽  
Qiao-Lin Zhu ◽  
...  
Keyword(s):  
Anterior Chamber Depth ◽  
Case Series ◽  
Rank Test ◽  
Test Results ◽  
Iol Implantation ◽  
Signed Rank ◽  
Malignant Glaucoma ◽  
Long Time ◽  
Signed Rank Test ◽  
Phakic Eyes

AIM: To assess the effectiveness of core vitrectomy-phacoemulsification-intraocular lens (IOL) implantation-capsulo-hyaloidotomy in treating phakic eye at least 1mo after the onset of malignant glaucoma. METHODS: A retrospective analysis were performed on malignant glaucoma patients treated in Zhongshan Ophthalmic Center between 2016 and 2018. Demographic and clinical data were described. The preoperative and postoperative visual acuity (VA), intraocular pressure (IOP), number of IOP-lowering medications used, and anterior chamber depth (ACD) of the case series were compared by Wilcoxon signed-rank test. RESULTS: Thirteen phakic eyes with long time intervals between onset and surgery were identified in this case series. Core vitrectomy-phacoemulsification-IOL implantation-capsulo-hyaloidotomy reduced the IOP (P=0.046) and the number of IOP-lowering medications used (P=0.004), deepened the ACD (P=0.005). Complete success was achieved in 38.5% of the eyes, and anatomical success was achieved in 100% of the eyes without any recurrence. The only postoperative complication observed is corneal endothelial decompensation. It occurred in two cases. CONCLUSION: Core vitrectomy-phacoemulsification-IOL implantation-capsulo-hyaloidotomy is safe and effective for treatment of long onset phakic malignant glaucoma.

Pengaruh Pelatihan Pertolongan Pertama Pada Kecelakaan (P3K) Terhadap Tingkat Pengetahuan Siswi Kelas X Tentang Pertologan Pertama Pada Kecelakaan

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Mohamad Mursid ◽  
Maslichah Maslichah
Keyword(s):  
Health Workers ◽  
First Aid ◽  
Rank Test ◽  
Test Results ◽  
Student Knowledge ◽  
Signed Rank ◽  
Post Test ◽  
Signed Rank Test ◽  
Experimental Subjects ◽  
The Given

ABSTRAKSiap siaga merupakan landasan bagi setiap orang untuk melakukan pertolongan pertama pada kecelakaan. Dengan melalui pendidikan baik pengajaran atau pelatihan yang diberikan oleh suatu lembaga atau perseorangan dapat berpengaruh terhadap kemampuan atuapun skill yang dimiliki oleh seseorang.Tujuan dari penelitian ini untuk mengetahui pengaruh pelatihan pertolongan pertama pada kecelakaan terhadap tingkat pengetahuan siswi MA Al Rosyid Kabupaten Bojonegoro.Jenis penelitian adalah pra eksperimental. Subjek penelitian adalah siswi kelas X MA Al Rosyid sejumlah 34 responden dimana sebelum diberikan pelatihan dilakukan pre test terlebih dahulu setelah itu diberikan intervensi dan selanjutnya dilakuakan post test. Analisis yang digunakan uji wilcoxon signed rank-test.Hasil Penelitian menunjukan bahwa sebelum diberikan pelatihan tentang pertolongan pertama pada kecelakaan (P3K), mayoritas responden berpengetahuan kurang sebanyak 20 responden (58,82%), sesudah diberikan pelatihan lebih dari sebagian responden berpengetahuan baik sebanyak 23 responden (67,64%). Hasil  uji Wilcoxon Signed Ranks Test didapatkan hasil Sig. 0,000 lebih kecil dari p = 0,05.Pelatihan pertolongan pertama pada kecelakaan berpengaruh terhadap tingkat pengetahuan siswi dalam menangani korban kecelakaan dengan benar sehingga perlu bagi tenaga kesehatan untuk ikut serta dalam memberikan pendidikan kesehatan lebih lanjut. Kata Kunci : Pertolongan Pertama Pada Kecelakaan (P3K), Pengetahuan   ABSTRACTAlert is a platform for everyone to do first aid. With a good education through teaching or training provided by an institution or individual can affect the ability atuapun skills possessed by seseorang. Purpose of this study was to determine the effect of training in first aid on the level of student knowledge MA Al Rosyid Bojonegoro.This type of research is pre-experimental. Subjects were students of class X MA Al Rosyid number of 34 respondents which are given training before the first pre-test conducted after the given intervention and subsequent dilakuakan post test. The analysis used Wilcoxon signed rank test-test.Research shows that before being given training in first aid (P3K), the majority of respondents are knowledgeable about as many as 20 respondents (58.82%), after the training given over most knowledgeable respondents either as many as 23 respondents (67.64%). Results Wilcoxon Signed Ranks Test results obtained Sig. 0.000 of p = 0.05.Training first at the accident affect the level of student knowledge in dealing with victims of accidents properly so the need for health workers to participate sertadalam provide more health education. Keywords: First Aid (P3K), Knowledge

scholarly journals Comparison of Peak Aerobic Capacity Between the Treadmill and a Skiing Ergometer

2021 ◽  
Vol 4 (3) ◽  
Author(s):  
Hannah Nelson ◽  
Andy Bosak ◽  
Russell Lowell ◽  
Maggie McDermott ◽  
Branden Ziebell ◽  
...  
Keyword(s):  
Rank Test ◽  
Fitness Testing ◽  
Test Results ◽  
Alternative Mode ◽  
Paired Samples ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Ideal Tool ◽  
Peak Aerobic Capacity ◽  
Total Body

Introduction: The Concept2 SkiErg is increasing in popularity and is widely used to provide a low impact total body workout. Because of these benefits, the SkiErg could be an ideal tool for fitness testing. Therefore, the purpose of this study was to compare VO2peak values elicited from a treadmill (TM) and SkiErg (SE) graded exercise test (GXT). Methods: Twenty-two averagely fit females completed 2 GXT protocols to volitional exhaustion on a TM and SE. Peak VO2, HR, VE, TTE, and RER were compared using paired-samples t-tests with significant differences at p≤0.05. Max RPE was compared using a Wilcoxon Signed Rank Test. Results: TM was significantly greater than SE for VO2peak (43.82±1.07 vs 33.97±5.01 ml/kg/min, p<0.01), HR (189±8 vs 182±11 bpm, p<0.01), RPE (18.91+1.11vs 17.26+2.03, p=0.02), VE (95.44±11.26 vs 86.21±2.90 L/min, p=0.015), and TTE (550.16+137.56 vs 391.86±81.20 sec, p<0.01). RER was significantly greater on the SE (1.16±0.08 vs 1.12±0.06, p=0.024). Conclusion: Results suggest that TM elicits higher max values for VO2, HR, TTE, VE, and RPE compared to SE, while SE elicits a higher RER in the current population. SE could be used as an alternative mode of testing in averagely-fit females but does not directly compare to TM values.

scholarly journals Discordant QuantiFERON-TB Gold Test Results Among US Healthcare Workers With Increased Risk of Latent Tuberculosis Infection: A Problem or Solution?

2008 ◽  
Vol 29 (9) ◽  
pp. 878-886 ◽  
Author(s):  
Nira R. Pollock ◽  
Antonio Campos-Neto ◽  
Suely Kashino ◽  
Danielle Napolitano ◽  
Samuel M. Behar ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Test Results ◽  
Negative Results ◽  
Increased Risk ◽  
Release Assay ◽  
Positive Results

Objective.In late 2006, our hospital implemented use of the QuantiFERON-TB Gold (QFT-G) assay, a whole-blood interferon-γ release assay, for detection of tuberculosis infection. All newly hired healthcare workers (HCWs) with positive Mantoux tuberculin skin test (TST) results were routinely tested with the QFT-G assay, to take advantage of its higher specificity. We then undertook a quality assurance review to evaluate the QFT-G test results in HCWs with multiple risk factors for latent tuberculosis infection (LTBI).Methods.The clinical records for TST-positive HCWs tested with the QFT-G assay were reviewed. HCWs with 2 or more risk factors commonly associated with LTBI were classified as “increased risk” (IR). IR HCWs who had negative QFT-G test results underwent repeat QFT-G testing and were offered testing with a different interferon-γ release assay (T-SPOT.TB) and with extended T cell stimulation assays.Results.Ofl43 TST-positive HCWs tested with the QFT-G assay, 26 (18%) had positive results, 115 (81%) had negative results, and 2 (1 %) had indeterminate results. Of 82 IR HCWs, 23 (28%) had positive QFT-G test results, and 57 (70%) had negative results. Of the 57 IR HCWs with negative results, 43 underwent repeat QFT-G testing: 41 had negative results again, and 2 had positive results. These 43 HCWs were also offered additional testing with the T-SPOT.TB diagnostic, and 36 consented: 31/36 tested negative, and 5/36 tested positive. Extended assays using the antigens ESAT-6 and CFP-10 confirmed the positive results detected by the overnight assays and yielded positive results for an additional 7/36 (19%) of individuals; strikingly, all 36 HCWs had strongly positive test results with assays using purified protein derivative.Conclusions.The extreme discordance between the results of our clinical diagnostic algorithm and the results of QFT-G testing raises concern about the sensitivity of the QFT-G assay for detection of LTBI in our HCWs. Results of extended stimulation assays suggest that many of our IR HCWs have indeed been sensitized to Mycobacterium tuberculosis. It is possible that the QFT-G assay identifies those at higher reactivation risk rather than all previously infected, but, in the absence of long-term follow-up data, we should interpret negative QFT-G results with some caution.

scholarly journals Trapeziometacarpal Fusion With and Without Distal Scaphoid Excision: A Cadaveric Model Comparing Thumb Range of Motion

Hand ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. 824-827
Author(s):  
Katherine C. Faust ◽  
Gary M. Lourie
Keyword(s):  
Range Of Motion ◽  
Rank Test ◽  
Test Results ◽  
Signed Rank ◽  
Lateral Plane ◽  
Fresh Frozen ◽  
Signed Rank Test ◽  
Biomechanical Changes ◽  
The Mean ◽  
Thumb Carpometacarpal

Purpose: To describe the biomechanical changes seen after thumb carpometacarpal (CMC) fusion with distal scaphoid excision (DSE), a surgical technique used for pantrapezial disease in high-demand individuals. Methods: A cadaveric study with 13 fresh-frozen cadaveric specimens was conducted. Fluoroscopic measurements in posteroanterior (PA) and lateral planes were performed. Thumb CMC fusion was then simulated. The same images were taken after fusion. The distal scaphoid was excised, and the measurements were obtained again. The angle between the index finger and thumb metacarpals was recorded. Statistical analysis was performed using Wilcoxon signed rank test. Results: The mean arcs of motion in the PA plane pre-fusion, post-fusion, and post-fusion with DSE were 48.5°, 25.1°, and 34.6°, respectively. An increase in arc of 9.5° was obtained after DSE compared with thumb CMC fusion alone. The mean arcs of motion in the lateral plane pre-fusion, post-fusion, and post-fusion with DSE were 53.4°, 22.4°, and 33.6°, respectively. A statistically significant increase in arc of motion of 11.2° in the lateral plane was obtained after DSE compared with thumb CMC fusion alone. This was a 20% and 21% increase in pre-fusion range of motion in the PA and lateral planes, respectively, from fusion alone compared with fusion and DSE. Conclusions: Thumb CMC fusion combined with DSE maintains motion lost in simple CMC arthrodesis.

Sign in / Sign up

Export Citation Format

Share Document